GREMLIN Database
EUTR - HTH-type transcriptional regulator eutR
UniProt: P36547 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12190
Length: 350 (274)
Sequences: 10372 (8451)
Seq/√Len: 510.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
252_N255_E4.1981.00
294_L334_F3.9721.00
250_L292_I3.4961.00
291_R333_L3.3271.00
248_Y252_N3.2321.00
300_E318_W3.0621.00
260_L270_R3.0171.00
309_M317_Q3.0011.00
296_A299_R2.9221.00
249_V289_L2.7821.00
255_E261_D2.6541.00
300_E317_Q2.6401.00
283_I291_R2.6001.00
330_Y341_T2.5501.00
298_R334_F2.5491.00
268_V273_L2.4921.00
277_F288_W2.4091.00
248_Y265_Q2.4021.00
268_V272_T2.2751.00
298_R341_T2.2261.00
247_E251_E2.1931.00
258_T261_D2.1821.00
336_E344_Q2.0971.00
245_A266_L2.0801.00
248_Y257_V2.0721.00
272_T275_N2.0491.00
249_V292_I1.9551.00
296_A300_E1.9461.00
312_K323_L1.9231.00
245_A273_L1.9111.00
253_M292_I1.9061.00
309_M313_D1.8781.00
301_L311_V1.8521.00
259_V274_Q1.8421.00
262_L285_P1.8421.00
270_R274_Q1.8161.00
272_T276_A1.8011.00
296_A318_W1.8001.00
310_T313_D1.7891.00
313_D317_Q1.7841.00
297_V318_W1.7831.00
294_L333_L1.7571.00
297_V326_F1.7531.00
298_R302_I1.7181.00
300_E309_M1.7111.00
250_L288_W1.7091.00
299_R303_S1.7011.00
285_P289_L1.6501.00
78_R138_T1.6411.00
284_G287_A1.6341.00
260_L264_N1.6261.00
245_A265_Q1.6191.00
105_G114_C1.6161.00
271_R275_N1.6061.00
283_I287_A1.5951.00
245_A262_L1.5631.00
325_Q329_D1.5551.00
246_R250_L1.5171.00
246_R288_W1.5171.00
312_K316_M1.5111.00
257_V262_L1.5021.00
290_K329_D1.4921.00
292_I295_N1.4781.00
309_M314_A1.4691.00
261_D265_Q1.4681.00
103_T138_T1.4551.00
248_Y266_L1.4501.00
304_P314_A1.4351.00
287_A290_K1.4261.00
327_A337_K1.4181.00
241_L268_V1.4161.00
170_S174_V1.4161.00
339_S343_H1.4131.00
291_R295_N1.3921.00
304_P342_L1.3851.00
107_Q114_C1.3841.00
208_V211_D1.3771.00
288_W292_I1.3591.00
323_L327_A1.3461.00
295_N333_L1.3371.00
313_D316_M1.3351.00
183_W187_Q1.3351.00
314_A318_W1.3281.00
243_S247_E1.2921.00
336_E340_L1.2821.00
336_E341_T1.2771.00
340_L344_Q1.2611.00
337_K340_L1.2601.00
105_G116_G1.2491.00
241_L266_L1.2381.00
246_R281_L1.2261.00
294_L326_F1.1891.00
245_A277_F1.1881.00
252_N265_Q1.1811.00
322_H325_Q1.1801.00
109_F130_E1.1781.00
111_G127_T1.1761.00
304_P309_M1.1741.00
269_S272_T1.1721.00
249_V257_V1.1701.00
249_V262_L1.1691.00
294_L320_F1.1521.00
253_M296_A1.1481.00
249_V288_W1.1481.00
311_V314_A1.1411.00
286_N290_K1.1381.00
102_A140_L1.1321.00
304_P308_S1.1291.00
295_N298_R1.1271.00
298_R336_E1.1261.00
110_I113_Q1.1221.00
297_V314_A1.1211.00
212_N216_A1.1181.00
311_V339_S1.1141.00
239_R280_I1.0851.00
203_P207_K1.0851.00
244_R265_Q1.0801.00
242_L276_A1.0761.00
329_D332_Q1.0731.00
209_L212_N1.0721.00
324_G327_A1.0651.00
238_Y279_A1.0641.00
292_I296_A1.0621.00
320_F329_D1.0591.00
262_L265_Q1.0581.00
115_L121_A1.0551.00
300_E314_A1.0541.00
208_V212_N1.0411.00
261_D264_N1.0391.00
242_L245_A1.0371.00
253_M257_V1.0351.00
107_Q132_S1.0341.00
116_G119_E1.0341.00
215_M219_A1.0291.00
187_Q191_A1.0261.00
263_C270_R1.0211.00
320_F325_Q1.0201.00
259_V270_R1.0161.00
254_S296_A1.0161.00
273_L285_P1.0101.00
314_A342_L1.0071.00
163_L167_R0.9961.00
295_N334_F0.9881.00
327_A339_S0.9831.00
145_S148_V0.9811.00
101_P106_E0.9781.00
257_V261_D0.9761.00
328_T332_Q0.9731.00
100_I120_I0.9681.00
167_R170_S0.9641.00
242_L281_L0.9631.00
223_E226_P0.9621.00
171_A175_K0.9601.00
146_E150_T0.9581.00
259_V285_P0.9571.00
254_S317_Q0.9551.00
124_P127_T0.9541.00
239_R243_S0.9501.00
274_Q285_P0.9491.00
208_V215_M0.9421.00
222_E226_P0.9421.00
246_R280_I0.9401.00
320_F326_F0.9371.00
331_Q337_K0.9331.00
184_G188_Q0.9291.00
271_R274_Q0.9261.00
144_L147_D0.9201.00
287_A291_R0.9201.00
286_N289_L0.9131.00
181_A185_F0.9081.00
252_N257_V0.8961.00
276_A279_A0.8831.00
101_P123_R0.8821.00
293_R318_W0.8821.00
171_A174_V0.8821.00
302_I345_R0.8771.00
277_F285_P0.8691.00
325_Q328_T0.8661.00
188_Q192_T0.8651.00
297_V300_E0.8601.00
170_S173_E0.8561.00
184_G187_Q0.8491.00
268_V276_A0.8451.00
80_Y138_T0.8391.00
315_A323_L0.8371.00
334_F341_T0.8341.00
278_H284_G0.8341.00
295_N299_R0.8341.00
150_T153_A0.8291.00
300_E303_S0.8291.00
289_L293_R0.8261.00
173_E176_E0.8251.00
301_L314_A0.8241.00
172_L176_E0.8241.00
298_R330_Y0.8181.00
242_L246_R0.8151.00
323_L326_F0.8141.00
130_E133_T0.8131.00
239_R276_A0.8121.00
322_H332_Q0.8081.00
125_G128_E0.8041.00
192_T219_A0.7961.00
144_L151_R0.7851.00
144_L149_I0.7831.00
248_Y261_D0.7791.00
302_I341_T0.7761.00
240_R244_R0.7741.00
97_W129_F0.7741.00
341_T345_R0.7741.00
275_N279_A0.7721.00
98_F102_A0.7681.00
178_H181_A0.7671.00
253_M318_W0.7671.00
243_S246_R0.7651.00
204_A208_V0.7651.00
241_L244_R0.7621.00
225_Q229_T0.7611.00
249_V285_P0.7561.00
99_G125_G0.7561.00
191_A195_E0.7551.00
192_T196_N0.7531.00
253_M289_L0.7531.00
245_A248_Y0.7521.00
226_P229_T0.7511.00
147_D151_R0.7401.00
250_L296_A0.7391.00
167_R171_A0.7391.00
248_Y262_L0.7361.00
150_T154_N0.7331.00
219_A222_E0.7331.00
245_A249_V0.7281.00
244_R266_L0.7271.00
259_V263_C0.7271.00
245_A268_V0.7261.00
276_A280_I0.7201.00
192_T195_E0.7191.00
241_L276_A0.7181.00
244_R247_E0.7171.00
290_K325_Q0.7151.00
297_V320_F0.7131.00
212_N219_A0.7131.00
278_H281_L0.7101.00
137_Y143_V0.7041.00
327_A331_Q0.7011.00
207_K211_D0.7001.00
181_A184_G0.6951.00
83_L88_S0.6911.00
246_R277_F0.6901.00
315_A320_F0.6891.00
286_N325_Q0.6811.00
232_S235_H0.6791.00
185_F189_A0.6781.00
290_K332_Q0.6771.00
202_Q206_R0.6761.00
184_G191_A0.6751.00
311_V323_L0.6741.00
262_L266_L0.6731.00
257_V289_L0.6711.00
132_S135_D0.6691.00
169_Q172_L0.6691.00
340_L343_H0.6691.00
205_V212_N0.6651.00
211_D215_M0.6651.00
274_Q284_G0.6641.00
153_A156_L0.6621.00
150_T155_F0.6611.00
108_G121_A0.6611.00
216_A221_L0.6611.00
91_V129_F0.6571.00
316_M323_L0.6571.00
242_L268_V0.6561.00
152_Q156_L0.6561.00
124_P128_E0.6551.00
321_W325_Q0.6541.00
242_L266_L0.6511.00
97_W101_P0.6501.00
181_A191_A0.6491.00
281_L288_W0.6481.00
152_Q157_H0.6481.00
98_F122_T0.6471.00
212_N215_M0.6461.00
256_P261_D0.6451.00
205_V209_L0.6451.00
151_R154_N0.6441.00
168_N172_L0.6411.00
221_L224_A0.6401.00
259_V286_N0.6391.00
177_Q181_A0.6391.00
131_L134_P0.6381.00
181_A188_Q0.6381.00
119_E173_E0.6351.00
103_T117_S0.6351.00
96_F101_P0.6341.00
274_Q278_H0.6331.00
274_Q286_N0.6331.00
283_I288_W0.6331.00
240_R243_S0.6301.00
301_L342_L0.6291.00
242_L280_I0.6281.00
206_R209_L0.6281.00
287_A333_L0.6251.00
316_M321_W0.6241.00
216_A220_M0.6241.00
65_E80_Y0.6231.00
153_A157_H0.6221.00
266_L273_L0.6221.00
210_G217_M0.6221.00
96_F102_A0.6211.00
330_Y336_E0.6191.00
236_Q239_R0.6181.00
321_W326_F0.6171.00
322_H328_T0.6171.00
138_T141_G0.6161.00
109_F112_S0.6151.00
326_F330_Y0.6121.00
103_T123_R0.6111.00
185_F188_Q0.6071.00
73_D210_G0.6071.00
326_F334_F0.6051.00
210_G215_M0.6051.00
142_V145_S0.6020.99
273_L281_L0.5990.99
262_L289_L0.5990.99
246_R292_I0.5950.99
85_L193_F0.5950.99
120_I124_P0.5930.99
324_G328_T0.5910.99
124_P146_E0.5910.99
259_V289_L0.5900.99
301_L304_P0.5900.99
311_V326_F0.5870.99
256_P321_W0.5840.99
244_R248_Y0.5840.99
176_E179_K0.5820.99
229_T233_I0.5820.99
310_T314_A0.5800.99
184_G192_T0.5780.99
98_F101_P0.5770.99
294_L298_R0.5740.99
111_G130_E0.5720.99
180_A183_W0.5700.99
172_L175_K0.5690.99
278_H287_A0.5680.99
96_F99_G0.5670.99
106_E131_L0.5650.99
149_I153_A0.5640.99
169_Q173_E0.5640.99
90_L94_N0.5630.99
96_F100_I0.5620.99
242_L288_W0.5620.99
182_L185_F0.5610.99
84_A88_S0.5610.99
125_G129_F0.5600.99
180_A184_G0.5560.99
84_A87_Q0.5540.99
93_P129_F0.5500.99
146_E153_A0.5500.99
197_P223_E0.5480.99
251_E265_Q0.5460.99
94_N146_E0.5450.99
149_I152_Q0.5450.99
301_L341_T0.5440.99
178_H184_G0.5430.99
152_Q155_F0.5430.99
102_A105_G0.5420.99
281_L284_G0.5400.99
188_Q196_N0.5390.99
219_A223_E0.5380.99
64_G68_E0.5370.99
207_K210_G0.5370.99
225_Q230_A0.5360.99
253_M262_L0.5350.99
109_F132_S0.5340.99
181_A193_F0.5320.99
121_A125_G0.5300.99
181_A196_N0.5280.99
275_N278_H0.5280.99
182_L213_L0.5270.99
290_K333_L0.5230.99
101_P115_L0.5220.99
121_A124_P0.5220.99
84_A89_C0.5200.99
173_E179_K0.5200.99
171_A176_E0.5200.99
218_G221_L0.5190.98
236_Q240_R0.5180.98
263_C266_L0.5170.98
148_V153_A0.5160.98
151_R156_L0.5160.98
271_R278_H0.5160.98
177_Q180_A0.5160.98
163_L166_L0.5150.98
247_E250_L0.5150.98
105_G134_P0.5150.98
181_A190_L0.5150.98
146_E149_I0.5140.98
176_E181_A0.5120.98
99_G123_R0.5120.98
140_L143_V0.5110.98
141_G144_L0.5110.98
145_S149_I0.5110.98
123_R131_L0.5080.98
67_T78_R0.5080.98
134_P137_Y0.5060.98
73_D145_S0.5060.98
168_N171_A0.5060.98
81_T85_L0.5060.98
257_V265_Q0.5040.98
308_S342_L0.5030.98
123_R137_Y0.5000.98
304_P317_Q0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gbgA 1 0.7143 100 0.403 Contact Map
3oioA 1 0.32 100 0.557 Contact Map
1bl0A 1 0.3143 100 0.558 Contact Map
3oouA 1 0.3 100 0.56 Contact Map
3mn2A 1 0.3029 100 0.562 Contact Map
3w6vA 1 0.3114 100 0.565 Contact Map
3mklA 1 0.3171 100 0.565 Contact Map
2k9sA 1 0.3029 100 0.569 Contact Map
3lsgA 2 0.2914 100 0.576 Contact Map
1d5yA 1 0.3143 99.9 0.581 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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