GREMLIN Database
TRER - HTH-type transcriptional regulator TreR
UniProt: P36673 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12202
Length: 315 (301)
Sequences: 35891 (25728)
Seq/√Len: 1482.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
160_E200_A3.3471.00
13_L45_Q3.0781.00
175_H234_T3.0591.00
166_L262_A2.6461.00
195_H199_L2.6171.00
121_G295_L2.6141.00
175_H260_Q2.5171.00
153_A298_Q2.3991.00
266_N281_D2.3901.00
164_K204_A2.3121.00
33_Q37_E2.2811.00
41_A45_Q2.2251.00
222_Y253_E2.2091.00
226_A254_Q2.2041.00
87_A90_E2.1941.00
87_A293_C2.1771.00
37_E41_A2.1491.00
168_Q201_F2.1281.00
171_Y205_H2.1101.00
161_G165_I2.1091.00
164_K201_F2.0791.00
226_A250_Y2.0531.00
164_K200_A2.0471.00
290_Q293_C2.0251.00
24_V39_V2.0041.00
88_F292_A1.9891.00
160_E196_E1.9341.00
36_R40_E1.9091.00
87_A289_R1.9011.00
162_A264_V1.8991.00
8_K18_K1.8991.00
170_L235_A1.8721.00
163_I167_M1.8691.00
25_L43_M1.8661.00
83_T288_G1.8511.00
230_T254_Q1.8431.00
168_Q172_D1.8381.00
251_L259_L1.8161.00
167_M198_Y1.8141.00
297_A302_R1.8111.00
163_I237_L1.7851.00
168_Q205_H1.7811.00
169_R173_Q1.7811.00
13_L42_V1.7701.00
86_P285_A1.7661.00
221_G246_G1.7361.00
14_S42_V1.7331.00
164_K168_Q1.7131.00
179_S233_T1.7111.00
225_V247_A1.6651.00
180_Y239_A1.6601.00
87_A91_Q1.6551.00
83_T285_A1.6521.00
238_C247_A1.6481.00
66_A119_I1.6431.00
222_Y250_Y1.6431.00
283_G286_E1.6371.00
250_Y254_Q1.6171.00
145_L291_A1.5901.00
161_G164_K1.5581.00
91_Q296_I1.5441.00
177_N232_E1.5281.00
169_R172_D1.5191.00
40_E44_N1.5161.00
250_Y253_E1.4971.00
171_Y201_F1.4941.00
286_E290_Q1.4901.00
252_Q274_H1.4871.00
196_E200_A1.4871.00
24_V43_M1.4571.00
262_A278_V1.4561.00
63_K120_D1.4381.00
10_I42_V1.4291.00
40_E43_M1.4271.00
286_E289_R1.4121.00
199_L203_K1.4121.00
193_R196_E1.4111.00
201_F204_A1.4021.00
158_D161_G1.3921.00
133_E137_H1.3751.00
87_A292_A1.3721.00
177_N234_T1.3641.00
222_Y226_A1.3631.00
251_L256_I1.3591.00
296_I300_T1.3591.00
177_N210_V1.3461.00
215_G220_Q1.3441.00
8_K12_R1.3391.00
222_Y249_K1.3351.00
167_M171_Y1.3261.00
13_L46_H1.3231.00
226_A253_E1.3221.00
167_M201_F1.3211.00
179_S228_V1.3111.00
9_D12_R1.3111.00
38_R42_V1.2981.00
225_V236_L1.2941.00
226_A230_T1.2861.00
42_V45_Q1.2801.00
33_Q36_R1.2791.00
123_V291_A1.2611.00
63_K93_Y1.2611.00
165_I168_Q1.2561.00
167_M197_A1.2521.00
225_V251_L1.2501.00
65_V88_F1.2481.00
293_C297_A1.2461.00
160_E164_K1.2461.00
32_S35_T1.2351.00
163_I197_A1.2311.00
23_R28_E1.2281.00
197_A201_F1.2241.00
98_M110_H1.2201.00
248_S261_L1.2151.00
176_R234_T1.2131.00
7_I18_K1.2091.00
42_V46_H1.2091.00
168_Q204_A1.2081.00
88_F95_P1.1941.00
84_M292_A1.1941.00
169_R278_V1.1941.00
35_T38_R1.1891.00
98_M114_L1.1881.00
10_I14_S1.1801.00
285_A289_R1.1781.00
175_H235_A1.1781.00
66_A114_L1.1721.00
160_E193_R1.1621.00
201_F205_H1.1571.00
198_Y202_C1.1551.00
10_I46_H1.1501.00
84_M123_V1.1481.00
67_I84_M1.1361.00
160_E197_A1.1301.00
64_V94_D1.1251.00
181_L247_A1.1241.00
171_Y207_L1.1201.00
91_Q293_C1.1161.00
290_Q294_Q1.1091.00
41_A44_N1.1071.00
241_D279_T1.1071.00
24_V31_V1.1051.00
37_E40_E1.1011.00
178_I202_C1.1001.00
224_N227_K1.0971.00
85_L89_Y1.0961.00
219_K223_E1.0931.00
64_V96_I1.0931.00
180_Y195_H1.0891.00
166_L237_L1.0891.00
217_A220_Q1.0861.00
200_A204_A1.0841.00
67_I95_P1.0821.00
246_G250_Y1.0801.00
89_Y106_L1.0711.00
196_E199_L1.0631.00
177_N231_P1.0631.00
27_N36_R1.0591.00
236_L247_A1.0451.00
7_I21_V1.0431.00
288_G292_A1.0411.00
93_Y296_I1.0401.00
248_S273_L1.0371.00
153_A294_Q1.0301.00
289_R293_C1.0291.00
108_A112_G1.0261.00
198_Y237_L1.0141.00
91_Q300_T1.0071.00
238_C243_L1.0061.00
252_Q276_E1.0031.00
51_S57_M1.0021.00
192_K196_E1.0021.00
53_S56_A1.0001.00
223_E227_K0.9981.00
178_I235_A0.9971.00
189_T193_R0.9951.00
112_G134_M0.9941.00
43_M46_H0.9911.00
241_D263_S0.9901.00
173_Q260_Q0.9891.00
295_L299_V0.9871.00
172_D205_H0.9821.00
238_C244_A0.9791.00
220_Q223_E0.9771.00
218_M249_K0.9601.00
176_R207_L0.9561.00
106_L109_E0.9501.00
14_S21_V0.9451.00
225_V229_I0.9411.00
199_L209_P0.9401.00
112_G116_R0.9361.00
221_G225_V0.9351.00
90_E289_R0.9341.00
166_L280_V0.9331.00
157_Y283_G0.9311.00
123_V295_L0.9191.00
171_Y176_R0.9171.00
82_Q86_P0.9161.00
167_M202_C0.9141.00
51_S54_A0.9141.00
81_V85_L0.9101.00
236_L259_L0.9071.00
27_N40_E0.9031.00
272_F275_P0.9011.00
155_V294_Q0.8941.00
202_C207_L0.8891.00
65_V123_V0.8861.00
50_P55_R0.8841.00
54_A57_M0.8831.00
177_N208_H0.8811.00
256_I259_L0.8801.00
223_E226_A0.8801.00
294_Q297_A0.8761.00
86_P289_R0.8761.00
273_L276_E0.8741.00
103_S106_L0.8701.00
182_G195_H0.8631.00
266_N270_M0.8591.00
24_V40_E0.8571.00
229_I250_Y0.8541.00
84_M288_G0.8481.00
232_E256_I0.8471.00
76_S284_Y0.8401.00
220_Q224_N0.8391.00
67_I81_V0.8371.00
80_A145_L0.8351.00
6_T9_D0.8331.00
202_C209_P0.8301.00
241_D266_N0.8241.00
34_L37_E0.8221.00
200_A203_K0.8221.00
251_L261_L0.8171.00
225_V228_V0.8161.00
263_S279_T0.8131.00
157_Y282_P0.8091.00
16_V39_V0.8081.00
179_S236_L0.8081.00
183_V216_L0.8081.00
170_L262_A0.8061.00
83_T87_A0.8051.00
52_R55_R0.8001.00
134_M137_H0.7971.00
292_A296_I0.7971.00
225_V250_Y0.7961.00
121_G299_V0.7951.00
271_K276_E0.7951.00
86_P90_E0.7951.00
81_V97_M0.7891.00
62_D120_D0.7881.00
19_S23_R0.7841.00
181_L238_C0.7801.00
214_P243_L0.7791.00
159_D194_R0.7781.00
213_L227_K0.7751.00
79_L285_A0.7751.00
83_T289_R0.7721.00
193_R197_A0.7721.00
154_S307_Q0.7711.00
20_T23_R0.7701.00
64_V117_R0.7681.00
84_M95_P0.7661.00
61_S120_D0.7651.00
34_L38_R0.7631.00
115_K138_W0.7621.00
133_E136_A0.7601.00
165_I169_R0.7601.00
85_L95_P0.7591.00
249_K252_Q0.7521.00
186_S192_K0.7511.00
135_L142_L0.7511.00
70_T77_E0.7511.00
96_I119_I0.7491.00
297_A301_G0.7451.00
109_E112_G0.7451.00
180_Y237_L0.7411.00
229_I254_Q0.7401.00
165_I280_V0.7361.00
23_R29_S0.7341.00
244_A263_S0.7331.00
82_Q85_L0.7291.00
214_P220_Q0.7241.00
49_S116_R0.7211.00
23_R30_G0.7141.00
265_G282_P0.7121.00
136_A142_L0.7101.00
144_L149_A0.7091.00
65_V292_A0.7071.00
24_V36_R0.7041.00
234_T260_Q0.7031.00
207_L210_V0.7031.00
106_L110_H0.7021.00
249_K253_E0.7021.00
249_K276_E0.7021.00
142_L152_F0.6981.00
101_Q106_L0.6981.00
237_L262_A0.6971.00
66_A122_V0.6971.00
123_V145_L0.6961.00
68_I110_H0.6931.00
61_S300_T0.6921.00
156_C307_Q0.6901.00
164_K197_A0.6891.00
221_G224_N0.6871.00
241_D244_A0.6861.00
171_Y202_C0.6841.00
148_D307_Q0.6821.00
178_I234_T0.6811.00
105_Q109_E0.6751.00
85_L99_E0.6741.00
245_L273_L0.6731.00
121_G143_V0.6731.00
37_E44_N0.6681.00
49_S112_G0.6621.00
195_H211_A0.6611.00
227_K230_T0.6611.00
96_I117_R0.6611.00
191_G216_L0.6611.00
111_L122_V0.6601.00
180_Y198_Y0.6601.00
79_L284_Y0.6601.00
16_V35_T0.6591.00
143_V298_Q0.6591.00
136_A152_F0.6571.00
248_S252_Q0.6571.00
198_Y209_P0.6571.00
115_K140_S0.6471.00
30_G35_T0.6451.00
143_V295_L0.6441.00
185_H213_L0.6421.00
10_I21_V0.6391.00
153_A306_Q0.6381.00
178_I198_Y0.6361.00
44_N47_G0.6321.00
144_L152_F0.6311.00
135_L139_Q0.6311.00
143_V155_V0.6301.00
146_A190_T0.6291.00
216_L239_A0.6231.00
148_D154_S0.6221.00
245_L269_L0.6211.00
38_R41_A0.6211.00
82_Q285_A0.6161.00
121_G291_A0.6161.00
164_K167_M0.6161.00
170_L237_L0.6151.00
249_K274_H0.6151.00
122_V140_S0.6141.00
183_V191_G0.6141.00
8_K58_R0.6111.00
240_T265_G0.6111.00
240_T243_L0.6091.00
270_M277_I0.6071.00
83_T284_Y0.6051.00
104_P108_A0.6041.00
21_V43_M0.6011.00
251_L254_Q0.6001.00
74_S242_T0.5971.00
65_V121_G0.5971.00
159_D193_R0.5951.00
88_F93_Y0.5941.00
65_V93_Y0.5941.00
93_Y299_V0.5931.00
98_M113_V0.5921.00
270_M279_T0.5911.00
80_A284_Y0.5871.00
169_R262_A0.5861.00
218_M269_L0.5861.00
65_V299_V0.5851.00
294_Q298_Q0.5841.00
191_G239_A0.5831.00
62_D94_D0.5831.00
146_A159_D0.5821.00
177_N233_T0.5821.00
49_S53_S0.5811.00
195_H213_L0.5781.00
155_V290_Q0.5751.00
225_V246_G0.5731.00
219_K222_Y0.5731.00
23_R31_V0.5731.00
245_L267_T0.5721.00
93_Y120_D0.5711.00
76_S80_A0.5701.00
212_A228_V0.5691.00
143_V291_A0.5691.00
21_V24_V0.5681.00
222_Y225_V0.5681.00
143_V294_Q0.5641.00
237_L264_V0.5621.00
272_F276_E0.5561.00
218_M246_G0.5551.00
181_L224_N0.5551.00
64_V120_D0.5541.00
297_A306_Q0.5541.00
166_L235_A0.5521.00
134_M138_W0.5511.00
84_M88_F0.5481.00
290_Q297_A0.5471.00
31_V36_R0.5461.00
285_A288_G0.5461.00
144_L154_S0.5451.00
233_T236_L0.5441.00
159_D190_T0.5431.00
28_E31_V0.5421.00
247_A251_L0.5411.00
16_V21_V0.5401.00
224_N228_V0.5401.00
157_Y162_A0.5391.00
114_L119_I0.5391.00
112_G115_K0.5391.00
264_V282_P0.5381.00
252_Q275_P0.5371.00
82_Q101_Q0.5351.00
249_K271_K0.5311.00
55_R59_G0.5311.00
167_M205_H0.5291.00
182_G213_L0.5291.00
19_S28_E0.5281.00
119_I122_V0.5261.00
87_A296_I0.5251.00
27_N30_G0.5251.00
214_P221_G0.5251.00
14_S24_V0.5241.00
168_Q171_Y0.5241.00
298_Q301_G0.5231.00
21_V39_V0.5201.00
9_D13_L0.5201.00
160_E163_I0.5181.00
36_R39_V0.5181.00
222_Y246_G0.5181.00
113_V116_R0.5181.00
216_L243_L0.5161.00
74_S77_E0.5161.00
75_L242_T0.5151.00
238_C263_S0.5151.00
232_E258_T0.5151.00
271_K275_P0.5151.00
229_I251_L0.5141.00
77_E125_F0.5111.00
233_T256_I0.5111.00
109_E113_V0.5091.00
156_C159_D0.5071.00
73_D79_L0.5071.00
62_D93_Y0.5061.00
88_F296_I0.5061.00
212_A224_N0.5051.00
253_E274_H0.5051.00
235_A260_Q0.5031.00
267_T270_M0.5031.00
56_A59_G0.5021.00
182_G239_A0.5011.00
133_E138_W0.5011.00
29_S36_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bilA 2 0.7619 100 0.088 Contact Map
2o20A 2 0.819 100 0.096 Contact Map
3dbiA 2 0.8095 100 0.097 Contact Map
4o5aA 2 0.7968 100 0.103 Contact Map
3jvdA 2 0.7841 100 0.107 Contact Map
3ctpA 2 0.7968 100 0.109 Contact Map
1qpzA 2 0.9841 100 0.112 Contact Map
3e3mA 2 0.7873 100 0.113 Contact Map
2hsgA 1 0.9778 100 0.115 Contact Map
3h5oA 2 0.7968 100 0.116 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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