GREMLIN Database
CUEO - Blue copper oxidase CueO
UniProt: P36649 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12318
Length: 516 (442)
Sequences: 5794 (4290)
Seq/√Len: 204.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_K163_E5.4321.00
87_T128_T4.9321.00
85_A128_T4.3831.00
51_T93_Q4.1461.00
49_Q89_D4.0251.00
89_D126_S3.8531.00
49_Q91_Y3.7471.00
279_E470_K3.7421.00
230_W284_L3.5951.00
77_A159_L3.5441.00
55_G68_G3.4931.00
235_L283_V3.3151.00
473_V482_V3.2641.00
90_I119_I3.1241.00
91_Y124_K3.0731.00
57_S66_T3.0161.00
47_R87_T2.9881.00
258_A282_E2.8851.00
254_L283_V2.7441.00
235_L246_F2.7171.00
434_I445_F2.6641.00
275_V281_F2.6201.00
253_P269_K2.5761.00
159_L236_L2.5701.00
230_W286_E2.5511.00
56_Q63_T2.5391.00
433_V483_L2.4231.00
47_R89_D2.3841.00
425_A428_Q2.3001.00
233_L283_V2.2531.00
184_I238_G2.2471.00
56_Q65_T2.2451.00
111_V125_R2.2401.00
248_T285_V2.2271.00
82_R164_D2.2021.00
253_P271_S2.1871.00
140_F158_G2.1541.00
51_T91_Y2.1151.00
120_P123_G2.1051.00
54_A65_T2.0811.00
179_D229_G2.0671.00
68_G73_L2.0331.00
228_R287_V2.0301.00
226_A287_V2.0271.00
53_G93_Q2.0221.00
433_V481_E2.0041.00
81_Q163_E1.9921.00
85_A130_N1.9921.00
262_G451_Q1.9811.00
434_I484_V1.9581.00
97_E120_P1.9551.00
431_R485_K1.9511.00
476_E480_S1.9421.00
159_L184_I1.9291.00
232_R282_E1.8551.00
452_F484_V1.8411.00
243_S474_K1.8171.00
431_R455_L1.8101.00
259_S281_F1.7971.00
343_L346_L1.7621.00
432_W484_V1.7541.00
235_L273_L1.7371.00
345_G348_V1.6991.00
89_D124_K1.6871.00
255_Y269_K1.6781.00
280_R471_D1.6761.00
239_C244_L1.6731.00
273_L281_F1.6661.00
191_S195_Q1.6611.00
331_P334_L1.6611.00
52_I98_T1.6511.00
80_L86_V1.6491.00
337_L340_L1.6491.00
232_R257_I1.6451.00
497_M511_M1.6401.00
46_N84_K1.6171.00
54_A95_T1.6161.00
157_A186_Q1.6161.00
456_S483_L1.6051.00
345_G349_R1.6011.00
296_V317_M1.5961.00
77_A182_P1.5781.00
52_I90_I1.5711.00
138_C261_G1.5611.00
346_L349_R1.5561.00
434_I498_A1.5551.00
276_L474_K1.5551.00
142_P151_Q1.5131.00
183_V235_L1.5061.00
495_A513_G1.4891.00
69_Y140_F1.4841.00
82_R165_D1.4561.00
447_I486_F1.4531.00
349_R352_Q1.4501.00
159_L182_P1.4371.00
205_A208_G1.4301.00
225_A320_Q1.4271.00
429_Y487_N1.4261.00
60_G190_F1.4191.00
424_A430_E1.4181.00
356_D359_L1.4151.00
352_Q355_M1.3921.00
343_L347_T1.3901.00
334_L337_L1.3771.00
256_V281_F1.3731.00
80_L131_V1.3681.00
246_F273_L1.3631.00
346_L350_K1.3551.00
66_T188_K1.3541.00
87_T126_S1.3441.00
453_R469_W1.3291.00
405_H408_N1.3231.00
209_W212_D1.3151.00
273_L283_V1.3121.00
223_Q318_R1.3081.00
391_G394_N1.3081.00
58_T63_T1.3021.00
375_A379_M1.3001.00
454_I473_V1.2981.00
347_T351_L1.2821.00
98_T151_Q1.2811.00
332_D335_S1.2601.00
342_S346_L1.2561.00
456_S481_E1.2471.00
250_D297_T1.2461.00
501_H505_H1.2401.00
447_I498_A1.2381.00
153_A240_N1.2371.00
315_P319_I1.2331.00
216_T315_P1.2331.00
506_E511_M1.2331.00
381_H384_M1.2311.00
246_F296_V1.2301.00
86_V160_V1.2301.00
254_L285_V1.2291.00
330_L333_T1.2291.00
317_M321_P1.2281.00
67_W156_L1.2231.00
82_R133_Q1.2201.00
358_M361_M1.2181.00
430_E486_F1.2161.00
390_H393_M1.2131.00
442_L474_K1.2071.00
449_G496_Y1.2011.00
503_L506_E1.2011.00
256_V270_V1.2001.00
364_M367_L1.1991.00
316_V319_I1.1981.00
376_M379_M1.1951.00
248_T254_L1.1931.00
348_V351_L1.1911.00
266_E466_R1.1811.00
52_I69_Y1.1771.00
186_Q215_L1.1681.00
163_E180_D1.1631.00
500_C505_H1.1621.00
48_I80_L1.1561.00
226_A231_L1.1551.00
294_D298_L1.1511.00
408_N411_N1.1421.00
245_N272_E1.1361.00
245_N274_P1.1341.00
76_P140_F1.1281.00
369_E372_G1.1141.00
143_H500_C1.1111.00
152_V503_L1.1081.00
412_G415_F1.1071.00
109_G113_G1.1071.00
53_G68_G1.1041.00
342_S345_G1.1001.00
137_T234_R1.0941.00
119_I125_R1.0851.00
325_S331_P1.0841.00
349_R353_L1.0831.00
370_K373_D1.0811.00
431_R483_L1.0801.00
99_T115_P1.0611.00
50_L78_V1.0561.00
157_A238_G1.0561.00
57_S68_G1.0531.00
309_P312_K1.0531.00
409_K416_D1.0521.00
405_H409_K1.0521.00
259_S470_K1.0511.00
345_G352_Q1.0501.00
221_Y224_H1.0501.00
69_Y156_L1.0471.00
67_W154_M1.0461.00
349_R355_M1.0371.00
346_L352_Q1.0291.00
251_N289_D1.0271.00
351_L355_M1.0261.00
219_A222_P1.0201.00
367_L370_K1.0181.00
387_H390_H1.0171.00
294_D300_V1.0071.00
353_L356_D1.0051.00
226_A317_M1.0021.00
154_M193_D1.0021.00
330_L335_S0.9991.00
457_E480_S0.9981.00
90_I98_T0.9951.00
443_H501_H0.9951.00
81_Q84_K0.9911.00
345_G351_L0.9901.00
341_P344_E0.9901.00
192_A195_Q0.9821.00
315_P321_P0.9801.00
297_T300_V0.9791.00
348_V353_L0.9791.00
234_R282_E0.9791.00
115_P144_Q0.9771.00
445_F510_M0.9731.00
116_Q125_R0.9691.00
345_G354_S0.9691.00
293_F297_T0.9691.00
214_L244_L0.9681.00
81_Q165_D0.9671.00
90_I100_L0.9661.00
143_H501_H0.9651.00
312_K316_V0.9620.99
350_K353_L0.9620.99
76_P158_G0.9610.99
222_P226_A0.9590.99
314_H317_M0.9570.99
137_T236_L0.9570.99
185_V246_F0.9550.99
408_N412_G0.9520.99
243_S276_L0.9510.99
355_M359_L0.9500.99
316_V321_P0.9480.99
350_K355_M0.9460.99
235_L275_V0.9450.99
372_G375_A0.9440.99
443_H500_C0.9410.99
355_M361_M0.9400.99
353_L359_L0.9370.99
253_P288_N0.9370.99
371_Y374_Q0.9330.99
75_G218_G0.9310.99
67_W94_L0.9300.99
184_I236_L0.9300.99
342_S349_R0.9300.99
344_E348_V0.9250.99
355_M358_M0.9230.99
189_K196_I0.9200.99
180_D234_R0.9160.99
347_T354_S0.9130.99
327_S332_D0.9120.99
379_M382_S0.9100.99
452_F473_V0.9090.99
357_P361_M0.9080.99
80_L160_V0.9080.99
252_R319_I0.9060.99
45_R87_T0.8960.99
226_A285_V0.8960.99
214_L313_P0.8940.99
248_T296_V0.8920.99
374_Q378_G0.8920.99
231_L287_V0.8900.99
379_M384_M0.8890.99
324_I327_S0.8860.99
341_P345_G0.8850.99
79_K180_D0.8840.99
335_S338_P0.8800.99
331_P338_P0.8790.99
143_H499_H0.8780.99
444_P502_L0.8760.99
499_H505_H0.8750.99
191_S199_Q0.8730.99
329_A332_D0.8720.99
407_A410_I0.8720.99
345_G350_K0.8720.99
455_L485_K0.8720.99
257_I284_L0.8700.99
164_D167_I0.8690.99
347_T359_L0.8670.99
424_A488_H0.8650.99
141_H500_C0.8650.99
73_L157_A0.8630.99
182_P236_L0.8630.99
329_A333_T0.8620.99
368_M372_G0.8610.99
355_M360_D0.8600.99
344_E349_R0.8580.99
411_N414_A0.8580.99
443_H446_H0.8570.99
330_L334_L0.8570.99
213_T220_I0.8570.99
141_H501_H0.8550.99
427_G488_H0.8530.99
313_P316_V0.8510.99
318_R323_A0.8510.99
454_I482_V0.8510.99
362_M366_M0.8500.99
96_E151_Q0.8480.99
233_L285_V0.8480.99
319_I322_I0.8470.99
318_R321_P0.8460.99
102_W129_L0.8440.99
75_G156_L0.8430.99
390_H394_N0.8430.99
204_T208_G0.8390.99
451_Q469_W0.8380.99
71_G74_L0.8380.99
314_H319_I0.8360.99
105_L160_V0.8300.98
181_V233_L0.8290.98
349_R356_D0.8290.98
463_A466_R0.8270.98
185_V244_L0.8260.98
339_A343_L0.8250.98
106_E451_Q0.8250.98
408_N414_A0.8240.98
354_S360_D0.8190.98
103_H143_H0.8150.98
357_P360_D0.8140.98
320_Q323_A0.8070.98
294_D301_S0.8050.98
256_V273_L0.8020.98
80_L162_I0.8010.98
372_G376_M0.8000.98
297_T302_Q0.7990.98
327_S330_L0.7980.98
167_I170_L0.7980.98
370_K374_Q0.7970.98
333_T337_L0.7970.98
343_L349_R0.7970.98
82_R134_P0.7970.98
387_H391_G0.7950.98
497_M506_E0.7950.98
342_S347_T0.7950.98
339_A342_S0.7950.98
294_D297_T0.7940.98
346_L353_L0.7930.98
258_A263_L0.7930.98
110_E113_G0.7930.98
204_T207_V0.7930.98
354_S357_P0.7920.98
387_H392_N0.7910.98
313_P317_M0.7900.98
308_A311_D0.7890.98
335_S339_A0.7880.98
432_W514_F0.7860.98
45_R85_A0.7850.98
350_K356_D0.7840.98
406_H411_N0.7830.98
247_A271_S0.7830.98
356_D360_D0.7820.98
69_Y100_L0.7820.98
58_T61_G0.7810.98
428_Q488_H0.7790.98
352_Q357_P0.7770.98
443_H448_H0.7760.98
186_Q238_G0.7730.98
106_E489_D0.7720.98
259_S264_L0.7710.98
317_M320_Q0.7700.98
240_N504_E0.7670.97
443_H505_H0.7670.97
48_I86_V0.7630.97
373_D377_A0.7630.97
347_T350_K0.7620.97
389_G394_N0.7620.97
47_R128_T0.7620.97
348_V352_Q0.7580.97
380_D384_M0.7570.97
344_E347_T0.7570.97
366_M369_E0.7560.97
52_I156_L0.7540.97
447_I484_V0.7540.97
343_L348_V0.7530.97
351_L356_D0.7510.97
348_V355_M0.7490.97
141_H443_H0.7470.97
378_G381_H0.7470.97
106_E490_A0.7460.97
103_H141_H0.7430.97
297_T301_S0.7420.97
368_M371_Y0.7400.97
295_L299_P0.7360.97
436_G477_G0.7320.97
413_Q416_D0.7320.97
90_I102_W0.7320.97
376_M381_H0.7280.97
315_P318_R0.7280.97
105_L162_I0.7260.96
103_H501_H0.7250.96
353_L361_M0.7240.96
344_E353_L0.7240.96
343_L352_Q0.7240.96
103_H500_C0.7210.96
101_H143_H0.7190.96
463_A467_A0.7180.96
356_D361_M0.7170.96
185_V235_L0.7140.96
389_G393_M0.7120.96
131_V160_V0.7090.96
325_S329_A0.7080.96
247_A272_E0.7070.96
208_G211_G0.7070.96
50_L140_F0.7060.96
353_L358_M0.7060.96
446_H500_C0.7060.96
221_Y226_A0.7040.96
99_T144_Q0.7040.96
365_Q368_M0.7020.96
93_Q122_G0.7010.96
346_L351_L0.7010.96
264_L268_V0.6990.96
409_K412_G0.6990.96
77_A161_V0.6980.96
310_F321_P0.6980.96
70_N74_L0.6980.96
88_V102_W0.6970.96
70_N76_P0.6940.95
203_M208_G0.6930.95
387_H394_N0.6930.95
169_K284_L0.6930.95
157_A184_I0.6920.95
86_V129_L0.6920.95
346_L355_M0.6900.95
295_L300_V0.6900.95
377_A380_D0.6900.95
445_F498_A0.6870.95
180_D232_R0.6870.95
152_V157_A0.6860.95
374_Q377_A0.6860.95
342_S351_L0.6820.95
300_V303_M0.6820.95
352_Q356_D0.6810.95
252_R288_N0.6800.95
137_T159_L0.6790.95
69_Y75_G0.6770.95
138_C162_I0.6750.95
203_M207_V0.6750.95
343_L350_K0.6750.95
411_N415_F0.6750.95
75_G140_F0.6720.95
324_I328_G0.6710.95
333_T338_P0.6710.95
498_A512_L0.6700.95
332_D337_L0.6690.94
342_S348_V0.6690.94
443_H499_H0.6680.94
103_H443_H0.6680.94
181_V231_L0.6670.94
447_I452_F0.6650.94
166_E170_L0.6620.94
296_V300_V0.6620.94
203_M206_A0.6600.94
329_A334_L0.6600.94
354_S359_L0.6600.94
333_T336_S0.6590.94
310_F319_I0.6580.94
60_G64_A0.6580.94
53_G71_G0.6560.94
169_K263_L0.6550.94
143_H505_H0.6550.94
375_A378_G0.6540.94
416_D419_K0.6530.94
164_D263_L0.6500.94
208_G441_M0.6500.94
410_I416_D0.6490.94
77_A80_L0.6490.94
294_D299_P0.6480.94
344_E352_Q0.6460.93
102_W160_V0.6450.93
379_M445_F0.6420.93
376_M380_D0.6410.93
425_A430_E0.6400.93
77_A163_E0.6400.93
405_H412_G0.6390.93
415_F418_N0.6380.93
259_S279_E0.6370.93
190_F213_T0.6360.93
317_M322_I0.6360.93
315_P323_A0.6360.93
318_R322_I0.6340.93
372_G377_A0.6320.93
325_S332_D0.6320.93
427_G487_N0.6310.93
161_V236_L0.6310.93
54_A67_W0.6300.93
367_L371_Y0.6300.93
383_Q386_G0.6290.92
223_Q320_Q0.6290.92
227_P288_N0.6260.92
255_Y286_E0.6260.92
367_L372_G0.6250.92
350_K354_S0.6240.92
252_R294_D0.6230.92
62_K190_F0.6230.92
422_F512_L0.6220.92
361_M364_M0.6210.92
256_V268_V0.6200.92
388_M392_N0.6200.92
77_A140_F0.6200.92
350_K357_P0.6190.92
314_H321_P0.6180.92
435_S481_E0.6170.92
239_C277_M0.6150.92
376_M382_S0.6140.92
446_H501_H0.6140.92
386_G391_G0.6130.92
94_L121_P0.6120.91
319_I323_A0.6110.91
222_P225_A0.6090.91
331_P336_S0.6090.91
342_S354_S0.6060.91
259_S468_G0.6060.91
346_L356_D0.6060.91
371_Y375_A0.6040.91
384_M387_H0.6020.91
256_V283_V0.6000.91
409_K413_Q0.6000.91
133_Q162_I0.5980.91
178_I231_L0.5980.91
426_K491_P0.5980.91
243_S274_P0.5970.90
309_P313_P0.5960.90
309_P314_H0.5940.90
412_G416_D0.5920.90
352_Q358_M0.5920.90
328_G332_D0.5900.90
42_T45_R0.5900.90
325_S328_G0.5880.90
407_A414_A0.5870.90
410_I413_Q0.5860.90
369_E374_Q0.5860.90
475_V482_V0.5850.90
447_I450_T0.5840.89
351_L357_P0.5830.89
327_S331_P0.5830.89
143_H448_H0.5800.89
101_H448_H0.5800.89
54_A94_L0.5790.89
295_L298_L0.5780.89
276_L279_E0.5740.89
313_P319_I0.5740.89
299_P302_Q0.5730.89
106_E132_D0.5720.88
389_G392_N0.5720.88
433_V484_V0.5710.88
335_S340_L0.5710.88
190_F212_D0.5700.88
350_K359_L0.5690.88
369_E375_A0.5690.88
177_G180_D0.5690.88
67_W95_T0.5680.88
360_D364_M0.5670.88
327_S333_T0.5670.88
170_L263_L0.5660.88
139_W143_H0.5660.88
345_G356_D0.5650.88
410_I414_A0.5650.88
49_Q72_N0.5650.88
312_K319_I0.5640.88
375_A380_D0.5630.88
103_H448_H0.5620.88
71_G75_G0.5620.88
227_P287_V0.5620.88
59_F190_F0.5610.88
111_V129_L0.5610.88
458_N481_E0.5610.88
80_L105_L0.5610.88
364_M369_E0.5600.87
348_V360_D0.5600.87
101_H104_G0.5590.87
345_G353_L0.5580.87
254_L270_V0.5560.87
380_D383_Q0.5560.87
309_P319_I0.5550.87
296_V299_P0.5550.87
326_A331_P0.5550.87
351_L360_D0.5550.87
105_L138_C0.5550.87
264_L468_G0.5540.87
101_H112_D0.5540.87
448_H499_H0.5530.87
342_S355_M0.5520.87
328_G334_L0.5520.87
252_R287_V0.5490.86
90_I127_V0.5460.86
77_A160_V0.5460.86
336_S339_A0.5460.86
375_A381_H0.5440.86
298_L303_M0.5440.86
332_D336_S0.5430.86
105_L129_L0.5420.86
221_Y225_A0.5420.86
101_H443_H0.5410.86
69_Y90_I0.5400.85
289_D294_D0.5400.85
334_L340_L0.5390.85
409_K414_A0.5380.85
251_N288_N0.5380.85
44_A84_K0.5370.85
381_H385_M0.5370.85
143_H443_H0.5360.85
129_L160_V0.5340.85
316_V323_A0.5340.85
80_L84_K0.5320.85
90_I118_I0.5320.85
78_V160_V0.5320.85
314_H318_R0.5310.85
325_S330_L0.5310.85
293_F298_L0.5310.85
106_E133_Q0.5290.84
378_G384_M0.5280.84
103_H505_H0.5280.84
221_Y316_V0.5270.84
225_A318_R0.5260.84
132_D490_A0.5250.84
353_L360_D0.5250.84
102_W449_G0.5240.84
379_M383_Q0.5230.84
343_L353_L0.5230.84
131_V134_P0.5230.84
348_V356_D0.5230.84
137_T180_D0.5220.84
347_T353_L0.5210.83
368_M375_A0.5210.83
498_A514_F0.5200.83
354_S358_M0.5200.83
456_S482_V0.5190.83
410_I445_F0.5180.83
167_I177_G0.5180.83
382_S385_M0.5180.83
405_H410_I0.5170.83
369_E373_D0.5150.83
101_H499_H0.5140.83
320_Q325_S0.5130.82
102_W107_V0.5130.82
350_K361_M0.5130.82
372_G379_M0.5130.82
116_Q119_I0.5130.82
334_L338_P0.5130.82
68_G71_G0.5120.82
293_F300_V0.5120.82
109_G114_G0.5120.82
255_Y267_P0.5110.82
374_Q379_M0.5110.82
310_F318_R0.5110.82
346_L354_S0.5100.82
341_P349_R0.5100.82
214_L300_V0.5100.82
362_M365_Q0.5090.82
408_N416_D0.5090.82
224_H233_L0.5090.82
205_A209_W0.5090.82
362_M368_M0.5080.82
54_A68_G0.5070.82
323_A328_G0.5070.82
448_H501_H0.5060.82
448_H500_C0.5060.82
137_T258_A0.5050.82
490_A496_Y0.5040.81
103_H499_H0.5040.81
112_D115_P0.5030.81
323_A327_S0.5030.81
98_T156_L0.5010.81
457_E482_V0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4e9sA 1 0.9147 100 0.209 Contact Map
1zpuA 3 0.8605 100 0.216 Contact Map
2uxtA 1 0.8043 100 0.225 Contact Map
3zx1A 1 0.874 100 0.226 Contact Map
2xu9A 1 0.8198 100 0.229 Contact Map
3gyrA 4 0.9089 100 0.233 Contact Map
3sqrA 1 0.8605 100 0.233 Contact Map
3abgA 1 0.8585 100 0.235 Contact Map
1aozA 3 0.8876 100 0.235 Contact Map
2wsdA 1 0.8643 100 0.241 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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