GREMLIN Database
MDTD - Putative multidrug resistance protein MdtD
UniProt: P36554 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12136
Length: 471 (440)
Sequences: 49231 (37587)
Seq/√Len: 1791.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
96_G100_E5.9731.00
86_T174_G4.4381.00
84_L111_G4.1071.00
93_A168_L3.8821.00
99_N103_L3.6701.00
91_F104_A3.6551.00
97_T100_E3.0821.00
74_V125_K3.0211.00
382_L390_G2.8961.00
57_T106_A2.7961.00
202_L244_H2.7801.00
295_S298_H2.6271.00
206_G238_L2.6261.00
88_G111_G2.5561.00
53_S106_A2.5311.00
313_M365_M2.5241.00
309_G361_F2.4921.00
43_S46_H2.4661.00
79_F182_L2.4141.00
61_M110_V2.3691.00
275_I405_G2.3671.00
271_F401_S2.3121.00
256_K386_L2.2931.00
42_E98_L2.2731.00
98_L102_L2.2711.00
92_C104_A2.2531.00
131_Q134_A2.2151.00
205_V237_A2.2071.00
88_G104_A2.2071.00
161_A165_W2.1921.00
95_S100_E2.1911.00
88_G107_L2.1341.00
343_L359_V2.1211.00
179_I183_L2.1111.00
213_A231_V2.1001.00
79_F178_A2.0621.00
16_A142_P2.0561.00
437_L441_L2.0551.00
100_E104_A2.0371.00
383_P386_L2.0281.00
210_L234_G2.0251.00
65_S114_M2.0171.00
133_M322_N1.9731.00
198_S244_H1.9661.00
127_V135_A1.9531.00
81_A114_M1.9451.00
157_L165_W1.9401.00
70_D388_S1.9111.00
239_V243_L1.8901.00
46_H98_L1.8631.00
50_V101_L1.8601.00
340_V363_Q1.8551.00
279_M409_A1.8421.00
181_T185_M1.8191.00
162_S165_W1.8091.00
68_L77_I1.8081.00
92_C101_L1.8021.00
75_R79_F1.7951.00
128_P131_Q1.7881.00
53_S102_L1.7841.00
354_Y358_F1.7801.00
42_E46_H1.7531.00
333_T369_T1.7231.00
254_S386_L1.7181.00
278_G402_M1.6981.00
228_A232_A1.6741.00
61_M113_A1.6591.00
90_L171_I1.6531.00
18_G78_F1.6521.00
287_F292_L1.6481.00
256_K259_R1.6411.00
319_Q323_R1.6281.00
165_W172_P1.6281.00
83_V178_A1.6251.00
289_Q299_A1.6241.00
95_S104_A1.6201.00
196_D199_G1.5981.00
90_L94_L1.5881.00
338_S342_L1.5601.00
336_G366_V1.5531.00
159_E297_F1.5431.00
35_S38_Q1.5401.00
340_V366_V1.5141.00
209_V230_L1.5141.00
79_F181_T1.5021.00
355_V359_V1.5021.00
69_A74_V1.5011.00
69_A118_V1.4981.00
37_A47_M1.4951.00
32_A158_V1.4931.00
348_A351_G1.4831.00
67_W71_K1.4801.00
12_L127_V1.4721.00
264_S268_A1.4681.00
318_V322_N1.4621.00
86_T178_A1.4571.00
32_A166_I1.4561.00
68_L72_V1.4461.00
217_S222_L1.4431.00
298_H301_L1.4361.00
338_S444_A1.4311.00
91_F94_L1.4241.00
80_T84_L1.4121.00
20_F146_G1.4051.00
342_L440_A1.3981.00
345_M437_L1.3961.00
294_F302_M1.3891.00
99_N102_L1.3791.00
229_G233_V1.3771.00
248_N251_A1.3771.00
206_G234_G1.3751.00
267_L397_I1.3751.00
197_L201_L1.3671.00
66_G70_D1.3671.00
353_Y357_P1.3601.00
28_I166_I1.3551.00
334_T446_P1.3511.00
89_S170_N1.3461.00
325_G328_R1.3421.00
258_F264_S1.3401.00
180_A184_L1.3401.00
306_M364_G1.3361.00
328_R331_V1.3361.00
91_F100_E1.3341.00
84_L88_G1.3331.00
294_F298_H1.3331.00
244_H248_N1.3301.00
54_Y112_G1.3211.00
76_N187_N1.3201.00
209_V237_A1.3121.00
335_L447_A1.3091.00
25_D28_I1.3021.00
246_R256_K1.2971.00
129_R132_Y1.2931.00
87_L91_F1.2741.00
354_Y357_P1.2591.00
416_F420_H1.2551.00
309_G313_M1.2491.00
86_T171_I1.2431.00
57_T109_G1.2311.00
225_L229_G1.2271.00
14_I184_L1.2201.00
335_L339_L1.2191.00
159_E295_S1.2161.00
352_W355_V1.2141.00
14_I177_G1.2101.00
194_R197_L1.2071.00
49_M53_S1.2071.00
266_G378_T1.2061.00
195_F199_G1.2041.00
60_V204_A1.2021.00
75_R182_L1.2001.00
216_G220_T1.1971.00
242_L246_R1.1931.00
434_Y438_S1.1901.00
206_G237_A1.1901.00
124_M132_Y1.1891.00
17_F177_G1.1881.00
338_S447_A1.1871.00
317_V369_T1.1851.00
444_A448_F1.1831.00
103_L107_L1.1821.00
209_V233_V1.1771.00
74_V187_N1.1761.00
79_F83_V1.1751.00
156_L160_Y1.1711.00
426_G430_T1.1681.00
172_P176_I1.1681.00
153_L156_L1.1671.00
416_F434_Y1.1661.00
195_F200_F1.1471.00
263_F267_L1.1451.00
23_S143_G1.1401.00
213_A234_G1.1391.00
276_G443_I1.1341.00
92_C167_F1.1331.00
342_L346_T1.1251.00
76_N80_T1.1221.00
57_T61_M1.1141.00
96_G164_H1.1051.00
73_G76_N1.1041.00
319_Q322_N1.1031.00
423_V427_T1.0901.00
157_L169_I1.0891.00
78_F122_T1.0881.00
340_V362_L1.0831.00
70_D74_V1.0821.00
202_L237_A1.0771.00
243_L246_R1.0761.00
343_L346_T1.0741.00
39_S164_H1.0701.00
16_A138_F1.0701.00
123_V139_V1.0671.00
315_R319_Q1.0661.00
53_S57_T1.0651.00
316_I319_Q1.0581.00
86_T175_I1.0501.00
94_L168_L1.0491.00
35_S39_S1.0471.00
243_L247_N1.0461.00
234_G238_L1.0391.00
59_A403_S1.0331.00
194_R250_R1.0321.00
100_E103_L1.0321.00
284_T360_L1.0311.00
205_V209_V1.0311.00
205_V208_A1.0291.00
337_L366_V1.0271.00
14_I180_A1.0261.00
175_I179_I1.0201.00
39_S163_W1.0191.00
298_H302_M1.0181.00
86_T90_L1.0181.00
220_T227_I1.0161.00
355_V358_F1.0131.00
72_V77_I1.0101.00
338_S440_A1.0091.00
171_I175_I1.0081.00
440_A444_A1.0051.00
178_A182_L1.0051.00
76_N79_F1.0021.00
241_Y245_A1.0011.00
333_T370_R1.0011.00
242_L255_L1.0011.00
96_G99_N1.0001.00
50_V98_L0.9991.00
401_S405_G0.9991.00
273_G370_R0.9971.00
416_F419_Q0.9951.00
320_V324_F0.9951.00
160_Y297_F0.9871.00
261_R265_L0.9821.00
267_L393_L0.9801.00
15_V119_G0.9791.00
216_G219_G0.9761.00
340_V359_V0.9761.00
434_Y437_L0.9751.00
412_L416_F0.9701.00
345_M440_A0.9681.00
213_A227_I0.9681.00
233_V237_A0.9621.00
333_T366_V0.9611.00
56_L403_S0.9601.00
240_L243_L0.9601.00
165_W168_L0.9591.00
408_I411_L0.9561.00
199_G244_H0.9531.00
378_T394_L0.9511.00
89_S108_Q0.9491.00
288_L302_M0.9491.00
326_Y380_K0.9461.00
130_E134_A0.9451.00
93_A164_H0.9431.00
124_M387_A0.9421.00
88_G108_Q0.9421.00
313_M316_I0.9411.00
156_L297_F0.9401.00
342_L345_M0.9391.00
238_L242_L0.9341.00
270_S394_L0.9341.00
220_T226_T0.9271.00
222_L227_I0.9271.00
437_L440_A0.9231.00
25_D170_N0.9221.00
405_G408_I0.9211.00
332_A336_G0.9191.00
70_D389_S0.9121.00
33_L47_M0.9091.00
260_T386_L0.9061.00
202_L240_L0.9001.00
220_T224_P0.8961.00
313_M368_S0.8941.00
337_L443_I0.8941.00
424_D428_T0.8931.00
134_A322_N0.8901.00
82_I178_A0.8891.00
288_L292_L0.8891.00
420_H427_T0.8871.00
260_T383_P0.8851.00
331_V335_L0.8841.00
32_A36_M0.8831.00
168_L172_P0.8771.00
195_F198_S0.8751.00
36_M101_L0.8751.00
81_A111_G0.8731.00
260_T264_S0.8721.00
244_H247_N0.8711.00
223_S228_A0.8681.00
261_R264_S0.8661.00
179_I182_L0.8641.00
235_V239_V0.8631.00
308_L312_G0.8621.00
231_V235_V0.8601.00
302_M305_P0.8591.00
125_K387_A0.8591.00
271_F397_I0.8571.00
80_T83_V0.8521.00
193_R197_L0.8521.00
417_G420_H0.8501.00
331_V447_A0.8481.00
82_I177_G0.8471.00
134_A319_Q0.8451.00
331_V338_S0.8441.00
172_P175_I0.8421.00
427_T431_V0.8411.00
313_M369_T0.8371.00
194_R198_S0.8351.00
334_T370_R0.8351.00
429_Q433_M0.8351.00
77_I80_T0.8311.00
88_G91_F0.8281.00
347_T351_G0.8221.00
201_L205_V0.8221.00
418_S422_S0.8211.00
216_G221_G0.8201.00
126_I186_P0.8201.00
51_I282_F0.8181.00
18_G82_I0.8181.00
85_F111_G0.8171.00
283_M410_G0.8161.00
170_N174_G0.8111.00
320_V329_V0.8101.00
272_A446_P0.8091.00
289_Q296_P0.8081.00
313_M317_V0.8081.00
78_F181_T0.8081.00
42_E47_M0.8071.00
418_S421_V0.8061.00
122_T126_I0.8041.00
301_L305_P0.8041.00
206_G209_V0.8031.00
144_Q310_S0.8021.00
103_L106_A0.8021.00
96_G104_A0.8011.00
75_R187_N0.8011.00
26_T55_V0.8001.00
340_V343_L0.8001.00
29_V50_V0.7961.00
334_T447_A0.7941.00
132_Y380_K0.7931.00
193_R196_D0.7921.00
155_G296_P0.7911.00
134_A138_F0.7901.00
122_T185_M0.7881.00
25_D105_R0.7871.00
133_M137_T0.7861.00
213_A230_L0.7851.00
83_V87_L0.7841.00
441_L445_L0.7841.00
21_M174_G0.7841.00
189_T192_T0.7821.00
335_L338_S0.7801.00
123_V135_A0.7791.00
411_L415_L0.7791.00
425_S428_T0.7791.00
183_L186_P0.7791.00
339_L343_L0.7781.00
205_V233_V0.7761.00
288_L294_F0.7741.00
236_V240_L0.7741.00
173_V176_I0.7741.00
268_A449_I0.7721.00
432_F436_W0.7711.00
92_C95_S0.7701.00
146_G150_G0.7701.00
430_T434_Y0.7681.00
433_M437_L0.7681.00
423_V426_G0.7671.00
57_T110_V0.7661.00
357_P361_F0.7651.00
226_T230_L0.7621.00
312_G315_R0.7621.00
358_F362_L0.7611.00
157_L166_I0.7611.00
337_L340_V0.7601.00
438_S441_L0.7601.00
302_M353_Y0.7591.00
46_H99_N0.7591.00
25_D85_F0.7581.00
104_A107_L0.7571.00
55_V402_M0.7551.00
18_G115_M0.7541.00
239_V242_L0.7531.00
136_M376_T0.7511.00
262_T381_D0.7511.00
263_F382_L0.7511.00
28_I154_G0.7511.00
358_F361_F0.7501.00
341_T363_Q0.7451.00
251_A254_S0.7441.00
74_V121_L0.7441.00
346_T359_V0.7441.00
54_Y58_V0.7441.00
180_A183_L0.7421.00
14_I181_T0.7381.00
155_G300_G0.7361.00
418_S423_V0.7341.00
321_V373_S0.7321.00
152_A304_I0.7311.00
94_L104_A0.7311.00
369_T373_S0.7301.00
329_V332_A0.7261.00
430_T433_M0.7261.00
58_V399_Q0.7251.00
24_L150_G0.7251.00
376_T380_K0.7241.00
232_A236_V0.7201.00
269_G449_I0.7191.00
420_H423_V0.7191.00
54_Y105_R0.7191.00
439_M443_I0.7161.00
150_G154_G0.7161.00
133_M318_V0.7151.00
254_S389_S0.7151.00
327_R331_V0.7151.00
197_L200_F0.7151.00
70_D73_G0.7151.00
265_L449_I0.7151.00
233_V240_L0.7151.00
263_F390_G0.7131.00
36_M40_L0.7131.00
356_L359_V0.7121.00
164_H168_L0.7121.00
332_A335_L0.7111.00
121_L388_S0.7111.00
332_A369_T0.7091.00
206_G242_L0.7081.00
424_D427_T0.7071.00
66_G392_S0.7071.00
194_R199_G0.7071.00
309_G365_M0.7051.00
105_R108_Q0.7001.00
22_Q115_M0.7001.00
325_G329_V0.6991.00
161_A164_H0.6981.00
328_R332_A0.6971.00
148_L307_V0.6971.00
253_F393_L0.6961.00
431_V435_T0.6951.00
395_S398_M0.6931.00
85_F174_G0.6921.00
66_G388_S0.6921.00
186_P189_T0.6911.00
379_L387_A0.6901.00
37_A42_E0.6871.00
33_L51_I0.6871.00
231_V234_G0.6871.00
286_V290_I0.6871.00
310_S368_S0.6861.00
141_L145_V0.6851.00
198_S201_L0.6851.00
157_L161_A0.6821.00
287_F291_G0.6811.00
253_F256_K0.6801.00
227_I230_L0.6801.00
78_F119_G0.6801.00
59_A396_M0.6791.00
37_A44_P0.6791.00
379_L391_N0.6791.00
199_G248_N0.6791.00
428_T432_F0.6781.00
127_V131_Q0.6771.00
92_C108_Q0.6761.00
20_F149_L0.6751.00
141_L144_Q0.6751.00
353_Y356_L0.6741.00
144_Q314_K0.6741.00
341_T345_M0.6721.00
217_S220_T0.6721.00
20_F142_P0.6701.00
19_F143_G0.6701.00
324_F329_V0.6701.00
417_G421_V0.6681.00
187_N190_M0.6671.00
345_M433_M0.6671.00
436_W440_A0.6661.00
90_L168_L0.6641.00
65_S81_A0.6621.00
352_W356_L0.6611.00
24_L170_N0.6601.00
306_M363_Q0.6591.00
212_L216_G0.6591.00
72_V76_N0.6551.00
69_A121_L0.6541.00
324_F328_R0.6531.00
64_A200_F0.6521.00
240_L244_H0.6491.00
61_M64_A0.6471.00
124_M136_M0.6461.00
223_S226_T0.6461.00
417_G431_V0.6451.00
426_G429_Q0.6441.00
224_P227_I0.6441.00
165_W169_I0.6411.00
226_T229_G0.6401.00
204_A208_A0.6391.00
352_W357_P0.6331.00
410_G414_G0.6321.00
267_L394_L0.6321.00
125_K188_Y0.6311.00
50_V53_S0.6301.00
400_L404_I0.6301.00
305_P309_G0.6301.00
285_P299_A0.6281.00
52_V215_D0.6281.00
154_G158_V0.6281.00
73_G77_I0.6261.00
119_G139_V0.6261.00
372_S376_T0.6221.00
203_L207_M0.6211.00
77_I114_M0.6201.00
419_Q423_V0.6181.00
237_A240_L0.6181.00
137_T141_L0.6171.00
36_M47_M0.6131.00
218_K221_G0.6121.00
339_L342_L0.6101.00
142_P146_G0.6091.00
61_M65_S0.6091.00
338_S443_I0.6081.00
52_V403_S0.6061.00
411_L414_G0.6041.00
32_A167_F0.6031.00
433_M436_W0.6021.00
262_T266_G0.6001.00
75_R186_P0.6001.00
317_V368_S0.5991.00
206_G210_L0.5971.00
168_L171_I0.5951.00
262_T265_L0.5941.00
431_V434_Y0.5931.00
149_L152_A0.5931.00
24_L28_I0.5931.00
375_N394_L0.5921.00
295_S299_A0.5921.00
159_E296_P0.5921.00
221_G224_P0.5911.00
392_S396_M0.5901.00
138_F141_L0.5891.00
67_W389_S0.5881.00
428_T431_V0.5881.00
334_T338_S0.5881.00
194_R249_N0.5861.00
85_F112_G0.5851.00
403_S407_T0.5841.00
331_V334_T0.5841.00
23_S146_G0.5831.00
20_F24_L0.5821.00
27_T147_P0.5821.00
84_L107_L0.5811.00
246_R255_L0.5811.00
193_R198_S0.5801.00
245_A248_N0.5801.00
65_S77_I0.5801.00
315_R318_V0.5781.00
82_I181_T0.5781.00
419_Q422_S0.5771.00
235_V238_L0.5771.00
200_F204_A0.5771.00
229_G232_A0.5751.00
198_S202_L0.5751.00
34_P38_Q0.5741.00
74_V188_Y0.5731.00
212_L230_L0.5731.00
62_L395_S0.5731.00
420_H424_D0.5731.00
259_R264_S0.5731.00
36_M39_S0.5711.00
282_F406_V0.5701.00
304_I308_L0.5701.00
48_H52_V0.5691.00
187_N191_Q0.5681.00
263_F378_T0.5671.00
321_V376_T0.5671.00
415_L418_S0.5671.00
268_A272_A0.5651.00
193_R250_R0.5651.00
136_M140_T0.5651.00
317_V320_V0.5631.00
89_S171_I0.5631.00
412_L438_S0.5621.00
202_L205_V0.5621.00
58_V116_V0.5601.00
302_M357_P0.5591.00
427_T430_T0.5591.00
270_S398_M0.5591.00
224_P229_G0.5591.00
364_G368_S0.5581.00
38_Q41_G0.5581.00
438_S442_I0.5561.00
158_V166_I0.5541.00
176_I180_A0.5531.00
252_L255_L0.5521.00
413_L435_T0.5501.00
225_L228_A0.5491.00
147_P307_V0.5491.00
143_G147_P0.5491.00
134_A137_T0.5471.00
297_F301_L0.5461.00
435_T438_S0.5451.00
442_I446_P0.5451.00
441_L448_F0.5451.00
93_A171_I0.5441.00
316_I320_V0.5441.00
13_W17_F0.5431.00
436_W439_M0.5431.00
63_P67_W0.5421.00
202_L206_G0.5411.00
30_N51_I0.5391.00
60_V208_A0.5381.00
118_V121_L0.5361.00
59_A400_L0.5351.00
46_H50_V0.5351.00
257_L260_T0.5331.00
260_T381_D0.5321.00
288_L357_P0.5321.00
10_W13_W0.5311.00
65_S117_P0.5301.00
120_R136_M0.5291.00
40_L98_L0.5271.00
35_S158_V0.5271.00
330_L374_M0.5261.00
58_V112_G0.5261.00
88_G95_S0.5261.00
87_L90_L0.5261.00
37_A43_S0.5251.00
277_S367_N0.5251.00
47_M50_V0.5241.00
361_F365_M0.5221.00
274_R398_M0.5221.00
236_V239_V0.5221.00
224_P228_A0.5211.00
321_V325_G0.5211.00
16_A20_F0.5211.00
209_V234_G0.5201.00
399_Q402_M0.5201.00
406_V410_G0.5191.00
211_T403_S0.5181.00
120_R139_V0.5161.00
320_V323_R0.5161.00
362_L366_V0.5141.00
95_S101_L0.5141.00
156_L161_A0.5121.00
144_Q147_P0.5101.00
83_V86_T0.5101.00
18_G177_G0.5101.00
69_A388_S0.5091.00
207_M400_L0.5091.00
106_A110_V0.5071.00
59_A399_Q0.5061.00
316_I365_M0.5041.00
159_E162_S0.5031.00
275_I409_A0.5031.00
129_R133_M0.5021.00
145_V149_L0.5021.00
384_D387_A0.5021.00
21_M25_D0.5011.00
12_L135_A0.5011.00
209_V213_A0.5001.00
407_T411_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pw4A 1 0.8705 100 0.313 Contact Map
4j05A 3 0.8089 100 0.335 Contact Map
3wdoA 1 0.8535 100 0.354 Contact Map
4pypA 1 0.8769 100 0.355 Contact Map
2gfpA 2 0.7962 100 0.377 Contact Map
4ldsA 2 0.8705 100 0.381 Contact Map
3o7qA 1 0.8153 100 0.39 Contact Map
4zw9A 1 0.9151 100 0.391 Contact Map
4gc0A 1 0.9108 100 0.391 Contact Map
2cfqA 1 0.8556 100 0.393 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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