GREMLIN Database
ACON2 - Aconitate hydratase 2
UniProt: P36683 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12316
Length: 865 (840)
Sequences: 594 (142)
Seq/√Len: 4.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
551_H683_C6.0680.99
153_A368_V5.4180.98
148_Q152_D5.0910.97
610_K659_E4.8760.96
260_D268_R4.7170.95
168_V309_V4.6080.95
613_K617_I4.5400.94
47_D51_N4.5120.94
612_N615_P4.4690.94
187_D203_K4.2340.92
177_T235_Y4.1880.91
683_C691_A4.0320.90
120_S145_Q4.0190.89
681_I693_P3.9550.89
610_K660_A3.9220.88
165_K308_D3.8760.88
721_G753_Y3.8560.87
537_K673_D3.7940.86
786_V806_A3.7070.85
165_K310_Y3.6760.85
551_H691_A3.6750.85
419_P456_T3.6150.83
233_L257_M3.5850.83
55_P264_V3.5390.82
274_L296_V3.5250.82
588_K615_P3.4770.81
486_M627_L3.3090.77
782_G800_G3.2090.75
814_A820_L3.1520.74
72_A105_A3.1390.73
586_D612_N3.1380.73
628_K649_E3.1090.73
107_D135_K3.1090.73
167_T231_F3.1040.72
168_V272_L3.0350.71
551_H684_A3.0070.70
296_V316_V2.9810.69
454_V457_H2.9660.69
560_Q668_A2.9660.69
250_T286_M2.9590.69
823_P827_Q2.8810.66
722_K725_D2.8270.65
573_I668_A2.8260.65
133_E360_A2.8180.65
389_V528_M2.8180.65
335_L852_Y2.7680.63
588_K613_K2.7680.63
355_T371_Q2.7350.62
70_A75_E2.7320.62
813_V830_V2.7170.62
585_P683_C2.7060.61
131_D639_R2.6910.61
684_A692_R2.6300.59
465_M636_G2.5880.58
6_R41_E2.5760.57
133_E137_K2.5100.55
92_T263_H2.4960.55
778_R801_A2.4940.55
437_L627_L2.4890.54
700_E804_F2.4560.53
273_C286_M2.4370.53
225_A228_Q2.4230.52
202_L235_Y2.4160.52
169_T231_F2.3970.51
579_L599_S2.3950.51
642_E646_Q2.3760.51
551_H692_R2.3470.50
301_L325_L2.3250.49
89_L105_A2.2880.48
779_V785_V2.2820.48
836_T840_T2.2790.48
628_K645_I2.2720.47
781_D801_A2.2540.47
112_A142_Y2.2240.46
168_V234_A2.2210.46
681_I691_A2.1910.45
308_D319_H2.1710.44
249_A404_C2.1540.44
249_A707_I2.1510.44
85_K88_E2.1430.43
650_K653_A2.1360.43
616_I659_E2.1190.43
169_T229_K2.1090.42
117_K120_S2.0930.42
539_K675_A2.0820.41
167_T308_D2.0820.41
537_K671_D2.0740.41
167_T310_Y2.0530.41
388_M766_I2.0230.40
806_A814_A2.0230.40
17_I199_L2.0220.40
786_V794_P2.0040.39
786_V814_A2.0010.39
35_K67_F1.9910.39
62_Y66_G1.9800.38
551_H585_P1.9780.38
627_L645_I1.9510.37
206_R427_D1.9450.37
556_Y560_Q1.9430.37
206_R250_T1.9430.37
612_N617_I1.9320.37
395_V398_I1.9180.36
332_T427_D1.8870.36
15_E199_L1.8840.35
613_K659_E1.8740.35
646_Q649_E1.8660.35
683_C692_R1.8620.35
310_Y317_R1.8620.35
781_D800_G1.8600.35
149_S154_E1.8570.35
707_I720_A1.8510.34
504_I615_P1.8290.34
133_E147_M1.8260.34
427_D683_C1.8060.33
249_A720_A1.8060.33
38_P42_E1.8030.33
69_A101_P1.7760.32
693_P823_P1.7720.32
616_I652_L1.7650.32
100_H104_D1.7640.32
510_A514_L1.7530.32
167_T306_V1.7370.31
432_G639_R1.7260.31
161_A340_R1.7160.31
745_A764_I1.7050.30
286_M332_T1.7020.30
496_G510_A1.7000.30
37_P42_E1.6980.30
427_D551_H1.6930.30
588_K617_I1.6850.30
99_I125_M1.6610.29
272_L309_V1.6600.29
588_K618_E1.6550.29
277_K575_S1.6330.28
289_A844_L1.6250.28
169_T226_L1.6230.28
205_A427_D1.6150.28
378_S399_R1.6150.28
504_I658_L1.5960.27
318_N324_L1.5930.27
682_L786_V1.5930.27
609_I660_A1.5880.27
682_L806_A1.5820.27
794_P806_A1.5810.27
120_S149_S1.5800.27
165_K317_R1.5770.27
222_Q303_M1.5770.27
781_D799_T1.5760.27
101_P852_Y1.5670.27
612_N616_I1.5640.27
62_Y458_H1.5630.27
504_I612_N1.5630.27
617_I621_N1.5560.26
62_Y639_R1.5530.26
585_P615_P1.5480.26
84_E114_I1.5470.26
383_S676_D1.5460.26
83_P108_D1.5310.26
683_C806_A1.5240.26
130_Y639_R1.5170.26
10_A653_A1.5110.25
588_K612_N1.5080.25
407_K819_K1.5040.25
556_Y559_K1.4730.24
130_Y432_G1.4640.24
37_P78_S1.4580.24
615_P683_C1.4580.24
562_L668_A1.4530.24
203_K303_M1.4530.24
693_P696_A1.4500.24
427_D521_T1.4470.24
234_A274_L1.4400.24
384_L658_L1.4320.23
551_H806_A1.4300.23
55_P59_E1.4270.23
404_C707_I1.4270.23
332_T786_V1.4250.23
403_Y549_L1.4190.23
599_S607_C1.4100.23
253_V316_V1.4040.23
38_P80_L1.4000.23
286_M334_V1.4000.23
16_G398_I1.3980.23
250_T334_V1.3950.23
49_L81_L1.3920.23
2_L89_L1.3910.23
684_A691_A1.3860.22
66_G70_A1.3860.22
425_L520_A1.3800.22
87_I669_V1.3790.22
53_V82_T1.3780.22
72_A89_L1.3760.22
135_K190_S1.3740.22
478_V649_E1.3700.22
105_A296_V1.3640.22
53_V721_G1.3620.22
142_Y145_Q1.3590.22
585_P692_R1.3590.22
190_S540_M1.3530.22
187_D200_A1.3530.22
518_A524_M1.3490.22
377_E380_R1.3450.22
136_A139_G1.3440.22
250_T273_C1.3420.21
82_T307_I1.3410.21
103_I108_D1.3390.21
250_T254_L1.3390.21
286_M427_D1.3390.21
277_K295_E1.3360.21
190_S425_L1.3330.21
430_C520_A1.3280.21
219_P575_S1.3270.21
133_E139_G1.3240.21
250_T332_T1.3220.21
462_D478_V1.3190.21
207_E521_T1.3170.21
231_F306_V1.3120.21
205_A332_T1.3050.21
273_C334_V1.3030.21
43_E313_K1.2980.21
29_A103_I1.2930.20
588_K849_L1.2920.20
585_P588_K1.2920.20
613_K616_I1.2850.20
35_K70_A1.2780.20
374_D402_A1.2770.20
778_R781_D1.2730.20
754_Y764_I1.2710.20
747_Q844_L1.2690.20
120_S852_Y1.2650.20
334_V427_D1.2650.20
794_P802_N1.2650.20
478_V830_V1.2630.20
820_L823_P1.2490.20
82_T164_E1.2470.19
549_L596_T1.2460.19
13_A33_L1.2420.19
608_T652_L1.2390.19
391_R658_L1.2380.19
478_V738_A1.2340.19
308_D321_T1.2290.19
579_L604_A1.2280.19
42_E79_P1.2260.19
55_P94_Q1.2150.19
206_R332_T1.2130.19
123_L473_R1.2090.19
207_E219_P1.1920.18
162_L273_C1.1890.18
824_E828_T1.1840.18
231_F317_R1.1820.18
37_P79_P1.1790.18
118_A382_F1.1760.18
308_D427_D1.1740.18
615_P659_E1.1710.18
446_A766_I1.1700.18
599_S847_N1.1680.18
478_V842_R1.1660.18
118_A327_T1.1650.18
204_N799_T1.1630.18
250_T427_D1.1630.18
192_P452_V1.1630.18
419_P628_K1.1620.18
618_E845_N1.1590.18
352_G458_H1.1590.18
32_E35_K1.1590.18
277_K452_V1.1560.18
786_V820_L1.1530.18
35_K458_H1.1530.18
187_D286_M1.1450.18
625_V847_N1.1430.17
699_G720_A1.1430.17
71_I78_S1.1420.17
205_A208_G1.1400.17
551_H615_P1.1380.17
254_L269_G1.1380.17
627_L641_L1.1360.17
586_D756_V1.1340.17
174_T302_N1.1270.17
206_R286_M1.1250.17
436_D643_R1.1250.17
721_G733_T1.1230.17
33_L38_P1.1210.17
206_R723_L1.1170.17
754_Y767_P1.1120.17
37_P80_L1.1110.17
71_I729_G1.1100.17
165_K321_T1.1100.17
103_I297_D1.1100.17
66_G458_H1.1090.17
207_E585_P1.1080.17
205_A334_V1.1080.17
20_K222_Q1.1060.17
94_Q684_A1.1050.17
40_G80_L1.1020.17
588_K683_C1.0950.17
33_L45_L1.0910.17
585_P660_A1.0910.17
407_K701_K1.0910.17
404_C430_C1.0910.17
206_R219_P1.0900.17
72_A83_P1.0890.17
268_R692_R1.0880.16
4_E228_Q1.0870.16
403_Y596_T1.0860.16
782_G830_V1.0850.16
103_I299_S1.0830.16
73_K78_S1.0830.16
88_E833_V1.0820.16
131_D432_G1.0810.16
135_K852_Y1.0770.16
62_Y70_A1.0750.16
286_M331_K1.0750.16
26_Q388_M1.0750.16
235_Y257_M1.0730.16
286_M521_T1.0710.16
50_T85_K1.0700.16
234_A272_L1.0680.16
742_R753_Y1.0680.16
398_I402_A1.0670.16
257_M569_G1.0650.16
437_L486_M1.0650.16
645_I833_V1.0650.16
427_D691_A1.0620.16
721_G757_F1.0600.16
585_P691_A1.0580.16
438_V519_A1.0580.16
182_L235_Y1.0570.16
94_Q551_H1.0560.16
161_A164_E1.0550.16
617_I683_C1.0550.16
171_F309_V1.0540.16
62_Y371_Q1.0520.16
633_E840_T1.0490.16
830_V833_V1.0470.16
170_V307_I1.0450.16
380_R663_D1.0450.16
120_S749_T1.0450.16
439_M627_L1.0450.16
182_L202_L1.0440.16
504_I613_K1.0430.16
466_N636_G1.0410.16
226_L233_L1.0400.16
166_L272_L1.0390.16
38_P41_E1.0360.16
71_I76_A1.0350.16
203_K615_P1.0330.16
621_N847_N1.0330.16
169_T724_L1.0320.16
692_R699_G1.0310.16
257_M352_G1.0270.15
187_D303_M1.0270.15
315_E327_T1.0260.15
724_L735_L1.0260.15
612_N659_E1.0250.15
835_K844_L1.0200.15
753_Y756_V1.0180.15
430_C720_A1.0180.15
845_N848_Q1.0160.15
332_T794_P1.0160.15
148_Q357_A1.0150.15
200_A324_L1.0140.15
6_R37_P1.0130.15
113_P142_Y1.0120.15
53_V94_Q1.0110.15
133_E357_A1.0100.15
734_R801_A1.0080.15
25_N104_D1.0080.15
348_I604_A1.0070.15
203_K286_M1.0030.15
219_P309_V1.0020.15
250_T844_L1.0000.15
556_Y681_I0.9960.15
187_D596_T0.9940.15
189_W794_P0.9930.15
219_P332_T0.9930.15
278_I293_P0.9920.15
733_T753_Y0.9910.15
419_P605_A0.9890.15
177_T202_L0.9870.15
692_R698_Q0.9860.15
20_K256_F0.9860.15
520_A699_G0.9850.15
456_T628_K0.9850.15
203_K206_R0.9850.15
533_L669_V0.9840.15
18_A840_T0.9840.15
721_G742_R0.9840.15
105_A274_L0.9820.15
154_E306_V0.9820.15
348_I579_L0.9790.15
613_K621_N0.9770.15
462_D637_D0.9770.15
264_V675_A0.9750.15
222_Q427_D0.9740.15
249_A575_S0.9740.15
78_S111_L0.9730.15
403_Y607_C0.9710.15
113_P117_K0.9700.15
588_K614_E0.9690.14
4_E39_A0.9660.14
107_D852_Y0.9650.14
190_S806_A0.9650.14
226_L257_M0.9630.14
62_Y432_G0.9620.14
824_E851_Q0.9620.14
226_L735_L0.9580.14
192_P430_C0.9540.14
34_L815_A0.9540.14
614_E617_I0.9530.14
723_L813_V0.9520.14
588_K616_I0.9520.14
37_P40_G0.9510.14
355_T521_T0.9510.14
228_Q233_L0.9510.14
606_G802_N0.9480.14
478_V670_I0.9480.14
704_E752_G0.9460.14
722_K836_T0.9460.14
71_I114_I0.9450.14
615_P621_N0.9450.14
478_V836_T0.9440.14
75_E539_K0.9430.14
837_A842_R0.9420.14
132_V139_G0.9420.14
31_V478_V0.9410.14
678_K824_E0.9390.14
471_S733_T0.9380.14
88_E117_K0.9370.14
332_T806_A0.9350.14
673_D810_L0.9350.14
645_I652_L0.9340.14
120_S154_E0.9340.14
388_M596_T0.9340.14
579_L840_T0.9320.14
504_I571_K0.9310.14
569_G659_E0.9310.14
31_V352_G0.9290.14
104_D379_D0.9290.14
41_E44_F0.9280.14
53_V163_A0.9250.14
190_S794_P0.9240.14
321_T521_T0.9230.14
478_V627_L0.9230.14
135_K806_A0.9190.14
457_H628_K0.9190.14
104_D682_L0.9180.14
147_M357_A0.9180.14
378_S663_D0.9180.14
113_P120_S0.9170.14
23_D104_D0.9160.14
186_P427_D0.9120.14
139_G296_V0.9100.14
457_H836_T0.9090.14
569_G617_I0.9080.14
187_D496_G0.9050.13
164_E313_K0.9050.13
588_K659_E0.9040.13
229_K306_V0.9040.13
126_F425_L0.9040.13
199_L220_I0.9030.13
621_N624_I0.9020.13
682_L702_I0.8990.13
128_N159_R0.8970.13
579_L670_I0.8970.13
135_K577_R0.8970.13
836_T842_R0.8930.13
616_I656_E0.8920.13
446_A764_I0.8910.13
408_M720_A0.8910.13
612_N816_L0.8900.13
120_S813_V0.8890.13
126_F334_V0.8880.13
132_V253_V0.8850.13
235_Y799_T0.8850.13
186_P457_H0.8840.13
263_H616_I0.8840.13
749_T764_I0.8840.13
836_T839_D0.8830.13
190_S786_V0.8830.13
135_K189_W0.8820.13
446_A571_K0.8810.13
188_A414_Q0.8800.13
28_A103_I0.8790.13
457_H605_A0.8780.13
168_V219_P0.8770.13
462_D636_G0.8730.13
254_L478_V0.8720.13
673_D676_D0.8710.13
276_G299_S0.8710.13
540_M612_N0.8710.13
139_G427_D0.8700.13
219_P797_L0.8700.13
160_P259_D0.8680.13
222_Q250_T0.8670.13
226_L229_K0.8670.13
698_Q720_A0.8640.13
755_S820_L0.8640.13
419_P596_T0.8620.13
99_I398_I0.8620.13
20_K806_A0.8610.13
289_A334_V0.8610.13
273_C738_A0.8580.13
609_I617_I0.8580.13
38_P268_R0.8550.13
395_V840_T0.8550.13
162_L815_A0.8550.13
382_F555_L0.8540.13
87_I764_I0.8540.13
357_A521_T0.8510.13
205_A250_T0.8500.13
581_I607_C0.8490.13
471_S780_A0.8490.13
308_D521_T0.8480.13
357_A604_A0.8470.13
20_K551_H0.8460.13
111_L407_K0.8460.13
15_E674_L0.8440.13
520_A628_K0.8440.13
120_S296_V0.8410.13
813_V833_V0.8410.13
308_D332_T0.8400.13
54_P351_R0.8400.13
523_V606_G0.8390.13
521_T835_K0.8380.13
432_G717_F0.8380.13
273_C332_T0.8380.13
388_M848_Q0.8370.13
80_L649_E0.8350.12
39_A80_L0.8340.12
206_R334_V0.8340.12
541_Q678_K0.8340.12
555_L559_K0.8340.12
551_H588_K0.8330.12
7_K10_A0.8330.12
681_I696_A0.8330.12
649_E842_R0.8330.12
249_A430_C0.8310.12
784_T802_N0.8300.12
268_R699_G0.8300.12
273_C456_T0.8290.12
359_E367_D0.8280.12
380_R399_R0.8270.12
62_Y128_N0.8260.12
144_K324_L0.8260.12
228_Q737_V0.8250.12
192_P520_A0.8250.12
541_Q675_A0.8250.12
365_H371_Q0.8240.12
311_P735_L0.8240.12
717_F783_A0.8240.12
62_Y606_G0.8230.12
374_D399_R0.8210.12
389_V492_V0.8190.12
134_E639_R0.8180.12
49_L82_T0.8180.12
94_Q783_A0.8180.12
27_M145_Q0.8170.12
586_D833_V0.8170.12
439_M797_L0.8160.12
691_A806_A0.8140.12
129_F360_A0.8140.12
617_I659_E0.8140.12
203_K250_T0.8110.12
229_K566_E0.8110.12
532_V668_A0.8110.12
30_L734_R0.8090.12
103_I120_S0.8080.12
596_T607_C0.8080.12
31_V67_F0.8060.12
3_E99_I0.8050.12
504_I604_A0.8050.12
319_H427_D0.8050.12
629_W794_P0.8050.12
399_R663_D0.8050.12
388_M618_E0.8040.12
364_P819_K0.8030.12
596_T759_K0.8030.12
427_D794_P0.8030.12
604_A615_P0.8020.12
348_I840_T0.8000.12
726_A806_A0.8000.12
126_F642_E0.7980.12
786_V802_N0.7970.12
162_L333_D0.7970.12
21_P351_R0.7960.12
147_M676_D0.7930.12
295_E627_L0.7930.12
254_L794_P0.7930.12
205_A806_A0.7920.12
641_L830_V0.7920.12
186_P606_G0.7910.12
41_E842_R0.7900.12
187_D250_T0.7900.12
551_H786_V0.7900.12
555_L721_G0.7900.12
182_L648_M0.7890.12
108_D120_S0.7890.12
377_E723_L0.7890.12
717_F840_T0.7880.12
158_N815_A0.7880.12
166_L324_L0.7880.12
647_G693_P0.7870.12
326_A391_R0.7870.12
219_P521_T0.7840.12
136_A144_K0.7840.12
94_Q683_C0.7840.12
313_K317_R0.7840.12
113_P145_Q0.7840.12
104_D157_L0.7830.12
91_G124_L0.7820.12
18_A257_M0.7820.12
144_K148_Q0.7820.12
182_L250_T0.7810.12
478_V837_A0.7800.12
187_D403_Y0.7800.12
723_L830_V0.7800.12
408_M487_L0.7800.12
334_V794_P0.7800.12
575_S707_I0.7790.12
59_E62_Y0.7770.12
356_K742_R0.7770.12
660_A847_N0.7770.12
430_C699_G0.7760.12
219_P717_F0.7750.12
332_T684_A0.7740.12
187_D206_R0.7740.12
750_E827_Q0.7740.12
717_F723_L0.7720.12
230_G682_L0.7720.12
606_G764_I0.7710.12
259_D388_M0.7700.12
250_T521_T0.7680.12
404_C720_A0.7670.12
334_V370_R0.7670.12
2_L6_R0.7670.12
596_T721_G0.7670.12
17_I250_T0.7660.12
614_E659_E0.7650.12
604_A840_T0.7650.12
162_L264_V0.7650.12
684_A806_A0.7650.12
588_K757_F0.7640.12
174_T303_M0.7630.12
20_K816_L0.7630.12
402_A616_I0.7630.12
59_E407_K0.7610.11
114_I568_K0.7610.11
492_V528_M0.7580.11
558_I565_V0.7580.11
225_A647_G0.7580.11
388_M658_L0.7580.11
332_T521_T0.7570.11
231_F308_D0.7570.11
189_W192_P0.7560.11
332_T336_I0.7560.11
189_W604_A0.7550.11
520_A698_Q0.7540.11
253_V257_M0.7540.11
456_T834_D0.7530.11
62_Y462_D0.7520.11
159_R683_C0.7520.11
250_T723_L0.7520.11
79_P127_D0.7510.11
24_A63_V0.7510.11
391_R675_A0.7510.11
588_K845_N0.7510.11
73_K104_D0.7510.11
398_I578_I0.7510.11
137_K586_D0.7500.11
319_H683_C0.7480.11
199_L219_P0.7480.11
256_F286_M0.7480.11
146_V398_I0.7480.11
69_A784_T0.7470.11
165_K682_L0.7460.11
3_E63_V0.7460.11
309_V432_G0.7460.11
409_T707_I0.7450.11
263_H585_P0.7430.11
228_Q257_M0.7430.11
189_W348_I0.7430.11
408_M649_E0.7430.11
7_K157_L0.7430.11
333_D707_I0.7430.11
46_L83_P0.7410.11
690_D717_F0.7400.11
146_V364_P0.7400.11
806_A829_Y0.7400.11
617_I660_A0.7380.11
120_S569_G0.7380.11
38_P78_S0.7380.11
717_F847_N0.7360.11
357_A464_I0.7350.11
31_V403_Y0.7340.11
696_A823_P0.7330.11
352_G596_T0.7330.11
144_K671_D0.7320.11
7_K221_K0.7310.11
35_K76_A0.7270.11
120_S319_H0.7260.11
835_K840_T0.7250.11
335_L658_L0.7250.11
799_T814_A0.7240.11
464_I471_S0.7240.11
227_Q845_N0.7240.11
722_K756_V0.7230.11
419_P492_V0.7230.11
122_T182_L0.7230.11
745_A749_T0.7230.11
202_L206_R0.7210.11
628_K642_E0.7210.11
158_N659_E0.7210.11
23_D834_D0.7200.11
71_I168_V0.7190.11
794_P829_Y0.7190.11
425_L430_C0.7180.11
403_Y599_S0.7160.11
578_I848_Q0.7150.11
819_K830_V0.7130.11
42_E78_S0.7120.11
224_E733_T0.7110.11
786_V832_Q0.7110.11
25_N224_E0.7100.11
127_D542_P0.7100.11
133_E136_A0.7090.11
206_R222_Q0.7080.11
682_L697_V0.7080.11
541_Q827_Q0.7070.11
154_E638_R0.7070.11
379_D653_A0.7060.11
25_N306_V0.7060.11
189_W786_V0.7060.11
430_C698_Q0.7060.11
682_L725_D0.7050.11
207_E627_L0.7050.11
272_L332_T0.7050.11
487_L720_A0.7030.11
116_A120_S0.7030.11
116_A154_E0.7030.11
604_A690_D0.7010.11
199_L352_G0.7010.11
409_T487_L0.7010.11
189_W425_L0.7010.11
117_K145_Q0.7000.11
537_K819_K0.7000.11
254_L575_S0.6990.11
333_D370_R0.6990.11
71_I87_I0.6980.11
299_S326_A0.6980.11
87_I129_F0.6960.11
368_V455_N0.6960.11
315_E398_I0.6960.11
520_A720_A0.6960.11
103_I165_K0.6950.11
235_Y253_V0.6940.11
46_L169_T0.6940.11
539_K747_Q0.6920.11
61_A296_V0.6920.11
257_M273_C0.6920.11
55_P785_V0.6910.11
27_M473_R0.6910.11
226_L724_L0.6910.11
457_H684_A0.6900.11
585_P659_E0.6900.11
721_G806_A0.6900.11
555_L693_P0.6900.11
228_Q675_A0.6880.11
160_P755_S0.6880.11
131_D395_V0.6880.11
254_L346_P0.6880.11
540_M549_L0.6880.11
17_I810_L0.6870.11
190_S452_V0.6870.11
169_T306_V0.6870.11
222_Q723_L0.6860.11
723_L786_V0.6860.11
229_K678_K0.6850.11
274_L399_R0.6840.11
726_A802_N0.6840.11
541_Q735_L0.6820.10
189_W806_A0.6790.10
15_E87_I0.6790.10
301_L318_N0.6790.10
88_E568_K0.6770.10
71_I764_I0.6770.10
682_L721_G0.6760.10
388_M556_Y0.6760.10
560_Q577_R0.6760.10
260_D699_G0.6760.10
208_G219_P0.6760.10
733_T742_R0.6750.10
202_L648_M0.6750.10
8_H26_Q0.6740.10
425_L786_V0.6740.10
168_V231_F0.6740.10
403_Y604_A0.6730.10
202_L422_R0.6720.10
29_A163_A0.6700.10
585_P684_A0.6700.10
257_M852_Y0.6690.10
9_V52_R0.6690.10
147_M560_Q0.6680.10
66_G371_Q0.6680.10
366_S707_I0.6680.10
461_P630_M0.6680.10
614_E747_Q0.6680.10
62_Y478_V0.6660.10
130_Y135_K0.6650.10
615_P758_G0.6640.10
187_D204_N0.6640.10
85_K624_I0.6630.10
360_A407_K0.6620.10
187_D609_I0.6620.10
208_G427_D0.6610.10
16_G646_Q0.6610.10
781_D813_V0.6610.10
135_K794_P0.6610.10
520_A527_D0.6600.10
380_R665_E0.6590.10
628_K646_Q0.6590.10
203_K596_T0.6590.10
192_P698_Q0.6590.10
79_P784_T0.6590.10
208_G222_Q0.6580.10
629_W721_G0.6580.10
103_I820_L0.6570.10
366_S409_T0.6570.10
10_A535_R0.6560.10
273_C596_T0.6560.10
274_L851_Q0.6550.10
726_A832_Q0.6550.10
391_R408_M0.6550.10
504_I617_I0.6550.10
556_Y675_A0.6540.10
203_K549_L0.6540.10
306_V701_K0.6530.10
613_K656_E0.6520.10
478_V559_K0.6520.10
118_A755_S0.6520.10
134_E624_I0.6520.10
103_I388_M0.6510.10
127_D131_D0.6510.10
135_K723_L0.6510.10
434_S588_K0.6500.10
182_L607_C0.6500.10
362_G388_M0.6500.10
407_K647_G0.6500.10
42_E80_L0.6500.10
259_D578_I0.6500.10
32_E44_F0.6490.10
299_S820_L0.6490.10
173_V652_L0.6490.10
829_Y832_Q0.6480.10
728_K759_K0.6480.10
425_L784_T0.6480.10
89_L263_H0.6480.10
202_L645_I0.6470.10
539_K824_E0.6460.10
84_E110_K0.6460.10
335_L683_C0.6460.10
162_L336_I0.6460.10
296_V725_D0.6450.10
532_V557_A0.6450.10
310_Y319_H0.6440.10
297_D301_L0.6440.10
465_M717_F0.6440.10
177_T182_L0.6430.10
157_L721_G0.6430.10
619_Y800_G0.6430.10
135_K786_V0.6410.10
66_G606_G0.6400.10
162_L168_V0.6400.10
130_Y541_Q0.6400.10
541_Q845_N0.6400.10
324_L822_T0.6390.10
112_A165_K0.6380.10
376_A382_F0.6370.10
348_I690_D0.6360.10
395_V677_I0.6360.10
588_K814_A0.6340.10
4_E105_A0.6340.10
581_I596_T0.6340.10
134_E820_L0.6340.10
169_T272_L0.6340.10
430_C437_L0.6340.10
31_V797_L0.6330.10
430_C527_D0.6320.10
595_L797_L0.6320.10
273_C569_G0.6320.10
253_V286_M0.6310.10
189_W430_C0.6310.10
139_G521_T0.6310.10
169_T797_L0.6310.10
10_A13_A0.6310.10
71_I756_V0.6310.10
94_Q264_V0.6310.10
92_T297_D0.6300.10
336_I370_R0.6300.10
253_V408_M0.6300.10
398_I663_D0.6290.10
541_Q811_A0.6290.10
559_K693_P0.6290.10
336_I456_T0.6290.10
722_K839_D0.6270.10
569_G758_G0.6260.10
404_C409_T0.6260.10
107_D663_D0.6250.10
734_R800_G0.6250.10
605_A681_I0.6250.10
842_R850_S0.6240.10
629_W742_R0.6240.10
274_L309_V0.6230.10
263_H568_K0.6220.10
2_L9_V0.6220.10
147_M158_N0.6210.10
456_T606_G0.6210.10
303_M510_A0.6200.10
295_E331_K0.6190.10
273_C465_M0.6180.10
539_K566_E0.6180.10
273_C427_D0.6180.10
145_Q610_K0.6170.10
40_G109_A0.6160.10
146_V375_V0.6150.10
662_A824_E0.6150.10
152_D364_P0.6140.10
699_G784_T0.6140.10
422_R607_C0.6140.10
487_L660_A0.6140.10
295_E437_L0.6140.10
129_F357_A0.6130.10
819_K822_T0.6120.10
72_A606_G0.6120.10
199_L264_V0.6110.10
549_L607_C0.6110.10
407_K849_L0.6110.10
540_M677_I0.6100.10
117_K161_A0.6100.10
690_D840_T0.6100.10
147_M842_R0.6100.10
167_T842_R0.6100.10
208_G419_P0.6090.10
136_A357_A0.6090.10
163_A847_N0.6090.10
346_P646_Q0.6090.10
478_V619_Y0.6090.10
20_K840_T0.6090.10
157_L653_A0.6080.10
99_I233_L0.6070.10
629_W829_Y0.6070.10
569_G749_T0.6070.10
18_A256_F0.6070.10
263_H419_P0.6060.10
234_A260_D0.6060.10
819_K831_A0.6060.10
575_S720_A0.6060.10
291_A486_M0.6050.10
206_R273_C0.6050.10
15_E322_G0.6050.10
118_A158_N0.6050.10
253_V388_M0.6050.10
208_G254_L0.6040.10
541_Q724_L0.6040.10
173_V587_L0.6040.10
104_D457_H0.6040.10
408_M628_K0.6040.10
18_A375_V0.6030.10
250_T331_K0.6030.10
189_W852_Y0.6030.10
28_A62_Y0.6030.10
289_A293_P0.6020.10
677_I681_I0.6010.10
289_A684_A0.6010.10
395_V459_T0.6000.10
365_H478_V0.6000.10
253_V269_G0.6000.10
36_N407_K0.6000.10
616_I621_N0.6000.10
616_I624_I0.6000.10
112_A121_H0.6000.10
89_L269_G0.5990.10
72_A117_K0.5990.10
7_K662_A0.5980.10
274_L691_A0.5970.10
637_D723_L0.5970.10
368_V375_V0.5960.09
407_K832_Q0.5960.09
273_C301_L0.5960.09
55_P273_C0.5960.09
359_E388_M0.5960.09
596_T738_A0.5950.09
41_E833_V0.5950.09
36_N161_A0.5940.09
438_V735_L0.5940.09
723_L802_N0.5940.09
357_A690_D0.5930.09
597_D630_M0.5930.09
62_Y637_D0.5930.09
308_D318_N0.5930.09
458_H733_T0.5920.09
436_D724_L0.5920.09
171_F303_M0.5910.09
802_N806_A0.5910.09
49_L633_E0.5910.09
274_L294_I0.5900.09
94_Q840_T0.5900.09
19_P164_E0.5900.09
259_D566_E0.5890.09
730_Q755_S0.5890.09
71_I83_P0.5890.09
78_S81_L0.5880.09
257_M596_T0.5870.09
296_V722_K0.5870.09
53_V370_R0.5860.09
168_V274_L0.5860.09
205_A286_M0.5860.09
144_K560_Q0.5860.09
332_T551_H0.5860.09
162_L370_R0.5850.09
629_W633_E0.5850.09
116_A852_Y0.5840.09
147_M658_L0.5840.09
132_V653_A0.5840.09
783_A797_L0.5830.09
723_L781_D0.5830.09
29_A668_A0.5830.09
294_I782_G0.5810.09
432_G643_R0.5810.09
607_C648_M0.5810.09
306_V473_R0.5800.09
128_N620_L0.5800.09
254_L286_M0.5800.09
370_R382_F0.5800.09
660_A681_I0.5800.09
698_Q725_D0.5800.09
136_A427_D0.5790.09
355_T391_R0.5790.09
596_T599_S0.5790.09
76_A79_P0.5790.09
303_M847_N0.5780.09
129_F147_M0.5780.09
165_K486_M0.5780.09
117_K566_E0.5780.09
317_R742_R0.5770.09
432_G618_E0.5770.09
473_R650_K0.5770.09
75_E658_L0.5760.09
30_L53_V0.5760.09
249_A254_L0.5760.09
767_P811_A0.5750.09
147_M556_Y0.5740.09
25_N157_L0.5740.09
355_T556_Y0.5740.09
126_F332_T0.5730.09
133_E521_T0.5730.09
72_A274_L0.5730.09
723_L726_A0.5730.09
724_L811_A0.5730.09
395_V726_A0.5730.09
471_S633_E0.5720.09
348_I357_A0.5720.09
167_T321_T0.5710.09
221_K551_H0.5710.09
70_A606_G0.5710.09
848_Q851_Q0.5710.09
227_Q232_P0.5710.09
468_G496_G0.5710.09
596_T609_I0.5710.09
311_P437_L0.5700.09
71_I112_A0.5700.09
650_K658_L0.5690.09
55_P126_F0.5690.09
14_A662_A0.5680.09
462_D641_L0.5680.09
82_T682_L0.5670.09
346_P781_D0.5670.09
232_P287_E0.5670.09
256_F427_D0.5670.09
308_D317_R0.5660.09
219_P794_P0.5650.09
6_R70_A0.5650.09
319_H551_H0.5650.09
157_L234_A0.5640.09
219_P725_D0.5640.09
275_G388_M0.5630.09
219_P334_V0.5630.09
457_H749_T0.5630.09
301_L316_V0.5630.09
579_L667_A0.5630.09
731_L760_S0.5630.09
559_K837_A0.5620.09
520_A722_K0.5610.09
315_E840_T0.5610.09
174_T253_V0.5610.09
51_N782_G0.5600.09
700_E784_T0.5600.09
348_I403_Y0.5590.09
345_I682_L0.5590.09
575_S794_P0.5590.09
816_L837_A0.5590.09
39_A42_E0.5580.09
556_Y676_D0.5580.09
29_A44_F0.5580.09
2_L105_A0.5580.09
190_S407_K0.5580.09
132_V141_E0.5570.09
348_I615_P0.5570.09
205_A222_Q0.5570.09
272_L559_K0.5570.09
555_L571_K0.5570.09
222_Q407_K0.5560.09
766_I836_T0.5560.09
190_S434_S0.5550.09
578_I817_I0.5540.09
527_D699_G0.5530.09
631_I642_E0.5530.09
630_M681_I0.5520.09
269_G289_A0.5510.09
573_I850_S0.5510.09
21_P42_E0.5510.09
373_K402_A0.5510.09
62_Y355_T0.5510.09
146_V230_G0.5500.09
101_P478_V0.5500.09
487_L847_N0.5490.09
7_K72_A0.5490.09
77_K309_V0.5490.09
723_L731_L0.5490.09
311_P314_G0.5480.09
332_T370_R0.5470.09
109_A136_A0.5470.09
334_V786_V0.5460.09
577_R637_D0.5460.09
83_P161_A0.5460.09
145_Q391_R0.5460.09
357_A569_G0.5460.09
616_I749_T0.5450.09
16_G207_E0.5450.09
36_N782_G0.5450.09
610_K673_D0.5450.09
35_K66_G0.5440.09
223_I432_G0.5440.09
167_T317_R0.5430.09
135_K738_A0.5430.09
336_I427_D0.5420.09
146_V562_L0.5420.09
78_S147_M0.5420.09
722_K766_I0.5410.09
136_A147_M0.5410.09
2_L72_A0.5400.09
31_V851_Q0.5400.09
459_T800_G0.5380.09
578_I850_S0.5380.09
189_W452_V0.5370.09
132_V643_R0.5370.09
371_Q568_K0.5360.09
738_A806_A0.5360.09
274_L670_I0.5360.09
532_V573_I0.5350.09
187_D549_L0.5350.09
690_D820_L0.5350.09
4_E675_A0.5340.09
319_H521_T0.5340.09
49_L294_I0.5330.09
540_M596_T0.5330.09
606_G784_T0.5330.09
62_Y780_A0.5330.09
737_V827_Q0.5330.09
71_I329_E0.5330.09
30_L78_S0.5320.09
117_K160_P0.5320.09
141_E228_Q0.5320.09
276_G325_L0.5320.09
127_D130_Y0.5320.09
82_T117_K0.5310.09
20_K726_A0.5300.09
70_A458_H0.5290.09
430_C692_R0.5290.09
296_V835_K0.5280.09
410_S630_M0.5280.09
199_L407_K0.5270.09
109_A141_E0.5270.09
383_S745_A0.5270.09
137_K356_K0.5260.09
51_N419_P0.5260.09
629_W806_A0.5260.09
94_Q332_T0.5250.09
745_A766_I0.5250.09
407_K537_K0.5250.09
205_A794_P0.5240.09
738_A786_V0.5240.09
24_A800_G0.5240.09
573_I613_K0.5240.09
107_D728_K0.5230.09
158_N620_L0.5230.09
31_V581_I0.5230.09
103_I455_N0.5220.09
124_L354_T0.5210.09
455_N806_A0.5210.09
589_V636_G0.5200.09
520_A692_R0.5190.09
126_F208_G0.5190.09
8_H19_P0.5190.09
53_V732_P0.5190.09
135_K836_T0.5190.09
646_Q840_T0.5190.09
208_G225_A0.5190.09
203_K403_Y0.5180.09
487_L717_F0.5170.09
23_D163_A0.5170.09
26_Q178_N0.5170.09
722_K837_A0.5170.09
32_E578_I0.5160.09
35_K131_D0.5150.09
4_E53_V0.5150.09
158_N628_K0.5150.09
208_G273_C0.5150.09
157_L379_D0.5140.09
606_G731_L0.5130.09
430_C707_I0.5130.09
87_I568_K0.5120.09
573_I819_K0.5120.09
575_S816_L0.5120.09
136_A173_V0.5120.09
3_E537_K0.5110.09
575_S822_T0.5110.09
802_N829_Y0.5110.09
396_K675_A0.5110.09
222_Q806_A0.5110.09
425_L437_L0.5110.09
308_D549_L0.5100.09
675_A721_G0.5100.09
362_G747_Q0.5100.09
17_I681_I0.5100.09
59_E388_M0.5100.09
61_A254_L0.5100.09
51_N136_A0.5090.09
157_L253_V0.5080.09
43_E653_A0.5080.09
226_L438_V0.5080.09
23_D263_H0.5080.09
190_S759_K0.5070.09
422_R549_L0.5070.09
83_P650_K0.5060.09
158_N728_K0.5060.09
464_I633_E0.5060.09
510_A589_V0.5060.09
101_P690_D0.5050.09
778_R800_G0.5050.09
579_L615_P0.5040.09
192_P478_V0.5040.09
616_I625_V0.5030.09
43_E742_R0.5030.09
152_D368_V0.5030.09
549_L581_I0.5020.09
220_I835_K0.5020.09
457_H764_I0.5020.09
120_S168_V0.5010.09
139_G560_Q0.5000.08
502_F591_Q0.5000.08
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1l5jA 1 0.9965 100 0.406 Contact Map
4kp1A 1 0.4728 100 0.808 Contact Map
4kp2A 2 0.4694 100 0.809 Contact Map
1c96A 1 0.5561 100 0.826 Contact Map
2b3yA 1 0.5757 100 0.846 Contact Map
2pkpA 2 0.1931 99.9 0.946 Contact Map
3vbaA 2 0.1931 99.9 0.947 Contact Map
1v7lA 6 0.1884 99.9 0.947 Contact Map
2hcuA 1 0.1954 99.9 0.95 Contact Map
3h5jA 1 0.1827 99.9 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0194 seconds.