GREMLIN Database
PTTBC - PTS system trehalose-specific EIIBC component
UniProt: P36672 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12127
Length: 473 (440)
Sequences: 4098 (2329)
Seq/√Len: 111.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_R47_E4.5091.00
412_L448_I4.1161.00
405_G452_I3.8381.00
311_F407_G3.7511.00
8_T12_R3.6721.00
358_G454_I3.5591.00
238_A274_A3.3861.00
265_C269_L3.2621.00
40_P59_T3.2271.00
37_L43_A3.2141.00
14_I79_L3.0521.00
9_D51_L2.9601.00
16_L44_R2.9311.00
46_K49_E2.9111.00
176_C190_G2.8621.00
45_P64_F2.8191.00
242_L266_S2.7801.00
412_L441_V2.7591.00
39_Q42_N2.7231.00
408_L452_I2.6871.00
253_V261_V2.5171.00
56_G67_V2.4931.00
352_Q392_N2.4761.00
401_C460_I2.4501.00
101_M106_Q2.4481.00
363_S368_E2.4281.00
20_R84_G2.4271.00
35_F66_V2.4031.00
78_A81_A2.3611.00
24_A38_N2.3351.00
177_W191_I2.3111.00
332_M339_T2.3021.00
249_L265_C2.2951.00
248_R252_I2.2721.00
16_L51_L2.2631.00
16_L47_E2.2411.00
45_P49_E2.2401.00
45_P59_T2.2071.00
52_P367_N2.1911.00
412_L416_N2.1691.00
35_F79_L2.1671.00
250_K258_Y2.1581.00
78_A82_S2.1391.00
416_N441_V2.1251.00
241_A273_L2.1151.00
443_A447_A2.0781.00
173_V195_V2.0671.00
17_V35_F2.0601.00
26_V79_L2.0401.00
177_W187_P2.0151.00
12_R51_L2.0031.00
131_F135_I1.9551.00
11_D82_S1.9421.00
14_I83_T1.9381.00
310_G406_S1.9311.00
26_V35_F1.9301.00
13_L48_I1.8901.00
110_H183_M1.8281.00
400_L404_I1.8171.00
25_T36_V1.8041.00
257_L261_V1.7831.00
455_V459_F1.7631.00
48_I51_L1.7381.00
284_M288_G1.7331.00
360_I373_V1.7301.00
244_V248_R1.7171.00
28_H76_Y1.7161.00
413_C445_A1.7011.00
47_E50_Q1.7001.00
354_S450_I1.7001.00
357_I376_A1.6951.00
244_V247_T1.6921.00
12_R15_E1.6851.00
354_S453_P1.6671.00
401_C456_L1.6641.00
441_V444_L1.6601.00
76_Y80_I1.6561.00
356_V387_A1.6491.00
307_A411_L1.6371.00
129_L165_E1.6361.00
388_M399_M1.6341.00
173_V191_I1.6321.00
249_L253_V1.6281.00
237_L282_G1.6231.00
456_L460_I1.6161.00
353_G379_A1.5961.00
185_G239_G1.5931.00
338_G419_M1.5931.00
395_Y398_P1.5801.00
306_A410_G1.5781.00
401_C405_G1.5671.00
11_D15_E1.5541.00
13_L68_I1.5501.00
135_I140_M1.5391.00
10_I79_L1.5331.00
245_I270_A1.5311.00
287_D291_F1.5151.00
362_S461_Y1.5111.00
315_P403_M1.5051.00
240_L243_G1.5011.00
17_V37_L1.4841.00
103_W106_Q1.4821.00
109_S182_K1.4811.00
181_K187_P1.4651.00
58_F67_V1.4641.00
261_V265_C1.4611.00
452_I456_L1.4491.00
451_I455_V1.4451.00
288_G292_A1.4361.00
307_A407_G1.4331.00
365_K368_E1.4161.00
23_I85_Q1.3991.00
314_A349_N1.3921.00
26_V80_I1.3841.00
311_F315_P1.3801.00
368_E395_Y1.3741.00
457_T461_Y1.3711.00
177_W188_I1.3601.00
180_V239_G1.3591.00
179_A240_L1.3481.00
395_Y462_Q1.3451.00
14_I82_S1.3391.00
127_L264_V1.3361.00
240_L244_V1.3100.99
193_L267_L1.2960.99
411_L415_L1.2760.99
306_A411_L1.2740.99
159_F223_I1.2680.99
245_I269_L1.2580.99
405_G453_P1.2360.99
412_L444_L1.2350.99
103_W107_L1.2290.99
190_G194_G1.2280.99
435_Q438_Y1.2280.99
16_L48_I1.2260.99
270_A274_A1.2210.99
292_A295_H1.2210.99
48_I64_F1.2200.99
359_I363_S1.2180.99
354_S449_A1.2160.99
241_A278_I1.2150.99
361_I454_I1.2140.99
397_F463_R1.2080.99
346_A442_F1.2070.99
412_L445_A1.2000.99
178_S188_I1.1970.99
258_Y262_V1.1900.99
454_I458_S1.1870.99
142_N153_L1.1850.99
40_P62_G1.1810.99
408_L448_I1.1780.99
163_I271_V1.1780.99
358_G458_S1.1700.99
180_V187_P1.1630.99
23_I83_T1.1620.99
175_I232_V1.1580.99
248_R251_R1.1530.99
306_A414_G1.1520.99
185_G242_L1.1500.99
9_D53_M1.1470.99
10_I82_S1.1450.99
289_V316_L1.1440.99
14_I23_I1.1440.99
233_I237_L1.1360.99
115_F232_V1.1330.98
397_F461_Y1.1320.98
125_G167_I1.1270.98
249_L262_V1.1270.98
165_E169_F1.1250.98
404_I456_L1.1220.98
347_L413_C1.1220.98
376_A380_W1.1210.98
12_R47_E1.1170.98
48_I54_V1.1160.98
79_L82_S1.1140.98
362_S462_Q1.1100.98
241_A270_A1.1030.98
180_V190_G1.1000.98
179_A236_L1.0990.98
361_I457_T1.0940.98
303_P415_L1.0920.98
184_G247_T1.0920.98
68_I75_Y1.0860.98
79_L83_T1.0830.98
193_L235_A1.0730.98
277_L281_F1.0720.98
401_C457_T1.0710.98
388_M402_A1.0690.98
180_V185_G1.0620.98
186_T246_E1.0550.98
20_R83_T1.0490.97
239_G243_G1.0460.97
194_G235_A1.0430.97
51_L54_V1.0410.97
128_I164_G1.0350.97
132_R157_Y1.0330.97
340_P343_P1.0310.97
448_I452_I1.0270.97
8_T11_D1.0260.97
166_A195_V1.0240.97
440_Q443_A1.0180.97
118_L178_S1.0180.97
351_A402_A1.0170.97
405_G409_A1.0160.97
354_S358_G1.0140.97
30_I383_V1.0100.97
118_L171_L1.0080.97
409_A449_A1.0070.97
183_M240_L1.0070.97
243_G247_T1.0040.97
409_A448_I1.0010.97
196_T271_V0.9990.97
71_N74_D0.9980.97
285_I288_G0.9970.97
392_N398_P0.9880.96
294_R298_T0.9840.96
293_V340_P0.9830.96
357_I361_I0.9830.96
307_A408_L0.9820.96
170_Y200_P0.9800.96
110_H114_I0.9800.96
374_P378_S0.9780.96
13_L51_L0.9780.96
355_A392_N0.9740.96
368_E391_I0.9720.96
346_A430_G0.9720.96
282_G286_G0.9710.96
313_Y344_L0.9710.96
281_F285_I0.9660.96
9_D13_L0.9610.96
80_I85_Q0.9600.96
438_Y441_V0.9570.96
113_V182_K0.9570.96
288_G291_F0.9560.96
310_G410_G0.9560.96
40_P64_F0.9550.96
71_N255_D0.9540.96
77_Q81_A0.9540.96
73_G77_Q0.9530.96
57_C64_F0.9510.96
24_A36_V0.9500.96
359_I372_S0.9480.95
15_E47_E0.9480.95
156_I159_F0.9360.95
185_G190_G0.9330.95
355_A402_A0.9330.95
316_L325_T0.9310.95
193_L270_A0.9310.95
205_A216_W0.9310.95
368_E464_K0.9290.95
10_I78_A0.9280.95
179_A183_M0.9270.95
398_P401_C0.9240.95
413_C418_V0.9220.95
350_I353_G0.9110.94
174_G192_V0.9090.94
59_T64_F0.9030.94
436_P439_W0.9030.94
245_I249_L0.9010.94
354_S380_W0.9000.94
361_I453_P0.9000.94
348_S352_Q0.9000.94
176_C194_G0.8990.94
12_R52_P0.8960.94
194_G266_S0.8930.94
447_A451_I0.8900.94
134_V138_L0.8900.94
440_Q444_L0.8870.94
233_I282_G0.8850.93
183_M243_G0.8830.93
352_Q402_A0.8830.93
45_P57_C0.8830.93
359_I391_I0.8790.93
176_C235_A0.8780.93
237_L278_I0.8770.93
351_A355_A0.8770.93
12_R16_L0.8750.93
90_K97_A0.8720.93
355_A398_P0.8710.93
365_K464_K0.8690.93
100_N106_Q0.8690.93
315_P399_M0.8680.93
175_I235_A0.8680.93
303_P411_L0.8670.93
163_I196_T0.8650.93
17_V64_F0.8630.93
114_I236_L0.8630.93
416_N448_I0.8620.93
8_T52_P0.8610.93
284_M287_D0.8610.93
107_L110_H0.8610.93
360_I372_S0.8590.92
28_H72_V0.8580.92
311_F400_L0.8560.92
37_L64_F0.8540.92
176_C191_I0.8530.92
142_N154_Q0.8510.92
184_G190_G0.8470.92
99_H103_W0.8470.92
11_D78_A0.8440.92
176_C239_G0.8430.92
278_I282_G0.8420.92
418_V445_A0.8400.92
311_F403_M0.8380.91
306_A310_G0.8350.91
165_E199_S0.8300.91
40_P45_P0.8280.91
46_K50_Q0.8250.91
331_Q335_S0.8250.91
424_G433_S0.8240.91
255_D258_Y0.8230.91
26_V83_T0.8220.91
379_A384_T0.8220.91
408_L412_L0.8220.91
392_N402_A0.8190.91
241_A245_I0.8150.90
238_A273_L0.8140.90
448_I451_I0.8110.90
67_V389_Y0.8100.90
250_K262_V0.8070.90
95_K98_R0.8070.90
198_V229_Q0.8060.90
45_P48_I0.8040.90
48_I66_V0.7970.89
167_I174_G0.7970.89
398_P457_T0.7950.89
253_V257_L0.7930.89
223_I276_A0.7930.89
301_F304_I0.7890.89
99_H106_Q0.7890.89
446_M449_A0.7860.89
49_E394_K0.7860.89
325_T329_D0.7840.89
174_G195_V0.7840.89
38_N42_N0.7830.88
450_I453_P0.7830.88
132_R164_G0.7810.88
11_D20_R0.7810.88
363_S464_K0.7790.88
306_A344_L0.7780.88
442_F446_M0.7770.88
21_G38_N0.7750.88
96_A99_H0.7740.88
431_I443_A0.7720.88
174_G191_I0.7710.88
14_I17_V0.7710.88
319_T389_Y0.7680.87
228_Y234_P0.7670.87
458_S461_Y0.7670.87
371_I375_A0.7670.87
125_G166_A0.7660.87
185_G246_E0.7660.87
347_L406_S0.7640.87
235_A239_G0.7620.87
173_V194_G0.7620.87
41_A44_R0.7610.87
273_L278_I0.7590.87
15_E44_R0.7580.87
13_L16_L0.7550.87
47_E51_L0.7540.87
352_Q387_A0.7530.86
416_N444_L0.7520.86
74_D255_D0.7490.86
43_A57_C0.7490.86
81_A84_G0.7480.86
49_E57_C0.7480.86
352_Q355_A0.7420.86
391_I395_Y0.7400.85
177_W192_V0.7400.85
43_A64_F0.7380.85
254_P257_L0.7380.85
80_I83_T0.7360.85
384_T387_A0.7360.85
99_H102_K0.7360.85
17_V23_I0.7340.85
412_L415_L0.7310.85
317_V348_S0.7300.85
192_V196_T0.7300.85
245_I266_S0.7290.85
347_L409_A0.7290.85
362_S458_S0.7260.84
360_I369_R0.7240.84
303_P307_A0.7230.84
109_S113_V0.7210.84
379_A387_A0.7200.84
166_A196_T0.7190.84
110_H240_L0.7190.84
449_A453_P0.7160.84
21_G42_N0.7140.83
13_L17_V0.7110.83
98_R106_Q0.7110.83
307_A310_G0.7090.83
77_Q80_I0.7090.83
49_E56_G0.7070.83
302_A305_G0.7070.83
400_L403_M0.7060.83
80_I84_G0.7040.83
312_L403_M0.7040.83
359_I398_P0.7040.83
314_A388_M0.7010.82
134_V140_M0.7010.82
266_S270_A0.7000.82
352_Q379_A0.6990.82
309_F316_L0.6980.82
104_H107_L0.6970.82
154_Q158_D0.6970.82
9_D68_I0.6960.82
218_F276_A0.6950.82
158_D161_W0.6910.81
257_L381_L0.6910.81
357_I454_I0.6900.81
166_A199_S0.6880.81
253_V265_C0.6880.81
9_D12_R0.6880.81
351_A405_G0.6870.81
418_V441_V0.6860.81
203_M207_L0.6840.81
309_F327_A0.6820.81
9_D75_Y0.6810.80
359_I368_E0.6790.80
16_L46_K0.6790.80
409_A445_A0.6790.80
30_I426_G0.6780.80
358_G457_T0.6780.80
29_C32_R0.6780.80
253_V262_V0.6770.80
189_L242_L0.6750.80
42_N50_Q0.6740.80
14_I20_R0.6730.80
291_F295_H0.6710.79
108_I393_L0.6710.79
177_W181_K0.6700.79
202_L206_Y0.6700.79
397_F462_Q0.6690.79
134_V137_D0.6680.79
38_N85_Q0.6660.79
314_A348_S0.6650.79
405_G408_L0.6650.79
162_L199_S0.6640.79
350_I427_G0.6630.79
446_M450_I0.6630.79
369_R373_V0.6630.79
35_F64_F0.6590.78
114_I183_M0.6560.78
291_F294_R0.6550.78
405_G456_L0.6540.78
27_S62_G0.6530.78
136_G157_Y0.6520.77
402_A452_I0.6500.77
184_G246_E0.6500.77
314_A399_M0.6480.77
295_H302_A0.6480.77
168_F171_L0.6470.77
127_L130_G0.6470.77
20_R85_Q0.6440.77
89_D94_K0.6440.77
460_I464_K0.6410.76
10_I81_A0.6400.76
315_P319_T0.6390.76
376_A379_A0.6390.76
33_L68_I0.6380.76
352_Q384_T0.6370.76
79_L84_G0.6370.76
246_E250_K0.6350.76
410_G414_G0.6330.75
138_L141_S0.6300.75
458_S462_Q0.6290.75
397_F464_K0.6270.75
126_G130_G0.6270.75
394_K398_P0.6250.74
312_L315_P0.6250.74
380_W428_L0.6250.74
190_G239_G0.6250.74
37_L59_T0.6240.74
16_L43_A0.6240.74
16_L50_Q0.6230.74
102_K105_E0.6230.74
246_E262_V0.6230.74
241_A244_V0.6230.74
29_C34_R0.6220.74
98_R101_M0.6210.74
169_F229_Q0.6210.74
453_P461_Y0.6200.74
422_G433_S0.6180.74
392_N399_M0.6180.74
401_C455_V0.6160.73
362_S464_K0.6150.73
426_G430_G0.6140.73
408_L411_L0.6140.73
283_R287_D0.6130.73
269_L272_F0.6130.73
153_L158_D0.6130.73
356_V360_I0.6120.73
314_A352_Q0.6110.73
286_G321_V0.6110.73
290_A325_T0.6100.73
380_W450_I0.6090.73
372_S376_A0.6080.72
228_Y286_G0.6080.72
273_L277_L0.6080.72
77_Q87_Q0.6060.72
114_I179_A0.6060.72
317_V352_Q0.6060.72
135_I141_S0.6040.72
129_L169_F0.6020.72
115_F327_A0.6000.71
239_G242_L0.5980.71
119_L382_G0.5980.71
9_D16_L0.5970.71
125_G171_L0.5960.71
56_G319_T0.5960.71
10_I83_T0.5930.71
155_T217_D0.5920.70
175_I179_A0.5910.70
350_I450_I0.5910.70
341_V345_I0.5910.70
401_C404_I0.5900.70
417_G437_S0.5890.70
120_P123_I0.5870.70
401_C459_F0.5870.70
80_I87_Q0.5860.70
9_D48_I0.5850.70
217_D220_M0.5850.70
121_A192_V0.5840.69
311_F314_A0.5840.69
441_V448_I0.5840.69
43_A66_V0.5830.69
163_I270_A0.5820.69
133_N161_W0.5810.69
102_K106_Q0.5800.69
42_N48_I0.5800.69
447_A455_V0.5790.69
233_I318_I0.5790.69
310_G407_G0.5790.69
128_I264_V0.5760.68
309_F325_T0.5760.68
130_G306_A0.5750.68
21_G47_E0.5750.68
330_L334_Q0.5750.68
431_I446_M0.5740.68
425_V433_S0.5740.68
349_N402_A0.5740.68
406_S410_G0.5730.68
238_A270_A0.5720.68
211_Q214_E0.5720.68
156_I218_F0.5710.68
129_L199_S0.5710.68
228_Y279_G0.5710.68
399_M402_A0.5710.68
348_S409_A0.5700.68
224_A283_R0.5680.67
355_A359_I0.5680.67
349_N376_A0.5680.67
12_R54_V0.5670.67
11_D23_I0.5670.67
169_F200_P0.5630.67
365_K465_Y0.5630.67
330_L423_I0.5630.67
349_N384_T0.5620.66
42_N66_V0.5620.66
49_E55_K0.5610.66
186_T250_K0.5600.66
356_V392_N0.5600.66
353_G450_I0.5580.66
309_F344_L0.5580.66
348_S406_S0.5580.66
40_P43_A0.5560.66
461_Y464_K0.5560.66
350_I446_M0.5560.66
292_A296_L0.5550.66
418_V439_W0.5550.66
347_L449_A0.5550.66
324_T327_A0.5530.65
194_G242_L0.5530.65
161_W165_E0.5520.65
361_I458_S0.5490.65
404_I407_G0.5490.65
215_V224_A0.5490.65
185_G243_G0.5490.65
27_S66_V0.5460.64
158_D162_L0.5450.64
119_L123_I0.5450.64
152_S156_I0.5440.64
40_P99_H0.5430.64
84_G88_V0.5430.64
42_N90_K0.5430.64
181_K184_G0.5430.64
68_I71_N0.5420.64
185_G266_S0.5420.64
249_L266_S0.5410.64
156_I219_G0.5400.63
130_G399_M0.5400.63
114_I130_G0.5400.63
142_N152_S0.5390.63
88_V101_M0.5380.63
202_L275_H0.5370.63
88_V97_A0.5360.63
74_D78_A0.5340.63
166_A192_V0.5340.63
251_R364_R0.5330.62
259_L262_V0.5320.62
155_T216_W0.5320.62
30_I259_L0.5320.62
13_L75_Y0.5320.62
348_S384_T0.5320.62
309_F345_I0.5310.62
23_I80_I0.5310.62
349_N387_A0.5310.62
27_S30_I0.5290.62
36_V62_G0.5290.62
55_K68_I0.5290.62
362_S368_E0.5280.62
362_S397_F0.5280.62
264_V267_L0.5270.62
204_N207_L0.5260.61
20_R82_S0.5260.61
67_V319_T0.5250.61
86_A451_I0.5240.61
41_A47_E0.5240.61
80_I88_V0.5230.61
355_A401_C0.5230.61
398_P402_A0.5220.61
33_L72_V0.5210.61
359_I395_Y0.5200.61
249_L252_I0.5190.60
363_S366_H0.5180.60
210_Q214_E0.5180.60
20_R80_I0.5160.60
380_W429_P0.5160.60
353_G376_A0.5150.60
95_K99_H0.5150.60
233_I406_S0.5150.60
184_G239_G0.5140.60
26_V85_Q0.5140.60
368_E462_Q0.5130.60
429_P432_L0.5120.59
365_K369_R0.5120.59
10_I75_Y0.5120.59
435_Q439_W0.5110.59
85_Q251_R0.5110.59
191_I194_G0.5100.59
281_F284_M0.5100.59
357_I360_I0.5100.59
21_G41_A0.5090.59
187_P239_G0.5090.59
129_L168_F0.5080.59
55_K70_T0.5070.59
180_V242_L0.5060.58
9_D71_N0.5050.58
359_I392_N0.5050.58
326_L330_L0.5050.58
339_T343_P0.5040.58
314_A384_T0.5030.58
27_S63_Q0.5030.58
104_H108_I0.5020.58
122_L323_Q0.5010.58
126_G423_I0.5010.58
12_R81_A0.5010.58
53_M75_Y0.5000.58
460_I465_Y0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qnqA 2 0.7928 100 0.659 Contact Map
3ipjA 1 0.1987 100 0.797 Contact Map
3bp3A 1 0.1712 100 0.802 Contact Map
1ibaA 1 0.1649 100 0.802 Contact Map
4n8nA 1 0.1015 40.9 0.974 Contact Map
4nv5A 1 0.1353 28.6 0.976 Contact Map
2h8eA 2 0.1882 27 0.977 Contact Map
4qn1A 1 0.1691 24.8 0.977 Contact Map
3q9vA 1 0.1226 24.6 0.977 Contact Map
2hwvA 1 0.129 18.1 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0135 seconds.