GREMLIN Database
RDGC - Recombination-associated protein RdgC
UniProt: P36767 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12158
Length: 303 (296)
Sequences: 714 (490)
Seq/√Len: 28.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
128_M150_T5.6551.00
45_W157_S4.8211.00
84_L111_V4.3771.00
79_V120_F3.7371.00
73_K121_S3.7281.00
84_L107_L3.4651.00
234_L242_F3.3031.00
66_I128_M3.1391.00
131_D134_N3.1221.00
81_K85_E3.0981.00
66_I150_T3.0871.00
67_C127_M2.9351.00
90_K94_E2.8401.00
196_E208_R2.7581.00
63_Q129_W2.7261.00
57_T64_I2.6250.99
212_Q227_K2.5670.99
172_I176_L2.4520.99
110_E114_S2.4250.99
91_L99_L2.2950.99
87_K114_S2.2600.98
250_L289_L2.2070.98
129_W138_M2.1930.98
270_D273_Q2.1460.98
32_F69_R2.1330.98
175_T297_L2.1230.98
242_F289_L2.1070.97
97_R103_E2.0860.97
243_V252_R2.0720.97
3_W282_M2.0710.97
62_G132_T2.0200.97
82_Q123_F2.0090.97
148_E155_R2.0030.97
43_M68_A1.9940.96
172_I248_G1.9570.96
63_Q283_T1.9540.96
77_S191_L1.9420.96
87_K110_E1.9390.96
223_I278_D1.8770.95
196_E231_K1.7880.94
72_E151_L1.7520.93
136_L290_I1.7520.93
84_L88_I1.7390.93
244_M297_L1.7380.93
189_F296_G1.7370.93
24_E55_A1.7050.92
58_H276_D1.7020.92
67_C125_Q1.6990.92
39_D42_K1.6960.92
75_L79_V1.6690.91
194_E252_R1.6660.91
274_R278_D1.6640.91
36_G39_D1.6620.91
176_L244_M1.6510.90
89_A93_A1.6470.90
292_N296_G1.6260.90
129_W283_T1.6240.90
19_R22_E1.6180.90
255_F259_L1.5920.89
62_G133_V1.5610.88
65_V279_F1.5360.87
88_I99_L1.5090.86
239_R285_E1.5050.86
188_G292_N1.5030.86
155_R160_S1.5000.86
234_L244_M1.4660.84
79_V115_L1.4410.83
131_D287_A1.4330.83
4_F282_M1.4210.82
106_S110_E1.4180.82
33_T42_K1.4120.82
9_V138_M1.4110.82
178_E182_S1.4040.81
32_F121_S1.3960.81
40_M112_L1.3920.81
134_N291_Q1.3860.81
235_D238_Q1.3840.81
83_A86_A1.3770.80
71_E123_F1.3540.79
155_R159_G1.3450.79
69_R125_Q1.3400.78
209_A219_I1.3350.78
153_L157_S1.3320.78
196_E206_V1.3240.77
33_T39_D1.3080.77
83_A87_K1.3060.76
218_E227_K1.2940.76
20_A57_T1.2860.75
124_S146_K1.2780.75
198_K228_V1.2520.73
101_K105_D1.2410.73
171_P176_L1.2370.72
11_R136_L1.2340.72
151_L163_V1.2250.72
231_K243_V1.2230.72
91_L95_Q1.2010.70
11_R298_G1.1940.70
255_F282_M1.1800.69
84_L104_K1.1800.69
218_E253_L1.1730.68
108_K112_L1.1680.68
49_M275_F1.1670.68
38_Q113_H1.1640.68
88_I104_K1.1630.68
177_T212_Q1.1500.67
31_A56_L1.1430.66
152_A195_A1.1430.66
7_L253_L1.1390.66
3_W252_R1.1340.66
138_M250_L1.1140.64
50_G58_H1.1120.64
148_E151_L1.1030.63
177_T229_V1.1020.63
45_W236_W1.0970.63
9_V290_I1.0950.63
237_Q288_A1.0940.63
10_Y181_R1.0870.62
145_K219_I1.0860.62
238_Q258_E1.0840.62
36_G280_I1.0820.62
76_P119_A1.0740.61
263_N278_D1.0680.61
7_L138_M1.0670.61
285_E288_A1.0640.61
136_L166_L1.0570.60
83_A111_V1.0560.60
127_M140_D1.0520.60
80_I267_D1.0500.60
30_M156_K1.0490.59
38_Q94_E1.0430.59
168_M176_L1.0390.59
66_I77_S1.0370.59
222_H227_K1.0320.58
63_Q131_D1.0230.58
233_A243_V1.0190.57
114_S118_R1.0190.57
100_K205_G1.0190.57
3_W75_L1.0140.57
217_E225_A1.0060.56
45_W154_L1.0060.56
76_P120_F1.0050.56
76_P79_V1.0030.56
240_I253_L0.9940.55
59_V62_G0.9920.55
294_I299_G0.9840.55
106_S171_P0.9710.54
280_I284_G0.9660.53
65_V275_F0.9650.53
7_L255_F0.9640.53
158_L250_L0.9620.53
118_R212_Q0.9570.52
276_D285_E0.9550.52
202_E217_E0.9550.52
137_I151_L0.9550.52
75_L112_L0.9510.52
64_I132_T0.9500.52
80_I240_I0.9420.51
59_V64_I0.9330.51
235_D241_Q0.9330.51
112_L145_K0.9310.50
220_T223_I0.9270.50
63_Q287_A0.9250.50
101_K164_V0.9220.50
68_A153_L0.9220.50
79_V108_K0.9210.50
45_W275_F0.9200.50
139_V142_A0.9160.49
61_N283_T0.9110.49
212_Q218_E0.9040.48
173_E228_V0.9010.48
66_I130_I0.8970.48
232_L242_F0.8910.47
81_K190_Q0.8880.47
152_A248_G0.8860.47
242_F257_D0.8860.47
3_W79_V0.8760.46
188_G296_G0.8730.46
68_A149_D0.8710.46
47_P234_L0.8670.46
21_E25_K0.8650.45
244_M250_L0.8640.45
3_W142_A0.8610.45
85_E104_K0.8590.45
165_P176_L0.8560.45
190_Q235_D0.8560.45
9_V166_L0.8540.45
207_I212_Q0.8500.44
193_D211_K0.8450.44
5_K199_S0.8430.44
217_E220_T0.8420.44
185_A189_F0.8380.43
152_A156_K0.8340.43
250_L293_L0.8320.43
292_N295_E0.8320.43
20_A283_T0.8310.43
194_E202_E0.8220.42
192_L235_D0.8210.42
92_E253_L0.8170.42
139_V287_A0.8170.42
110_E113_H0.8160.42
95_Q202_E0.8150.42
107_L238_Q0.8100.41
109_D151_L0.8090.41
197_L217_E0.8060.41
26_Q30_M0.8030.41
189_F292_N0.8010.40
88_I103_E0.7990.40
71_E194_E0.7960.40
183_G191_L0.7960.40
69_R123_F0.7820.39
4_F45_W0.7800.39
78_P111_V0.7800.39
76_P244_M0.7780.39
92_E248_G0.7760.39
8_M192_L0.7750.39
155_R162_P0.7740.39
66_I202_E0.7720.38
185_A191_L0.7710.38
166_L294_I0.7710.38
199_S253_L0.7690.38
43_M70_K0.7690.38
236_W275_F0.7650.38
83_A114_S0.7620.38
195_A263_N0.7610.38
236_W292_N0.7610.38
134_N287_A0.7590.37
189_F234_L0.7580.37
81_K108_K0.7570.37
26_Q157_S0.7560.37
272_A298_G0.7540.37
71_E82_Q0.7530.37
198_K206_V0.7520.37
42_K226_G0.7440.36
101_K268_R0.7440.36
258_E289_L0.7430.36
59_V132_T0.7400.36
160_S165_P0.7390.36
122_R242_F0.7370.36
75_L121_S0.7360.36
61_N133_V0.7310.35
102_T181_R0.7300.35
168_M248_G0.7270.35
170_N174_L0.7250.35
191_L233_A0.7230.35
8_M144_A0.7140.34
72_E122_R0.7120.34
166_L257_D0.7110.34
150_T270_D0.7100.34
73_K91_L0.7100.34
86_A149_D0.7090.34
199_S202_E0.7060.34
57_T294_I0.7050.34
9_V281_L0.7050.34
58_H279_F0.7030.33
57_T66_I0.7020.33
80_I123_F0.7020.33
142_A207_I0.7000.33
84_L112_L0.6980.33
217_E221_N0.6970.33
188_G237_Q0.6970.33
68_A150_T0.6960.33
22_E238_Q0.6950.33
236_W259_L0.6940.33
8_M45_W0.6940.33
192_L199_S0.6920.33
91_L98_K0.6910.33
20_A59_V0.6900.33
62_G98_K0.6900.33
115_L256_C0.6800.32
74_I78_P0.6790.32
109_D180_V0.6790.32
100_K106_S0.6750.32
22_E158_L0.6740.31
31_A248_G0.6730.31
239_R288_A0.6710.31
91_L97_R0.6700.31
67_C207_I0.6690.31
142_A295_E0.6650.31
104_K297_L0.6630.31
57_T94_E0.6610.31
162_P204_G0.6600.31
17_S273_Q0.6570.30
43_M149_D0.6560.30
142_A286_L0.6560.30
240_I289_L0.6550.30
131_D226_G0.6550.30
117_P179_W0.6530.30
201_L292_N0.6530.30
60_A77_S0.6520.30
74_I114_S0.6510.30
179_W186_A0.6500.30
88_I111_V0.6480.30
2_L260_R0.6480.30
65_V281_L0.6470.30
49_M58_H0.6460.30
2_L127_M0.6440.30
100_K168_M0.6420.29
133_V291_Q0.6390.29
124_S247_D0.6350.29
211_K227_K0.6340.29
64_I130_I0.6340.29
122_R261_D0.6340.29
172_I211_K0.6330.29
145_K189_F0.6330.29
188_G222_H0.6310.29
121_S142_A0.6300.29
84_L108_K0.6280.28
229_V297_L0.6270.28
72_E255_F0.6260.28
89_A166_L0.6240.28
48_P275_F0.6230.28
194_E210_K0.6210.28
45_W176_L0.6200.28
53_S272_A0.6190.28
103_E109_D0.6180.28
33_T46_V0.6170.28
148_E166_L0.6160.28
240_I258_E0.6160.28
123_F157_S0.6150.28
87_K189_F0.6150.28
171_P174_L0.6140.28
6_N140_D0.6100.27
67_C128_M0.6100.27
23_M282_M0.6080.27
235_D256_C0.6080.27
46_V105_D0.6050.27
35_C71_E0.6050.27
106_S109_D0.6040.27
126_T264_E0.6020.27
138_M290_I0.6010.27
11_R299_G0.6010.27
187_Q295_E0.6010.27
173_E223_I0.6010.27
127_M219_I0.6010.27
138_M253_L0.6000.27
99_L262_Q0.5990.27
202_E205_G0.5990.27
74_I79_V0.5980.27
73_K103_E0.5980.27
71_E107_L0.5980.27
89_A291_Q0.5980.27
107_L280_I0.5950.26
156_K260_R0.5950.26
30_M136_L0.5910.26
191_L264_E0.5900.26
193_D254_K0.5900.26
20_A64_I0.5890.26
154_L161_L0.5870.26
138_M203_D0.5870.26
85_E122_R0.5860.26
105_D152_A0.5850.26
12_L128_M0.5840.26
77_S217_E0.5830.26
77_S293_L0.5830.26
156_K199_S0.5830.26
17_S231_K0.5830.26
41_A95_Q0.5820.26
252_R276_D0.5820.26
168_M299_G0.5810.26
98_K109_D0.5790.26
80_I115_L0.5780.25
68_A232_L0.5780.25
45_W63_Q0.5780.25
80_I235_D0.5770.25
10_Y195_A0.5760.25
68_A168_M0.5760.25
111_V262_Q0.5750.25
160_S195_A0.5740.25
157_S169_E0.5730.25
15_E73_K0.5720.25
196_E246_D0.5720.25
137_I238_Q0.5720.25
77_S234_L0.5690.25
7_L142_A0.5680.25
89_A98_K0.5680.25
247_D274_R0.5680.25
168_M192_L0.5660.25
96_A99_L0.5650.25
129_W209_A0.5640.25
199_S241_Q0.5630.25
21_E93_A0.5630.25
56_L277_A0.5610.24
39_D199_S0.5600.24
201_L204_G0.5590.24
172_I297_L0.5570.24
284_G288_A0.5560.24
77_S80_I0.5550.24
155_R214_L0.5540.24
95_Q168_M0.5540.24
90_K282_M0.5530.24
157_S186_A0.5530.24
236_W289_L0.5530.24
161_L177_T0.5530.24
59_V283_T0.5520.24
143_S146_K0.5510.24
142_A147_A0.5500.24
204_G228_V0.5490.24
5_K171_P0.5490.24
30_M45_W0.5490.24
189_F230_T0.5480.24
54_D80_I0.5480.24
189_F240_I0.5480.24
212_Q273_Q0.5480.24
56_L219_I0.5480.24
34_P249_S0.5470.24
162_P270_D0.5460.24
139_V155_R0.5460.24
169_E237_Q0.5460.24
96_A238_Q0.5450.24
216_S219_I0.5420.23
71_E118_R0.5410.23
107_L213_D0.5380.23
25_K28_A0.5370.23
269_E273_Q0.5340.23
75_L95_Q0.5320.23
59_V80_I0.5320.23
24_E262_Q0.5290.23
161_L274_R0.5280.23
43_M274_R0.5270.23
166_L199_S0.5270.23
11_R150_T0.5270.23
31_A54_D0.5260.23
107_L187_Q0.5250.22
148_E214_L0.5240.22
110_E203_D0.5230.22
113_H297_L0.5220.22
263_N274_R0.5220.22
180_V229_V0.5220.22
74_I122_R0.5210.22
118_R218_E0.5200.22
88_I182_S0.5190.22
152_A263_N0.5180.22
15_E135_G0.5180.22
80_I233_A0.5160.22
12_L282_M0.5150.22
22_E80_I0.5120.22
182_S223_I0.5080.22
12_L163_V0.5070.22
88_I97_R0.5050.21
9_V250_L0.5010.21
158_L277_A0.5010.21
30_M157_S0.5000.21
28_A107_L0.5000.21
139_V250_L0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2owlA 2 0.9967 100 0.033 Contact Map
2owyA 2 0.9967 100 0.043 Contact Map
3gmeA 3 0.7591 14.6 0.97 Contact Map
3h7hB 1 0.2937 14.2 0.97 Contact Map
1fjeB 1 0.4983 12.1 0.971 Contact Map
3vwbA 1 0.363 10.4 0.972 Contact Map
2yh0A 1 0.5512 9.5 0.972 Contact Map
3znuA 5 0.1584 8.5 0.973 Contact Map
4uw8A 3 0.2772 8.5 0.973 Contact Map
1mliA 5 0.165 8.1 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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