GREMLIN Database
DTPB - Dipeptide and tripeptide permease B
UniProt: P36837 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12232
Length: 489 (461)
Sequences: 4651 (2906)
Seq/√Len: 135.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
166_I178_L4.3181.00
364_A459_G3.5481.00
362_T388_F3.5431.00
281_F392_G3.4551.00
314_F379_P3.4391.00
73_V78_L3.3871.00
49_Q298_N3.2341.00
78_L83_T3.1251.00
93_I114_T2.9621.00
302_H308_S2.9531.00
351_L395_F2.8791.00
73_V77_L2.8691.00
463_L467_G2.8471.00
291_S296_A2.8101.00
293_N296_A2.7411.00
97_M111_A2.7061.00
321_W387_L2.6801.00
97_M114_T2.6371.00
400_G420_W2.5851.00
354_F469_A2.5281.00
167_A312_V2.5251.00
78_L86_L2.5241.00
29_G95_Y2.4891.00
247_I250_T2.4831.00
92_A184_I2.4721.00
198_K201_G2.4641.00
89_L93_I2.4531.00
87_G121_L2.4411.00
383_V387_L2.4391.00
355_M391_L2.4251.00
39_V293_N2.3741.00
303_E308_S2.3631.00
258_F262_K2.3631.00
23_E27_R2.2991.00
296_A382_I2.2311.00
168_D311_P2.2241.00
98_T111_A2.1371.00
328_I332_I2.1311.00
26_E123_K2.1281.00
361_L462_G2.1261.00
99_G180_G2.1211.00
344_S347_M2.1191.00
250_T253_F2.1091.00
81_K194_R2.0601.00
362_T384_L2.0371.00
85_V191_I2.0201.00
325_A391_L2.0181.00
470_V474_L2.0131.00
291_S295_F2.0111.00
282_Y397_S2.0041.00
30_Y60_A1.9951.00
247_I251_I1.9891.00
23_E26_E1.9781.00
145_F405_A1.9771.00
471_V475_M1.9251.00
38_A42_V1.9031.00
335_H339_K1.8701.00
466_L470_V1.8661.00
357_S466_L1.8601.00
317_L383_V1.8601.00
328_I331_G1.8571.00
258_F263_T1.8131.00
67_I74_G1.7931.00
66_L69_I1.7861.00
130_L144_A1.7861.00
47_F55_T1.7491.00
23_E123_K1.7361.00
354_F358_L1.7261.00
94_G115_I1.7121.00
91_L122_F1.6741.00
49_Q294_F1.6701.00
368_M455_T1.6701.00
150_M323_V1.6631.00
332_I336_L1.6551.00
318_N390_S1.6461.00
262_K265_R1.6431.00
194_R199_D1.6381.00
235_V238_A1.6151.00
318_N322_V1.6111.00
66_L116_A1.5971.00
324_L328_I1.5961.00
206_F212_S1.5601.00
293_N297_I1.5571.00
358_L388_F1.5501.00
236_E239_N1.5401.00
43_K172_Y1.5391.00
228_C231_L1.5301.00
171_G174_V1.5291.00
96_F180_G1.5271.00
39_V311_P1.5271.00
280_V468_V1.5221.00
209_M212_S1.5211.00
157_L323_V1.5171.00
239_N242_L1.5141.00
48_S51_Q1.5001.00
310_N313_S1.4871.00
127_A421_F1.4851.00
174_V177_N1.4791.00
469_A473_L1.4781.00
148_F152_I1.4751.00
357_S469_A1.4571.00
56_F290_T1.4461.00
283_I427_A1.4351.00
477_P480_K1.4341.00
197_V201_G1.4231.00
350_T469_A1.4191.00
359_G389_Q1.4141.00
216_Y220_G1.4071.00
41_F56_F1.4051.00
377_T381_F1.3991.00
278_A423_T1.3941.00
246_S250_T1.3911.00
214_L218_L1.3871.00
474_L478_W1.3851.00
164_P312_V1.3841.00
367_G370_F1.3791.00
229_A232_M1.3741.00
94_G118_G1.3501.00
460_K464_V1.3441.00
336_L339_K1.3371.00
24_L151_S1.3361.00
86_L89_L1.3261.00
299_N375_G1.3261.00
255_R268_M1.3241.00
285_Y288_M1.3221.00
150_M326_S1.3071.00
257_A265_R1.3041.00
203_E206_F1.2941.00
54_V436_T1.2871.00
460_K463_L1.2841.00
132_K405_A1.2831.00
153_N318_N1.2771.00
38_A52_A1.2741.00
363_A385_V1.2731.00
302_H311_P1.2681.00
258_F265_R1.2661.00
238_A241_V1.2571.00
350_T473_L1.2541.00
18_M193_C1.2511.00
70_G120_G1.2491.00
166_I170_F1.2471.00
217_V221_S1.2461.00
219_L223_V1.2451.00
205_D208_P1.2451.00
343_L351_L1.2401.00
355_M392_G1.2371.00
331_G335_H1.2361.00
152_I421_F1.2341.00
322_V393_E1.2301.00
321_W390_S1.2291.00
149_Y393_E1.2291.00
92_A96_F1.2281.00
111_A115_I1.2211.00
38_A294_F1.2201.00
32_G163_A1.2181.00
397_S401_L1.2181.00
162_L178_L1.2161.00
119_N123_K1.2071.00
299_N376_L1.1971.00
40_F101_S1.1951.00
24_L154_I1.1921.00
259_K263_T1.1911.00
346_P476_V1.1911.00
206_F211_F1.1850.99
92_A187_L1.1840.99
301_H376_L1.1820.99
201_G206_F1.1820.99
347_M476_V1.1740.99
164_P313_S1.1600.99
459_G463_L1.1580.99
27_R123_K1.1580.99
163_A166_I1.1580.99
207_R213_K1.1530.99
366_A381_F1.1510.99
25_W182_G1.1470.99
27_R30_Y1.1470.99
226_F232_M1.1440.99
78_L82_R1.1430.99
119_N122_F1.1400.99
337_G342_D1.1390.99
336_L341_K1.1390.99
142_D402_A1.1380.99
414_G418_G1.1380.99
365_A369_W1.1340.99
249_V253_F1.1330.99
292_L296_A1.1320.99
127_A148_F1.1290.99
149_Y322_V1.1290.99
134_Y144_A1.1260.99
23_E148_F1.1250.99
349_F396_I1.1240.99
73_V83_T1.1200.99
181_A185_I1.1070.99
254_F257_A1.1030.99
260_L265_R1.1000.99
123_K421_F1.0970.99
458_F461_I1.0880.99
80_T132_K1.0840.99
307_F313_S1.0820.99
387_L391_L1.0790.99
235_V240_L1.0750.99
233_H238_A1.0750.99
228_C232_M1.0740.99
315_Q319_P1.0720.99
165_V170_F1.0700.99
152_I401_L1.0680.99
71_G414_G1.0660.99
156_S319_P1.0630.99
357_S361_L1.0580.99
288_M389_Q1.0570.99
290_T296_A1.0490.99
209_M213_K1.0470.99
236_E240_L1.0470.99
207_R211_F1.0450.99
352_G396_I1.0440.99
101_S107_L1.0430.99
26_E31_Y1.0410.99
188_L192_A1.0410.99
403_M479_L1.0390.99
322_V327_P1.0370.99
210_S213_K1.0340.99
259_K265_R1.0330.99
303_E306_G1.0330.99
326_S398_A1.0250.98
239_N243_I1.0230.98
456_N459_G1.0170.98
63_V116_A1.0150.98
161_S313_S1.0120.98
66_L120_G1.0070.98
302_H310_N1.0060.98
23_E122_F1.0060.98
34_Q56_F1.0050.98
130_L133_C1.0050.98
41_F108_I1.0040.98
63_V66_L1.0030.98
177_N181_A1.0020.98
192_A195_G1.0010.98
208_P212_S1.0010.98
10_L13_P1.0000.98
91_L119_N0.9970.98
263_T266_N0.9960.98
257_A263_T0.9950.98
34_Q286_A0.9940.98
437_F441_P0.9850.98
336_L343_L0.9840.98
47_F51_Q0.9830.98
206_F210_S0.9760.98
358_L362_T0.9740.98
245_L248_V0.9730.98
235_V239_N0.9720.98
477_P481_R0.9710.98
262_K266_N0.9640.98
25_W126_P0.9620.98
55_T109_F0.9610.98
127_A417_L0.9570.98
260_L264_G0.9540.98
237_V241_V0.9540.98
261_D264_G0.9540.98
220_G223_V0.9520.98
216_Y219_L0.9520.98
202_S205_D0.9500.98
335_H338_N0.9500.98
223_V243_I0.9490.98
149_Y153_N0.9490.98
212_S262_K0.9450.97
300_V382_I0.9450.97
27_R31_Y0.9390.97
43_K168_D0.9390.97
257_A260_L0.9380.97
131_S405_A0.9380.97
478_W482_M0.9370.97
177_N180_G0.9370.97
378_S381_F0.9330.97
285_Y390_S0.9310.97
325_A387_L0.9280.97
283_I430_L0.9270.97
234_N239_N0.9250.97
235_V241_V0.9200.97
255_R265_R0.9190.97
54_V432_G0.9190.97
42_V294_F0.9160.97
94_G98_T0.9140.97
393_E397_S0.9080.97
62_L429_L0.9080.97
71_G418_G0.9070.97
12_Q16_F0.9000.97
92_A180_G0.8970.97
299_N454_Y0.8960.96
42_V49_Q0.8950.96
40_F108_I0.8950.96
294_F297_I0.8920.96
204_P220_G0.8890.96
158_I161_S0.8870.96
259_K262_K0.8860.96
39_V43_K0.8840.96
397_S420_W0.8830.96
48_S52_A0.8820.96
292_L297_I0.8810.96
247_I252_I0.8800.96
325_A394_L0.8800.96
317_L321_W0.8800.96
307_F310_N0.8770.96
288_M393_E0.8760.96
234_N237_V0.8750.96
64_Y123_K0.8710.96
321_W383_V0.8690.96
85_V88_A0.8680.96
397_S400_G0.8650.96
51_Q54_V0.8650.96
20_F151_S0.8630.96
260_L263_T0.8620.96
284_L465_T0.8620.96
284_L389_Q0.8580.96
122_F126_P0.8550.95
281_F322_V0.8520.95
278_A420_W0.8510.95
362_T385_V0.8500.95
309_I313_S0.8490.95
255_R259_K0.8490.95
433_Y437_F0.8490.95
247_I253_F0.8490.95
457_V461_I0.8470.95
207_R210_S0.8430.95
24_L152_I0.8420.95
64_Y421_F0.8420.95
292_L385_V0.8410.95
347_M350_T0.8390.95
57_G431_G0.8390.95
237_V240_L0.8370.95
296_A300_V0.8370.95
326_S330_A0.8370.95
467_G471_V0.8340.95
13_P16_F0.8300.95
211_F215_L0.8290.95
164_P167_A0.8280.95
93_I97_M0.8280.95
300_V379_P0.8270.95
329_L391_L0.8270.95
355_M388_F0.8260.94
143_G330_A0.8260.94
220_G225_I0.8200.94
475_M478_W0.8190.94
23_E152_I0.8170.94
331_G334_T0.8130.94
26_E183_L0.8130.94
127_A401_L0.8120.94
367_G455_T0.8110.94
274_L349_F0.8100.94
402_A406_A0.8080.94
284_L356_C0.8060.94
103_L173_S0.8050.94
257_A262_K0.8050.94
277_E472_M0.8040.94
75_D79_G0.8040.94
329_L332_I0.8030.94
407_L483_I0.8020.94
68_S72_Y0.8010.94
167_A171_G0.7990.93
285_Y397_S0.7980.93
221_S226_F0.7960.93
349_F400_G0.7920.93
410_Q413_M0.7920.93
29_G119_N0.7910.93
235_V242_L0.7900.93
168_D312_V0.7880.93
147_L150_M0.7870.93
234_N241_V0.7850.93
285_Y318_N0.7840.93
201_G204_P0.7830.93
132_K413_M0.7830.93
286_A428_F0.7820.93
291_S294_F0.7810.93
275_M404_I0.7790.93
68_S418_G0.7790.93
25_W28_F0.7780.93
27_R152_I0.7760.92
72_Y77_L0.7710.92
18_M196_M0.7700.92
309_I379_P0.7700.92
160_L316_A0.7690.92
292_L386_Y0.7680.92
438_T460_K0.7680.92
302_H379_P0.7670.92
193_C196_M0.7640.92
234_N238_A0.7640.92
467_G474_L0.7630.92
148_F393_E0.7620.92
38_A293_N0.7610.92
63_V125_N0.7610.92
325_A328_I0.7610.92
220_G224_M0.7610.92
286_A424_Q0.7600.92
215_L219_L0.7550.91
162_L166_I0.7530.91
288_M386_Y0.7510.91
165_V169_R0.7510.91
127_A152_I0.7500.91
291_S297_I0.7480.91
36_V175_T0.7470.91
12_Q15_P0.7470.91
239_N251_I0.7470.91
90_V117_V0.7460.91
347_M473_L0.7440.91
375_G378_S0.7440.91
350_T354_F0.7410.91
281_F396_I0.7410.91
85_V187_L0.7360.90
363_A366_A0.7340.90
157_L319_P0.7340.90
148_F401_L0.7310.90
173_S177_N0.7290.90
221_S225_I0.7270.90
350_T476_V0.7260.90
213_K217_V0.7230.90
162_L165_V0.7220.89
283_I434_V0.7210.89
346_P481_R0.7210.89
243_I247_I0.7180.89
236_E243_I0.7140.89
39_V298_N0.7120.89
227_V232_M0.7120.89
82_R86_L0.7120.89
364_A455_T0.7110.89
215_L220_G0.7090.89
26_E30_Y0.7090.89
295_F382_I0.7090.89
90_V111_A0.7090.89
352_G392_G0.7080.89
430_L433_Y0.7060.88
95_Y180_G0.7010.88
245_L249_V0.6990.88
318_N393_E0.6970.88
261_D265_R0.6970.88
234_N242_L0.6940.88
26_E287_Q0.6940.88
234_N270_V0.6920.87
230_W233_H0.6920.87
364_A461_I0.6910.87
220_G231_L0.6900.87
236_E241_V0.6900.87
248_V252_I0.6890.87
281_F318_N0.6890.87
427_A430_L0.6890.87
131_S145_F0.6880.87
193_C197_V0.6860.87
246_S249_V0.6860.87
462_G466_L0.6860.87
280_V464_V0.6850.87
230_W234_N0.6840.87
274_L403_M0.6840.87
217_V222_V0.6830.87
366_A385_V0.6820.87
290_T435_A0.6810.87
365_A368_M0.6810.87
257_A264_G0.6800.86
99_G177_N0.6780.86
222_V226_F0.6780.86
30_Y123_K0.6770.86
255_R262_K0.6770.86
60_A63_V0.6760.86
74_G84_I0.6750.86
240_L243_I0.6750.86
217_V241_V0.6740.86
438_T442_D0.6740.86
83_T121_L0.6730.86
478_W481_R0.6720.86
153_N319_P0.6700.86
223_V226_F0.6690.86
170_F310_N0.6670.85
254_F268_M0.6670.85
39_V42_V0.6650.85
86_L191_I0.6650.85
85_V89_L0.6640.85
38_A53_F0.6640.85
244_V250_T0.6630.85
191_I194_R0.6610.85
220_G248_V0.6600.85
190_Y194_R0.6590.85
14_R17_F0.6590.85
124_A128_S0.6580.85
233_H242_L0.6560.84
258_F261_D0.6560.84
64_Y153_N0.6540.84
333_Y342_D0.6540.84
279_V427_A0.6530.84
236_E242_L0.6520.84
274_L475_M0.6520.84
288_M318_N0.6510.84
62_L116_A0.6490.84
213_K241_V0.6470.84
204_P208_P0.6470.84
364_A368_M0.6440.83
88_A183_L0.6440.83
329_L394_L0.6440.83
471_V474_L0.6420.83
233_H236_E0.6420.83
65_G428_F0.6410.83
472_M476_V0.6400.83
47_F105_P0.6400.83
216_Y257_A0.6380.83
157_L320_F0.6370.83
36_V41_F0.6370.83
290_T294_F0.6360.83
218_L221_S0.6350.83
238_A246_S0.6350.83
84_I190_Y0.6350.83
216_Y223_V0.6330.82
153_N156_S0.6330.82
288_M359_G0.6330.82
255_R260_L0.6320.82
241_V246_S0.6320.82
153_N393_E0.6310.82
126_P152_I0.6310.82
287_Q291_S0.6310.82
238_A242_L0.6280.82
128_S417_L0.6270.82
167_A170_F0.6260.82
40_F330_A0.6260.82
224_M227_V0.6250.82
53_F438_T0.6240.81
255_R269_F0.6240.81
42_V297_I0.6230.81
149_Y318_N0.6230.81
239_N266_N0.6200.81
271_A404_I0.6190.81
167_A172_Y0.6180.81
334_T337_G0.6170.81
456_N463_L0.6160.81
350_T472_M0.6160.81
226_F231_L0.6150.80
54_V58_A0.6150.80
84_I414_G0.6140.80
149_Y315_Q0.6140.80
364_A367_G0.6120.80
17_F21_F0.6120.80
126_P129_L0.6110.80
125_N414_G0.6110.80
168_D302_H0.6090.80
243_I246_S0.6080.80
57_G432_G0.6070.80
337_G340_G0.6070.80
70_G134_Y0.6060.80
122_F125_N0.6060.80
333_Y337_G0.6060.80
333_Y343_L0.6060.80
224_M230_W0.6040.79
127_A397_S0.6040.79
212_S215_L0.6040.79
31_Y319_P0.6040.79
20_F24_L0.6030.79
431_G461_I0.6020.79
18_M189_V0.6020.79
282_Y285_Y0.6010.79
96_F100_M0.6010.79
249_V252_I0.6000.79
396_I420_W0.6000.79
27_R183_L0.5980.79
145_F274_L0.5980.79
22_V151_S0.5960.78
92_A150_M0.5940.78
36_V49_Q0.5920.78
99_G187_L0.5910.78
27_R119_N0.5900.78
320_F324_L0.5900.78
356_C359_G0.5900.78
153_N397_S0.5890.78
23_E32_G0.5880.77
95_Y183_L0.5870.77
148_F408_V0.5860.77
294_F298_N0.5840.77
115_I120_G0.5840.77
248_V251_I0.5840.77
165_V312_V0.5830.77
122_F148_F0.5810.77
339_K361_L0.5810.77
203_E210_S0.5810.77
135_P198_K0.5800.77
174_V179_C0.5800.77
339_K342_D0.5800.77
217_V224_M0.5800.77
254_F258_F0.5800.77
73_V250_T0.5790.76
125_N179_C0.5790.76
203_E207_R0.5780.76
159_A431_G0.5760.76
208_P211_F0.5760.76
27_R32_G0.5740.76
355_M395_F0.5740.76
333_Y340_G0.5730.76
222_V225_I0.5710.75
270_V482_M0.5700.75
366_A377_T0.5690.75
150_M154_I0.5680.75
335_H340_G0.5670.75
42_V52_A0.5670.75
273_V479_L0.5660.75
356_C465_T0.5650.75
280_V392_G0.5620.74
361_L365_A0.5620.74
15_P18_M0.5610.74
224_M229_A0.5610.74
184_I211_F0.5600.74
53_F290_T0.5580.74
234_N240_L0.5550.73
435_A438_T0.5550.73
255_R258_F0.5540.73
95_Y99_G0.5530.73
309_I387_L0.5530.73
237_V242_L0.5510.73
233_H239_N0.5510.73
64_Y318_N0.5510.73
230_W235_V0.5500.73
69_I427_A0.5490.73
142_D348_K0.5490.73
322_V326_S0.5480.72
172_Y176_Y0.5480.72
64_Y148_F0.5480.72
56_F428_F0.5480.72
106_D110_I0.5470.72
284_L461_I0.5470.72
27_R148_F0.5470.72
239_N256_Q0.5460.72
213_K216_Y0.5460.72
299_N374_Q0.5460.72
257_A261_D0.5450.72
146_T330_A0.5450.72
41_F45_L0.5440.72
158_I162_L0.5430.72
91_L115_I0.5420.72
358_L361_L0.5420.72
220_G228_C0.5400.71
213_K220_G0.5400.71
150_M327_P0.5390.71
456_N460_K0.5390.71
401_L417_L0.5370.71
460_K467_G0.5370.71
43_K297_I0.5360.71
26_E32_G0.5360.71
25_W29_G0.5350.71
80_T414_G0.5330.70
465_T469_A0.5330.70
284_L462_G0.5330.70
149_Y152_I0.5330.70
454_Y457_V0.5320.70
88_A179_C0.5310.70
14_R196_M0.5310.70
222_V227_V0.5300.70
466_L469_A0.5300.70
64_Y152_I0.5290.70
49_Q53_F0.5280.70
213_K228_C0.5280.70
185_I189_V0.5270.69
206_F209_M0.5270.69
61_A429_L0.5270.69
32_G79_G0.5260.69
318_N389_Q0.5250.69
411_H418_G0.5230.69
53_F294_F0.5220.69
103_L115_I0.5210.69
212_S228_C0.5200.68
215_L240_L0.5190.68
244_V248_V0.5160.68
23_E30_Y0.5160.68
94_G111_A0.5150.68
59_F63_V0.5150.68
122_F127_A0.5150.68
35_G160_L0.5150.68
238_A252_I0.5140.68
26_E122_F0.5130.67
234_N243_I0.5120.67
437_F440_V0.5100.67
354_F470_V0.5100.67
152_I397_S0.5090.67
168_D310_N0.5090.67
56_F112_L0.5080.67
30_Y34_Q0.5080.67
50_E53_F0.5080.67
145_F408_V0.5080.67
82_R231_L0.5080.67
12_Q134_Y0.5070.67
393_E400_G0.5070.67
66_L87_G0.5060.66
28_F182_G0.5060.66
29_G33_V0.5060.66
61_A367_G0.5040.66
161_S316_A0.5040.66
88_A125_N0.5040.66
157_L316_A0.5030.66
218_L227_V0.5030.66
125_N134_Y0.5010.66
65_G69_I0.5010.66
379_P382_I0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4oh3A 2 0.9714 100 0.521 Contact Map
4uvmA 1 0.9591 100 0.53 Contact Map
4q65A 1 0.8773 100 0.596 Contact Map
4tphA 2 0.8916 100 0.614 Contact Map
4ikvA 1 0.955 100 0.632 Contact Map
4xnjA 1 0.9121 100 0.643 Contact Map
4w6vA 1 0.9387 100 0.731 Contact Map
2cfqA 1 0.8364 99.9 0.772 Contact Map
3wdoA 1 0.816 99.9 0.772 Contact Map
4pypA 1 0.8773 99.9 0.776 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0138 seconds.