GREMLIN Database
HOFB - Protein transport protein HofB homolog
UniProt: P36645 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12106
Length: 461 (447)
Sequences: 4625 (3196)
Seq/√Len: 151.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
354_L382_A4.6451.00
405_T428_A4.5081.00
207_F235_A4.0121.00
210_A344_L3.8711.00
411_L424_H3.5911.00
360_R383_P3.5301.00
179_K245_N3.5161.00
134_T180_V3.4311.00
359_R380_W3.3631.00
320_S323_E3.2991.00
244_I287_V3.1951.00
357_H387_H3.1651.00
208_A238_K3.1101.00
361_Q378_P3.0071.00
54_W59_M2.8341.00
219_L314_S2.7211.00
360_R381_Q2.6831.00
247_C280_L2.6471.00
354_L447_T2.6221.00
437_G451_L2.6051.00
411_L416_T2.5871.00
353_K396_T2.5681.00
249_V276_V2.5451.00
362_Q381_Q2.5421.00
354_L359_R2.4571.00
167_F182_L2.4231.00
221_T316_L2.4051.00
175_R253_V2.3801.00
426_R435_E2.3481.00
424_H428_A2.3231.00
204_L208_A2.3001.00
163_N186_Q2.2861.00
211_L235_A2.2831.00
362_Q379_H2.2681.00
346_I401_V2.2351.00
109_Y130_G2.2251.00
150_L269_A2.2141.00
24_V50_E2.2121.00
405_T424_H2.2111.00
172_L263_T2.1781.00
404_I412_I2.1701.00
85_L133_L2.1471.00
396_T445_L2.1321.00
436_N440_A2.1141.00
209_H403_P2.0951.00
28_A54_W2.0871.00
293_I302_A2.0731.00
424_H427_Q2.0731.00
407_V428_A2.0561.00
431_R439_L2.0451.00
365_P368_I2.0411.00
55_T58_Q2.0361.00
320_S422_E2.0321.00
408_I421_L1.9951.00
96_R393_Y1.9781.00
143_L171_T1.9561.00
382_A447_T1.9291.00
179_K261_N1.9211.00
410_Q414_A1.9151.00
20_A47_K1.8991.00
121_P124_D1.8771.00
239_L287_V1.8631.00
170_A283_Q1.8431.00
9_L13_Y1.8401.00
137_L169_I1.8141.00
385_C388_C1.7911.00
141_G169_I1.7801.00
439_L443_Q1.7641.00
322_C402_L1.7521.00
118_V453_R1.7491.00
438_C442_E1.7451.00
203_Q399_F1.7381.00
185_L255_I1.7361.00
118_V352_R1.7181.00
201_P205_A1.6971.00
355_C358_C1.6891.00
167_F184_L1.6891.00
325_L342_L1.6891.00
29_V51_I1.6781.00
26_H52_T1.6651.00
171_T180_V1.6581.00
203_Q401_V1.6351.00
41_L49_I1.6321.00
396_T440_A1.6151.00
27_V41_L1.6111.00
110_R121_P1.6101.00
200_Q203_Q1.6011.00
174_C261_N1.5981.00
355_C388_C1.5941.00
432_T435_E1.5891.00
417_D420_S1.5881.00
108_A124_D1.5851.00
113_L122_L1.5821.00
213_Q343_T1.5801.00
202_L431_R1.5781.00
416_T420_S1.5771.00
355_C385_C1.5671.00
357_H393_Y1.5601.00
358_C388_C1.5561.00
272_T275_G1.5481.00
358_C385_C1.5401.00
249_V280_L1.5371.00
434_F455_L1.5211.00
362_Q368_I1.5131.00
19_D26_H1.5091.00
218_V311_L1.4951.00
97_A115_I1.4891.00
440_A445_L1.4871.00
402_L430_M1.4811.00
329_Q338_L1.4731.00
203_Q436_N1.4671.00
364_E379_H1.4621.00
193_D196_T1.4431.00
199_M399_F1.4281.00
356_P359_R1.4151.00
266_H269_A1.4101.00
361_Q380_W1.4061.00
263_T280_L1.4051.00
121_P242_A1.4051.00
379_H441_V1.4051.00
18_L52_T1.4011.00
102_I109_Y1.3991.00
103_E112_R1.3761.00
354_L383_P1.3761.00
407_V424_H1.3591.00
203_Q206_D1.3581.00
441_V451_L1.3551.00
18_L28_A1.3481.00
14_H30_V1.3361.00
300_E304_K1.3351.00
299_A333_V1.3351.00
423_T427_Q1.3331.00
354_L380_W1.3291.00
414_A420_S1.3221.00
14_H60_E1.3211.00
25_V45_T1.3101.00
118_V243_D1.3081.00
115_I120_H1.3031.00
30_V59_M1.2901.00
10_C63_A1.2891.00
31_D34_S1.2801.00
224_T285_P1.2791.00
205_A209_H1.2791.00
85_L137_L1.2711.00
329_Q335_R1.2701.00
11_L64_S1.2651.00
240_N246_I1.2631.00
179_K247_C1.2591.00
195_N204_L1.2591.00
407_V427_Q1.2481.00
14_H56_R1.2471.00
218_V344_L1.2461.00
202_L206_D1.2451.00
223_P349_R1.2291.00
239_L313_L1.2251.00
221_T318_T1.2221.00
392_F446_T1.2191.00
195_N208_A1.2141.00
293_I314_S1.2081.00
276_V280_L1.2061.00
422_E426_R1.2061.00
16_V59_M1.2011.00
212_Q238_K1.2011.00
35_H39_D1.1961.00
224_T310_H1.1961.00
206_D403_P1.1951.00
406_P409_R1.1941.00
425_A430_M1.1871.00
199_M207_F1.1851.00
199_M231_T1.1801.00
209_H213_Q1.1801.00
303_I333_V1.1801.00
381_Q449_E1.1761.00
210_A401_V1.1661.00
38_L51_I1.1551.00
158_V167_F1.1511.00
322_C421_L1.1461.00
91_S95_Q1.1421.00
219_L293_I1.1351.00
156_F167_F1.1230.99
392_F447_T1.1210.99
18_L26_H1.1180.99
408_I425_A1.1180.99
377_L442_E1.1110.99
364_E369_P1.0960.99
93_L165_V1.0920.99
140_L156_F1.0890.99
23_E47_K1.0820.99
240_N259_G1.0810.99
217_L312_V1.0790.99
366_I370_D1.0760.99
426_R430_M1.0680.99
426_R432_T1.0620.99
307_Q337_M1.0610.99
16_V62_H1.0580.99
15_G27_V1.0570.99
420_S423_T1.0530.99
345_V402_L1.0510.99
324_T345_V1.0470.99
26_H50_E1.0440.99
316_L324_T1.0430.99
61_G65_R1.0430.99
358_C384_G1.0400.99
153_D170_A1.0400.99
231_T348_Q1.0390.99
442_E445_L1.0340.99
200_Q439_L1.0340.99
446_T450_E1.0310.99
165_V184_L1.0280.99
304_K307_Q1.0250.99
347_A433_L1.0160.99
211_L218_V1.0140.99
232_L289_M1.0130.99
159_E164_A1.0110.99
278_R297_E1.0110.99
28_A52_T1.0090.99
322_C422_E1.0060.99
438_C441_V1.0060.99
200_Q443_Q1.0010.99
342_L345_V1.0000.99
138_K178_E0.9980.99
203_Q346_I0.9950.99
398_L437_G0.9900.99
441_V448_F0.9880.99
384_G388_C0.9880.99
425_A429_G0.9860.99
296_G300_E0.9850.99
105_A110_R0.9810.99
439_L442_E0.9810.99
288_I305_A0.9750.99
114_R284_D0.9700.99
351_V446_T0.9660.98
164_A187_Q0.9640.98
80_P83_E0.9610.98
38_L42_H0.9610.98
199_M397_A0.9590.98
59_M63_A0.9560.98
210_A343_T0.9540.98
56_R60_E0.9530.98
376_P379_H0.9500.98
280_L288_I0.9390.98
210_A218_V0.9390.98
239_L246_I0.9390.98
304_K330_Q0.9350.98
292_E317_H0.9350.98
116_D352_R0.9340.98
169_I182_L0.9330.98
220_V231_T0.9330.98
200_Q440_A0.9320.98
352_R450_E0.9230.98
88_T111_I0.9210.98
322_C430_M0.9200.98
438_C448_F0.9190.98
215_Q320_S0.9170.98
96_R115_I0.9110.98
127_P130_G0.9100.98
274_Q297_E0.9040.98
263_T276_V0.9040.98
247_C261_N0.9040.98
241_T244_I0.9020.98
221_T324_T0.9010.98
364_E368_I0.9010.98
170_A181_V0.8970.98
150_L271_L0.8940.97
10_C15_G0.8900.97
179_K283_Q0.8820.97
211_L313_L0.8810.97
363_G378_P0.8770.97
92_A113_L0.8770.97
68_Q72_V0.8760.97
200_Q436_N0.8750.97
398_L455_L0.8740.97
245_N261_N0.8730.97
378_P381_Q0.8700.97
15_G41_L0.8660.97
42_H48_R0.8610.97
165_V186_Q0.8600.97
82_A136_R0.8560.97
329_Q415_N0.8550.97
253_V264_Q0.8520.97
220_V346_I0.8510.97
247_C263_T0.8490.97
240_N243_D0.8480.97
249_V265_I0.8450.96
338_L342_L0.8450.96
13_Y37_L0.8440.96
293_I299_A0.8440.96
136_R140_L0.8440.96
353_K445_L0.8430.96
254_E317_H0.8420.96
351_V398_L0.8390.96
29_V34_S0.8380.96
32_A53_C0.8370.96
440_A443_Q0.8370.96
108_A258_A0.8360.96
410_Q423_T0.8320.96
282_R292_E0.8310.96
270_G275_G0.8250.96
40_A43_F0.8210.96
30_V56_R0.8210.96
267_P271_L0.8210.96
411_L420_S0.8200.96
88_T102_I0.8130.96
228_K317_H0.8130.96
190_Q193_D0.8070.95
436_N439_L0.8040.95
143_L180_V0.8030.95
335_R415_N0.8010.95
181_V283_Q0.8000.95
228_K292_E0.7990.95
282_R317_H0.7970.95
88_T100_I0.7910.95
99_D317_H0.7900.95
339_S413_S0.7880.95
294_R317_H0.7880.95
404_I409_R0.7870.95
447_T450_E0.7860.95
249_V263_T0.7860.95
355_C384_G0.7860.95
194_V208_A0.7850.95
90_Q94_E0.7850.95
95_Q389_Y0.7850.95
25_V47_K0.7820.95
13_Y40_A0.7810.95
45_T48_R0.7790.94
207_F401_V0.7780.94
361_Q364_E0.7770.94
95_Q120_H0.7720.94
34_S37_L0.7700.94
303_I337_M0.7690.94
325_L412_I0.7680.94
215_Q343_T0.7670.94
144_D268_R0.7670.94
277_L301_I0.7670.94
30_V33_P0.7650.94
402_L408_I0.7630.94
408_I424_H0.7630.94
300_E334_A0.7590.94
398_L454_V0.7580.94
89_L167_F0.7570.94
404_I408_I0.7560.94
175_R256_P0.7550.93
379_H382_A0.7540.93
421_L425_A0.7520.93
431_R435_E0.7520.93
426_R429_G0.7520.93
170_A279_A0.7510.93
74_V77_K0.7500.93
388_C391_G0.7500.93
448_F452_I0.7490.93
60_E63_A0.7480.93
30_V54_W0.7480.93
15_G37_L0.7460.93
23_E26_H0.7460.93
416_T421_L0.7460.93
434_F437_G0.7450.93
398_L440_A0.7440.93
93_L160_L0.7400.93
221_T347_A0.7400.93
210_A403_P0.7400.93
37_L41_L0.7380.93
254_E292_E0.7380.93
282_R294_R0.7370.93
385_C391_G0.7360.93
93_L184_L0.7350.93
101_H181_V0.7340.92
315_T318_T0.7310.92
232_L313_L0.7300.92
291_G317_H0.7270.92
29_V38_L0.7250.92
62_H65_R0.7240.92
229_T233_Y0.7240.92
99_D282_R0.7230.92
99_D228_K0.7220.92
369_P377_L0.7190.92
339_S412_I0.7180.92
322_C418_V0.7170.92
172_L283_Q0.7160.92
106_D176_G0.7160.92
166_S187_Q0.7130.91
233_Y257_I0.7120.91
229_T257_I0.7110.91
99_D292_E0.7100.91
137_L180_V0.7090.91
410_Q419_E0.7080.91
237_Q240_N0.7050.91
245_N283_Q0.7030.91
194_V234_S0.7020.91
406_P419_E0.7010.91
407_V411_L0.7010.91
450_E453_R0.7010.91
28_A59_M0.7000.91
446_T451_L0.7000.91
29_V37_L0.7000.91
194_V204_L0.6990.91
101_H284_D0.6980.90
84_L88_T0.6960.90
281_L305_A0.6950.90
202_L439_L0.6950.90
310_H327_R0.6950.90
220_V232_L0.6920.90
156_F169_I0.6880.90
318_T321_T0.6880.90
217_L302_A0.6870.90
418_V422_E0.6870.90
229_T255_I0.6850.90
254_E294_R0.6840.90
272_T297_E0.6830.90
437_G440_A0.6830.90
17_L20_A0.6790.89
60_E64_S0.6770.89
420_S424_H0.6760.89
186_Q190_Q0.6740.89
89_L100_I0.6730.89
271_L276_V0.6720.89
231_T346_I0.6720.89
103_E148_H0.6700.89
202_L205_A0.6690.89
352_R392_F0.6690.89
186_Q189_G0.6660.88
215_Q319_N0.6660.88
82_A86_T0.6630.88
203_Q431_R0.6610.88
15_G29_V0.6610.88
115_I122_L0.6590.88
31_D37_L0.6580.88
130_G134_T0.6580.88
407_V410_Q0.6560.88
218_V343_T0.6550.88
224_T286_D0.6550.88
267_P272_T0.6540.87
280_L290_I0.6520.87
102_I130_G0.6510.87
228_K254_E0.6490.87
99_D254_E0.6480.87
22_E47_K0.6480.87
183_R317_H0.6470.87
344_L401_V0.6470.87
374_P377_L0.6470.87
191_A237_Q0.6470.87
10_C17_L0.6450.87
150_L275_G0.6430.87
172_L280_L0.6420.86
168_R252_P0.6390.86
403_P430_M0.6390.86
354_L360_R0.6390.86
206_D209_H0.6370.86
86_T136_R0.6370.86
144_D149_R0.6350.86
218_V346_I0.6320.86
406_P423_T0.6320.86
330_Q413_S0.6310.86
333_V338_L0.6300.85
278_R295_D0.6280.85
143_L169_I0.6280.85
183_R292_E0.6270.85
402_L421_L0.6260.85
21_S26_H0.6260.85
9_L44_A0.6260.85
228_K282_R0.6250.85
437_G441_V0.6250.85
20_A23_E0.6250.85
452_I455_L0.6240.85
21_S24_V0.6240.85
228_K294_R0.6220.85
85_L140_L0.6210.85
58_Q61_G0.6210.85
20_A25_V0.6210.85
380_W383_P0.6200.85
163_N188_V0.6200.85
138_K152_Q0.6200.85
363_G376_P0.6190.84
438_C451_L0.6190.84
374_P378_P0.6180.84
99_D294_R0.6160.84
299_A328_L0.6160.84
318_T324_T0.6160.84
326_V418_V0.6150.84
183_R294_R0.6150.84
126_S129_A0.6150.84
183_R254_E0.6120.84
141_G156_F0.6120.84
108_A121_P0.6110.84
375_S378_P0.6100.84
105_A108_A0.6090.83
21_S50_E0.6060.83
99_D252_P0.6060.83
137_L182_L0.6040.83
224_T308_T0.6030.83
45_T49_I0.6030.83
364_E377_L0.6020.83
437_G446_T0.6010.83
285_P310_H0.6010.83
224_T282_R0.6000.83
183_R282_R0.6000.83
73_A76_E0.6000.83
208_A212_Q0.5990.82
42_H49_I0.5990.82
214_P319_N0.5970.82
155_Q166_S0.5940.82
57_Q61_G0.5930.82
403_P406_P0.5920.82
135_A145_I0.5910.82
431_R436_N0.5910.82
201_P204_L0.5900.81
36_E39_D0.5900.81
222_G291_G0.5890.81
249_V301_I0.5880.81
367_H370_D0.5860.81
103_E261_N0.5860.81
296_G332_G0.5840.81
273_F298_T0.5830.81
277_L280_L0.5800.80
438_C455_L0.5790.80
252_P292_E0.5780.80
207_F346_I0.5780.80
158_V184_L0.5780.80
379_H442_E0.5780.80
349_R433_L0.5770.80
39_D42_H0.5760.80
224_T292_E0.5750.80
143_L170_A0.5730.80
239_L244_I0.5730.80
224_T294_R0.5720.79
210_A346_I0.5710.79
378_P382_A0.5710.79
228_K291_G0.5700.79
91_S113_L0.5700.79
254_E282_R0.5690.79
366_I369_P0.5690.79
157_T167_F0.5690.79
41_L45_T0.5680.79
351_V396_T0.5680.79
357_H386_V0.5670.79
416_T424_H0.5670.79
288_I310_H0.5660.79
99_D183_R0.5650.79
157_T164_A0.5650.79
295_D298_T0.5650.79
269_A275_G0.5650.79
99_D168_R0.5640.79
31_D53_C0.5620.78
339_S343_T0.5620.78
222_G226_S0.5610.78
362_Q365_P0.5600.78
101_H119_L0.5590.78
138_K154_G0.5580.78
435_E438_C0.5570.78
236_L289_M0.5560.78
94_E161_A0.5560.78
109_Y133_L0.5540.77
183_R228_K0.5520.77
369_P376_P0.5520.77
356_P387_H0.5500.77
172_L279_A0.5500.77
419_E423_T0.5500.77
9_L12_R0.5500.77
13_Y34_S0.5490.77
252_P317_H0.5470.76
331_M399_F0.5460.76
308_T319_N0.5460.76
61_G64_S0.5460.76
9_L15_G0.5450.76
23_E48_R0.5450.76
29_V32_A0.5450.76
303_I341_A0.5440.76
193_D238_K0.5430.76
22_E50_E0.5430.76
308_T327_R0.5420.76
217_L344_L0.5420.76
75_Q78_H0.5420.76
112_R261_N0.5410.76
187_Q255_I0.5400.76
47_K51_I0.5400.76
176_G256_P0.5390.75
308_T317_H0.5380.75
230_V255_I0.5380.75
322_C400_E0.5360.75
168_R317_H0.5340.75
307_Q341_A0.5340.75
102_I111_I0.5330.75
67_Q71_P0.5320.74
251_D264_Q0.5320.74
169_I180_V0.5320.74
224_T317_H0.5320.74
322_C326_V0.5320.74
95_Q115_I0.5310.74
368_I449_E0.5310.74
109_Y134_T0.5310.74
292_E327_R0.5300.74
116_D353_K0.5300.74
144_D150_L0.5300.74
70_L73_A0.5300.74
110_R124_D0.5290.74
433_L437_G0.5290.74
98_S395_R0.5290.74
367_H371_N0.5290.74
130_G180_V0.5280.74
197_L399_F0.5280.74
84_L133_L0.5270.74
110_R242_A0.5260.74
111_I125_V0.5260.74
318_T347_A0.5260.74
107_N258_A0.5260.74
150_L270_G0.5260.74
217_L303_I0.5250.73
323_E418_V0.5240.73
257_I260_L0.5240.73
52_T58_Q0.5240.73
254_E291_G0.5240.73
291_G309_G0.5240.73
86_T140_L0.5240.73
407_V414_A0.5230.73
195_N238_K0.5230.73
434_F438_C0.5230.73
29_V36_E0.5230.73
99_D273_F0.5220.73
21_S25_V0.5220.73
354_L361_Q0.5220.73
68_Q71_P0.5220.73
215_Q455_L0.5210.73
409_R419_E0.5210.73
361_Q377_L0.5200.73
18_L25_V0.5200.73
269_A272_T0.5200.73
360_R363_G0.5200.73
34_S40_A0.5190.73
357_H448_F0.5190.73
292_E315_T0.5180.73
101_H114_R0.5180.73
145_I149_R0.5170.72
159_E162_G0.5170.72
97_A113_L0.5160.72
303_I307_Q0.5160.72
240_N244_I0.5150.72
434_F451_L0.5150.72
360_R382_A0.5150.72
98_S181_V0.5130.72
68_Q76_E0.5120.72
101_H168_R0.5120.72
254_E327_R0.5120.72
418_V421_L0.5120.72
168_R254_E0.5120.72
139_V145_I0.5110.71
29_V44_A0.5100.71
317_H327_R0.5100.71
129_A133_L0.5090.71
155_Q249_V0.5090.71
359_R378_P0.5080.71
57_Q60_E0.5080.71
22_E48_R0.5070.71
91_S94_E0.5070.71
72_V86_T0.5060.71
87_R91_S0.5060.71
173_P319_N0.5050.71
10_C13_Y0.5050.71
323_E326_V0.5050.71
24_V48_R0.5050.71
170_A179_K0.5050.71
139_V245_N0.5040.70
10_C330_Q0.5040.70
222_G309_G0.5030.70
99_D291_G0.5030.70
207_F218_V0.5020.70
200_Q431_R0.5010.70
381_Q407_V0.5010.70
422_E432_T0.5010.70
152_Q178_E0.5010.70
34_S38_L0.5000.70
274_Q279_A0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4phtA 1 0.9349 100 0.259 Contact Map
4ksrA 3 0.7896 100 0.335 Contact Map
1p9rA 1 0.8156 100 0.358 Contact Map
2ewvA 3 0.7072 100 0.52 Contact Map
3jvvA 3 0.6985 100 0.531 Contact Map
2oap1 3 0.9371 100 0.564 Contact Map
4ihqA 3 0.9436 100 0.606 Contact Map
2eyuA 1 0.4924 100 0.658 Contact Map
4bloA 4 0.5618 100 0.716 Contact Map
2gzaA 3 0.6247 100 0.722 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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