GREMLIN Database
HEM6 - Oxygen-dependent coproporphyrinogen-III oxidase
UniProt: P36553 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12189
Length: 299 (288)
Sequences: 1692 (748)
Seq/√Len: 44.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
172_Y177_N4.1751.00
101_Y137_F3.8911.00
149_R153_L3.8371.00
141_A182_I3.6851.00
102_V217_V3.4681.00
187_F202_M3.2811.00
165_K169_E3.0191.00
203_Q207_K3.0121.00
24_T30_E2.9411.00
152_C201_F2.9021.00
155_F204_A2.8631.00
101_Y229_E2.7501.00
105_S209_Y2.5821.00
55_F217_V2.5731.00
49_L58_A2.5581.00
17_D45_R2.5501.00
226_G229_E2.5401.00
137_F220_R2.4951.00
14_N18_T2.4441.00
11_F207_K2.4291.00
55_F58_A2.3901.00
146_R150_D2.3101.00
151_L208_G2.3081.00
231_N273_R2.2401.00
229_E285_P2.2231.00
220_R223_M2.2171.00
285_P288_A2.1751.00
156_G159_V2.1211.00
194_D197_R2.0800.99
22_Q210_T2.0780.99
26_V218_E2.0700.99
9_K13_L2.0680.99
234_L271_L2.0630.99
23_L95_V2.0100.99
138_E288_A1.9890.99
179_Q294_K1.9500.99
33_E45_R1.9330.99
58_A95_V1.8980.99
33_E47_R1.8980.99
154_P204_A1.8920.99
94_V266_M1.8820.99
287_A291_E1.8680.99
15_L206_G1.8530.99
232_F290_S1.8030.98
12_L202_M1.7760.98
17_D33_E1.7640.98
163_Y201_F1.7510.98
101_Y223_M1.7270.98
101_Y226_G1.7250.98
129_F208_G1.7020.98
193_P198_C1.6830.97
59_G266_M1.6790.97
54_V221_K1.6680.97
137_F223_M1.6420.97
129_F148_A1.6310.97
18_T207_K1.6310.97
159_V190_L1.6250.97
26_V54_V1.6080.97
48_V61_N1.5960.97
61_N266_M1.5700.96
151_L204_A1.5550.96
134_F272_V1.5120.95
284_S287_A1.5080.95
101_Y228_R1.4800.95
138_E292_F1.4630.94
21_Q24_T1.4620.94
136_G179_Q1.4580.94
190_L201_F1.4550.94
19_I93_L1.4470.94
18_T22_Q1.4310.94
7_Q196_D1.4240.93
190_L193_P1.4180.93
227_E231_N1.4180.93
11_F206_G1.4100.93
230_R234_L1.3790.92
252_L256_Q1.3770.92
179_Q272_V1.3770.92
163_Y190_L1.3730.92
20_C47_R1.3710.92
27_D53_G1.3630.92
8_V12_L1.3560.92
162_R169_E1.3470.91
173_L247_W1.3370.91
93_L107_A1.3320.91
159_V193_P1.3220.91
17_D47_R1.3150.90
64_H87_E1.3150.90
159_V163_Y1.3130.90
26_V214_L1.2960.90
50_R275_E1.2950.90
143_H215_P1.2910.90
193_P197_R1.2870.89
136_G292_F1.2780.89
109_V205_V1.2690.89
50_R57_Q1.2650.89
199_F203_Q1.2470.88
231_N275_E1.2440.88
139_E219_R1.2410.88
178_E239_R1.2390.87
144_W148_A1.2260.87
143_H147_T1.2250.87
22_Q214_L1.2230.87
38_R43_G1.2140.86
259_G264_I1.1970.86
173_L246_V1.1910.85
11_F15_L1.1660.84
140_D220_R1.1610.84
129_F144_W1.1540.83
51_N98_H1.1520.83
212_A215_P1.1510.83
158_D162_R1.1340.82
26_V221_K1.1330.82
29_A53_G1.1230.82
22_Q211_D1.1200.82
11_F203_Q1.1140.81
291_E294_K1.1010.80
65_V88_A1.0910.80
107_A185_L1.0880.80
87_E111_F1.0870.80
54_V102_V1.0850.79
268_M272_V1.0830.79
136_G141_A1.0800.79
162_R192_T1.0700.78
200_A203_Q1.0650.78
230_R271_L1.0630.78
93_L105_S1.0580.78
15_L19_I1.0550.77
87_E113_I1.0480.77
28_G53_G1.0430.77
152_C185_L1.0380.76
136_G232_F1.0330.76
192_T198_C1.0330.76
190_L198_C1.0310.76
197_R200_A1.0300.76
146_R149_R1.0260.75
278_Y290_S1.0210.75
194_D198_C1.0160.75
98_H230_R1.0130.75
112_F123_W1.0110.74
164_K168_D1.0100.74
35_S45_R1.0080.74
19_I206_G1.0080.74
24_T31_F1.0070.74
282_D287_A1.0070.74
23_L97_P0.9960.73
32_V277_D0.9820.72
178_E236_R0.9790.72
241_V272_V0.9760.72
204_A208_G0.9660.71
153_L157_E0.9620.71
283_G287_A0.9560.70
34_D263_S0.9520.70
142_I146_R0.9520.70
291_E295_V0.9410.69
216_I220_R0.9390.69
34_D187_F0.9370.69
228_R281_K0.9360.69
232_F278_Y0.9340.68
12_L62_F0.9300.68
34_D260_R0.9210.67
35_S46_S0.9210.67
98_H225_Y0.9210.67
143_H219_R0.9150.67
231_N271_L0.9140.67
105_S129_F0.9140.67
40_A86_F0.9080.66
234_L273_R0.9070.66
7_Q203_Q0.9070.66
196_D200_A0.8980.65
20_C60_V0.8970.65
58_A97_P0.8960.65
84_R115_E0.8880.64
172_Y179_Q0.8880.64
215_P219_R0.8870.64
246_V255_L0.8870.64
155_F200_A0.8790.64
9_K64_H0.8670.63
204_A207_K0.8640.62
104_T134_F0.8610.62
67_G88_A0.8600.62
123_W191_N0.8590.62
284_S291_E0.8540.61
57_Q275_E0.8530.61
49_L231_N0.8530.61
131_L182_I0.8510.61
218_E221_K0.8500.61
138_E296_R0.8490.61
153_L159_V0.8490.61
22_Q25_A0.8420.60
132_T241_V0.8420.60
143_H214_L0.8410.60
38_R41_G0.8380.60
84_R116_K0.8350.60
136_G182_I0.8340.60
17_D21_Q0.8310.59
61_N94_V0.8280.59
147_T150_D0.8270.59
18_T210_T0.8260.59
38_R66_H0.8260.59
163_Y166_W0.8120.57
214_L218_E0.8100.57
21_Q25_A0.8090.57
153_L156_G0.8040.57
147_T212_A0.8020.57
155_F197_R0.7950.56
19_I209_Y0.7880.55
135_Y286_E0.7870.55
140_D219_R0.7810.55
26_V217_V0.7800.54
165_K297_D0.7790.54
59_G94_V0.7790.54
260_R263_S0.7780.54
61_N86_F0.7750.54
169_E174_K0.7670.53
62_F91_V0.7650.53
185_L205_V0.7620.53
26_V102_V0.7610.53
191_N198_C0.7610.53
132_T236_R0.7590.52
289_L293_I0.7560.52
152_C159_V0.7550.52
12_L89_M0.7540.52
147_T215_P0.7530.52
135_Y232_F0.7530.52
65_V86_F0.7530.52
193_P201_F0.7520.52
11_F202_M0.7510.52
252_L272_V0.7480.51
19_I105_S0.7470.51
76_A84_R0.7390.50
69_A77_H0.7370.50
158_D161_P0.7300.50
292_F295_V0.7300.50
57_Q208_G0.7270.49
70_M77_H0.7250.49
210_T214_L0.7240.49
139_E220_R0.7240.49
105_S144_W0.7200.49
55_F95_V0.7190.49
90_G108_N0.7180.48
78_R189_D0.7170.48
91_V206_G0.7160.48
61_N268_M0.7160.48
144_W209_Y0.7150.48
173_L241_V0.7130.48
135_Y229_E0.7080.47
13_L45_R0.7040.47
134_F289_L0.7010.47
232_F236_R0.7010.47
167_C178_E0.7010.47
45_R48_V0.7010.47
129_F185_L0.6950.46
231_N234_L0.6950.46
57_Q129_F0.6950.46
66_H86_F0.6940.46
91_V109_V0.6940.46
132_T178_E0.6920.46
15_L93_L0.6920.46
23_L58_A0.6890.46
21_Q30_E0.6840.45
95_V209_Y0.6820.45
73_S77_H0.6800.45
150_D153_L0.6790.45
52_G55_F0.6770.45
144_W185_L0.6760.44
179_Q295_V0.6760.44
90_G106_H0.6750.44
174_K252_L0.6730.44
136_G295_V0.6700.44
138_E142_I0.6680.44
97_P213_Y0.6670.44
99_N225_Y0.6650.43
28_G54_V0.6640.43
15_L91_V0.6630.43
91_V195_F0.6630.43
281_K287_A0.6600.43
106_H251_T0.6590.43
290_S294_K0.6550.42
64_H89_M0.6540.42
225_Y230_R0.6520.42
137_F219_R0.6480.42
246_V265_L0.6430.41
11_F151_L0.6420.41
95_V105_S0.6410.41
280_P287_A0.6410.41
280_P290_S0.6400.41
90_G175_H0.6390.41
6_H10_Q0.6380.41
20_C152_C0.6360.41
20_C24_T0.6350.41
177_N211_D0.6340.40
72_A256_Q0.6330.40
68_E85_S0.6330.40
74_A84_R0.6310.40
187_F258_G0.6260.40
275_E278_Y0.6250.40
206_G209_Y0.6240.40
8_V202_M0.6240.40
236_R239_R0.6230.39
108_N175_H0.6220.39
102_V220_R0.6210.39
67_G86_F0.6190.39
235_Y275_E0.6190.39
235_Y290_S0.6170.39
155_F201_F0.6170.39
29_A49_L0.6170.39
95_V107_A0.6160.39
284_S288_A0.6140.39
149_R165_K0.6120.38
166_W258_G0.6120.38
18_T211_D0.6120.38
134_F236_R0.6110.38
202_M205_V0.6100.38
139_E142_I0.6090.38
143_H212_A0.6080.38
69_A268_M0.6070.38
167_C173_L0.6060.38
107_A129_F0.6060.38
97_P104_T0.6060.38
167_C246_V0.6050.38
86_F266_M0.6010.37
213_Y217_V0.6010.37
12_L129_F0.5970.37
247_W255_L0.5970.37
158_D228_R0.5960.37
54_V217_V0.5900.36
14_N25_A0.5900.36
50_R95_V0.5890.36
30_E53_G0.5880.36
232_F235_Y0.5850.36
105_S179_Q0.5850.36
20_C46_S0.5840.36
268_M271_L0.5840.36
20_C57_Q0.5820.36
149_R222_A0.5810.36
34_D276_Y0.5800.36
198_C202_M0.5790.36
290_S296_R0.5780.35
20_C33_E0.5750.35
10_Q14_N0.5740.35
105_S148_A0.5740.35
139_E143_H0.5720.35
43_G60_V0.5720.35
292_F296_R0.5710.35
19_I60_V0.5670.34
128_G186_F0.5660.34
38_R86_F0.5650.34
29_A51_N0.5640.34
73_S123_W0.5640.34
151_L154_P0.5630.34
99_N229_E0.5630.34
102_V221_K0.5620.34
94_V263_S0.5610.34
105_S246_V0.5600.34
283_G291_E0.5600.34
179_Q290_S0.5590.34
148_A205_V0.5590.34
163_Y185_L0.5580.34
76_A252_L0.5580.34
34_D262_E0.5580.34
207_K211_D0.5570.34
25_A218_E0.5570.34
109_V202_M0.5560.34
231_N235_Y0.5560.34
34_D46_S0.5550.33
265_L268_M0.5550.33
84_R113_I0.5540.33
57_Q268_M0.5530.33
142_I296_R0.5520.33
108_N251_T0.5500.33
69_A73_S0.5500.33
50_R58_A0.5490.33
49_L52_G0.5490.33
86_F187_F0.5480.33
151_L161_P0.5480.33
279_Q290_S0.5460.33
233_Q236_R0.5460.33
161_P211_D0.5440.32
283_G288_A0.5440.32
256_Q259_G0.5390.32
40_A68_E0.5380.32
152_C190_L0.5380.32
18_T25_A0.5360.32
31_F166_W0.5350.32
14_N21_Q0.5350.32
241_V265_L0.5350.32
234_L275_E0.5340.32
102_V137_F0.5340.32
235_Y278_Y0.5330.32
229_E286_E0.5320.31
51_N216_I0.5310.31
87_E115_E0.5310.31
61_N152_C0.5310.31
16_Q46_S0.5300.31
245_L267_S0.5300.31
174_K246_V0.5300.31
22_Q26_V0.5280.31
86_F257_T0.5280.31
134_F232_F0.5260.31
279_Q294_K0.5250.31
280_P284_S0.5230.31
137_F212_A0.5220.31
72_A257_T0.5220.31
134_F179_Q0.5210.31
90_G241_V0.5210.31
70_M87_E0.5200.30
173_L290_S0.5200.30
151_L201_F0.5190.30
74_A109_V0.5190.30
288_A291_E0.5180.30
271_L275_E0.5170.30
281_K296_R0.5170.30
8_V195_F0.5160.30
132_T173_L0.5160.30
251_T265_L0.5140.30
153_L208_G0.5130.30
111_F252_L0.5110.30
294_K297_D0.5110.30
199_F206_G0.5110.30
41_G66_H0.5090.30
15_L203_Q0.5090.30
23_L26_V0.5090.30
93_L209_Y0.5050.29
43_G277_D0.5050.29
240_Y250_G0.5050.29
111_F123_W0.5040.29
30_E149_R0.5030.29
219_R223_M0.5030.29
111_F195_F0.5020.29
78_R166_W0.5010.29
159_V201_F0.5000.29
147_T211_D0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1txnA 2 0.8094 100 0.011 Contact Map
1vjuA 1 0.9699 100 0.018 Contact Map
2aexA 2 1 100 0.02 Contact Map
1xg4A 4 0.5017 32.1 0.977 Contact Map
3b8iA 4 0.4916 23.1 0.978 Contact Map
1zlpA 4 0.5084 22 0.979 Contact Map
2z15A 1 0.3311 21.9 0.979 Contact Map
3eooA 4 0.5151 19.2 0.979 Contact Map
2bpoA 1 0.796 13.4 0.981 Contact Map
2gibA 3 0.3211 9.8 0.982 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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