GREMLIN Database
SMTA - Protein SmtA
UniProt: P36566 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12167
Length: 261 (203)
Sequences: 11484 (8168)
Seq/√Len: 573.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_R68_Q3.4781.00
136_W200_W3.4121.00
76_A99_H2.9801.00
53_G71_L2.8011.00
72_C100_C2.6771.00
52_G121_V2.6451.00
68_Q96_Q2.5491.00
129_R197_E2.4851.00
76_A80_D2.4491.00
116_I139_L2.3601.00
127_D130_S2.3321.00
134_T137_S2.2711.00
70_I113_V2.2631.00
116_I135_L2.2321.00
135_L145_L2.2021.00
82_A97_F2.1961.00
48_V62_M2.1861.00
49_L113_V2.1781.00
60_I86_A2.1031.00
114_D140_R2.0981.00
81_R84_Q2.0801.00
139_L145_L2.0771.00
129_R133_Q2.0691.00
187_D190_Q2.0351.00
107_S113_V2.0301.00
64_E89_K2.0141.00
128_P194_W2.0071.00
79_I99_H1.9381.00
51_A135_L1.9281.00
53_G59_A1.9241.00
59_A69_V1.9211.00
125_V131_V1.8361.00
139_L143_G1.8221.00
79_I97_F1.8201.00
129_R194_W1.7831.00
7_D75_S1.7651.00
43_P46_L1.7281.00
70_I98_I1.7151.00
192_Y196_E1.7101.00
47_R70_I1.7081.00
101_A104_D1.6421.00
139_L200_W1.6191.00
7_D77_Q1.6141.00
134_T138_V1.5431.00
110_E137_S1.5261.00
59_A71_L1.4871.00
47_R113_V1.4751.00
74_L101_A1.4611.00
80_D83_K1.4581.00
130_S133_Q1.4561.00
86_A97_F1.4271.00
100_C106_A1.3871.00
73_D79_I1.3641.00
70_I96_Q1.3501.00
193_L197_E1.3411.00
192_Y205_K1.3401.00
109_L112_P1.3391.00
118_F121_V1.3211.00
48_V115_L1.3191.00
49_L116_I1.3191.00
60_I85_A1.3051.00
71_L97_F1.2991.00
47_R140_R1.2791.00
52_G118_F1.2681.00
166_D169_Q1.2601.00
84_Q88_A1.2411.00
51_A102_A1.2261.00
59_A95_M1.2221.00
188_P207_G1.2211.00
71_L82_A1.2161.00
46_L67_H1.2161.00
46_L115_L1.2131.00
33_D37_V1.2081.00
26_R29_I1.1771.00
14_S55_E1.1641.00
77_Q80_D1.1561.00
60_I89_K1.1491.00
63_A94_N1.1431.00
47_R112_P1.1391.00
102_A121_V1.1301.00
61_K65_R1.1221.00
45_K67_H1.1181.00
121_V125_V1.1171.00
32_Q36_R1.1121.00
105_V134_T1.1021.00
61_K64_E1.0881.00
193_L196_E1.0851.00
105_V138_V1.0811.00
33_D206_T1.0791.00
86_A95_M1.0791.00
132_L195_L1.0751.00
129_R198_A1.0731.00
166_D170_A1.0641.00
80_D84_Q1.0611.00
75_S78_M1.0611.00
98_I107_S1.0511.00
83_K87_E1.0501.00
116_I138_V1.0501.00
72_C98_I1.0431.00
23_G26_R1.0391.00
133_Q198_A1.0351.00
161_V165_F1.0271.00
132_L198_A1.0051.00
171_G177_K1.0021.00
120_A123_E0.9991.00
135_L139_L0.9931.00
33_D36_R0.9911.00
22_K26_R0.9911.00
103_Q127_D0.9861.00
25_L28_A0.9771.00
23_G27_Q0.9771.00
47_R114_D0.9771.00
84_Q87_E0.9731.00
131_V135_L0.9631.00
53_G82_A0.9611.00
62_M117_L0.9541.00
79_I83_K0.9491.00
122_L125_V0.9411.00
35_D65_R0.9311.00
58_T119_H0.9261.00
49_L138_V0.9211.00
60_I64_E0.9161.00
53_G73_D0.9161.00
56_G97_F0.9071.00
179_T182_P0.9001.00
85_A88_A0.8971.00
20_T27_Q0.8661.00
167_Y170_A0.8641.00
57_Q61_K0.8631.00
122_L191_V0.8581.00
40_E43_P0.8571.00
51_A72_C0.8511.00
64_E91_V0.8491.00
106_A134_T0.8431.00
14_S85_A0.8411.00
48_V69_V0.8381.00
145_L195_L0.8351.00
190_Q193_L0.8341.00
161_V164_N0.8331.00
22_K25_L0.8301.00
45_K66_G0.8271.00
171_G174_K0.8261.00
46_L144_V0.8261.00
167_Y171_G0.8261.00
86_A91_V0.8181.00
119_H148_M0.8181.00
107_S137_S0.8121.00
70_I107_S0.8091.00
145_L200_W0.8091.00
110_E134_T0.8041.00
122_L131_V0.8021.00
173_P176_K0.8001.00
56_G82_A0.7991.00
122_L132_L0.7981.00
130_S134_T0.7941.00
120_A124_W0.7921.00
76_A83_K0.7911.00
118_F147_L0.7891.00
107_S110_E0.7871.00
103_Q125_V0.7801.00
19_G24_Q0.7771.00
58_T117_L0.7711.00
11_E81_R0.7681.00
27_Q31_W0.7681.00
176_K179_T0.7671.00
37_V206_T0.7621.00
7_D76_A0.7611.00
21_T25_L0.7541.00
123_E149_F0.7531.00
6_F124_W0.7511.00
50_D71_L0.7471.00
51_A116_I0.7471.00
136_W198_A0.7461.00
19_G23_G0.7411.00
102_A131_V0.7381.00
55_E85_A0.7361.00
133_Q137_S0.7361.00
31_W35_D0.7341.00
211_F214_Y0.7321.00
104_D130_S0.7281.00
132_L191_V0.7271.00
21_T24_Q0.7271.00
72_C105_V0.7131.00
120_A148_M0.7131.00
85_A89_K0.7071.00
73_D78_M0.7041.00
20_T25_L0.7031.00
9_I12_K0.7031.00
24_Q28_A0.7011.00
162_A165_F0.7011.00
118_F125_V0.6961.00
194_W198_A0.6951.00
105_V113_V0.6941.00
25_L29_I0.6931.00
48_V117_L0.6891.00
132_L147_L0.6881.00
79_I82_A0.6861.00
77_Q81_R0.6831.00
27_Q30_L0.6801.00
81_R85_A0.6761.00
211_F215_L0.6741.00
32_Q61_K0.6741.00
19_G22_K0.6711.00
160_M163_G0.6711.00
28_A31_W0.6661.00
46_L114_D0.6651.00
24_Q27_Q0.6631.00
122_L149_F0.6621.00
152_A187_D0.6621.00
18_Y21_T0.6581.00
33_D208_V0.6561.00
34_L146_S0.6491.00
63_A91_V0.6471.00
60_I91_V0.6461.00
86_A89_K0.6441.00
102_A125_V0.6431.00
107_S138_V0.6421.00
57_Q85_A0.6391.00
20_T24_Q0.6361.00
133_Q197_E0.6351.00
87_E90_G0.6311.00
115_L143_G0.6271.00
170_A174_K0.6271.00
111_T140_R0.6251.00
83_K96_Q0.6251.00
83_K97_F0.6231.00
122_L147_L0.6221.00
53_G72_C0.6161.00
157_M161_V0.6161.00
115_L144_V0.6091.00
103_Q130_S0.6041.00
188_P205_K0.5911.00
207_G210_V0.5911.00
49_L107_S0.5891.00
60_I97_F0.5891.00
119_H123_E0.5891.00
124_W150_Y0.5871.00
22_K27_Q0.5871.00
196_E202_I0.5831.00
111_T141_P0.5831.00
175_K179_T0.5821.00
50_D69_V0.5811.00
135_L147_L0.5781.00
167_Y174_K0.5781.00
18_Y22_K0.5771.00
37_V204_G0.5761.00
107_S134_T0.5731.00
6_F123_E0.5680.99
168_V173_P0.5680.99
91_V95_M0.5650.99
52_G125_V0.5640.99
196_E203_M0.5640.99
35_D61_K0.5580.99
74_L99_H0.5580.99
38_L115_L0.5580.99
151_N207_G0.5580.99
71_L95_M0.5560.99
152_A190_Q0.5550.99
55_E78_M0.5540.99
195_L200_W0.5530.99
104_D134_T0.5530.99
112_P137_S0.5530.99
189_A193_L0.5520.99
36_R65_R0.5510.99
86_A90_G0.5500.99
175_K178_R0.5490.99
59_A97_F0.5480.99
62_M115_L0.5470.99
195_L198_A0.5460.99
26_R30_L0.5460.99
113_V138_V0.5420.99
158_H162_A0.5420.99
48_V66_G0.5410.99
39_A43_P0.5390.99
158_H161_V0.5320.99
8_D11_E0.5290.99
123_E150_Y0.5290.99
20_T23_G0.5280.99
107_S112_P0.5260.99
103_Q126_A0.5240.99
118_F135_L0.5230.99
48_V67_H0.5220.99
132_L194_W0.5220.99
34_L38_L0.5210.99
160_M165_F0.5200.99
172_M175_K0.5170.99
106_A137_S0.5160.99
189_A205_K0.5150.99
168_V171_G0.5140.99
58_T61_K0.5140.99
120_A150_Y0.5120.99
137_S140_R0.5120.99
35_D40_E0.5110.99
212_H216_R0.5100.99
106_A109_L0.5090.99
189_A192_Y0.5080.99
190_Q197_E0.5070.99
47_R111_T0.5060.99
21_T27_Q0.5040.99
192_Y202_I0.5030.99
169_Q173_P0.5030.99
5_N9_I0.5030.99
50_D124_W0.5000.99
110_E138_V0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4htfA 2 0.9617 100 0.338 Contact Map
2o57A 2 0.931 100 0.426 Contact Map
4pneA 2 0.908 100 0.427 Contact Map
4kdcA 1 0.8314 100 0.432 Contact Map
2yqzA 1 0.9425 100 0.436 Contact Map
4obxA 2 0.8084 100 0.441 Contact Map
3ccfA 1 0.8659 100 0.447 Contact Map
3busA 1 0.8582 100 0.453 Contact Map
3bkxA 2 0.9464 100 0.453 Contact Map
1vl5A 1 0.8238 100 0.454 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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