GREMLIN Database
LRHA - Probable HTH-type transcriptional regulator LrhA
UniProt: P36771 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12123
Length: 312 (275)
Sequences: 79601 (58363)
Seq/√Len: 3519.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
80_K84_F3.6541.00
25_L34_A3.4331.00
164_L285_E2.7181.00
77_Y91_S2.4631.00
104_G149_V2.4161.00
21_A34_A2.3051.00
229_V236_T2.2991.00
120_R287_Y2.2801.00
170_P240_V2.2591.00
168_T263_E2.2211.00
100_V131_D2.2161.00
165_N168_T2.2081.00
100_V129_A2.1441.00
165_N263_E2.1121.00
30_A33_A2.0951.00
55_K70_H2.0941.00
168_T261_D2.0741.00
24_D79_R2.0661.00
18_T45_Q2.0411.00
120_R283_A2.0031.00
77_Y84_F1.9871.00
102_T131_D1.9861.00
20_V75_L1.9801.00
20_V79_R1.9791.00
226_R246_D1.9601.00
20_V24_D1.9161.00
21_A25_L1.9051.00
21_A24_D1.9021.00
140_M152_M1.9001.00
172_H240_V1.8871.00
81_I85_N1.8771.00
23_A67_L1.8751.00
188_P191_L1.8641.00
18_T42_V1.8611.00
179_Y195_P1.8471.00
75_L79_R1.8121.00
28_F46_M1.7731.00
230_K246_D1.7721.00
59_A66_L1.7481.00
73_Q91_S1.6811.00
163_A265_L1.6761.00
74_L88_A1.6751.00
143_M148_E1.6271.00
23_A75_L1.6101.00
121_V280_I1.5751.00
25_L30_A1.5731.00
20_V78_A1.5661.00
162_K270_P1.5561.00
19_F75_L1.5411.00
184_G191_L1.5391.00
18_T37_R1.5381.00
24_D34_A1.5371.00
15_L52_L1.5091.00
196_S216_A1.5031.00
29_A39_Q1.5011.00
15_L45_Q1.4941.00
96_N127_K1.4871.00
121_V128_L1.4791.00
77_Y80_K1.4691.00
156_H265_L1.4561.00
164_L268_Y1.4521.00
15_L48_R1.4521.00
142_E146_S1.4501.00
27_T30_A1.4471.00
38_T41_A1.4441.00
69_E72_I1.4381.00
12_D15_L1.4261.00
56_E59_A1.4191.00
281_Y285_E1.4151.00
21_A35_V1.4081.00
162_K268_Y1.3991.00
154_T267_C1.3961.00
20_V82_L1.3871.00
273_N277_A1.3871.00
77_Y87_E1.3761.00
268_Y281_Y1.3561.00
81_I88_A1.3461.00
102_T133_R1.3411.00
111_D223_P1.3351.00
120_R124_V1.3351.00
98_Q127_K1.3331.00
169_S241_E1.3201.00
279_V282_Q1.3151.00
266_L281_Y1.2981.00
143_M149_V1.2971.00
144_L152_M1.2941.00
13_L85_N1.2911.00
250_L254_D1.2911.00
74_L89_C1.2831.00
199_R203_L1.2821.00
175_C235_V1.2801.00
61_H66_L1.2761.00
124_V283_A1.2721.00
225_V236_T1.2641.00
151_L277_A1.2621.00
84_F87_E1.2601.00
230_K251_S1.2541.00
151_L266_L1.2521.00
76_G80_K1.2381.00
145_E160_A1.2251.00
77_Y88_A1.2231.00
227_A230_K1.2131.00
122_S216_A1.2121.00
172_H254_D1.2081.00
73_Q76_G1.1961.00
47_Q51_Q1.1901.00
165_N265_L1.1761.00
72_I76_G1.1751.00
119_N123_S1.1751.00
240_V244_S1.1591.00
19_F58_F1.1541.00
37_R41_A1.1451.00
163_A267_C1.1441.00
120_R123_S1.1381.00
192_L197_P1.1361.00
190_V193_D1.1341.00
52_L89_C1.1211.00
44_Q47_Q1.1201.00
119_N231_A1.1181.00
19_F23_A1.1111.00
44_Q48_R1.1101.00
125_Y279_V1.1001.00
187_I191_L1.0941.00
269_D272_S1.0901.00
206_L211_I1.0891.00
282_Q285_E1.0791.00
219_A225_V1.0781.00
19_F57_L1.0761.00
135_K143_M1.0751.00
190_V197_P1.0691.00
28_F65_K1.0681.00
283_A287_Y1.0681.00
80_K87_E1.0681.00
43_S47_Q1.0671.00
101_L280_I1.0591.00
110_A134_V1.0571.00
73_Q77_Y1.0511.00
131_D218_V1.0511.00
14_D17_R1.0491.00
81_I84_F1.0491.00
278_Q282_Q1.0421.00
226_R230_K1.0411.00
185_E253_V1.0361.00
16_L78_A1.0351.00
116_F231_A1.0311.00
22_V31_A1.0301.00
240_V254_D1.0301.00
21_A31_A1.0281.00
17_R86_D1.0281.00
164_L281_Y1.0251.00
176_A232_G1.0231.00
121_V283_A1.0221.00
117_L284_M1.0221.00
198_F234_G1.0191.00
45_Q48_R1.0181.00
244_S248_R1.0171.00
227_A231_A1.0061.00
175_C179_Y1.0011.00
245_P249_V0.9961.00
177_A251_S0.9931.00
247_L250_L0.9801.00
200_D205_T0.9761.00
89_C93_M0.9751.00
190_V198_F0.9711.00
170_P261_D0.9681.00
173_W235_V0.9681.00
86_D90_S0.9681.00
246_D251_S0.9671.00
190_V195_P0.9611.00
86_D89_C0.9611.00
200_D203_L0.9561.00
67_L71_G0.9521.00
83_R87_E0.9461.00
23_A58_F0.9431.00
283_A286_S0.9421.00
37_R42_V0.9401.00
219_A228_A0.9401.00
18_T35_V0.9391.00
11_L52_L0.9381.00
121_V125_Y0.9351.00
174_Y243_M0.9351.00
143_M146_S0.9341.00
180_I195_P0.9331.00
74_L78_A0.9281.00
124_V286_S0.9201.00
133_R143_M0.9101.00
19_F67_L0.9091.00
31_A42_V0.9081.00
160_A270_P0.9061.00
175_C253_V0.9051.00
55_K92_L0.9051.00
22_V28_F0.9041.00
48_R51_Q0.9031.00
117_L283_A0.8971.00
274_N277_A0.8941.00
19_F49_L0.8901.00
104_G140_M0.8891.00
58_F65_K0.8841.00
30_A34_A0.8831.00
246_D249_V0.8801.00
76_G79_R0.8721.00
149_V152_M0.8691.00
195_P235_V0.8651.00
191_L195_P0.8641.00
26_N66_L0.8581.00
61_H64_N0.8571.00
175_C180_I0.8561.00
122_S196_S0.8511.00
129_A214_R0.8441.00
80_K83_R0.8431.00
156_H263_E0.8421.00
254_D257_P0.8411.00
162_K165_N0.8381.00
23_A71_G0.8371.00
174_Y236_T0.8351.00
99_G276_L0.8301.00
107_D221_T0.8291.00
192_L196_S0.8271.00
191_L197_P0.8251.00
104_G154_T0.8251.00
128_L276_L0.8241.00
179_Y196_S0.8241.00
282_Q286_S0.8191.00
200_D204_A0.8181.00
29_A33_A0.8181.00
161_F267_C0.8161.00
141_A145_E0.8161.00
133_R149_V0.8111.00
103_I151_L0.8091.00
14_D45_Q0.8061.00
70_H92_L0.8051.00
35_V42_V0.8051.00
205_T209_A0.8041.00
135_K140_M0.7961.00
170_P254_D0.7931.00
177_A249_V0.7931.00
104_G152_M0.7901.00
13_L82_L0.7901.00
187_I190_V0.7861.00
196_S214_R0.7821.00
180_I185_E0.7811.00
119_N233_L0.7781.00
199_R205_T0.7751.00
273_N278_Q0.7751.00
47_Q56_E0.7741.00
19_F74_L0.7691.00
26_N72_I0.7671.00
176_A233_L0.7661.00
23_A26_N0.7651.00
99_G128_L0.7531.00
85_N88_A0.7481.00
117_L287_Y0.7431.00
84_F88_A0.7431.00
275_E279_V0.7421.00
189_L192_L0.7411.00
25_L31_A0.7401.00
228_A233_L0.7391.00
24_D75_L0.7381.00
39_Q43_S0.7371.00
87_E91_S0.7371.00
183_K196_S0.7371.00
26_N64_N0.7361.00
85_N89_C0.7361.00
151_L280_I0.7361.00
122_S233_L0.7351.00
97_L125_Y0.7341.00
22_V46_M0.7341.00
70_H73_Q0.7331.00
145_E161_F0.7291.00
191_L194_D0.7281.00
22_V58_F0.7201.00
120_R286_S0.7141.00
243_M246_D0.7141.00
15_L18_T0.7131.00
121_V279_V0.7101.00
17_R21_A0.7101.00
124_V279_V0.7101.00
88_A92_L0.7091.00
251_S255_G0.7041.00
59_A68_T0.7021.00
199_R218_V0.6971.00
28_F42_V0.6921.00
105_A110_A0.6921.00
67_L72_I0.6911.00
174_Y238_R0.6901.00
179_Y183_K0.6891.00
176_A179_Y0.6881.00
78_A81_I0.6821.00
204_A207_N0.6811.00
204_A208_K0.6791.00
203_L207_N0.6781.00
79_R83_R0.6781.00
41_A45_Q0.6751.00
202_V206_L0.6741.00
22_V42_V0.6731.00
201_M205_T0.6731.00
179_Y182_Q0.6711.00
66_L72_I0.6701.00
239_P242_M0.6651.00
221_T224_A0.6621.00
72_I75_L0.6601.00
70_H74_L0.6591.00
189_L259_L0.6501.00
50_E55_K0.6491.00
87_E90_S0.6491.00
150_D277_A0.6491.00
11_L89_C0.6481.00
147_Q269_D0.6481.00
230_K249_V0.6441.00
102_T149_V0.6431.00
279_V283_A0.6431.00
59_A64_N0.6411.00
174_Y247_L0.6371.00
250_L256_L0.6371.00
69_E73_Q0.6351.00
83_R86_D0.6341.00
186_P256_L0.6321.00
178_E232_G0.6291.00
74_L92_L0.6291.00
102_T150_D0.6271.00
111_D227_A0.6221.00
202_V205_T0.6211.00
129_A218_V0.6211.00
198_F225_V0.6151.00
251_S254_D0.6151.00
107_D136_R0.6141.00
201_M204_A0.6141.00
77_Y81_I0.6131.00
14_D48_R0.6081.00
33_A36_C0.6071.00
105_A114_L0.6071.00
196_S215_L0.6041.00
245_P248_R0.6031.00
17_R20_V0.6021.00
50_E60_R0.6001.00
217_Y228_A0.5981.00
155_T262_T0.5961.00
46_M50_E0.5961.00
101_L276_L0.5951.00
206_L213_W0.5951.00
22_V27_T0.5941.00
78_A82_L0.5941.00
192_L195_P0.5941.00
153_V284_M0.5921.00
173_W237_A0.5871.00
31_A35_V0.5851.00
181_L184_G0.5851.00
114_L117_L0.5841.00
189_L197_P0.5821.00
247_L254_D0.5811.00
197_P213_W0.5771.00
268_Y278_Q0.5761.00
116_F120_R0.5751.00
243_M247_L0.5731.00
190_V196_S0.5711.00
169_S262_T0.5711.00
151_L281_Y0.5691.00
90_S94_F0.5681.00
73_Q92_L0.5661.00
280_I284_M0.5631.00
205_T208_K0.5631.00
134_V220_S0.5621.00
228_A234_G0.5621.00
275_E278_Q0.5591.00
193_D196_S0.5581.00
98_Q129_A0.5571.00
55_K59_A0.5561.00
28_F64_N0.5561.00
67_L75_L0.5541.00
167_R264_Y0.5511.00
253_V257_P0.5511.00
41_A44_Q0.5501.00
116_F119_N0.5501.00
14_D18_T0.5501.00
134_V221_T0.5501.00
144_L267_C0.5491.00
101_L151_L0.5461.00
203_L206_L0.5461.00
179_Y235_V0.5461.00
40_S44_Q0.5451.00
195_P198_F0.5431.00
144_L161_F0.5431.00
109_S113_I0.5401.00
178_E182_Q0.5391.00
17_R82_L0.5351.00
219_A224_A0.5351.00
53_V92_L0.5341.00
162_K271_S0.5341.00
171_T237_A0.5341.00
175_C255_G0.5321.00
178_E181_L0.5311.00
192_L198_F0.5301.00
38_T44_Q0.5281.00
58_F67_L0.5271.00
225_V229_V0.5271.00
76_G91_S0.5221.00
118_L130_L0.5221.00
238_R243_M0.5211.00
53_V74_L0.5211.00
125_Y128_L0.5141.00
53_V56_E0.5131.00
99_G127_K0.5131.00
181_L187_I0.5101.00
82_L86_D0.5101.00
175_C181_L0.5101.00
257_P260_P0.5071.00
174_Y252_G0.5051.00
194_D197_P0.5041.00
222_L239_P0.5031.00
111_D221_T0.5021.00
180_I184_G0.5021.00
183_K186_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ixcA 4 0.8974 100 0.209 Contact Map
2esnA 3 0.9135 100 0.215 Contact Map
2h98A 2 0.6474 100 0.219 Contact Map
2h9bA 2 0.6474 100 0.222 Contact Map
1uthA 2 0.6795 100 0.222 Contact Map
3fzvA 4 0.8814 100 0.226 Contact Map
1al3A 1 0.6923 100 0.234 Contact Map
4x6gA 4 0.9359 100 0.235 Contact Map
3fxqA 3 0.891 100 0.239 Contact Map
3szpA 3 0.8846 100 0.244 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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