GREMLIN Database
HOFC - Protein transport protein HofC homolog
UniProt: P36646 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11798
Length: 400 (389)
Sequences: 4806 (3670)
Seq/√Len: 186.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_G40_V5.3731.00
64_I125_Y4.7211.00
23_L31_L4.3301.00
201_A205_G4.1381.00
103_D116_P3.7871.00
25_A31_L3.6201.00
288_R301_T3.4161.00
110_F114_L3.2141.00
237_R240_W3.1081.00
242_I298_Q2.8981.00
31_L45_L2.8281.00
202_L380_T2.7931.00
303_I317_L2.6941.00
154_Q353_E2.6601.00
271_A345_D2.5631.00
339_S342_L2.5271.00
63_V97_L2.5241.00
13_T17_N2.4681.00
72_K143_F2.3391.00
28_R32_L2.3151.00
189_A211_D2.2901.00
67_L80_G2.2541.00
156_T160_K2.2421.00
99_S117_W2.2271.00
268_T352_R2.2231.00
201_A204_Q2.2111.00
234_L240_W2.1671.00
79_E336_A2.1641.00
204_Q208_T2.1521.00
13_T19_Q2.0911.00
10_H20_D2.0881.00
42_P45_L2.0681.00
85_A98_Q2.0631.00
81_L104_L2.0551.00
68_A146_A2.0461.00
235_M244_R2.0381.00
103_D108_I2.0331.00
7_W28_R2.0071.00
115_L130_R1.9911.00
151_A356_M1.9701.00
175_M179_A1.9541.00
9_W21_G1.9531.00
10_H44_S1.9521.00
10_H18_A1.9501.00
178_V182_H1.9481.00
284_V300_L1.9291.00
99_S103_D1.9191.00
229_I233_L1.9081.00
67_L142_C1.9031.00
275_S341_D1.8861.00
285_E304_Q1.8821.00
103_D113_A1.8641.00
376_G380_T1.8511.00
81_L97_L1.8431.00
179_A183_F1.8421.00
228_A232_K1.8221.00
82_A101_A1.8201.00
158_K360_D1.8021.00
245_Q294_P1.8001.00
202_L387_L1.7781.00
306_D311_Q1.7601.00
171_A175_M1.7581.00
212_F220_L1.7521.00
125_Y145_L1.7311.00
202_L205_G1.7311.00
260_G354_N1.7011.00
34_A38_Q1.6861.00
198_P204_Q1.6781.00
65_H150_K1.6771.00
391_H394_D1.6761.00
72_K346_N1.6711.00
137_K140_E1.6591.00
232_K236_R1.6371.00
270_L283_G1.6341.00
101_A105_E1.6281.00
386_Y390_F1.6261.00
306_D316_A1.6091.00
170_L174_I1.6061.00
243_V247_L1.6041.00
26_E30_L1.6031.00
111_S133_E1.5681.00
306_D319_N1.5671.00
219_L223_F1.5671.00
59_K90_S1.5531.00
125_Y149_Q1.5281.00
12_I18_A1.5241.00
114_L129_I1.5201.00
22_M48_I1.5041.00
167_I171_A1.5001.00
134_L282_Q1.4731.00
206_I384_A1.4671.00
158_K356_M1.4651.00
245_Q293_C1.4641.00
30_L34_A1.4591.00
85_A101_A1.4541.00
31_L42_P1.4401.00
153_R157_D1.4401.00
311_Q315_L1.4371.00
27_S30_L1.4331.00
68_A143_F1.4081.00
211_D214_G1.3961.00
258_M262_K1.3871.00
245_Q248_L1.3811.00
205_G208_T1.3761.00
187_E190_A1.3741.00
268_T349_H1.3731.00
234_L237_R1.3581.00
288_R304_Q1.3511.00
260_G358_L1.3491.00
108_I112_N1.3381.00
218_W222_L1.3331.00
282_Q285_E1.3291.00
216_W219_L1.3151.00
266_I300_L1.3121.00
131_T135_T1.3021.00
302_Q320_T1.2871.00
8_R48_I1.2821.00
239_T243_V1.2761.00
268_T348_A1.2681.00
294_P297_V1.2581.00
233_L236_R1.2561.00
280_F313_I1.2531.00
267_F327_C1.2431.00
241_L294_P1.2421.00
88_H93_W1.2351.00
227_L231_N1.2261.00
304_Q308_S1.2251.00
72_K139_D1.2181.00
165_Y169_I1.2151.00
263_L327_C1.2131.00
242_I295_Y1.2121.00
264_T355_T1.2061.00
122_P125_Y1.1881.00
151_A352_R1.1851.00
243_V246_K1.1801.00
291_M300_L1.1671.00
96_L120_V1.1661.00
57_G156_T1.1641.00
88_H97_L1.1631.00
100_L114_L1.1561.00
262_K296_W1.1561.00
177_V377_I1.1561.00
188_F386_Y1.1491.00
188_F390_F1.1451.00
212_F216_W1.1321.00
230_A234_L1.1261.00
164_R168_I1.1221.00
224_G228_A1.1211.00
112_N115_L1.1201.00
273_T283_G1.1201.00
211_D215_E1.1191.00
299_L320_T1.1191.00
367_E371_L1.1161.00
256_S260_G1.1141.00
64_I145_L1.1141.00
71_L142_C1.1111.00
169_I374_T1.1071.00
264_T352_R1.1061.00
180_M381_L1.1061.00
270_L344_L1.1041.00
317_L331_V1.1041.00
122_P149_Q1.0931.00
61_A146_A1.0901.00
225_F229_I1.0871.00
31_L34_A1.0861.00
18_A43_L1.0801.00
35_L38_Q1.0791.00
302_Q305_H1.0781.00
143_F147_R1.0761.00
260_G355_T1.0741.00
379_G383_V1.0591.00
65_H147_R1.0581.00
77_L110_F1.0571.00
270_L280_F1.0551.00
231_N244_R1.0551.00
23_L34_A1.0511.00
200_P203_T1.0511.00
207_M211_D1.0481.00
148_Q152_Q1.0471.00
130_R134_L1.0451.00
115_L126_Q1.0441.00
205_G209_L1.0341.00
154_Q158_K1.0331.00
28_R47_R1.0321.00
242_I294_P1.0311.00
300_L303_I1.0291.00
247_L251_I1.0231.00
182_H213_S1.0221.00
96_L121_F1.0191.00
230_A233_L1.0141.00
327_C347_L1.0090.99
55_W93_W1.0080.99
57_G153_R1.0070.99
19_Q40_V1.0030.99
161_S360_D1.0020.99
266_I270_L1.0010.99
141_C145_L0.9990.99
91_K94_Q0.9930.99
208_T212_F0.9920.99
96_L117_W0.9910.99
177_V381_L0.9900.99
249_L293_C0.9900.99
67_L77_L0.9850.99
181_L209_L0.9840.99
226_L230_A0.9730.99
21_G35_L0.9670.99
34_A37_Q0.9670.99
275_S345_D0.9650.99
165_Y368_P0.9580.99
74_G277_G0.9580.99
391_H395_A0.9530.99
284_V307_I0.9530.99
189_A193_K0.9490.99
169_I378_I0.9420.99
28_R46_K0.9410.99
314_W335_E0.9320.99
55_W120_V0.9320.99
58_D157_D0.9290.99
234_L243_V0.9280.99
11_G21_G0.9260.99
147_R151_A0.9210.99
33_M37_Q0.9190.99
199_L203_T0.9150.99
288_R300_L0.9110.99
246_K250_R0.9030.99
69_T343_M0.9030.99
70_L80_G0.8980.99
229_I232_K0.8960.99
128_M141_C0.8930.99
389_I393_G0.8930.99
291_M296_W0.8930.99
115_L123_P0.8920.99
345_D349_H0.8910.99
318_K332_R0.8910.99
103_D117_W0.8880.99
157_D353_E0.8850.99
11_G19_Q0.8840.99
312_P315_L0.8830.99
11_G42_P0.8830.99
179_A184_V0.8810.99
388_P391_H0.8780.99
132_G141_C0.8760.99
261_Q355_T0.8760.99
203_T384_A0.8720.99
9_W35_L0.8720.99
103_D106_Q0.8710.98
305_H309_N0.8670.98
154_Q356_M0.8660.98
362_L366_L0.8660.98
371_L374_T0.8640.98
109_A112_N0.8620.98
377_I380_T0.8610.98
66_Q330_L0.8580.98
32_L45_L0.8540.98
231_N235_M0.8510.98
297_V301_T0.8490.98
353_E357_A0.8480.98
242_I246_K0.8460.98
169_I173_A0.8450.98
266_I317_L0.8430.98
123_P289_E0.8420.98
151_A154_Q0.8410.98
112_N130_R0.8400.98
100_L113_A0.8380.98
31_L35_L0.8380.98
58_D153_R0.8370.98
330_L347_L0.8370.98
134_L286_S0.8310.98
334_G338_G0.8230.98
8_R20_D0.8220.98
118_S121_F0.8210.98
301_T304_Q0.8210.98
299_L322_E0.8210.98
314_W332_R0.8180.98
248_L258_M0.8160.98
93_W96_L0.8140.98
82_A105_E0.8140.98
279_T283_G0.8120.98
144_E275_S0.8110.98
60_S122_P0.8100.98
14_G39_M0.8060.98
160_K164_R0.8040.97
78_S101_A0.8020.97
271_A348_A0.8000.97
57_G61_A0.7990.97
172_M176_V0.7980.97
178_V213_S0.7950.97
108_I116_P0.7920.97
130_R289_E0.7890.97
261_Q265_Q0.7880.97
161_S361_N0.7850.97
159_V366_L0.7850.97
126_Q130_R0.7850.97
382_V390_F0.7800.97
61_A149_Q0.7780.97
189_A207_M0.7780.97
164_R364_A0.7760.97
233_L237_R0.7730.97
195_F395_A0.7720.97
246_K295_Y0.7710.97
241_L245_Q0.7710.97
355_T359_A0.7700.97
303_I316_A0.7680.97
305_H308_S0.7660.97
288_R297_V0.7650.97
82_A86_E0.7640.97
251_I254_M0.7620.97
65_H146_A0.7620.97
164_R167_I0.7610.96
238_P242_I0.7610.96
131_T269_I0.7570.96
69_T337_S0.7570.96
141_C272_L0.7570.96
64_I142_C0.7570.96
164_R361_N0.7540.96
307_I313_I0.7530.96
28_R31_L0.7530.96
129_I142_C0.7520.96
255_G259_R0.7490.96
7_W47_R0.7480.96
181_L185_L0.7470.96
331_V340_L0.7450.96
170_L370_L0.7450.96
188_F192_Y0.7440.96
102_H106_Q0.7420.96
118_S126_Q0.7410.96
223_F227_L0.7410.96
232_K235_M0.7390.96
140_E275_S0.7370.96
118_S122_P0.7360.96
64_I149_Q0.7360.96
148_Q269_I0.7340.96
172_M372_I0.7340.96
256_S358_L0.7330.96
27_S33_M0.7330.96
267_F355_T0.7230.95
263_L347_L0.7150.95
111_S130_R0.7140.95
133_E338_G0.7140.95
183_F187_E0.7140.95
192_Y392_L0.7130.95
108_I113_A0.7110.95
262_K292_R0.7100.95
18_A42_P0.7090.95
306_D309_N0.7090.95
324_S351_H0.7080.95
85_A97_L0.7070.95
185_L207_M0.7030.95
264_T348_A0.7020.95
97_L100_L0.7020.95
386_Y389_I0.7000.94
59_K93_W0.7000.94
269_I290_T0.6990.94
238_P294_P0.6980.94
11_G43_L0.6970.94
295_Y299_L0.6950.94
251_I255_G0.6930.94
197_T395_A0.6930.94
10_H43_L0.6930.94
335_E338_G0.6930.94
61_A153_R0.6920.94
206_I380_T0.6910.94
346_N349_H0.6900.94
303_I331_V0.6880.94
8_R22_M0.6870.94
99_S116_P0.6860.94
61_A68_A0.6850.94
217_S221_V0.6850.94
313_I317_L0.6840.94
203_T388_P0.6830.94
361_N364_A0.6790.93
40_V43_L0.6790.93
295_Y298_Q0.6780.93
94_Q98_Q0.6730.93
76_T79_E0.6730.93
86_E318_K0.6720.93
168_I365_L0.6720.93
184_V188_F0.6710.93
299_L323_F0.6680.93
115_L118_S0.6670.93
198_P202_L0.6660.93
263_L267_F0.6660.93
356_M360_D0.6600.93
56_R59_K0.6590.92
157_D357_A0.6570.92
365_L369_A0.6560.92
247_L250_R0.6550.92
299_L302_Q0.6530.92
144_E345_D0.6520.92
107_G310_G0.6520.92
188_F191_I0.6510.92
110_F142_C0.6500.92
386_Y393_G0.6500.92
311_Q319_N0.6490.92
121_F129_I0.6490.92
205_G380_T0.6480.92
139_D341_D0.6480.92
302_Q306_D0.6470.92
321_G328_L0.6470.92
60_S64_I0.6460.92
274_Q341_D0.6450.92
370_L373_I0.6410.91
63_V93_W0.6410.91
72_K342_L0.6410.91
81_L101_A0.6400.91
23_L38_Q0.6390.91
106_Q309_N0.6380.91
317_L328_L0.6380.91
215_E218_W0.6370.91
181_L210_A0.6350.91
274_Q283_G0.6350.91
209_L212_F0.6350.91
324_S327_C0.6340.91
221_V225_F0.6330.91
114_L125_Y0.6320.91
9_W23_L0.6300.91
56_R90_S0.6300.91
263_L351_H0.6300.91
66_Q326_L0.6270.90
206_I374_T0.6270.90
8_R49_A0.6260.90
163_L370_L0.6260.90
202_L384_A0.6260.90
84_L97_L0.6230.90
19_Q38_Q0.6230.90
86_E325_P0.6230.90
139_D358_L0.6210.90
326_L330_L0.6210.90
380_T387_L0.6200.90
80_G84_L0.6200.90
29_T36_Q0.6200.90
57_G149_Q0.6190.90
83_L333_T0.6180.90
289_E297_V0.6170.90
136_G338_G0.6160.90
180_M184_V0.6150.90
315_L319_N0.6140.90
303_I307_I0.6140.90
99_S102_H0.6110.89
27_S31_L0.6110.89
368_P375_G0.6110.89
173_A390_F0.6100.89
379_G382_V0.6080.89
190_A193_K0.6070.89
330_L351_H0.6060.89
202_L206_I0.6060.89
30_L37_Q0.6060.89
364_A367_E0.6060.89
208_T211_D0.6050.89
133_E136_G0.6040.89
311_Q316_A0.6040.89
68_A139_D0.6020.89
129_I132_G0.6010.89
129_I138_L0.6010.89
24_W30_L0.5990.88
180_M385_M0.5990.88
183_F375_G0.5980.88
219_L222_L0.5980.88
279_T282_Q0.5970.88
181_L213_S0.5970.88
14_G41_T0.5920.88
148_Q180_M0.5920.88
150_K346_N0.5900.88
268_T271_A0.5900.88
244_R248_L0.5890.88
337_S340_L0.5870.87
212_F215_E0.5870.87
53_A92_Q0.5860.87
165_Y367_E0.5860.87
50_I53_A0.5840.87
343_M371_L0.5840.87
82_A85_A0.5840.87
174_I178_V0.5840.87
333_T379_G0.5820.87
271_A274_Q0.5800.87
55_W92_Q0.5800.87
96_L100_L0.5800.87
83_L336_A0.5790.87
52_S92_Q0.5780.87
14_G48_I0.5780.87
273_T278_I0.5760.86
19_Q31_L0.5750.86
122_P152_Q0.5740.86
197_T392_L0.5740.86
315_L318_K0.5730.86
173_A195_F0.5730.86
185_L197_T0.5690.86
179_A182_H0.5690.86
259_R296_W0.5680.86
267_F344_L0.5680.86
44_S47_R0.5660.85
10_H19_Q0.5650.85
63_V67_L0.5630.85
369_A372_I0.5630.85
12_I43_L0.5620.85
227_L233_L0.5620.85
379_G384_A0.5610.85
254_M258_M0.5610.85
358_L361_N0.5610.85
7_W353_E0.5600.85
123_P297_V0.5590.85
332_R336_A0.5590.85
26_E29_T0.5580.85
259_R263_L0.5570.85
55_W96_L0.5540.84
266_I291_M0.5540.84
222_L239_T0.5520.84
366_L370_L0.5520.84
104_L110_F0.5520.84
9_W19_Q0.5510.84
373_I377_I0.5510.84
192_Y199_L0.5490.84
38_Q42_P0.5480.84
102_H105_E0.5470.83
191_I392_L0.5470.83
12_I41_T0.5470.83
240_W244_R0.5460.83
267_F347_L0.5450.83
204_Q207_M0.5440.83
273_T286_S0.5420.83
231_N240_W0.5420.83
146_A150_K0.5400.83
123_P292_R0.5400.83
65_H354_N0.5390.83
128_M132_G0.5390.83
131_T273_T0.5390.83
369_A373_I0.5380.82
235_M241_L0.5380.82
343_M346_N0.5370.82
9_W31_L0.5370.82
96_L114_L0.5370.82
334_G340_L0.5360.82
42_P46_K0.5360.82
239_T242_I0.5340.82
65_H68_A0.5330.82
50_I228_A0.5330.82
318_K321_G0.5330.82
375_G393_G0.5310.82
36_Q43_L0.5280.81
121_F126_Q0.5280.81
176_V180_M0.5270.81
285_E301_T0.5270.81
210_A214_G0.5260.81
288_R291_M0.5260.81
92_Q95_A0.5250.81
263_L324_S0.5250.81
33_M46_K0.5240.81
365_L389_I0.5220.81
294_P298_Q0.5220.81
250_R259_R0.5220.81
252_P255_G0.5220.81
276_A290_T0.5220.81
301_T305_H0.5190.80
191_I274_Q0.5180.80
52_S119_E0.5180.80
8_R46_K0.5170.80
79_E329_Q0.5160.80
390_F393_G0.5150.80
180_M187_E0.5150.80
98_Q223_F0.5150.80
19_Q39_M0.5150.80
245_Q249_L0.5140.80
334_G367_E0.5130.79
75_L333_T0.5130.79
23_L35_L0.5120.79
128_M371_L0.5110.79
200_P204_Q0.5110.79
256_S259_R0.5100.79
176_V381_L0.5100.79
382_V389_I0.5100.79
132_G135_T0.5100.79
147_R345_D0.5100.79
79_E282_Q0.5090.79
145_L265_Q0.5080.79
262_K297_V0.5080.79
367_E388_P0.5080.79
159_V163_L0.5070.79
66_Q87_Q0.5050.78
280_F340_L0.5040.78
299_L328_L0.5040.78
32_L42_P0.5020.78
73_A343_M0.5010.78
368_P388_P0.5000.78
137_K275_S0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c1qA 2 0.3025 99.9 0.735 Contact Map
4hhxA 1 0.2525 99.8 0.738 Contact Map
2whnA 1 0.275 99.8 0.765 Contact Map
4ev6A 3 0.465 31.1 0.959 Contact Map
4i0uA 4 0.4825 25.7 0.961 Contact Map
2vldA 2 0.12 23 0.962 Contact Map
2m8rA 1 0.245 17.8 0.963 Contact Map
3tweA 2 0.065 12 0.966 Contact Map
4g3bA 3 0.0575 10.5 0.967 Contact Map
2db2A 1 0.18 9.6 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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