GREMLIN Database
TORD - Chaperone protein TorD
UniProt: P36662 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12195
Length: 199 (176)
Sequences: 1311 (1034)
Seq/√Len: 78.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
108_L132_L4.1571.00
20_F188_L3.3101.00
77_D178_F3.1341.00
105_K123_A3.0971.00
169_V188_L2.6651.00
126_L165_L2.6261.00
173_R189_L2.6061.00
168_F172_C2.5991.00
94_A160_A2.5891.00
9_I153_L2.5701.00
9_I13_Y2.4851.00
13_Y195_D2.4491.00
9_I195_D2.3231.00
133_L153_L2.3161.00
94_A129_Y2.1681.00
21_S127_A2.1641.00
16_L188_L2.1631.00
111_A152_S2.1391.00
74_L180_F2.1371.00
165_L192_V2.0611.00
173_R186_Q1.9891.00
97_Y171_R1.9211.00
172_C185_S1.9051.00
79_C83_L1.8961.00
26_D30_T1.8701.00
133_L157_T1.8641.00
19_L184_L1.7781.00
137_H153_L1.7661.00
94_A104_I1.7541.00
92_P168_F1.7511.00
132_L156_K1.7491.00
20_F184_L1.7281.00
94_A163_Q1.7241.00
17_A131_E1.6561.00
165_L169_V1.6211.00
13_Y153_L1.5841.00
179_G182_A1.5841.00
113_M135_H1.5490.99
134_S138_F1.5280.99
77_D176_D1.5230.99
91_L96_A1.5120.99
166_P189_L1.5060.99
155_Q159_T1.4940.99
104_I108_L1.4740.99
14_A134_S1.4680.99
14_A138_F1.4600.99
158_L196_H1.4540.99
104_I129_Y1.4360.99
78_F125_H1.4170.99
95_S122_P1.4150.99
57_L183_A1.3910.99
130_L192_V1.3820.99
13_Y191_L1.3810.99
133_L191_L1.3730.99
53_A190_V1.3570.98
85_T88_Q1.3030.98
126_L168_F1.3000.98
101_E104_I1.2700.98
161_L165_L1.2630.98
137_H195_D1.2570.97
17_A93_Y1.2550.97
18_Q25_D1.2370.97
9_I191_L1.2140.97
170_A189_L1.1910.97
126_L188_L1.1860.96
24_L28_Q1.1840.96
129_Y132_L1.1780.96
93_Y121_E1.1750.96
19_L180_F1.1460.96
20_F82_F1.1430.96
164_W168_F1.1410.96
110_E155_Q1.1330.95
23_E83_L1.1230.95
137_H140_L1.1110.95
93_Y122_P1.0950.94
64_L74_L1.0920.94
10_A138_F1.0880.94
83_L88_Q1.0870.94
20_F126_L1.0790.94
90_A96_A1.0640.94
75_A79_C1.0620.93
176_D179_G1.0590.93
126_L169_V1.0500.93
160_A163_Q1.0390.93
104_I156_K1.0320.92
9_I133_L1.0320.92
184_L188_L1.0310.92
167_E171_R1.0090.92
53_A183_A1.0080.92
77_D80_G1.0050.91
176_D182_A0.9990.91
101_E123_A0.9740.90
25_D31_Q0.9450.89
189_L193_E0.9400.88
21_S128_I0.9300.88
97_Y181_Y0.9290.88
110_E152_S0.9270.88
130_L188_L0.9180.87
92_P126_L0.9070.87
85_T93_Y0.9050.86
13_Y133_L0.9000.86
125_H128_I0.8930.86
140_L150_I0.8910.86
111_A132_L0.8890.85
92_P122_P0.8870.85
78_F82_F0.8830.85
162_W192_V0.8760.85
108_L128_I0.8760.85
56_E187_L0.8740.85
51_T55_N0.8720.84
85_T101_E0.8550.83
129_Y156_K0.8520.83
76_A79_C0.8480.83
90_A97_Y0.8400.82
56_E59_N0.8350.82
94_A98_K0.8350.82
156_K164_W0.8340.82
169_V185_S0.8320.81
23_E79_C0.8300.81
110_E117_G0.8300.81
84_M88_Q0.8190.80
106_R110_E0.8190.80
81_L187_L0.8160.80
59_N63_T0.8100.80
93_Y101_E0.8100.80
35_A39_E0.8030.79
49_P53_A0.7980.79
101_E105_K0.7960.79
24_L78_F0.7950.78
133_L195_D0.7950.78
108_L129_Y0.7870.78
71_R75_A0.7850.78
9_I137_H0.7830.77
153_L195_D0.7790.77
107_L111_A0.7750.77
12_V54_V0.7720.76
26_D71_R0.7680.76
84_M122_P0.7500.74
173_R182_A0.7490.74
97_Y167_E0.7480.74
85_T98_K0.7420.74
50_L53_A0.7400.73
23_E98_K0.7370.73
78_F92_P0.7350.73
129_Y161_L0.7330.73
157_T162_W0.7320.73
157_T195_D0.7300.72
171_R174_Q0.7260.72
77_D182_A0.7220.71
83_L125_H0.7180.71
56_E186_Q0.7170.71
79_C88_Q0.7060.70
170_A173_R0.7060.70
58_E62_A0.7060.70
104_I172_C0.7030.69
129_Y140_L0.6990.69
23_E71_R0.6940.68
193_E196_H0.6890.68
103_E159_T0.6860.68
35_A133_L0.6760.66
81_L175_Y0.6750.66
167_E170_A0.6680.66
60_R183_A0.6670.65
18_Q74_L0.6660.65
51_T58_E0.6620.65
123_A160_A0.6540.64
185_S188_L0.6520.64
76_A105_K0.6470.63
107_L156_K0.6460.63
36_Q74_L0.6440.63
183_A187_L0.6430.63
110_E177_S0.6400.62
104_I132_L0.6400.62
191_L195_D0.6400.62
77_D172_C0.6390.62
93_Y131_E0.6360.62
12_V18_Q0.6330.61
72_L76_A0.6330.61
20_F172_C0.6300.61
99_Q114_E0.6290.61
131_E135_H0.6290.61
16_L191_L0.6270.61
117_G120_N0.6260.61
18_Q21_S0.6190.60
94_A132_L0.6160.59
49_P52_A0.6130.59
135_H138_F0.6090.58
14_A131_E0.6070.58
161_L184_L0.6050.58
56_E60_R0.6050.58
57_L184_L0.6030.58
156_K163_Q0.6020.58
77_D177_S0.6020.58
8_Q113_M0.6010.57
106_R109_V0.5980.57
166_P193_E0.5980.57
10_A134_S0.5930.56
82_F172_C0.5930.56
79_C85_T0.5850.55
125_H168_F0.5850.55
53_A56_E0.5830.55
23_E73_E0.5820.55
108_L123_A0.5820.55
183_A190_V0.5780.55
62_A139_S0.5780.55
31_Q116_S0.5760.54
82_F90_A0.5750.54
77_D112_G0.5740.54
153_L191_L0.5710.54
13_Y131_E0.5710.54
52_A186_Q0.5690.53
96_A101_E0.5650.53
71_R74_L0.5650.53
17_A134_S0.5630.53
113_M138_F0.5630.53
17_A191_L0.5610.52
78_F127_A0.5600.52
78_F185_S0.5570.52
13_Y29_L0.5570.52
20_F185_S0.5570.52
57_L159_T0.5530.51
18_Q126_L0.5530.51
33_A38_A0.5520.51
39_E43_L0.5510.51
111_A136_L0.5510.51
100_D104_I0.5490.51
139_S149_R0.5470.51
64_L186_Q0.5450.50
12_V191_L0.5430.50
17_A127_A0.5430.50
135_H139_S0.5400.50
16_L187_L0.5380.49
90_A165_L0.5370.49
129_Y163_Q0.5370.49
157_T192_V0.5370.49
126_L142_E0.5360.49
107_L191_L0.5350.49
32_I91_L0.5330.49
24_L83_L0.5320.49
163_Q166_P0.5320.49
104_I137_H0.5320.49
77_D89_A0.5310.49
10_A141_G0.5300.48
15_W32_I0.5290.48
21_S87_K0.5290.48
30_T36_Q0.5280.48
106_R190_V0.5270.48
90_A122_P0.5250.48
33_A62_A0.5230.47
162_W195_D0.5220.47
83_L92_P0.5190.47
79_C104_I0.5170.47
23_E74_L0.5160.47
60_R64_L0.5120.46
24_L104_I0.5100.46
102_Q123_A0.5100.46
73_E94_A0.5090.46
63_T174_Q0.5090.46
14_A97_Y0.5040.45
189_L192_V0.5030.45
10_A18_Q0.5020.45
77_D107_L0.5020.45
65_T106_R0.5020.45
186_Q193_E0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1n1cA 2 0.9347 100 0.242 Contact Map
1s9uA 1 0.8744 100 0.287 Contact Map
2o9xA 2 0.7688 100 0.406 Contact Map
2xolA 2 0.7739 100 0.412 Contact Map
3e56A 2 0.2915 7.3 0.95 Contact Map
2zqmA 5 0.3568 4.5 0.954 Contact Map
4jzaA 2 0.4171 4.4 0.954 Contact Map
3iu5A 1 0.5126 3.4 0.957 Contact Map
3c4rA 4 0.397 3 0.958 Contact Map
3mb4A 1 0.5126 2.4 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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