GREMLIN Database
COBT - Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
UniProt: P36562 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12151
Length: 359 (338)
Sequences: 2304 (1644)
Seq/√Len: 89.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
115_V246_G3.5211.00
202_I208_T3.4061.00
75_E137_N3.3951.00
132_A148_Q2.8931.00
187_I235_V2.7391.00
73_W179_A2.6441.00
138_I221_A2.5791.00
190_T222_I2.5541.00
136_G141_A2.5191.00
93_T126_L2.3561.00
82_K118_D2.3401.00
197_E219_R2.3071.00
188_V300_A2.3011.00
19_M48_G2.2831.00
141_A225_N2.2661.00
288_P306_L2.2451.00
132_A242_F2.2371.00
99_V323_A2.2341.00
42_L287_I2.2031.00
206_L210_K2.1911.00
291_L311_N2.1471.00
282_I286_L2.1291.00
288_P301_L2.1081.00
277_Q303_H2.0581.00
74_E140_S2.0361.00
129_M158_C2.0001.00
262_L329_I1.9861.00
152_L245_V1.9701.00
31_K40_E1.9651.00
46_L333_C1.9411.00
22_A47_A1.9361.00
189_S222_I1.9181.00
145_S148_Q1.9091.00
173_V247_I1.9051.00
202_I211_L1.8981.00
104_E338_N1.8051.00
61_K330_E1.7841.00
63_V172_G1.7821.00
64_L113_I1.7791.00
234_D238_K1.7471.00
165_K257_C1.7291.00
28_G343_A1.7281.00
63_V323_A1.7211.00
216_D220_R1.7121.00
135_S144_M1.7071.00
23_Q27_D1.7041.00
139_A220_R1.6811.00
92_M176_L1.6801.00
196_P219_R1.6751.00
234_D237_A1.6631.00
120_A130_R1.6611.00
115_V155_D1.6481.00
189_S196_P1.6461.00
210_K213_N1.6311.00
15_D51_G1.6201.00
195_D219_R1.6011.00
161_Q257_C1.5941.00
161_Q253_G1.5891.00
30_L91_N1.5751.00
66_M250_V1.5561.00
38_K41_V1.5521.00
72_V138_I1.5521.00
247_I271_A1.5471.00
253_G257_C1.5391.00
89_A117_I1.5311.00
207_P210_K1.5261.00
172_G322_A1.5151.00
164_A259_L1.5141.00
118_D133_R1.5141.00
213_N217_V1.5061.00
202_I295_K1.5041.00
224_L238_K1.4921.00
225_N238_K1.4871.00
132_A136_G1.4861.00
309_Y328_I1.4791.00
269_Y300_A1.4660.99
75_E139_A1.4570.99
109_N168_V1.4510.99
208_T211_L1.4440.99
25_H344_A1.4320.99
34_G315_R1.4300.99
219_R223_T1.4280.99
72_V182_T1.4130.99
87_I347_I1.4060.99
60_K169_T1.4040.99
272_A286_L1.4030.99
185_A199_V1.4000.99
154_L158_C1.3980.99
38_K307_E1.3900.99
42_L329_I1.3860.99
98_G339_M1.3840.99
19_M23_Q1.3810.99
114_D130_R1.3780.99
73_W82_K1.3690.99
270_A300_A1.3560.99
276_C283_K1.3550.99
44_I48_G1.3500.99
263_L288_P1.3490.99
192_T303_H1.3470.99
120_A133_R1.3460.99
138_I183_P1.3270.99
106_A331_A1.3160.99
12_P258_G1.3150.99
130_R133_R1.3130.99
200_V218_V1.3130.99
334_A338_N1.3120.99
63_V99_V1.2980.99
276_C281_A1.2910.99
45_Q287_I1.2900.99
188_V270_A1.2900.99
194_R198_E1.2880.99
136_G148_Q1.2880.99
269_Y297_A1.2880.99
91_N96_T1.2870.99
154_L157_I1.2870.99
245_V274_A1.2760.99
291_L298_R1.2720.99
150_E154_L1.2720.99
141_A224_L1.2710.99
216_D219_R1.2670.98
66_M246_G1.2660.98
64_L163_L1.2650.98
211_L215_I1.2610.98
23_Q44_I1.2550.98
146_R234_D1.2520.98
26_I43_A1.2430.98
97_T100_C1.2380.98
324_L331_A1.2350.98
49_M285_Y1.2340.98
191_I274_A1.2280.98
251_M263_L1.2270.98
172_G323_A1.2240.98
108_A326_M1.2140.98
64_L250_V1.2120.98
197_E215_I1.2100.98
60_K109_N1.2100.98
188_V199_V1.1990.98
49_M260_P1.1980.98
123_I126_L1.1940.98
86_A119_T1.1840.98
314_M324_L1.1790.98
172_G326_M1.1790.98
162_E166_N1.1750.98
66_M247_I1.1680.97
42_L309_Y1.1670.97
68_A183_P1.1640.97
293_A313_E1.1580.97
87_I90_E1.1570.97
159_Y253_G1.1560.97
138_I186_A1.1550.97
153_L248_A1.1500.97
63_V108_A1.1490.97
160_T250_V1.1470.97
276_C286_L1.1460.97
102_L335_I1.1370.97
63_V103_A1.1340.97
262_L287_I1.1320.97
281_A284_P1.1310.97
173_V251_M1.1300.97
146_R237_A1.1280.97
185_A266_F1.1280.97
171_F254_A1.1230.97
18_A51_G1.1210.97
215_I219_R1.1200.97
187_I274_A1.1150.97
170_L329_I1.1140.97
149_A237_A1.1100.97
196_P218_V1.1070.96
105_Q334_A1.1000.96
26_I335_I1.0980.96
142_P225_N1.0970.96
67_C89_A1.0880.96
160_T171_F1.0800.96
262_L289_S1.0790.96
75_E220_R1.0750.96
206_L211_L1.0730.96
146_R231_D1.0720.96
157_I253_G1.0690.96
20_S24_R1.0680.96
72_V139_A1.0580.95
75_E140_S1.0580.95
131_V148_Q1.0570.95
244_L267_L1.0490.95
298_R302_S1.0480.95
182_T218_V1.0480.95
18_A54_G1.0410.95
266_F296_G1.0260.95
253_G256_S1.0190.94
307_E313_E1.0180.94
74_E137_N1.0180.94
111_H162_E1.0180.94
27_D33_V1.0070.94
232_G274_A1.0040.94
19_M44_I1.0010.94
33_V80_S1.0000.94
194_R299_I0.9990.94
231_D234_D0.9860.93
161_Q165_K0.9860.93
149_A245_V0.9860.93
77_V179_A0.9840.93
287_I329_I0.9800.93
170_L326_M0.9790.93
146_R150_E0.9720.93
251_M286_L0.9720.93
227_P238_K0.9690.93
151_K155_D0.9570.92
88_Q97_T0.9540.92
18_A48_G0.9520.92
61_K326_M0.9510.92
192_T273_L0.9410.92
55_I337_N0.9360.91
164_A257_C0.9350.91
113_I159_Y0.9350.91
155_D246_G0.9340.91
62_A168_V0.9300.91
74_E82_K0.9250.91
196_P215_I0.9250.91
159_Y162_E0.9190.91
150_E233_V0.9180.91
139_A217_V0.9140.90
70_H183_P0.9090.90
87_I348_V0.9060.90
80_S204_A0.9020.90
62_A111_H0.9020.90
273_L277_Q0.9010.90
86_A90_E0.8990.90
189_S199_V0.8970.90
127_I162_E0.8860.89
30_L96_T0.8840.89
88_Q204_A0.8830.89
144_M242_F0.8790.89
38_K313_E0.8790.89
142_P238_K0.8720.88
15_D18_A0.8690.88
57_H169_T0.8670.88
254_A261_V0.8660.88
170_L262_L0.8660.88
87_I345_S0.8650.88
148_Q151_K0.8640.88
330_E334_A0.8620.88
14_I284_P0.8600.88
103_A110_V0.8590.87
341_E344_A0.8560.87
251_M261_V0.8510.87
283_K286_L0.8510.87
188_V192_T0.8480.87
59_G169_T0.8470.87
14_I19_M0.8450.87
22_A26_I0.8430.86
191_I235_V0.8420.86
293_A315_R0.8400.86
24_R27_D0.8390.86
18_A47_A0.8380.86
79_I206_L0.8360.86
115_V131_V0.8300.86
173_V268_S0.8300.86
62_A163_L0.8290.86
187_I270_A0.8270.85
178_M204_A0.8270.85
23_Q41_V0.8260.85
157_I256_S0.8260.85
100_C320_S0.8260.85
309_Y325_A0.8230.85
16_S19_M0.8220.85
129_M155_D0.8180.85
229_P232_G0.8150.85
289_S328_I0.8140.85
131_V151_K0.8130.84
30_L342_L0.8110.84
25_H29_L0.8110.84
52_L55_I0.8050.84
106_A327_P0.8040.84
186_A218_V0.8020.84
21_R24_R0.8000.83
11_I255_A0.8000.83
131_V242_F0.7980.83
83_E87_I0.7980.83
232_G277_Q0.7970.83
138_I218_V0.7970.83
138_I225_N0.7970.83
220_R223_T0.7910.83
35_S40_E0.7900.83
172_G262_L0.7880.83
29_L341_E0.7860.82
26_I44_I0.7850.82
228_N238_K0.7820.82
111_H163_L0.7810.82
131_V152_L0.7790.82
186_A239_V0.7790.82
198_E299_I0.7750.82
138_I239_V0.7740.81
70_H243_D0.7720.81
45_Q49_M0.7710.81
183_P243_D0.7700.81
89_A112_V0.7690.81
64_L159_Y0.7620.80
58_V170_L0.7600.80
242_F245_V0.7580.80
101_V105_Q0.7570.80
19_M45_Q0.7480.79
289_S325_A0.7450.79
122_P128_N0.7450.79
287_I309_Y0.7410.79
14_I48_G0.7410.79
61_K169_T0.7410.79
182_T196_P0.7400.78
160_T164_A0.7400.78
196_P200_V0.7370.78
90_E119_T0.7360.78
171_F250_V0.7360.78
272_A282_I0.7350.78
172_G289_S0.7330.78
195_D198_E0.7260.77
164_A253_G0.7250.77
146_R233_V0.7240.77
149_A274_A0.7230.77
46_L260_P0.7210.77
220_R224_L0.7210.77
147_R150_E0.7210.77
149_A233_V0.7180.76
188_V266_F0.7180.76
310_L325_A0.7180.76
61_K108_A0.7170.76
46_L50_P0.7160.76
212_A215_I0.7150.76
181_T214_K0.7140.76
80_S88_Q0.7140.76
248_A274_A0.7130.76
111_H159_Y0.7120.76
184_A270_A0.7110.76
41_V307_E0.7080.75
115_V159_Y0.7060.75
255_A285_Y0.7050.75
100_C110_V0.7010.75
148_Q242_F0.7000.74
201_G294_E0.7000.74
217_V220_R0.7000.74
26_I336_Y0.6970.74
25_H336_Y0.6970.74
344_A348_V0.6930.74
83_E86_A0.6900.73
111_H127_I0.6820.73
185_A200_V0.6800.72
279_S282_I0.6790.72
245_V248_A0.6770.72
251_M272_A0.6740.72
75_E217_V0.6740.72
30_L345_S0.6740.72
31_K339_M0.6720.71
194_R199_V0.6700.71
41_V45_Q0.6680.71
153_L233_V0.6650.71
22_A48_G0.6610.70
258_G285_Y0.6600.70
68_A242_F0.6600.70
183_P244_L0.6600.70
233_V237_A0.6600.70
233_V278_M0.6600.70
105_Q330_E0.6590.70
213_N216_D0.6590.70
147_R151_K0.6580.70
102_L320_S0.6570.70
190_T235_V0.6510.69
260_P287_I0.6490.69
38_K45_Q0.6480.69
161_Q256_S0.6460.68
263_L269_Y0.6440.68
24_R343_A0.6370.67
74_E118_D0.6370.67
137_N140_S0.6370.67
72_V218_V0.6370.67
244_L271_A0.6360.67
90_E123_I0.6350.67
65_V323_A0.6330.67
105_Q331_A0.6320.67
292_S314_M0.6300.67
103_A108_A0.6290.66
64_L173_V0.6280.66
173_V250_V0.6270.66
96_T100_C0.6250.66
16_S20_S0.6250.66
247_I268_S0.6240.66
170_L260_P0.6230.66
297_A301_L0.6230.66
14_I18_A0.6220.66
247_I251_M0.6210.65
212_A216_D0.6200.65
99_V320_S0.6200.65
149_A236_L0.6200.65
68_A135_S0.6190.65
18_A21_R0.6190.65
187_I238_K0.6170.65
202_I207_P0.6160.65
232_G270_A0.6160.65
135_S243_D0.6150.65
135_S183_P0.6150.65
60_K168_V0.6140.65
236_L274_A0.6120.64
101_V335_I0.6120.64
263_L306_L0.6090.64
158_C162_E0.6090.64
88_Q176_L0.6040.63
87_I96_T0.6020.63
299_I302_S0.6020.63
163_L168_V0.6010.63
227_P234_D0.6000.63
58_V333_C0.5990.63
191_I277_Q0.5950.62
34_G40_E0.5940.62
30_L340_G0.5930.62
207_P213_N0.5920.62
108_A323_A0.5890.61
13_A281_A0.5850.61
276_C304_L0.5840.61
88_Q100_C0.5840.61
209_D216_D0.5830.61
24_R28_G0.5830.61
251_M268_S0.5830.61
231_D235_V0.5810.60
88_Q178_M0.5810.60
246_G250_V0.5780.60
102_L106_A0.5760.60
146_R149_A0.5750.60
92_M99_V0.5710.59
115_V152_L0.5690.59
201_G214_K0.5690.59
135_S242_F0.5670.58
192_T300_A0.5660.58
142_P224_L0.5650.58
119_T133_R0.5650.58
342_L345_S0.5640.58
129_M162_E0.5600.58
290_H316_L0.5600.58
340_G344_A0.5600.58
75_E213_N0.5590.57
114_D128_N0.5570.57
21_R54_G0.5570.57
108_A172_G0.5560.57
89_A176_L0.5510.56
271_A289_S0.5500.56
30_L88_Q0.5480.56
88_Q92_M0.5480.56
283_K306_L0.5480.56
43_A333_C0.5470.56
68_A117_I0.5470.56
261_V286_L0.5470.56
63_V110_V0.5460.56
59_G330_E0.5450.56
51_G54_G0.5440.55
160_T253_G0.5420.55
91_N339_M0.5410.55
90_E94_R0.5410.55
72_V186_A0.5400.55
22_A336_Y0.5390.55
92_M112_V0.5380.55
283_K288_P0.5360.54
41_V44_I0.5360.54
274_A278_M0.5340.54
115_V242_F0.5320.54
205_N210_K0.5310.54
38_K311_N0.5300.53
186_A221_A0.5290.53
72_V221_A0.5290.53
178_M316_L0.5280.53
22_A44_I0.5270.53
125_G128_N0.5270.53
255_A275_A0.5260.53
93_T123_I0.5250.53
159_Y163_L0.5250.53
232_G278_M0.5240.53
139_A225_N0.5240.53
275_A282_I0.5230.53
140_S220_R0.5230.53
79_I204_A0.5230.53
25_H341_E0.5220.52
95_G104_E0.5220.52
11_I252_L0.5210.52
68_A241_G0.5210.52
32_P35_S0.5200.52
91_N176_L0.5190.52
163_L166_N0.5170.52
84_V347_I0.5170.52
102_L331_A0.5170.52
69_D114_D0.5150.51
208_T215_I0.5150.51
190_T218_V0.5120.51
157_I161_Q0.5100.51
69_D117_I0.5100.51
87_I204_A0.5090.51
78_A206_L0.5080.50
101_V339_M0.5070.50
136_G145_S0.5070.50
52_L169_T0.5070.50
80_S179_A0.5060.50
180_N318_E0.5060.50
67_C296_G0.5050.50
187_I191_I0.5040.50
13_A284_P0.5040.50
66_M115_V0.5040.50
68_A142_P0.5030.50
101_V104_E0.5030.50
190_T229_P0.5030.50
190_T239_V0.5030.50
45_Q306_L0.5010.50
28_G342_L0.5000.49
229_P235_V0.5000.49
342_L347_I0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kqiA 2 0.9443 100 0.071 Contact Map
4hdrA 1 0.9276 100 0.089 Contact Map
1wx1A 2 0.9164 100 0.098 Contact Map
4hdrB 1 0.9136 100 0.137 Contact Map
3l0zA 2 0.8691 100 0.463 Contact Map
3u4gA 2 0.7577 100 0.525 Contact Map
1g8fA 5 0.7159 35.9 0.973 Contact Map
4tx1A 5 0.5097 26.3 0.974 Contact Map
4fwgA 3 0.2869 22.5 0.975 Contact Map
4nicA 2 0.3259 10 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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