GREMLIN Database
CBPA - Curved DNA-binding protein
UniProt: P36659 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12193
Length: 306 (276)
Sequences: 3323 (2335)
Seq/√Len: 140.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_D20_T4.6731.00
43_E47_K3.7621.00
127_F130_E2.9761.00
245_S271_L2.8251.00
129_E201_H2.7611.00
218_S221_E2.7081.00
18_L59_E2.6771.00
123_E197_H2.6691.00
280_D283_T2.6281.00
130_E137_R2.5461.00
170_N197_H2.5421.00
158_K179_Q2.5271.00
227_K240_T2.3291.00
214_V270_V2.3251.00
214_V272_K2.3181.00
132_L258_L2.2851.00
4_K48_E2.2801.00
136_K163_K2.2261.00
30_R36_V2.2151.00
5_D8_A2.2131.00
212_E270_V2.1951.00
282_N285_A2.1831.00
127_F199_A2.1101.00
63_A67_Q2.0911.00
125_A197_H2.0891.00
286_L289_Q2.0781.00
221_E226_A2.0481.00
173_R193_W2.0391.00
216_P272_K2.0071.00
211_L267_L1.9901.00
207_V212_E1.9791.00
170_N198_I1.9591.00
285_A289_Q1.9501.00
250_R268_Y1.9321.00
125_A199_A1.9321.00
138_T161_N1.9191.00
41_D44_A1.8811.00
234_K264_T1.8511.00
284_A288_Q1.8411.00
136_K161_N1.8291.00
251_L271_L1.7961.00
19_K23_T1.7941.00
282_N289_Q1.7831.00
209_Q260_S1.7681.00
255_G266_D1.7441.00
121_E173_R1.7151.00
58_D61_R1.6981.00
168_V196_I1.6841.00
40_P43_E1.6461.00
252_R266_D1.6221.00
229_T236_S1.5811.00
243_P284_A1.5671.00
286_L290_L1.5651.00
45_R48_E1.5571.00
60_Q63_A1.5381.00
6_Y55_V1.5201.00
227_K238_L1.4941.00
212_E250_R1.4811.00
216_P274_V1.4811.00
233_L267_L1.4641.00
123_E195_V1.4551.00
203_L213_I1.4511.00
250_R270_V1.4471.00
239_L269_A1.4411.00
288_Q292_D1.4371.00
229_T238_L1.4341.00
126_V131_T1.4221.00
207_V210_D1.4221.00
131_T198_I1.4181.00
130_E135_H1.4161.00
44_A48_E1.4151.00
281_E285_A1.4101.00
168_V172_Q1.3951.00
37_S42_A1.3901.00
206_I258_L1.3861.00
205_D214_V1.3841.00
219_P275_M1.3721.00
25_Y50_A1.3641.00
279_P283_T1.3581.00
32_Y49_V1.3551.00
95_D98_F1.3451.00
12_V21_I1.3441.00
29_A46_F1.3261.00
160_L179_Q1.3231.00
210_D268_Y1.3171.00
285_A288_Q1.3151.00
59_E63_A1.3101.00
132_L233_L1.3041.00
138_T159_T1.2981.00
98_F102_F1.2951.00
118_H181_T1.2861.00
219_P287_W1.2861.00
289_Q292_D1.2761.00
215_V228_V1.2751.00
169_G209_Q1.2631.00
246_Q249_Q1.2601.00
117_G183_G1.2561.00
16_D21_I1.2531.00
121_E195_V1.2501.00
213_I269_A1.2441.00
4_K9_I1.2441.00
6_Y51_E1.2431.00
13_K20_T1.2381.00
7_Y66_D1.2371.00
44_A47_K1.2311.00
200_P205_D1.2261.00
203_L231_P1.2161.00
182_P189_N1.2051.00
288_Q291_A1.2031.00
212_E268_Y1.2001.00
237_I253_V1.1911.00
210_D266_D1.1851.00
80_Q83_H1.1741.00
28_L49_V1.1721.00
281_E284_A1.1671.00
223_A275_M1.1630.99
247_A273_I1.1500.99
14_P69_W1.1290.99
219_P223_A1.1140.99
246_Q277_P1.0980.99
260_S263_Q1.0970.99
75_P78_N1.0950.99
239_L251_L1.0890.99
15_T20_T1.0880.99
236_S256_K1.0810.99
94_F97_I1.0800.99
78_N81_F1.0570.99
78_N82_H1.0550.99
228_V241_I1.0490.99
228_V231_P1.0260.99
223_A279_P1.0260.99
128_L131_T1.0250.99
128_L211_L1.0250.99
198_I206_I1.0230.99
169_G172_Q1.0230.99
204_F213_I1.0190.99
131_T258_L1.0160.99
119_D190_G1.0150.99
213_I216_P1.0090.99
114_A185_N1.0060.99
222_A273_I1.0010.98
128_L233_L0.9990.98
172_Q261_K0.9990.98
211_L258_L0.9930.98
70_Q74_D0.9890.98
98_F101_I0.9760.98
95_D99_S0.9750.98
6_Y65_Y0.9720.98
64_E69_W0.9660.98
180_G191_D0.9640.98
247_A275_M0.9610.98
9_I48_E0.9590.98
204_F233_L0.9550.98
128_L258_L0.9500.98
281_E288_Q0.9490.98
119_D175_R0.9490.98
46_F50_A0.9490.98
119_D193_W0.9450.98
176_L179_Q0.9420.98
128_L132_L0.9360.98
111_Q114_A0.9250.97
120_I181_T0.9230.97
140_S159_T0.9210.97
234_K256_K0.9210.97
117_G190_G0.9160.97
245_S251_L0.9150.97
178_G190_G0.9130.97
79_R83_H0.9110.97
84_G90_N0.9080.97
96_D99_S0.9070.97
124_V196_I0.9020.97
54_E61_R0.9020.97
217_V271_L0.9020.97
5_D14_P0.9010.97
287_W290_L0.8990.97
60_Q64_E0.8980.97
131_T166_A0.8950.97
84_G87_Q0.8900.97
283_T290_L0.8900.97
28_L31_K0.8820.97
205_D212_E0.8820.97
209_Q258_L0.8810.97
132_L264_T0.8790.96
128_L206_I0.8770.96
50_A53_W0.8760.96
260_S264_T0.8760.96
259_V264_T0.8700.96
122_I194_L0.8700.96
69_W72_R0.8660.96
38_K41_D0.8620.96
244_G275_M0.8570.96
96_D100_S0.8570.96
37_S41_D0.8570.96
79_R82_H0.8540.96
71_H74_D0.8510.96
90_N93_D0.8510.96
4_K8_A0.8480.96
32_Y45_R0.8460.96
223_A287_W0.8420.96
55_V69_W0.8390.95
129_E133_T0.8350.95
11_G24_A0.8350.95
169_G206_I0.8340.95
142_N157_P0.8320.95
165_P168_V0.8290.95
248_G273_I0.8280.95
126_V130_E0.8260.95
8_A13_K0.8260.95
282_N286_L0.8240.95
162_V194_L0.8230.95
175_R193_W0.8130.95
252_R268_Y0.8040.94
92_E97_I0.7930.94
132_L234_K0.7920.94
97_I101_I0.7890.94
131_T134_E0.7880.94
247_A272_K0.7870.94
78_N83_H0.7870.94
140_S157_P0.7860.94
32_Y42_A0.7830.93
22_K26_R0.7810.93
182_P186_G0.7760.93
105_H108_Q0.7740.93
64_E73_N0.7710.93
77_F80_Q0.7690.93
201_H213_I0.7670.93
86_G89_F0.7660.93
246_Q274_V0.7650.93
217_V222_A0.7610.92
126_V135_H0.7600.92
205_D270_V0.7510.92
210_D265_G0.7500.92
206_I209_Q0.7490.92
45_R49_V0.7480.92
178_G188_P0.7470.92
106_A109_S0.7460.92
70_Q73_N0.7430.92
209_Q264_T0.7410.91
95_D102_F0.7390.91
116_R188_P0.7380.91
65_Y192_L0.7370.91
116_R119_D0.7360.91
226_A241_I0.7340.91
94_F98_F0.7260.91
237_I256_K0.7180.90
241_I271_L0.7160.90
12_V62_R0.7160.90
242_P251_L0.7110.90
85_D88_S0.7110.90
7_Y65_Y0.7080.89
97_I100_S0.7070.89
245_S249_Q0.7060.89
64_E71_H0.7060.89
18_L62_R0.7060.89
127_F137_R0.7030.89
256_K264_T0.6970.89
213_I231_P0.6900.88
33_H46_F0.6870.88
93_D96_D0.6850.88
220_W291_A0.6770.87
114_A186_G0.6760.87
88_S91_A0.6700.87
27_R30_R0.6690.87
178_G191_D0.6680.87
162_V165_P0.6670.86
166_A259_V0.6670.86
163_K179_Q0.6670.86
32_Y39_E0.6650.86
257_G265_G0.6600.86
164_I167_G0.6580.86
204_F267_L0.6580.86
128_L204_F0.6570.86
94_F99_S0.6570.86
160_L176_L0.6550.85
105_H110_R0.6540.85
128_L201_H0.6530.85
64_E68_M0.6510.85
51_E55_V0.6480.85
184_E188_P0.6470.85
223_A244_G0.6470.85
206_I219_P0.6460.85
133_T234_K0.6460.85
53_W57_S0.6460.85
232_T237_I0.6450.85
131_T168_V0.6410.84
5_D69_W0.6410.84
183_G186_G0.6390.84
73_N76_Q0.6350.84
31_K37_S0.6340.84
224_L288_Q0.6300.83
47_K51_E0.6290.83
117_G182_P0.6290.83
204_F230_V0.6270.83
6_Y70_Q0.6260.83
84_G88_S0.6260.83
73_N78_N0.6250.83
274_V277_P0.6230.83
10_M49_V0.6210.82
231_P267_L0.6210.82
231_P236_S0.6210.82
68_M71_H0.6190.82
71_H76_Q0.6190.82
41_D45_R0.6180.82
74_D77_F0.6180.82
139_I159_T0.6170.82
92_E96_D0.6150.82
174_I196_I0.6140.82
287_W291_A0.6130.82
222_A275_M0.6130.82
221_E228_V0.6120.81
135_H164_I0.6110.81
31_K39_E0.6100.81
126_V196_I0.6090.81
173_R195_V0.6070.81
64_E76_Q0.6050.81
223_A247_A0.6050.81
201_H204_F0.6040.81
128_L198_I0.6040.81
116_R178_G0.6010.80
12_V29_A0.6000.80
158_K189_N0.5950.80
183_G188_P0.5950.80
117_G189_N0.5940.79
124_V137_R0.5940.79
181_T184_E0.5940.79
220_W287_W0.5930.79
222_A225_G0.5920.79
198_I258_L0.5910.79
69_W73_N0.5910.79
139_I160_L0.5910.79
206_I265_G0.5890.79
248_G270_V0.5890.79
206_I287_W0.5880.79
120_I141_Y0.5850.78
248_G272_K0.5840.78
254_K266_D0.5800.78
36_V39_E0.5800.78
242_P271_L0.5780.78
221_E291_A0.5770.78
124_V194_L0.5760.77
40_P44_A0.5760.77
101_I104_Q0.5720.77
241_I251_L0.5710.77
215_V271_L0.5700.77
91_A101_I0.5700.77
224_L291_A0.5670.76
58_D196_I0.5660.76
98_F104_Q0.5640.76
271_L275_M0.5630.76
91_A97_I0.5600.75
25_Y233_L0.5570.75
117_G186_G0.5570.75
28_L32_Y0.5560.75
18_L57_S0.5550.75
101_I106_A0.5540.75
129_E233_L0.5510.74
111_Q115_T0.5500.74
128_L259_V0.5490.74
237_I267_L0.5480.74
142_N155_E0.5480.74
209_Q263_Q0.5470.74
20_T23_T0.5470.74
76_Q82_H0.5460.74
64_E72_R0.5440.73
232_T236_S0.5440.73
58_D66_D0.5430.73
134_E164_I0.5430.73
54_E72_R0.5430.73
38_K42_A0.5410.73
88_S92_E0.5410.73
165_P261_K0.5390.73
116_R183_G0.5380.73
51_E70_Q0.5380.73
213_I267_L0.5360.72
164_I174_I0.5340.72
69_W76_Q0.5330.72
220_W223_A0.5330.72
244_G279_P0.5310.72
230_V269_A0.5260.71
134_E167_G0.5260.71
139_I194_L0.5260.71
233_L264_T0.5240.71
9_I28_L0.5240.71
55_V75_P0.5240.71
51_E68_M0.5220.70
169_G207_V0.5210.70
168_V194_L0.5200.70
224_L286_L0.5200.70
10_M23_T0.5170.70
128_L200_P0.5170.70
206_I220_W0.5170.70
231_P239_L0.5150.69
22_K35_D0.5150.69
113_P185_N0.5140.69
168_V174_I0.5130.69
32_Y37_S0.5120.69
168_V173_R0.5110.69
133_T236_S0.5110.69
52_A56_L0.5100.69
72_R76_Q0.5090.68
112_R116_R0.5090.68
85_D90_N0.5080.68
113_P184_E0.5070.68
117_G188_P0.5070.68
37_S95_D0.5060.68
6_Y68_M0.5050.68
22_K246_Q0.5050.68
116_R191_D0.5050.68
127_F135_H0.5040.68
132_L259_V0.5040.68
279_P291_A0.5040.68
204_F232_T0.5040.68
174_I194_L0.5030.67
18_L22_K0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lz8A 2 0.6176 100 0.155 Contact Map
4j80A 2 0.8824 100 0.205 Contact Map
1nltA 1 0.5327 100 0.518 Contact Map
3agxA 2 0.5621 100 0.523 Contact Map
2q2gA 3 0.5621 100 0.525 Contact Map
1c3gA 2 0.5425 100 0.536 Contact Map
4j7zA 1 0.3464 100 0.679 Contact Map
1bq0A 1 0.2484 99.9 0.695 Contact Map
3i38A 5 0.3399 99.9 0.708 Contact Map
2ctrA 1 0.2778 99.9 0.714 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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