GREMLIN Database
WBBL - Rhamnosyltransferase WbbL
UniProt: P36667 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11986
Length: 264 (214)
Sequences: 40487 (34082)
Seq/√Len: 2329.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
176_F180_V3.2671.00
11_H90_P2.9701.00
12_E41_L2.6181.00
101_T214_A2.4541.00
197_D201_R2.4161.00
35_D56_S2.3691.00
57_G68_I2.2911.00
8_S42_L2.2241.00
68_I72_Y2.1791.00
25_D100_L2.1411.00
3_Y82_D2.1311.00
84_Y106_V2.0461.00
43_K56_S2.0311.00
30_K53_D2.0231.00
95_K218_I1.9981.00
43_K47_Q1.9791.00
34_R69_A1.9661.00
57_G60_Y1.9531.00
17_K220_Y1.9471.00
16_K20_E1.9361.00
111_Y210_H1.8671.00
5_I69_A1.8521.00
10_G39_S1.8381.00
66_N89_N1.8101.00
178_D207_V1.8011.00
60_Y64_H1.7891.00
94_M98_D1.7641.00
6_I31_I1.7631.00
105_Y212_V1.7261.00
41_L44_Q1.7221.00
86_L173_L1.6891.00
102_Y173_L1.6891.00
47_Q56_S1.6881.00
55_I72_Y1.6851.00
16_K49_Y1.6781.00
17_K93_I1.6681.00
64_H187_Q1.6601.00
3_Y30_K1.6521.00
97_D101_T1.6171.00
26_D103_I1.6151.00
53_D72_Y1.5961.00
35_D38_D1.5901.00
6_I18_L1.5871.00
98_D102_Y1.5671.00
12_E45_I1.5561.00
119_F218_I1.5241.00
68_I71_A1.5191.00
16_K48_H1.5121.00
112_A175_R1.4991.00
84_Y173_L1.4991.00
20_E49_Y1.4961.00
105_Y210_H1.4891.00
33_V46_C1.4731.00
57_G64_H1.4611.00
112_A207_V1.4571.00
30_K82_D1.4511.00
43_K54_Y1.4471.00
86_L98_D1.4421.00
181_R205_A1.4371.00
55_I68_I1.4211.00
16_K45_I1.4131.00
63_G194_E1.4111.00
106_V173_L1.4081.00
20_E24_A1.4021.00
26_D29_Y1.3961.00
93_I218_I1.3901.00
8_S33_V1.3841.00
9_H59_V1.3801.00
113_F209_L1.3741.00
177_S181_R1.3691.00
88_L94_M1.3681.00
100_L104_K1.3641.00
86_L99_L1.3611.00
21_N94_M1.3411.00
101_T104_K1.3191.00
186_D197_D1.3161.00
62_F66_N1.3091.00
105_Y109_K1.3061.00
70_V179_F1.2951.00
10_G38_D1.2921.00
8_S11_H1.2621.00
36_N59_V1.2401.00
45_I49_Y1.2251.00
85_I176_F1.2171.00
57_G65_N1.1941.00
172_M199_C1.1931.00
66_N87_F1.1861.00
181_R207_V1.1831.00
2_V99_L1.1701.00
178_D202_L1.1681.00
8_S90_P1.1621.00
97_D100_L1.1581.00
83_D175_R1.1541.00
3_Y73_V1.1531.00
11_H14_Y1.1521.00
2_V103_I1.1511.00
73_V176_F1.1441.00
177_S180_V1.1431.00
73_V82_D1.1301.00
34_R65_N1.1211.00
106_V114_S1.1201.00
70_V87_F1.1191.00
93_I220_Y1.1161.00
102_Y116_L1.1111.00
18_L88_L1.0871.00
62_F194_E1.0821.00
117_C211_Y1.0801.00
19_L31_I1.0761.00
104_K108_S1.0751.00
35_D43_K1.0561.00
30_K81_D1.0501.00
44_Q47_Q1.0421.00
24_A96_H1.0271.00
86_L94_M1.0241.00
109_K210_H1.0221.00
21_N93_I1.0141.00
66_N194_E1.0121.00
36_N57_G1.0071.00
121_D218_I1.0031.00
103_I107_E0.9991.00
84_Y103_I0.9961.00
25_D97_D0.9951.00
70_V85_I0.9951.00
93_I121_D0.9931.00
122_E126_L0.9851.00
175_R178_D0.9721.00
101_T212_V0.9631.00
118_L170_S0.9621.00
113_F202_L0.9581.00
7_V65_N0.9531.00
222_H225_N0.9451.00
179_F198_L0.9431.00
105_Y108_S0.9361.00
46_C54_Y0.9301.00
20_E23_N0.9271.00
71_A183_N0.9261.00
31_I52_L0.9251.00
23_N51_G0.9231.00
121_D125_S0.9151.00
23_N49_Y0.9141.00
45_I48_H0.9121.00
22_L88_L0.9081.00
19_L49_Y0.9041.00
53_D81_D0.9031.00
98_D116_L0.8961.00
102_Y114_S0.8921.00
3_Y32_I0.8921.00
105_Y114_S0.8911.00
119_F215_F0.8811.00
102_Y106_V0.8801.00
62_F169_G0.8741.00
36_N65_N0.8671.00
41_L45_I0.8601.00
112_A208_R0.8551.00
44_Q48_H0.8491.00
62_F226_R0.8461.00
64_H68_I0.8451.00
131_V134_F0.8431.00
37_K57_G0.8411.00
4_I22_L0.8371.00
23_N52_L0.8281.00
71_A184_G0.8201.00
29_Y99_L0.8151.00
179_F184_G0.8141.00
182_V205_A0.8071.00
63_G67_N0.8071.00
101_T105_Y0.8061.00
62_F89_N0.8061.00
18_L21_N0.8031.00
4_I86_L0.8021.00
22_L31_I0.7981.00
36_N61_G0.7971.00
14_Y220_Y0.7961.00
182_V202_L0.7951.00
8_S15_I0.7911.00
34_R68_I0.7851.00
169_G185_F0.7711.00
95_K119_F0.7701.00
70_V73_V0.7681.00
92_I219_H0.7661.00
8_S46_C0.7651.00
121_D220_Y0.7641.00
198_L202_L0.7591.00
106_V111_Y0.7581.00
98_D216_H0.7571.00
67_N187_Q0.7511.00
163_V208_R0.7471.00
17_K20_E0.7441.00
112_A178_D0.7431.00
83_D177_S0.7381.00
22_L94_M0.7371.00
7_V90_P0.7371.00
60_Y65_N0.7321.00
19_L33_V0.7281.00
116_L171_F0.7251.00
36_N60_Y0.7211.00
95_K216_H0.7151.00
32_I69_A0.7061.00
29_Y51_G0.7061.00
65_N68_I0.7051.00
116_L216_H0.7041.00
134_F137_L0.7011.00
170_S217_A0.7001.00
6_I22_L0.6981.00
26_D99_L0.6931.00
184_G198_L0.6921.00
202_L207_V0.6911.00
26_D100_L0.6901.00
32_I72_Y0.6891.00
19_L23_N0.6891.00
87_F185_F0.6871.00
178_D182_V0.6871.00
105_Y111_Y0.6851.00
174_V199_C0.6811.00
47_Q54_Y0.6801.00
103_I173_L0.6801.00
25_D96_H0.6731.00
120_R221_A0.6721.00
95_K98_D0.6681.00
12_E16_K0.6671.00
67_N185_F0.6661.00
98_D171_F0.6651.00
15_I45_I0.6621.00
60_Y68_I0.6601.00
117_C213_P0.6581.00
178_D181_R0.6571.00
169_G172_M0.6561.00
11_H222_H0.6551.00
62_F65_N0.6541.00
15_I90_P0.6531.00
14_Y222_H0.6521.00
43_K46_C0.6521.00
9_H36_N0.6491.00
109_K208_R0.6481.00
94_M99_L0.6441.00
225_N228_F0.6441.00
122_E125_S0.6411.00
104_K107_E0.6391.00
115_T211_Y0.6391.00
73_V85_I0.6321.00
4_I29_Y0.6311.00
212_V215_F0.6291.00
174_V198_L0.6261.00
2_V173_L0.6261.00
18_L22_L0.6251.00
4_I99_L0.6251.00
139_D142_V0.6221.00
7_V36_N0.6221.00
53_D56_S0.6211.00
32_I73_V0.6211.00
160_S163_V0.6151.00
89_N194_E0.6141.00
12_E15_I0.6111.00
25_D29_Y0.6071.00
36_N89_N0.6071.00
86_L171_F0.6051.00
115_T167_C0.6021.00
88_L92_I0.6011.00
67_N184_G0.5951.00
137_L141_I0.5941.00
137_L140_F0.5941.00
3_Y81_D0.5931.00
34_R57_G0.5931.00
106_V175_R0.5921.00
232_A236_H0.5911.00
32_I53_D0.5901.00
167_C199_C0.5881.00
37_K59_V0.5861.00
186_D201_R0.5831.00
101_T216_H0.5791.00
132_R135_P0.5781.00
112_A206_G0.5781.00
171_F217_A0.5741.00
138_S141_I0.5731.00
111_Y114_S0.5711.00
135_P138_S0.5701.00
111_Y175_R0.5691.00
180_V183_N0.5681.00
67_N71_A0.5651.00
161_D164_V0.5651.00
203_S209_L0.5641.00
12_E40_L0.5621.00
84_Y175_R0.5611.00
28_H51_G0.5611.00
7_V66_N0.5591.00
193_C196_I0.5581.00
12_E44_Q0.5561.00
92_I217_A0.5561.00
186_D189_Y0.5511.00
65_N89_N0.5491.00
23_N50_A0.5481.00
88_L217_A0.5441.00
178_D206_G0.5391.00
170_S219_H0.5391.00
15_I46_C0.5381.00
174_V179_F0.5371.00
39_S42_L0.5361.00
5_I73_V0.5331.00
23_N31_I0.5321.00
112_A115_T0.5321.00
6_I19_L0.5311.00
196_I200_L0.5291.00
231_K235_W0.5291.00
97_D214_A0.5291.00
62_F87_F0.5271.00
5_I34_R0.5261.00
103_I106_V0.5241.00
102_Y105_Y0.5211.00
83_D107_E0.5191.00
23_N29_Y0.5151.00
70_V184_G0.5131.00
73_V81_D0.5121.00
30_K73_V0.5101.00
8_S35_D0.5081.00
94_M217_A0.5081.00
18_L91_D0.5071.00
110_R175_R0.5061.00
135_P139_D0.5031.00
9_H37_K0.5021.00
124_K127_H0.5011.00
111_Y208_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xhbA 1 0.9242 100 0.261 Contact Map
5ajoA 1 0.9659 100 0.266 Contact Map
3bcvA 2 0.678 100 0.279 Contact Map
3l7iA 4 0 100 0.28 Contact Map
2d7iA 1 0.9659 100 0.287 Contact Map
1qg8A 1 0.8106 100 0.306 Contact Map
2z86A 2 0.8674 100 0.315 Contact Map
4fixA 3 0.9848 100 0.325 Contact Map
4p02A 1 0.9242 100 0.382 Contact Map
2bo4A 4 0.8902 100 0.409 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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