COBS - ECOLI - GREMLIN Contacts

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COBS - Adenosylcobinamide-GDP ribazoletransferase

UniProt:	P36561	Sequences: MSKLFWAMLSFITRLPVPRRWSQGLDFEHYSRGIITFPLIGLLLGAISGLVFMVLQAWCGAPLAALFSVLVLVLMTGGFHLDGLADTCDGVFSARSRDRMLEIMRDSRLGTHGGLALIFVVLAKILVLSELALRGESILASLAAACAVSRGTAALLMYRHRYAREEGLGNVFIGKIDGRQTCVTLGLAAIFAAVLLPGMHGVAAMVVTMVAIFILGQLLKRTLGGQTGDTLGAAIELGELVFLLALL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12150
Length:	247 (237)
Sequences:	2797 (2272)
Seq/√Len:	147.6

ECOLI - COBS
HALSA - COBS
SULSO - COBS

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
99_R	102_E	5.115	1.00
100_M	222_T	3.955	1.00
88_C	116_A	3.563	1.00
78_G	115_L	3.296	1.00
219_L	230_T	3.243	1.00
153_A	235_I	3.016	1.00
93_S	103_I	2.979	1.00
84_L	120_V	2.967	1.00
51_V	71_V	2.961	1.00
9_L	43_L	2.936	1.00
48_S	72_L	2.873	1.00
145_A	242_F	2.856	1.00
69_V	125_I	2.813	1.00
211_A	241_V	2.693	1.00
6_W	18_P	2.690	1.00
85_A	117_L	2.519	1.00
12_I	37_F	2.404	1.00
149_S	235_I	2.356	1.00
73_V	119_F	2.338	1.00
120_V	240_L	2.304	1.00
109_L	114_G	2.238	1.00
66_L	122_L	2.158	1.00
5_F	9_L	2.134	1.00
70_L	119_F	2.067	1.00
207_V	245_A	2.057	1.00
91_V	223_L	2.056	1.00
85_A	113_G	2.029	1.00
62_P	125_I	2.010	1.00
95_R	99_R	2.008	1.00
66_L	123_A	1.994	1.00
87_T	230_T	1.987	1.00
60_G	130_E	1.985	1.00
101_L	227_T	1.843	1.00
124_K	236_E	1.834	1.00
44_L	75_M	1.778	1.00
156_L	234_A	1.778	1.00
10_S	17_V	1.717	1.00
90_G	104_M	1.687	1.00
215_L	219_L	1.679	1.00
122_L	125_I	1.637	1.00
13_T	44_L	1.615	1.00
52_F	68_S	1.595	1.00
85_A	109_L	1.528	1.00
151_G	185_L	1.514	1.00
101_L	164_R	1.512	1.00
51_V	55_L	1.480	1.00
6_W	17_V	1.476	1.00
52_F	138_I	1.475	1.00
84_L	116_A	1.473	1.00
160_H	216_G	1.470	1.00
15_L	47_I	1.467	1.00
118_I	121_V	1.462	1.00
164_R	227_T	1.457	1.00
163_A	227_T	1.434	1.00
64_A	68_S	1.430	1.00
81_L	236_E	1.388	1.00
62_P	126_L	1.375	1.00
157_M	231_L	1.371	1.00
160_H	220_K	1.368	1.00
216_G	220_K	1.352	1.00
48_S	68_S	1.348	1.00
154_A	184_T	1.347	1.00
118_I	122_L	1.342	1.00
124_K	239_E	1.336	1.00
111_T	115_L	1.333	1.00
226_Q	231_L	1.319	1.00
204_A	242_F	1.314	1.00
97_R	101_L	1.307	1.00
11_F	79_F	1.301	1.00
47_I	71_V	1.292	1.00
63_L	127_V	1.278	1.00
170_N	174_G	1.273	1.00
91_V	100_M	1.267	1.00
127_V	244_L	1.264	1.00
87_T	91_V	1.261	1.00
109_L	117_L	1.250	1.00
49_G	139_L	1.228	1.00
84_L	88_C	1.216	1.00
161_R	220_K	1.211	1.00
109_L	113_G	1.210	1.00
123_A	240_L	1.210	1.00
198_G	201_G	1.202	1.00
66_L	125_I	1.197	1.00
177_D	180_Q	1.176	1.00
62_P	129_S	1.167	1.00
52_F	132_A	1.167	1.00
145_A	243_L	1.167	1.00
215_L	234_A	1.155	1.00
120_V	236_E	1.154	1.00
12_I	40_I	1.153	1.00
4_L	32_R	1.150	1.00
9_L	40_I	1.146	1.00
97_R	100_M	1.146	1.00
105_R	164_R	1.140	1.00
66_L	126_L	1.137	0.99
217_Q	221_R	1.135	0.99
146_C	239_E	1.131	0.99
194_V	197_P	1.129	0.99
65_A	129_S	1.125	0.99
96_S	99_R	1.124	0.99
73_V	81_L	1.101	0.99
115_L	121_V	1.101	0.99
100_M	223_L	1.098	0.99
164_R	167_G	1.095	0.99
85_A	111_T	1.095	0.99
63_L	126_L	1.094	0.99
84_L	237_L	1.092	0.99
5_F	36_T	1.090	0.99
67_F	123_A	1.082	0.99
44_L	48_S	1.080	0.99
146_C	236_E	1.074	0.99
81_L	117_L	1.072	0.99
208_T	238_G	1.070	0.99
26_D	29_H	1.065	0.99
152_T	212_I	1.064	0.99
7_A	10_S	1.057	0.99
101_L	104_M	1.041	0.99
92_F	112_H	1.030	0.99
214_I	218_L	1.029	0.99
55_L	58_W	1.029	0.99
15_L	43_L	1.001	0.99
12_I	153_A	1.000	0.99
93_S	100_M	1.000	0.99
120_V	124_K	0.981	0.99
208_T	242_F	0.977	0.98
152_T	238_G	0.975	0.98
55_L	59_C	0.971	0.98
55_L	68_S	0.970	0.98
211_A	237_L	0.967	0.98
73_V	115_L	0.966	0.98
108_R	111_T	0.965	0.98
72_L	146_C	0.959	0.98
53_M	57_A	0.936	0.98
217_Q	220_K	0.920	0.98
234_A	238_G	0.908	0.98
98_D	102_E	0.908	0.98
93_S	96_S	0.903	0.97
143_A	147_A	0.902	0.97
87_T	219_L	0.898	0.97
231_L	234_A	0.896	0.97
60_G	63_L	0.892	0.97
37_F	172_F	0.885	0.97
124_K	240_L	0.884	0.97
160_H	231_L	0.879	0.97
155_L	185_L	0.874	0.97
47_I	75_M	0.874	0.97
156_L	216_G	0.865	0.97
93_S	112_H	0.861	0.97
150_R	235_I	0.855	0.96
73_V	121_V	0.851	0.96
44_L	146_C	0.845	0.96
69_V	128_L	0.841	0.96
91_V	230_T	0.838	0.96
90_G	94_A	0.836	0.96
54_V	58_W	0.823	0.96
104_M	227_T	0.822	0.96
211_A	215_L	0.821	0.96
44_L	76_T	0.817	0.95
13_T	146_C	0.814	0.95
95_R	100_M	0.813	0.95
48_S	146_C	0.804	0.95
49_G	53_M	0.796	0.95
218_L	222_T	0.795	0.95
65_A	69_V	0.790	0.94
148_V	242_F	0.782	0.94
148_V	188_A	0.781	0.94
184_T	188_A	0.779	0.94
157_M	173_I	0.773	0.94
17_V	20_R	0.769	0.94
49_G	143_A	0.767	0.94
33_G	37_F	0.765	0.93
72_L	239_E	0.762	0.93
71_V	75_M	0.759	0.93
7_A	29_H	0.758	0.93
111_T	114_G	0.758	0.93
78_G	112_H	0.754	0.93
61_A	65_A	0.753	0.93
212_I	216_G	0.752	0.93
149_S	239_E	0.751	0.93
46_A	50_L	0.751	0.93
188_A	192_A	0.751	0.93
45_G	49_G	0.750	0.93
6_W	9_L	0.747	0.93
34_I	157_M	0.744	0.93
73_V	78_G	0.744	0.93
59_C	63_L	0.742	0.92
188_A	191_F	0.736	0.92
56_Q	64_A	0.735	0.92
238_G	242_F	0.731	0.92
113_G	116_A	0.730	0.92
8_M	37_F	0.730	0.92
59_C	244_L	0.726	0.92
90_G	233_A	0.720	0.91
50_L	53_M	0.716	0.91
226_Q	230_T	0.716	0.91
151_G	159_R	0.714	0.91
14_R	94_A	0.711	0.91
114_G	118_I	0.711	0.91
42_L	147_A	0.711	0.91
145_A	149_S	0.710	0.91
101_L	163_A	0.707	0.91
11_F	30_Y	0.706	0.90
155_L	212_I	0.705	0.90
90_G	107_S	0.701	0.90
151_G	181_T	0.700	0.90
81_L	93_S	0.699	0.90
160_H	226_Q	0.697	0.90
65_A	125_I	0.695	0.90
97_R	224_G	0.694	0.90
127_V	240_L	0.693	0.90
14_R	74_L	0.690	0.89
105_R	166_E	0.687	0.89
151_G	188_A	0.682	0.89
48_S	52_F	0.682	0.89
96_S	102_E	0.681	0.89
91_V	219_L	0.681	0.89
235_I	238_G	0.679	0.89
218_L	221_R	0.678	0.89
162_Y	169_G	0.678	0.89
86_D	228_G	0.676	0.88
45_G	146_C	0.674	0.88
14_R	77_G	0.672	0.88
4_L	29_H	0.672	0.88
183_V	193_A	0.671	0.88
100_M	112_H	0.669	0.88
13_T	17_V	0.669	0.88
11_F	168_L	0.666	0.88
41_G	45_G	0.664	0.88
50_L	54_V	0.663	0.87
85_A	114_G	0.663	0.87
123_A	244_L	0.662	0.87
62_P	69_V	0.661	0.87
114_G	117_L	0.658	0.87
12_I	33_G	0.658	0.87
8_M	12_I	0.653	0.87
7_A	25_L	0.651	0.87
55_L	64_A	0.643	0.86
165_E	170_N	0.643	0.86
11_F	77_G	0.642	0.86
156_L	226_Q	0.640	0.86
5_F	39_L	0.635	0.85
49_G	142_L	0.631	0.85
95_R	103_I	0.628	0.85
149_S	152_T	0.627	0.84
6_W	10_S	0.623	0.84
204_A	245_A	0.623	0.84
8_M	40_I	0.621	0.84
123_A	126_L	0.621	0.84
162_Y	166_E	0.618	0.84
161_R	173_I	0.615	0.83
51_V	67_F	0.613	0.83
177_D	186_G	0.611	0.83
210_V	214_I	0.609	0.83
36_T	39_L	0.608	0.83
125_I	129_S	0.608	0.83
103_I	112_H	0.608	0.83
6_W	20_R	0.607	0.82
85_A	231_L	0.606	0.82
113_G	238_G	0.604	0.82
143_A	146_C	0.602	0.82
44_L	150_R	0.602	0.82
81_L	124_K	0.602	0.82
215_L	237_L	0.600	0.82
165_E	227_T	0.599	0.82
142_L	146_C	0.597	0.81
43_L	147_A	0.596	0.81
164_R	226_Q	0.596	0.81
8_M	150_R	0.595	0.81
156_L	231_L	0.595	0.81
59_C	64_A	0.592	0.81
72_L	124_K	0.592	0.81
184_T	187_L	0.590	0.81
149_S	238_G	0.590	0.81
212_I	234_A	0.589	0.81
182_C	209_M	0.587	0.80
204_A	208_T	0.584	0.80
8_M	33_G	0.584	0.80
181_T	184_T	0.581	0.80
42_L	143_A	0.579	0.79
7_A	33_G	0.577	0.79
151_G	155_L	0.576	0.79
35_I	180_Q	0.576	0.79
8_M	36_T	0.574	0.79
106_D	111_T	0.574	0.79
112_H	116_A	0.573	0.79
107_S	111_T	0.572	0.79
68_S	142_L	0.570	0.78
157_M	169_G	0.570	0.78
15_L	32_R	0.569	0.78
147_A	188_A	0.568	0.78
228_G	232_G	0.567	0.78
199_M	202_V	0.566	0.78
67_F	127_V	0.564	0.78
111_T	117_L	0.564	0.78
6_W	13_T	0.562	0.77
94_A	99_R	0.559	0.77
99_R	103_I	0.559	0.77
231_L	235_I	0.556	0.77
94_A	112_H	0.555	0.77
148_V	208_T	0.553	0.76
77_G	106_D	0.553	0.76
31_S	175_K	0.552	0.76
79_F	95_R	0.550	0.76
152_T	234_A	0.549	0.76
62_P	130_E	0.549	0.76
127_V	243_L	0.549	0.76
87_T	92_F	0.548	0.76
102_E	106_D	0.548	0.76
77_G	157_M	0.548	0.76
85_A	100_M	0.547	0.76
42_L	191_F	0.545	0.75
140_A	143_A	0.542	0.75
88_C	233_A	0.541	0.75
96_S	100_M	0.541	0.75
44_L	71_V	0.540	0.75
141_S	145_A	0.538	0.74
40_I	43_L	0.538	0.74
163_A	225_G	0.537	0.74
94_A	223_L	0.537	0.74
101_L	161_R	0.535	0.74
44_L	72_L	0.534	0.74
153_A	231_L	0.534	0.74
62_P	65_A	0.533	0.74
120_V	237_L	0.532	0.74
183_V	199_M	0.531	0.73
37_F	153_A	0.531	0.73
30_Y	37_F	0.530	0.73
153_A	234_A	0.529	0.73
72_L	231_L	0.527	0.73
213_F	217_Q	0.526	0.73
34_I	226_Q	0.522	0.72
100_M	219_L	0.521	0.72
90_G	222_T	0.520	0.72
87_T	227_T	0.520	0.72
123_A	127_V	0.520	0.72
51_V	131_L	0.519	0.72
207_V	241_V	0.517	0.71
32_R	180_Q	0.517	0.71
10_S	19_R	0.516	0.71
66_L	119_F	0.516	0.71
53_M	56_Q	0.515	0.71
202_V	206_V	0.515	0.71
45_G	147_A	0.513	0.71
179_R	213_F	0.512	0.71
192_A	195_L	0.511	0.71
69_V	72_L	0.508	0.70
144_A	242_F	0.508	0.70
7_A	30_Y	0.508	0.70
16_P	77_G	0.507	0.70
162_Y	168_L	0.506	0.70
172_F	226_Q	0.506	0.70
93_S	108_R	0.505	0.70
36_T	43_L	0.503	0.69
190_I	206_V	0.503	0.69
155_L	209_M	0.501	0.69
68_S	72_L	0.500	0.69

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4qncA	2	0.3198	3.9	0.966	Contact Map
4o6mA	2	0.7854	3	0.968	Contact Map
3j45G	1	0.2429	2.3	0.97	Contact Map
4huqS	1	0.6032	1.5	0.973	Contact Map
2jttC	1	0.1134	1.5	0.973	Contact Map
4v3iA	2	0.0445	1.4	0.973	Contact Map
2cfqA	1	0.9393	1.3	0.974	Contact Map
3llqA	3	0.2348	1.1	0.975	Contact Map
4rngA	2	0.2915	1.1	0.975	Contact Map
3rr6A	1	0.2348	1	0.975	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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