GREMLIN Database
COBS - Adenosylcobinamide-GDP ribazoletransferase
UniProt: P36561 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12150
Length: 247 (237)
Sequences: 2797 (2272)
Seq/√Len: 147.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
99_R102_E5.1151.00
100_M222_T3.9551.00
88_C116_A3.5631.00
78_G115_L3.2961.00
219_L230_T3.2431.00
153_A235_I3.0161.00
93_S103_I2.9791.00
84_L120_V2.9671.00
51_V71_V2.9611.00
9_L43_L2.9361.00
48_S72_L2.8731.00
145_A242_F2.8561.00
69_V125_I2.8131.00
211_A241_V2.6931.00
6_W18_P2.6901.00
85_A117_L2.5191.00
12_I37_F2.4041.00
149_S235_I2.3561.00
73_V119_F2.3381.00
120_V240_L2.3041.00
109_L114_G2.2381.00
66_L122_L2.1581.00
5_F9_L2.1341.00
70_L119_F2.0671.00
207_V245_A2.0571.00
91_V223_L2.0561.00
85_A113_G2.0291.00
62_P125_I2.0101.00
95_R99_R2.0081.00
66_L123_A1.9941.00
87_T230_T1.9871.00
60_G130_E1.9851.00
101_L227_T1.8431.00
124_K236_E1.8341.00
44_L75_M1.7781.00
156_L234_A1.7781.00
10_S17_V1.7171.00
90_G104_M1.6871.00
215_L219_L1.6791.00
122_L125_I1.6371.00
13_T44_L1.6151.00
52_F68_S1.5951.00
85_A109_L1.5281.00
151_G185_L1.5141.00
101_L164_R1.5121.00
51_V55_L1.4801.00
6_W17_V1.4761.00
52_F138_I1.4751.00
84_L116_A1.4731.00
160_H216_G1.4701.00
15_L47_I1.4671.00
118_I121_V1.4621.00
164_R227_T1.4571.00
163_A227_T1.4341.00
64_A68_S1.4301.00
81_L236_E1.3881.00
62_P126_L1.3751.00
157_M231_L1.3711.00
160_H220_K1.3681.00
216_G220_K1.3521.00
48_S68_S1.3481.00
154_A184_T1.3471.00
118_I122_L1.3421.00
124_K239_E1.3361.00
111_T115_L1.3331.00
226_Q231_L1.3191.00
204_A242_F1.3141.00
97_R101_L1.3071.00
11_F79_F1.3011.00
47_I71_V1.2921.00
63_L127_V1.2781.00
170_N174_G1.2731.00
91_V100_M1.2671.00
127_V244_L1.2641.00
87_T91_V1.2611.00
109_L117_L1.2501.00
49_G139_L1.2281.00
84_L88_C1.2161.00
161_R220_K1.2111.00
109_L113_G1.2101.00
123_A240_L1.2101.00
198_G201_G1.2021.00
66_L125_I1.1971.00
177_D180_Q1.1761.00
62_P129_S1.1671.00
52_F132_A1.1671.00
145_A243_L1.1671.00
215_L234_A1.1551.00
120_V236_E1.1541.00
12_I40_I1.1531.00
4_L32_R1.1501.00
9_L40_I1.1461.00
97_R100_M1.1461.00
105_R164_R1.1401.00
66_L126_L1.1370.99
217_Q221_R1.1350.99
146_C239_E1.1310.99
194_V197_P1.1290.99
65_A129_S1.1250.99
96_S99_R1.1240.99
73_V81_L1.1010.99
115_L121_V1.1010.99
100_M223_L1.0980.99
164_R167_G1.0950.99
85_A111_T1.0950.99
63_L126_L1.0940.99
84_L237_L1.0920.99
5_F36_T1.0900.99
67_F123_A1.0820.99
44_L48_S1.0800.99
146_C236_E1.0740.99
81_L117_L1.0720.99
208_T238_G1.0700.99
26_D29_H1.0650.99
152_T212_I1.0640.99
7_A10_S1.0570.99
101_L104_M1.0410.99
92_F112_H1.0300.99
214_I218_L1.0290.99
55_L58_W1.0290.99
15_L43_L1.0010.99
12_I153_A1.0000.99
93_S100_M1.0000.99
120_V124_K0.9810.99
208_T242_F0.9770.98
152_T238_G0.9750.98
55_L59_C0.9710.98
55_L68_S0.9700.98
211_A237_L0.9670.98
73_V115_L0.9660.98
108_R111_T0.9650.98
72_L146_C0.9590.98
53_M57_A0.9360.98
217_Q220_K0.9200.98
234_A238_G0.9080.98
98_D102_E0.9080.98
93_S96_S0.9030.97
143_A147_A0.9020.97
87_T219_L0.8980.97
231_L234_A0.8960.97
60_G63_L0.8920.97
37_F172_F0.8850.97
124_K240_L0.8840.97
160_H231_L0.8790.97
155_L185_L0.8740.97
47_I75_M0.8740.97
156_L216_G0.8650.97
93_S112_H0.8610.97
150_R235_I0.8550.96
73_V121_V0.8510.96
44_L146_C0.8450.96
69_V128_L0.8410.96
91_V230_T0.8380.96
90_G94_A0.8360.96
54_V58_W0.8230.96
104_M227_T0.8220.96
211_A215_L0.8210.96
44_L76_T0.8170.95
13_T146_C0.8140.95
95_R100_M0.8130.95
48_S146_C0.8040.95
49_G53_M0.7960.95
218_L222_T0.7950.95
65_A69_V0.7900.94
148_V242_F0.7820.94
148_V188_A0.7810.94
184_T188_A0.7790.94
157_M173_I0.7730.94
17_V20_R0.7690.94
49_G143_A0.7670.94
33_G37_F0.7650.93
72_L239_E0.7620.93
71_V75_M0.7590.93
7_A29_H0.7580.93
111_T114_G0.7580.93
78_G112_H0.7540.93
61_A65_A0.7530.93
212_I216_G0.7520.93
149_S239_E0.7510.93
46_A50_L0.7510.93
188_A192_A0.7510.93
45_G49_G0.7500.93
6_W9_L0.7470.93
34_I157_M0.7440.93
73_V78_G0.7440.93
59_C63_L0.7420.92
188_A191_F0.7360.92
56_Q64_A0.7350.92
238_G242_F0.7310.92
113_G116_A0.7300.92
8_M37_F0.7300.92
59_C244_L0.7260.92
90_G233_A0.7200.91
50_L53_M0.7160.91
226_Q230_T0.7160.91
151_G159_R0.7140.91
14_R94_A0.7110.91
114_G118_I0.7110.91
42_L147_A0.7110.91
145_A149_S0.7100.91
101_L163_A0.7070.91
11_F30_Y0.7060.90
155_L212_I0.7050.90
90_G107_S0.7010.90
151_G181_T0.7000.90
81_L93_S0.6990.90
160_H226_Q0.6970.90
65_A125_I0.6950.90
97_R224_G0.6940.90
127_V240_L0.6930.90
14_R74_L0.6900.89
105_R166_E0.6870.89
151_G188_A0.6820.89
48_S52_F0.6820.89
96_S102_E0.6810.89
91_V219_L0.6810.89
235_I238_G0.6790.89
218_L221_R0.6780.89
162_Y169_G0.6780.89
86_D228_G0.6760.88
45_G146_C0.6740.88
14_R77_G0.6720.88
4_L29_H0.6720.88
183_V193_A0.6710.88
100_M112_H0.6690.88
13_T17_V0.6690.88
11_F168_L0.6660.88
41_G45_G0.6640.88
50_L54_V0.6630.87
85_A114_G0.6630.87
123_A244_L0.6620.87
62_P69_V0.6610.87
114_G117_L0.6580.87
12_I33_G0.6580.87
8_M12_I0.6530.87
7_A25_L0.6510.87
55_L64_A0.6430.86
165_E170_N0.6430.86
11_F77_G0.6420.86
156_L226_Q0.6400.86
5_F39_L0.6350.85
49_G142_L0.6310.85
95_R103_I0.6280.85
149_S152_T0.6270.84
6_W10_S0.6230.84
204_A245_A0.6230.84
8_M40_I0.6210.84
123_A126_L0.6210.84
162_Y166_E0.6180.84
161_R173_I0.6150.83
51_V67_F0.6130.83
177_D186_G0.6110.83
210_V214_I0.6090.83
36_T39_L0.6080.83
125_I129_S0.6080.83
103_I112_H0.6080.83
6_W20_R0.6070.82
85_A231_L0.6060.82
113_G238_G0.6040.82
143_A146_C0.6020.82
44_L150_R0.6020.82
81_L124_K0.6020.82
215_L237_L0.6000.82
165_E227_T0.5990.82
142_L146_C0.5970.81
43_L147_A0.5960.81
164_R226_Q0.5960.81
8_M150_R0.5950.81
156_L231_L0.5950.81
59_C64_A0.5920.81
72_L124_K0.5920.81
184_T187_L0.5900.81
149_S238_G0.5900.81
212_I234_A0.5890.81
182_C209_M0.5870.80
204_A208_T0.5840.80
8_M33_G0.5840.80
181_T184_T0.5810.80
42_L143_A0.5790.79
7_A33_G0.5770.79
151_G155_L0.5760.79
35_I180_Q0.5760.79
8_M36_T0.5740.79
106_D111_T0.5740.79
112_H116_A0.5730.79
107_S111_T0.5720.79
68_S142_L0.5700.78
157_M169_G0.5700.78
15_L32_R0.5690.78
147_A188_A0.5680.78
228_G232_G0.5670.78
199_M202_V0.5660.78
67_F127_V0.5640.78
111_T117_L0.5640.78
6_W13_T0.5620.77
94_A99_R0.5590.77
99_R103_I0.5590.77
231_L235_I0.5560.77
94_A112_H0.5550.77
148_V208_T0.5530.76
77_G106_D0.5530.76
31_S175_K0.5520.76
79_F95_R0.5500.76
152_T234_A0.5490.76
62_P130_E0.5490.76
127_V243_L0.5490.76
87_T92_F0.5480.76
102_E106_D0.5480.76
77_G157_M0.5480.76
85_A100_M0.5470.76
42_L191_F0.5450.75
140_A143_A0.5420.75
88_C233_A0.5410.75
96_S100_M0.5410.75
44_L71_V0.5400.75
141_S145_A0.5380.74
40_I43_L0.5380.74
163_A225_G0.5370.74
94_A223_L0.5370.74
101_L161_R0.5350.74
44_L72_L0.5340.74
153_A231_L0.5340.74
62_P65_A0.5330.74
120_V237_L0.5320.74
183_V199_M0.5310.73
37_F153_A0.5310.73
30_Y37_F0.5300.73
153_A234_A0.5290.73
72_L231_L0.5270.73
213_F217_Q0.5260.73
34_I226_Q0.5220.72
100_M219_L0.5210.72
90_G222_T0.5200.72
87_T227_T0.5200.72
123_A127_V0.5200.72
51_V131_L0.5190.72
207_V241_V0.5170.71
32_R180_Q0.5170.71
10_S19_R0.5160.71
66_L119_F0.5160.71
53_M56_Q0.5150.71
202_V206_V0.5150.71
45_G147_A0.5130.71
179_R213_F0.5120.71
192_A195_L0.5110.71
69_V72_L0.5080.70
144_A242_F0.5080.70
7_A30_Y0.5080.70
16_P77_G0.5070.70
162_Y168_L0.5060.70
172_F226_Q0.5060.70
93_S108_R0.5050.70
36_T43_L0.5030.69
190_I206_V0.5030.69
155_L209_M0.5010.69
68_S72_L0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qncA 2 0.3198 3.9 0.966 Contact Map
4o6mA 2 0.7854 3 0.968 Contact Map
3j45G 1 0.2429 2.3 0.97 Contact Map
4huqS 1 0.6032 1.5 0.973 Contact Map
2jttC 1 0.1134 1.5 0.973 Contact Map
4v3iA 2 0.0445 1.4 0.973 Contact Map
2cfqA 1 0.9393 1.3 0.974 Contact Map
3llqA 3 0.2348 1.1 0.975 Contact Map
4rngA 2 0.2915 1.1 0.975 Contact Map
3rr6A 1 0.2348 1 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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