GREMLIN Database
ZAPD - Cell division protein ZapD
UniProt: P36680 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12313
Length: 247 (243)
Sequences: 505 (355)
Seq/√Len: 22.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_W66_E4.5341.00
9_H215_I3.9091.00
226_F242_F3.8471.00
203_L215_I3.5451.00
63_L171_V3.3621.00
94_Q173_D2.7680.99
48_S118_I2.7420.99
204_N243_E2.6850.99
14_K18_W2.5840.99
10_P13_E2.4380.98
6_L52_D2.3990.98
217_G227_M2.3260.97
35_V151_D2.3230.97
64_L99_G2.2520.97
65_K113_R2.1920.96
18_W48_S2.1540.96
13_E16_R2.0720.95
181_F245_A2.0480.94
8_E13_E2.0380.94
141_I164_L2.0290.94
29_T165_T2.0120.94
168_L201_L2.0120.94
28_L158_I1.9430.92
205_L240_L1.9390.92
65_K217_G1.9370.92
206_S209_S1.9290.92
48_S52_D1.9250.92
18_W55_E1.8960.91
124_R130_G1.8800.91
184_Q191_Y1.8770.91
127_I136_L1.8640.91
128_P135_D1.8530.90
221_R246_C1.8390.90
54_F59_V1.8020.89
7_F70_Q1.7980.89
218_H222_F1.7740.88
43_F154_V1.7570.88
17_T60_R1.7290.87
140_H143_L1.6950.86
35_V147_Q1.6940.86
183_K243_E1.6910.86
66_E69_R1.6690.85
10_P16_R1.6660.85
42_H219_K1.6630.85
199_D214_Q1.6560.85
17_T23_F1.6250.83
19_L118_I1.6240.83
60_R232_E1.5980.82
101_V166_Q1.5920.82
219_K226_F1.5870.82
78_I89_E1.5810.82
65_K132_C1.5430.80
119_A139_L1.5430.80
186_S242_F1.5080.78
40_A48_S1.5030.78
110_Q230_D1.4990.78
102_L153_Q1.4760.77
170_M223_A1.4380.75
68_D97_A1.4360.75
97_A156_T1.4290.74
18_W125_L1.3930.73
98_A167_A1.3920.72
124_R135_D1.3600.71
65_K131_C1.3210.68
18_W168_L1.3150.68
62_E134_F1.3130.68
11_L221_R1.2950.67
202_R245_A1.2690.65
7_F182_R1.2620.65
212_Y221_R1.2390.63
115_D139_L1.2380.63
43_F214_Q1.2370.63
31_N219_K1.2330.63
140_H191_Y1.2290.63
146_P149_Q1.2210.62
5_V58_E1.2200.62
155_E159_A1.2200.62
14_K57_G1.2140.62
165_T169_T1.2120.62
228_P238_E1.2110.61
48_S235_Q1.2110.61
84_D221_R1.2090.61
58_E227_M1.2070.61
127_I132_C1.2030.61
203_L226_F1.1960.60
226_F240_L1.1870.60
190_F212_Y1.1860.60
43_F77_W1.1830.60
74_L81_P1.1800.59
187_L239_R1.1740.59
18_W95_L1.1620.58
60_R193_D1.1590.58
21_I207_L1.1460.57
146_P183_K1.1280.56
17_T112_L1.1140.55
174_L202_R1.1100.55
12_N224_I1.1100.55
51_L55_E1.1090.55
44_F116_R1.1080.55
47_V120_L1.1040.54
86_S89_E1.0970.54
77_W217_G1.0960.54
37_H229_L1.0960.54
178_S199_D1.0950.54
169_T238_E1.0950.54
175_I190_F1.0800.53
97_A166_Q1.0770.52
218_H223_A1.0740.52
11_L227_M1.0710.52
188_N208_D1.0690.52
17_T53_V1.0640.51
17_T127_I1.0620.51
190_F221_R1.0560.51
88_I177_Q1.0530.51
192_Q244_L1.0510.51
74_L200_L1.0500.51
127_I133_S1.0340.49
35_V152_S1.0280.49
28_L122_R1.0220.49
34_I39_G1.0190.48
146_P208_D1.0160.48
98_A224_I1.0110.48
15_M175_I1.0090.48
123_Q143_L1.0020.47
147_Q151_D0.9990.47
31_N42_H0.9910.46
108_I210_Q0.9880.46
61_T96_K0.9850.46
7_F10_P0.9780.46
33_P53_V0.9780.46
136_L215_I0.9760.45
33_P211_L0.9750.45
7_F21_I0.9710.45
94_Q174_L0.9690.45
97_A102_L0.9670.45
194_N217_G0.9660.45
7_F82_G0.9650.45
186_S239_R0.9630.45
12_N205_L0.9610.44
83_V88_I0.9570.44
108_I145_L0.9570.44
121_V136_L0.9550.44
108_I215_I0.9490.44
23_F133_S0.9390.43
28_L46_N0.9330.42
84_D212_Y0.9320.42
64_L95_L0.9310.42
7_F140_H0.9290.42
62_E136_L0.9290.42
194_N223_A0.9270.42
50_L122_R0.9230.42
146_P210_Q0.9220.42
40_A60_R0.9180.41
59_V164_L0.9160.41
60_R121_V0.9110.41
23_F50_L0.9050.41
90_A156_T0.9020.40
9_H224_I0.9010.40
74_L174_L0.8930.40
180_P240_L0.8850.39
122_R213_P0.8850.39
191_Y203_L0.8810.39
62_E124_R0.8790.39
203_L243_E0.8760.39
89_E93_Q0.8740.39
7_F15_M0.8680.38
168_L203_L0.8590.38
217_G222_F0.8580.38
190_F226_F0.8560.37
90_A238_E0.8540.37
32_L69_R0.8500.37
178_S205_L0.8430.37
77_W123_Q0.8370.36
5_V225_R0.8350.36
218_H221_R0.8310.36
9_H198_A0.8290.36
18_W214_Q0.8230.35
150_R166_Q0.8230.35
135_D216_S0.8230.35
108_I231_T0.8210.35
145_L149_Q0.8210.35
106_P225_R0.8120.35
24_L150_R0.8090.34
141_I222_F0.8070.34
172_L189_G0.8030.34
162_N241_D0.8020.34
112_L168_L0.8020.34
25_I110_Q0.8010.34
186_S240_L0.7930.33
94_Q165_T0.7920.33
67_L95_L0.7900.33
87_R107_R0.7890.33
127_I225_R0.7700.32
68_D191_Y0.7680.32
146_P233_N0.7640.32
31_N106_P0.7630.32
116_R214_Q0.7590.31
166_Q170_M0.7560.31
48_S218_H0.7550.31
86_S91_L0.7500.31
164_L204_N0.7500.31
55_E125_L0.7490.31
182_R185_T0.7480.31
161_L244_L0.7480.31
106_P199_D0.7470.31
107_R122_R0.7460.31
116_R195_G0.7430.30
185_T241_D0.7400.30
206_S210_Q0.7370.30
103_I197_D0.7270.29
51_L211_L0.7240.29
124_R217_G0.7220.29
36_D82_G0.7170.29
92_I219_K0.7170.29
80_V220_S0.7140.29
53_V84_D0.7120.29
33_P151_D0.7120.29
66_E178_S0.7110.29
50_L119_A0.7100.29
94_Q238_E0.7100.29
18_W235_Q0.7100.29
123_Q221_R0.7090.28
64_L224_I0.7080.28
94_Q97_A0.7080.28
23_F145_L0.7060.28
41_L44_F0.7050.28
14_K41_L0.7020.28
11_L18_W0.7020.28
54_F76_T0.7020.28
152_S208_D0.7020.28
8_E16_R0.7010.28
57_G141_I0.7010.28
8_E22_E0.6980.28
7_F211_L0.6960.28
78_I163_P0.6940.28
12_N15_M0.6920.28
124_R128_P0.6920.28
138_T200_L0.6910.27
56_R60_R0.6890.27
61_T65_K0.6870.27
41_L122_R0.6820.27
60_R239_R0.6760.27
156_T166_Q0.6720.26
153_Q164_L0.6720.26
43_F116_R0.6700.26
40_A212_Y0.6690.26
139_L245_A0.6670.26
25_I165_T0.6650.26
95_L170_M0.6650.26
11_L215_I0.6640.26
195_G201_L0.6630.26
118_I218_H0.6620.26
83_V196_G0.6540.25
156_T208_D0.6500.25
108_I193_D0.6470.25
75_Q89_E0.6470.25
12_N17_T0.6450.25
48_S214_Q0.6440.25
156_T243_E0.6430.25
94_Q241_D0.6430.25
171_V244_L0.6390.25
124_R216_S0.6390.25
19_L161_L0.6390.25
19_L157_W0.6380.25
52_D122_R0.6370.25
27_Q224_I0.6370.25
55_E245_A0.6360.25
70_Q73_K0.6320.24
9_H218_H0.6300.24
129_G135_D0.6300.24
220_S223_A0.6290.24
62_E217_G0.6290.24
159_A208_D0.6250.24
169_T243_E0.6240.24
19_L213_P0.6230.24
8_E31_N0.6210.24
147_Q156_T0.6140.23
33_P88_I0.6130.23
96_K230_D0.6120.23
139_L181_F0.6110.23
73_K228_P0.6100.23
28_L206_S0.6090.23
66_E174_L0.6080.23
41_L119_A0.6050.23
81_P213_P0.6040.23
108_I246_C0.6020.23
40_A214_Q0.6010.23
135_D192_Q0.6010.23
86_S208_D0.6010.23
137_P172_L0.5990.23
8_E135_D0.5990.23
145_L224_I0.5980.23
59_V102_L0.5960.23
14_K50_L0.5950.22
107_R227_M0.5950.22
153_Q156_T0.5920.22
77_W168_L0.5920.22
8_E19_L0.5920.22
41_L139_L0.5900.22
13_E56_R0.5880.22
42_H226_F0.5880.22
44_F214_Q0.5850.22
65_K134_F0.5820.22
205_L242_F0.5810.22
43_F199_D0.5790.22
15_M105_A0.5790.22
52_D119_A0.5780.22
188_N210_Q0.5760.22
113_R213_P0.5750.22
32_L150_R0.5740.21
122_R139_L0.5720.21
162_N244_L0.5670.21
58_E88_I0.5670.21
13_E216_S0.5600.21
86_S114_E0.5540.21
65_K218_H0.5530.21
10_P216_S0.5530.21
98_A170_M0.5470.20
72_R187_L0.5440.20
66_E150_R0.5430.20
104_S149_Q0.5430.20
93_Q159_A0.5410.20
179_A245_A0.5410.20
102_L200_L0.5380.20
36_D39_G0.5350.20
43_F60_R0.5350.20
18_W44_F0.5350.20
127_I130_G0.5340.20
14_K124_R0.5330.20
23_F66_E0.5330.20
99_G203_L0.5310.20
60_R80_V0.5310.20
5_V180_P0.5310.20
52_D211_L0.5280.19
48_S66_E0.5270.19
59_V170_M0.5270.19
54_F219_K0.5260.19
28_L159_A0.5250.19
97_A152_S0.5250.19
56_R171_V0.5240.19
128_P134_F0.5230.19
64_L82_G0.5220.19
159_A238_E0.5210.19
5_V106_P0.5200.19
120_L227_M0.5190.19
20_R66_E0.5170.19
198_A201_L0.5160.19
78_I117_L0.5160.19
95_L98_A0.5150.19
53_V213_P0.5150.19
209_S241_D0.5140.19
115_D120_L0.5100.19
113_R224_I0.5100.19
74_L178_S0.5100.19
116_R139_L0.5100.19
86_S90_A0.5090.19
188_N232_E0.5090.19
43_F196_G0.5090.19
139_L199_D0.5080.19
123_Q190_F0.5070.19
13_E20_R0.5020.18
34_I154_V0.5010.18
153_Q203_L0.5010.18
99_G206_S0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2oezA 2 0.9879 100 0.039 Contact Map
4v194 1 0.1741 18.8 0.968 Contact Map
4ghuA 3 0.3927 14.2 0.969 Contact Map
4ydhA 2 0.3482 13 0.97 Contact Map
4pacA 1 0.5263 11.8 0.97 Contact Map
3gqbA 1 0.413 10.8 0.971 Contact Map
2y3aB 1 0.7247 9 0.972 Contact Map
1kbhB 1 0.2267 7.9 0.973 Contact Map
1d00A 3 0.3077 7.6 0.973 Contact Map
1zoqC 1 0.1822 7.5 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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