MDTD - ECOLI - GREMLIN Contacts

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MDTD - Putative multidrug resistance protein MdtD

UniProt:	P36554	Sequences: MTDLPDSTRWQLWIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADKVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARALQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIGAIATLLLMPNYTMQTRRFDLSGFLLLAVGMAVLTLALDGSKGTGLSPLTIAGLVAVGVVALVLYLLHARNNNRALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRVLVATTLGLSLVTLLFMTTALLGWYYVLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMSIGVTIAGLLLGLFGSQHVSVDSGTTQTVFMYTWLSMALIIALPAFIFARVPNDTHQNVAISRRKRSAQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12136
Length:	471 (440)
Sequences:	49231 (37587)
Seq/√Len:	1791.9

ECOLI - MDTD EMRB HSRA EMRY YEBQ NANT EXUT UHPT YDJK XYLE YQCE ARAE RHMT GALP PROP YAAU MDTM MDTH YGCS ENTS YDJE YIHN YAJR GLPT UHPC YHJX ARAJ YDFJ MDTL YJJL BCR YDHC GUDP GARP MHPT YIHP AMPG MDFA YDIM YJHB UIDB MDTG YIHO TSGA SOTB SHIA XAPB YDIN YDHP YBJJ NUPG YGAY DGOT EMRD YHJE KGTP YICJ MELB NEPI SETA YNFM YEGT YDEE NARU YAGG LACY CYNX NARK FUCP SETC YHHS SETB FSR YCAD YEAN LPLT YJIJ YFCJ HCAT
BACSU - YUBD YHCA BMR3 LMRB YCNB YUSP YFIU MMR YVKA TCRB YWOD YFIS CSBC YVMA YNCC EXUT IOLT YWTG YFHI YCXA GUDP YXAM YBFB YFIG YITG YVQJ YTBD YQJV ARAE BMR2 IOLF YYBO YDGK YKUC YOAB YYAJ YWOG YWFA NASA YYBF YYCB GLPT CSBX NAIP GLCP GUTA YHJO YJBB YFKF YBCL YFNC YJMB YWBF NARK YNAJ YCEJ BMR1 YUXJ YQGE PBUE YFMI YDDS YFKL YDEG BBEX YTTB YFMO YXLH YDER YXIO
HALSA - O54630 Q9HPD6 Q9HN67 Q9HSM8 Q9HS33 Q9HRX5 Q9HMR5 Q9HSK3 Q9HMQ8 Q9HSE5
SULSO - Q97VC8 Q97YH0 Q97U91 Q97X47 Q97WR9 Q97Y15 Q97YY8 Q97VB9 Q97U43 Q97U99 Q97WR1 Q97VV2 Q97YL8 Q7LX71 Q97VU3 Q97V89 Q7LX65 Q97U80 Q97UY7 Q97UR4 Q97Y43 Q97WT1 Q97UD8 Q97Y11 Q97VT2 Q97U98 Q97WS7 Q97VB7 Q97U76 Q97X92 Q980K3 Q97ZC9 Q97XW7 Q97X63 Q97YG2 Q97Z36 Q97X02 Q97VQ5 Q97VD1 Q97Z07 Q97UJ4 Q97Z05 Q97WP8 Q97YI4 Q97UK1 Q97WJ7 Q97YW8 Q97U71

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
96_G	100_E	5.973	1.00
86_T	174_G	4.438	1.00
84_L	111_G	4.107	1.00
93_A	168_L	3.882	1.00
99_N	103_L	3.670	1.00
91_F	104_A	3.655	1.00
97_T	100_E	3.082	1.00
74_V	125_K	3.021	1.00
382_L	390_G	2.896	1.00
57_T	106_A	2.796	1.00
202_L	244_H	2.780	1.00
295_S	298_H	2.627	1.00
206_G	238_L	2.626	1.00
88_G	111_G	2.556	1.00
53_S	106_A	2.531	1.00
313_M	365_M	2.524	1.00
309_G	361_F	2.492	1.00
43_S	46_H	2.466	1.00
79_F	182_L	2.414	1.00
61_M	110_V	2.369	1.00
275_I	405_G	2.367	1.00
271_F	401_S	2.312	1.00
256_K	386_L	2.293	1.00
42_E	98_L	2.273	1.00
98_L	102_L	2.271	1.00
92_C	104_A	2.253	1.00
131_Q	134_A	2.215	1.00
205_V	237_A	2.207	1.00
88_G	104_A	2.207	1.00
161_A	165_W	2.192	1.00
95_S	100_E	2.191	1.00
88_G	107_L	2.134	1.00
343_L	359_V	2.121	1.00
179_I	183_L	2.111	1.00
213_A	231_V	2.100	1.00
79_F	178_A	2.062	1.00
16_A	142_P	2.056	1.00
437_L	441_L	2.055	1.00
100_E	104_A	2.037	1.00
383_P	386_L	2.028	1.00
210_L	234_G	2.025	1.00
65_S	114_M	2.017	1.00
133_M	322_N	1.973	1.00
198_S	244_H	1.966	1.00
127_V	135_A	1.953	1.00
81_A	114_M	1.945	1.00
157_L	165_W	1.940	1.00
70_D	388_S	1.911	1.00
239_V	243_L	1.890	1.00
46_H	98_L	1.863	1.00
50_V	101_L	1.860	1.00
340_V	363_Q	1.855	1.00
279_M	409_A	1.842	1.00
181_T	185_M	1.819	1.00
162_S	165_W	1.809	1.00
68_L	77_I	1.808	1.00
92_C	101_L	1.802	1.00
75_R	79_F	1.795	1.00
128_P	131_Q	1.788	1.00
53_S	102_L	1.784	1.00
354_Y	358_F	1.780	1.00
42_E	46_H	1.753	1.00
333_T	369_T	1.723	1.00
254_S	386_L	1.718	1.00
278_G	402_M	1.698	1.00
228_A	232_A	1.674	1.00
61_M	113_A	1.659	1.00
90_L	171_I	1.653	1.00
18_G	78_F	1.652	1.00
287_F	292_L	1.648	1.00
256_K	259_R	1.641	1.00
319_Q	323_R	1.628	1.00
165_W	172_P	1.628	1.00
83_V	178_A	1.625	1.00
289_Q	299_A	1.624	1.00
95_S	104_A	1.620	1.00
196_D	199_G	1.598	1.00
90_L	94_L	1.588	1.00
338_S	342_L	1.560	1.00
336_G	366_V	1.553	1.00
159_E	297_F	1.543	1.00
35_S	38_Q	1.540	1.00
340_V	366_V	1.514	1.00
209_V	230_L	1.514	1.00
79_F	181_T	1.502	1.00
355_V	359_V	1.502	1.00
69_A	74_V	1.501	1.00
69_A	118_V	1.498	1.00
37_A	47_M	1.495	1.00
32_A	158_V	1.493	1.00
348_A	351_G	1.483	1.00
67_W	71_K	1.480	1.00
12_L	127_V	1.472	1.00
264_S	268_A	1.468	1.00
318_V	322_N	1.462	1.00
86_T	178_A	1.457	1.00
32_A	166_I	1.456	1.00
68_L	72_V	1.446	1.00
217_S	222_L	1.443	1.00
298_H	301_L	1.436	1.00
338_S	444_A	1.431	1.00
91_F	94_L	1.424	1.00
80_T	84_L	1.412	1.00
20_F	146_G	1.405	1.00
342_L	440_A	1.398	1.00
345_M	437_L	1.396	1.00
294_F	302_M	1.389	1.00
99_N	102_L	1.379	1.00
229_G	233_V	1.377	1.00
248_N	251_A	1.377	1.00
206_G	234_G	1.375	1.00
267_L	397_I	1.375	1.00
197_L	201_L	1.367	1.00
66_G	70_D	1.367	1.00
353_Y	357_P	1.360	1.00
28_I	166_I	1.355	1.00
334_T	446_P	1.351	1.00
89_S	170_N	1.346	1.00
325_G	328_R	1.342	1.00
258_F	264_S	1.340	1.00
180_A	184_L	1.340	1.00
306_M	364_G	1.336	1.00
328_R	331_V	1.336	1.00
91_F	100_E	1.334	1.00
84_L	88_G	1.333	1.00
294_F	298_H	1.333	1.00
244_H	248_N	1.330	1.00
54_Y	112_G	1.321	1.00
76_N	187_N	1.320	1.00
209_V	237_A	1.312	1.00
335_L	447_A	1.309	1.00
25_D	28_I	1.302	1.00
246_R	256_K	1.297	1.00
129_R	132_Y	1.293	1.00
87_L	91_F	1.274	1.00
354_Y	357_P	1.259	1.00
416_F	420_H	1.255	1.00
309_G	313_M	1.249	1.00
86_T	171_I	1.243	1.00
57_T	109_G	1.231	1.00
225_L	229_G	1.227	1.00
14_I	184_L	1.220	1.00
335_L	339_L	1.219	1.00
159_E	295_S	1.216	1.00
352_W	355_V	1.214	1.00
14_I	177_G	1.210	1.00
194_R	197_L	1.207	1.00
49_M	53_S	1.207	1.00
266_G	378_T	1.206	1.00
195_F	199_G	1.204	1.00
60_V	204_A	1.202	1.00
75_R	182_L	1.200	1.00
216_G	220_T	1.197	1.00
242_L	246_R	1.193	1.00
434_Y	438_S	1.190	1.00
206_G	237_A	1.190	1.00
124_M	132_Y	1.189	1.00
17_F	177_G	1.188	1.00
338_S	447_A	1.187	1.00
317_V	369_T	1.185	1.00
444_A	448_F	1.183	1.00
103_L	107_L	1.182	1.00
209_V	233_V	1.177	1.00
74_V	187_N	1.176	1.00
79_F	83_V	1.175	1.00
156_L	160_Y	1.171	1.00
426_G	430_T	1.168	1.00
172_P	176_I	1.168	1.00
153_L	156_L	1.167	1.00
416_F	434_Y	1.166	1.00
195_F	200_F	1.147	1.00
263_F	267_L	1.145	1.00
23_S	143_G	1.140	1.00
213_A	234_G	1.139	1.00
276_G	443_I	1.134	1.00
92_C	167_F	1.133	1.00
342_L	346_T	1.125	1.00
76_N	80_T	1.122	1.00
57_T	61_M	1.114	1.00
96_G	164_H	1.105	1.00
73_G	76_N	1.104	1.00
319_Q	322_N	1.103	1.00
423_V	427_T	1.090	1.00
157_L	169_I	1.089	1.00
78_F	122_T	1.088	1.00
340_V	362_L	1.083	1.00
70_D	74_V	1.082	1.00
202_L	237_A	1.077	1.00
243_L	246_R	1.076	1.00
343_L	346_T	1.074	1.00
39_S	164_H	1.070	1.00
16_A	138_F	1.070	1.00
123_V	139_V	1.067	1.00
315_R	319_Q	1.066	1.00
53_S	57_T	1.065	1.00
316_I	319_Q	1.058	1.00
86_T	175_I	1.050	1.00
94_L	168_L	1.049	1.00
35_S	39_S	1.047	1.00
243_L	247_N	1.046	1.00
234_G	238_L	1.039	1.00
59_A	403_S	1.033	1.00
194_R	250_R	1.032	1.00
100_E	103_L	1.032	1.00
284_T	360_L	1.031	1.00
205_V	209_V	1.031	1.00
205_V	208_A	1.029	1.00
337_L	366_V	1.027	1.00
14_I	180_A	1.026	1.00
175_I	179_I	1.020	1.00
39_S	163_W	1.019	1.00
298_H	302_M	1.018	1.00
86_T	90_L	1.018	1.00
220_T	227_I	1.016	1.00
355_V	358_F	1.013	1.00
72_V	77_I	1.010	1.00
338_S	440_A	1.009	1.00
171_I	175_I	1.008	1.00
440_A	444_A	1.005	1.00
178_A	182_L	1.005	1.00
76_N	79_F	1.002	1.00
241_Y	245_A	1.001	1.00
333_T	370_R	1.001	1.00
242_L	255_L	1.001	1.00
96_G	99_N	1.000	1.00
50_V	98_L	0.999	1.00
401_S	405_G	0.999	1.00
273_G	370_R	0.997	1.00
416_F	419_Q	0.995	1.00
320_V	324_F	0.995	1.00
160_Y	297_F	0.987	1.00
261_R	265_L	0.982	1.00
267_L	393_L	0.980	1.00
15_V	119_G	0.979	1.00
216_G	219_G	0.976	1.00
340_V	359_V	0.976	1.00
434_Y	437_L	0.975	1.00
412_L	416_F	0.970	1.00
345_M	440_A	0.968	1.00
213_A	227_I	0.968	1.00
233_V	237_A	0.962	1.00
333_T	366_V	0.961	1.00
56_L	403_S	0.960	1.00
240_L	243_L	0.960	1.00
165_W	168_L	0.959	1.00
408_I	411_L	0.956	1.00
199_G	244_H	0.953	1.00
378_T	394_L	0.951	1.00
89_S	108_Q	0.949	1.00
288_L	302_M	0.949	1.00
326_Y	380_K	0.946	1.00
130_E	134_A	0.945	1.00
93_A	164_H	0.943	1.00
124_M	387_A	0.942	1.00
88_G	108_Q	0.942	1.00
313_M	316_I	0.941	1.00
156_L	297_F	0.940	1.00
342_L	345_M	0.939	1.00
238_L	242_L	0.934	1.00
270_S	394_L	0.934	1.00
220_T	226_T	0.927	1.00
222_L	227_I	0.927	1.00
437_L	440_A	0.923	1.00
25_D	170_N	0.922	1.00
405_G	408_I	0.921	1.00
332_A	336_G	0.919	1.00
70_D	389_S	0.912	1.00
33_L	47_M	0.909	1.00
260_T	386_L	0.906	1.00
202_L	240_L	0.900	1.00
220_T	224_P	0.896	1.00
313_M	368_S	0.894	1.00
337_L	443_I	0.894	1.00
424_D	428_T	0.893	1.00
134_A	322_N	0.890	1.00
82_I	178_A	0.889	1.00
288_L	292_L	0.889	1.00
420_H	427_T	0.887	1.00
260_T	383_P	0.885	1.00
331_V	335_L	0.884	1.00
32_A	36_M	0.883	1.00
168_L	172_P	0.877	1.00
195_F	198_S	0.875	1.00
36_M	101_L	0.875	1.00
81_A	111_G	0.873	1.00
260_T	264_S	0.872	1.00
244_H	247_N	0.871	1.00
223_S	228_A	0.868	1.00
261_R	264_S	0.866	1.00
179_I	182_L	0.864	1.00
235_V	239_V	0.863	1.00
308_L	312_G	0.862	1.00
231_V	235_V	0.860	1.00
302_M	305_P	0.859	1.00
125_K	387_A	0.859	1.00
271_F	397_I	0.857	1.00
80_T	83_V	0.852	1.00
193_R	197_L	0.852	1.00
417_G	420_H	0.850	1.00
331_V	447_A	0.848	1.00
82_I	177_G	0.847	1.00
134_A	319_Q	0.845	1.00
331_V	338_S	0.844	1.00
172_P	175_I	0.842	1.00
427_T	431_V	0.841	1.00
313_M	369_T	0.837	1.00
194_R	198_S	0.835	1.00
334_T	370_R	0.835	1.00
429_Q	433_M	0.835	1.00
77_I	80_T	0.831	1.00
88_G	91_F	0.828	1.00
347_T	351_G	0.822	1.00
201_L	205_V	0.822	1.00
418_S	422_S	0.821	1.00
216_G	221_G	0.820	1.00
126_I	186_P	0.820	1.00
51_I	282_F	0.818	1.00
18_G	82_I	0.818	1.00
85_F	111_G	0.817	1.00
283_M	410_G	0.816	1.00
170_N	174_G	0.811	1.00
320_V	329_V	0.810	1.00
272_A	446_P	0.809	1.00
289_Q	296_P	0.808	1.00
313_M	317_V	0.808	1.00
78_F	181_T	0.808	1.00
42_E	47_M	0.807	1.00
418_S	421_V	0.806	1.00
122_T	126_I	0.804	1.00
301_L	305_P	0.804	1.00
206_G	209_V	0.803	1.00
144_Q	310_S	0.802	1.00
103_L	106_A	0.802	1.00
96_G	104_A	0.801	1.00
75_R	187_N	0.801	1.00
26_T	55_V	0.800	1.00
340_V	343_L	0.800	1.00
29_V	50_V	0.796	1.00
334_T	447_A	0.794	1.00
132_Y	380_K	0.793	1.00
193_R	196_D	0.792	1.00
155_G	296_P	0.791	1.00
134_A	138_F	0.790	1.00
122_T	185_M	0.788	1.00
25_D	105_R	0.787	1.00
133_M	137_T	0.786	1.00
213_A	230_L	0.785	1.00
83_V	87_L	0.784	1.00
441_L	445_L	0.784	1.00
21_M	174_G	0.784	1.00
189_T	192_T	0.782	1.00
335_L	338_S	0.780	1.00
123_V	135_A	0.779	1.00
411_L	415_L	0.779	1.00
425_S	428_T	0.779	1.00
183_L	186_P	0.779	1.00
339_L	343_L	0.778	1.00
205_V	233_V	0.776	1.00
288_L	294_F	0.774	1.00
236_V	240_L	0.774	1.00
173_V	176_I	0.774	1.00
268_A	449_I	0.772	1.00
432_F	436_W	0.771	1.00
92_C	95_S	0.770	1.00
146_G	150_G	0.770	1.00
430_T	434_Y	0.768	1.00
433_M	437_L	0.768	1.00
423_V	426_G	0.767	1.00
57_T	110_V	0.766	1.00
357_P	361_F	0.765	1.00
226_T	230_L	0.762	1.00
312_G	315_R	0.762	1.00
358_F	362_L	0.761	1.00
157_L	166_I	0.761	1.00
337_L	340_V	0.760	1.00
438_S	441_L	0.760	1.00
302_M	353_Y	0.759	1.00
46_H	99_N	0.759	1.00
25_D	85_F	0.758	1.00
104_A	107_L	0.757	1.00
55_V	402_M	0.755	1.00
18_G	115_M	0.754	1.00
239_V	242_L	0.753	1.00
136_M	376_T	0.751	1.00
262_T	381_D	0.751	1.00
263_F	382_L	0.751	1.00
28_I	154_G	0.751	1.00
358_F	361_F	0.750	1.00
341_T	363_Q	0.745	1.00
251_A	254_S	0.744	1.00
74_V	121_L	0.744	1.00
346_T	359_V	0.744	1.00
54_Y	58_V	0.744	1.00
180_A	183_L	0.742	1.00
14_I	181_T	0.738	1.00
155_G	300_G	0.736	1.00
418_S	423_V	0.734	1.00
321_V	373_S	0.732	1.00
152_A	304_I	0.731	1.00
94_L	104_A	0.731	1.00
369_T	373_S	0.730	1.00
329_V	332_A	0.726	1.00
430_T	433_M	0.726	1.00
58_V	399_Q	0.725	1.00
24_L	150_G	0.725	1.00
376_T	380_K	0.724	1.00
232_A	236_V	0.720	1.00
269_G	449_I	0.719	1.00
420_H	423_V	0.719	1.00
54_Y	105_R	0.719	1.00
439_M	443_I	0.716	1.00
150_G	154_G	0.716	1.00
133_M	318_V	0.715	1.00
254_S	389_S	0.715	1.00
327_R	331_V	0.715	1.00
197_L	200_F	0.715	1.00
70_D	73_G	0.715	1.00
265_L	449_I	0.715	1.00
233_V	240_L	0.715	1.00
263_F	390_G	0.713	1.00
36_M	40_L	0.713	1.00
356_L	359_V	0.712	1.00
164_H	168_L	0.712	1.00
332_A	335_L	0.711	1.00
121_L	388_S	0.711	1.00
332_A	369_T	0.709	1.00
206_G	242_L	0.708	1.00
424_D	427_T	0.707	1.00
66_G	392_S	0.707	1.00
194_R	199_G	0.707	1.00
309_G	365_M	0.705	1.00
105_R	108_Q	0.700	1.00
22_Q	115_M	0.700	1.00
325_G	329_V	0.699	1.00
161_A	164_H	0.698	1.00
328_R	332_A	0.697	1.00
148_L	307_V	0.697	1.00
253_F	393_L	0.696	1.00
431_V	435_T	0.695	1.00
395_S	398_M	0.693	1.00
85_F	174_G	0.692	1.00
66_G	388_S	0.692	1.00
186_P	189_T	0.691	1.00
379_L	387_A	0.690	1.00
37_A	42_E	0.687	1.00
33_L	51_I	0.687	1.00
231_V	234_G	0.687	1.00
286_V	290_I	0.687	1.00
310_S	368_S	0.686	1.00
141_L	145_V	0.685	1.00
198_S	201_L	0.685	1.00
157_L	161_A	0.682	1.00
287_F	291_G	0.681	1.00
253_F	256_K	0.680	1.00
227_I	230_L	0.680	1.00
78_F	119_G	0.680	1.00
59_A	396_M	0.679	1.00
37_A	44_P	0.679	1.00
379_L	391_N	0.679	1.00
199_G	248_N	0.679	1.00
428_T	432_F	0.678	1.00
127_V	131_Q	0.677	1.00
92_C	108_Q	0.676	1.00
20_F	149_L	0.675	1.00
141_L	144_Q	0.675	1.00
353_Y	356_L	0.674	1.00
144_Q	314_K	0.674	1.00
341_T	345_M	0.672	1.00
217_S	220_T	0.672	1.00
20_F	142_P	0.670	1.00
19_F	143_G	0.670	1.00
324_F	329_V	0.670	1.00
417_G	421_V	0.668	1.00
187_N	190_M	0.667	1.00
345_M	433_M	0.667	1.00
436_W	440_A	0.666	1.00
90_L	168_L	0.664	1.00
65_S	81_A	0.662	1.00
352_W	356_L	0.661	1.00
24_L	170_N	0.660	1.00
306_M	363_Q	0.659	1.00
212_L	216_G	0.659	1.00
72_V	76_N	0.655	1.00
69_A	121_L	0.654	1.00
324_F	328_R	0.653	1.00
64_A	200_F	0.652	1.00
240_L	244_H	0.649	1.00
61_M	64_A	0.647	1.00
124_M	136_M	0.646	1.00
223_S	226_T	0.646	1.00
417_G	431_V	0.645	1.00
426_G	429_Q	0.644	1.00
224_P	227_I	0.644	1.00
165_W	169_I	0.641	1.00
226_T	229_G	0.640	1.00
204_A	208_A	0.639	1.00
352_W	357_P	0.633	1.00
410_G	414_G	0.632	1.00
267_L	394_L	0.632	1.00
125_K	188_Y	0.631	1.00
50_V	53_S	0.630	1.00
400_L	404_I	0.630	1.00
305_P	309_G	0.630	1.00
285_P	299_A	0.628	1.00
52_V	215_D	0.628	1.00
154_G	158_V	0.628	1.00
73_G	77_I	0.626	1.00
119_G	139_V	0.626	1.00
372_S	376_T	0.622	1.00
203_L	207_M	0.621	1.00
77_I	114_M	0.620	1.00
419_Q	423_V	0.618	1.00
237_A	240_L	0.618	1.00
137_T	141_L	0.617	1.00
36_M	47_M	0.613	1.00
218_K	221_G	0.612	1.00
339_L	342_L	0.610	1.00
142_P	146_G	0.609	1.00
61_M	65_S	0.609	1.00
338_S	443_I	0.608	1.00
52_V	403_S	0.606	1.00
411_L	414_G	0.604	1.00
32_A	167_F	0.603	1.00
433_M	436_W	0.602	1.00
262_T	266_G	0.600	1.00
75_R	186_P	0.600	1.00
317_V	368_S	0.599	1.00
206_G	210_L	0.597	1.00
168_L	171_I	0.595	1.00
262_T	265_L	0.594	1.00
431_V	434_Y	0.593	1.00
149_L	152_A	0.593	1.00
24_L	28_I	0.593	1.00
375_N	394_L	0.592	1.00
295_S	299_A	0.592	1.00
159_E	296_P	0.592	1.00
221_G	224_P	0.591	1.00
392_S	396_M	0.590	1.00
138_F	141_L	0.589	1.00
67_W	389_S	0.588	1.00
428_T	431_V	0.588	1.00
334_T	338_S	0.588	1.00
194_R	249_N	0.586	1.00
85_F	112_G	0.585	1.00
403_S	407_T	0.584	1.00
331_V	334_T	0.584	1.00
23_S	146_G	0.583	1.00
20_F	24_L	0.582	1.00
27_T	147_P	0.582	1.00
84_L	107_L	0.581	1.00
246_R	255_L	0.581	1.00
193_R	198_S	0.580	1.00
245_A	248_N	0.580	1.00
65_S	77_I	0.580	1.00
315_R	318_V	0.578	1.00
82_I	181_T	0.578	1.00
419_Q	422_S	0.577	1.00
235_V	238_L	0.577	1.00
200_F	204_A	0.577	1.00
229_G	232_A	0.575	1.00
198_S	202_L	0.575	1.00
34_P	38_Q	0.574	1.00
74_V	188_Y	0.573	1.00
212_L	230_L	0.573	1.00
62_L	395_S	0.573	1.00
420_H	424_D	0.573	1.00
259_R	264_S	0.573	1.00
36_M	39_S	0.571	1.00
282_F	406_V	0.570	1.00
304_I	308_L	0.570	1.00
48_H	52_V	0.569	1.00
187_N	191_Q	0.568	1.00
263_F	378_T	0.567	1.00
321_V	376_T	0.567	1.00
415_L	418_S	0.567	1.00
268_A	272_A	0.565	1.00
193_R	250_R	0.565	1.00
136_M	140_T	0.565	1.00
317_V	320_V	0.563	1.00
89_S	171_I	0.563	1.00
412_L	438_S	0.562	1.00
202_L	205_V	0.562	1.00
58_V	116_V	0.560	1.00
302_M	357_P	0.559	1.00
427_T	430_T	0.559	1.00
270_S	398_M	0.559	1.00
224_P	229_G	0.559	1.00
364_G	368_S	0.558	1.00
38_Q	41_G	0.558	1.00
438_S	442_I	0.556	1.00
158_V	166_I	0.554	1.00
176_I	180_A	0.553	1.00
252_L	255_L	0.552	1.00
413_L	435_T	0.550	1.00
225_L	228_A	0.549	1.00
147_P	307_V	0.549	1.00
143_G	147_P	0.549	1.00
134_A	137_T	0.547	1.00
297_F	301_L	0.546	1.00
435_T	438_S	0.545	1.00
442_I	446_P	0.545	1.00
441_L	448_F	0.545	1.00
93_A	171_I	0.544	1.00
316_I	320_V	0.544	1.00
13_W	17_F	0.543	1.00
436_W	439_M	0.543	1.00
63_P	67_W	0.542	1.00
202_L	206_G	0.541	1.00
30_N	51_I	0.539	1.00
60_V	208_A	0.538	1.00
118_V	121_L	0.536	1.00
59_A	400_L	0.535	1.00
46_H	50_V	0.535	1.00
257_L	260_T	0.533	1.00
260_T	381_D	0.532	1.00
288_L	357_P	0.532	1.00
10_W	13_W	0.531	1.00
65_S	117_P	0.530	1.00
120_R	136_M	0.529	1.00
40_L	98_L	0.527	1.00
35_S	158_V	0.527	1.00
330_L	374_M	0.526	1.00
58_V	112_G	0.526	1.00
88_G	95_S	0.526	1.00
87_L	90_L	0.526	1.00
37_A	43_S	0.525	1.00
277_S	367_N	0.525	1.00
47_M	50_V	0.524	1.00
361_F	365_M	0.522	1.00
274_R	398_M	0.522	1.00
236_V	239_V	0.522	1.00
224_P	228_A	0.521	1.00
321_V	325_G	0.521	1.00
16_A	20_F	0.521	1.00
209_V	234_G	0.520	1.00
399_Q	402_M	0.520	1.00
406_V	410_G	0.519	1.00
211_T	403_S	0.518	1.00
120_R	139_V	0.516	1.00
320_V	323_R	0.516	1.00
362_L	366_V	0.514	1.00
95_S	101_L	0.514	1.00
156_L	161_A	0.512	1.00
144_Q	147_P	0.510	1.00
83_V	86_T	0.510	1.00
18_G	177_G	0.510	1.00
69_A	388_S	0.509	1.00
207_M	400_L	0.509	1.00
106_A	110_V	0.507	1.00
59_A	399_Q	0.506	1.00
316_I	365_M	0.504	1.00
159_E	162_S	0.503	1.00
275_I	409_A	0.503	1.00
129_R	133_M	0.502	1.00
145_V	149_L	0.502	1.00
384_D	387_A	0.502	1.00
21_M	25_D	0.501	1.00
12_L	135_A	0.501	1.00
209_V	213_A	0.500	1.00
407_T	411_L	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1pw4A	1	0.8705	100	0.313	Contact Map
4j05A	3	0.8089	100	0.335	Contact Map
3wdoA	1	0.8535	100	0.354	Contact Map
4pypA	1	0.8769	100	0.355	Contact Map
2gfpA	2	0.7962	100	0.377	Contact Map
4ldsA	2	0.8705	100	0.381	Contact Map
3o7qA	1	0.8153	100	0.39	Contact Map
4zw9A	1	0.9151	100	0.391	Contact Map
4gc0A	1	0.9108	100	0.391	Contact Map
2cfqA	1	0.8556	100	0.393	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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