GREMLIN Database
AHPF - Alkyl hydroperoxide reductase subunit F
UniProt: P35340 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11385
Length: 521 (402)
Sequences: 1537 (820)
Seq/√Len: 40.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
463_E471_I6.1571.00
416_E428_E4.4421.00
368_V383_L4.1761.00
503_E506_K3.9691.00
357_R379_E3.9111.00
123_T151_H3.5921.00
118_D148_R3.4771.00
418_K425_V3.3361.00
430_R437_I3.1531.00
418_K428_E3.0021.00
125_Y153_A2.9871.00
359_A442_L2.8411.00
428_E439_N2.8291.00
484_F514_Y2.7311.00
394_Q398_D2.7231.00
426_G439_N2.7101.00
275_V278_D2.6881.00
417_V445_I2.6621.00
418_K426_G2.6601.00
400_L408_I2.6581.00
462_V480_V2.6541.00
455_T489_C2.6201.00
339_T419_G2.6181.00
357_R441_E2.5971.00
239_G285_I2.5831.00
357_R380_H2.5781.00
420_D425_V2.5561.00
400_L406_V2.5481.00
384_L440_I2.4981.00
332_P416_E2.4951.00
329_M417_V2.4431.00
473_D477_E2.4371.00
106_Q110_E2.4251.00
401_R408_I2.4061.00
227_A319_I2.3871.00
418_K439_N2.3531.00
409_I412_A2.3281.00
120_E150_K2.3161.00
417_V424_V2.2771.00
211_D236_I2.2481.00
122_E154_I2.2381.00
380_H407_D2.2091.00
368_V400_L2.1630.99
429_Y438_H2.1630.99
357_R443_A2.1460.99
182_G186_M2.1390.99
154_I196_D2.1040.99
480_V483_V2.0690.99
413_Q430_R2.0560.99
212_A237_R2.0260.99
465_N469_E1.9990.99
397_Q401_R1.9870.99
359_A427_L1.9760.99
149_I152_T1.9690.99
412_A429_Y1.9500.99
291_S308_A1.9330.99
173_A180_E1.9250.99
348_C374_L1.9230.99
399_K402_S1.9090.99
312_V482_G1.8910.98
322_T489_C1.8730.98
492_V503_E1.8500.98
459_E464_R1.8480.98
359_A440_I1.8470.98
396_L400_L1.8350.98
319_I511_A1.7280.97
428_E437_I1.7090.97
411_N433_V1.6950.97
329_M445_I1.6890.97
386_F432_R1.6890.97
161_N165_D1.6540.96
104_E141_L1.6490.96
263_K279_E1.6360.96
431_D438_H1.6330.96
397_Q400_L1.6210.96
218_V320_V1.6100.96
109_L113_R1.5940.96
116_D148_R1.5930.96
245_F277_V1.5910.96
318_I483_V1.5490.95
115_I195_I1.5470.95
290_A293_L1.5460.95
392_A396_L1.5430.95
379_E443_A1.5180.94
319_I486_A1.5060.94
269_L501_T1.4990.94
122_E166_R1.4860.94
243_E289_S1.4720.93
430_R435_G1.4710.93
218_V311_A1.4540.93
498_I501_T1.4460.93
107_S206_E1.4400.92
328_N335_D1.4190.92
329_M361_I1.4130.92
425_V439_N1.3950.91
303_H483_V1.3910.91
225_A277_V1.3880.91
415_T430_R1.3880.91
167_N422_S1.3780.91
271_G275_V1.3720.91
161_N164_T1.3660.90
119_F195_I1.3460.90
215_V319_I1.3320.89
237_R283_D1.3270.89
250_L270_A1.3220.89
123_T153_A1.3130.88
292_K306_E1.3030.88
287_S462_V1.3000.88
104_E109_L1.2980.88
393_D397_Q1.2930.88
397_Q402_S1.2880.87
419_G425_V1.2820.87
124_Y162_E1.2780.87
233_R276_H1.2770.87
306_E312_V1.2710.87
420_D423_K1.2700.87
300_G304_Q1.2700.87
318_I434_S1.2660.87
241_M315_A1.2620.86
270_A273_L1.2620.86
155_D158_T1.2590.86
210_R283_D1.2520.86
482_G514_Y1.2510.86
278_D284_V1.2470.86
102_S141_L1.2420.85
396_L399_K1.2420.85
321_A486_A1.2410.85
220_S242_G1.2320.85
293_L457_W1.2290.85
396_L402_S1.2260.85
108_L112_I1.2260.85
240_L281_D1.2190.84
285_I288_Q1.2180.84
141_L188_L1.2170.84
168_V175_F1.2100.84
210_R285_I1.2020.84
274_K278_D1.1970.83
474_A491_T1.1950.83
328_N334_E1.1940.83
387_A391_K1.1850.83
276_H280_Y1.1750.82
216_L315_A1.1730.82
505_A508_S1.1660.82
213_Y239_G1.1640.82
120_E123_T1.1580.81
330_N334_E1.1560.81
250_L271_G1.1490.81
476_C506_K1.1460.80
193_A202_R1.1450.80
388_P411_N1.1380.80
116_D119_F1.1340.80
340_K423_K1.1330.80
214_D237_R1.1280.79
291_S306_E1.1200.79
167_N170_G1.1070.78
382_T407_D1.1060.78
353_F444_G1.1040.78
290_A483_V1.1020.78
393_D396_L1.0950.77
262_P279_E1.0920.77
275_V279_E1.0910.77
142_M188_L1.0890.77
141_L144_V1.0860.77
329_M447_V1.0840.77
102_S105_A1.0810.76
108_L192_V1.0710.76
121_F176_V1.0710.76
348_C446_F1.0700.76
477_E514_Y1.0550.75
212_A302_L1.0540.75
217_I224_G1.0540.75
152_T155_D1.0540.75
128_S157_G1.0440.74
169_M173_A1.0430.74
119_F176_V1.0420.74
325_K456_N1.0420.74
203_A309_S1.0410.74
189_T286_D1.0400.74
392_A397_Q1.0320.73
346_P350_G1.0300.73
345_C349_D1.0300.73
409_I429_Y1.0270.73
218_V318_I1.0240.72
476_C510_S1.0200.72
226_A259_I1.0180.72
217_I227_A1.0140.72
170_G173_A1.0110.71
320_V464_R0.9980.70
109_L141_L0.9950.70
396_L401_R0.9920.70
401_R410_L0.9880.70
236_I512_F0.9850.69
345_C348_C0.9710.68
384_L429_Y0.9700.68
302_L314_K0.9580.67
185_R376_G0.9510.67
407_D410_L0.9510.67
431_D434_S0.9460.66
217_I501_T0.9410.66
392_A400_L0.9380.66
240_L284_V0.9370.66
167_N173_A0.9310.65
167_N183_Q0.9310.65
357_R440_I0.9280.65
305_I318_I0.9270.65
478_T485_A0.9230.64
477_E484_F0.9190.64
119_F177_N0.9140.64
223_A486_A0.9140.64
426_G441_E0.9140.64
378_V382_T0.9120.63
417_V447_V0.9090.63
394_Q397_Q0.9030.63
470_I489_C0.9000.62
142_M149_I0.8990.62
414_T445_I0.8990.62
164_T167_N0.8960.62
131_N135_V0.8950.62
160_Q164_T0.8950.62
217_I319_I0.8930.62
402_S406_V0.8870.61
375_A406_V0.8850.61
368_V402_S0.8840.61
342_V417_V0.8830.61
328_N344_Y0.8790.61
190_E194_K0.8780.60
391_K467_M0.8760.60
104_E108_L0.8740.60
290_A457_W0.8710.60
304_Q312_V0.8700.60
412_A415_T0.8680.60
465_N491_T0.8680.60
277_V282_V0.8670.59
304_Q314_K0.8660.59
391_K396_L0.8610.59
128_S155_D0.8610.59
393_D400_L0.8600.59
367_G385_E0.8540.58
393_D399_K0.8520.58
167_N423_K0.8520.58
131_N185_R0.8510.58
321_A328_N0.8490.58
472_I503_E0.8480.58
383_L400_L0.8420.57
472_I490_T0.8410.57
102_S192_V0.8330.56
232_A282_V0.8330.56
162_E166_R0.8300.56
506_K510_S0.8260.56
102_S108_L0.8250.56
203_A206_E0.8250.56
463_E479_N0.8230.55
210_R232_A0.8220.55
397_Q408_I0.8180.55
214_D314_K0.8170.55
224_G240_L0.8140.55
218_V305_I0.8120.54
106_Q394_Q0.8120.54
484_F512_F0.8120.54
160_Q230_Y0.8120.54
144_V156_G0.8100.54
371_A383_L0.8100.54
145_L438_H0.8100.54
140_N156_G0.8090.54
368_V387_A0.8080.54
110_E206_E0.8070.54
384_L413_Q0.8040.54
107_S110_E0.8030.54
299_E302_L0.8020.54
359_A384_L0.8020.54
119_F123_T0.8010.53
292_K302_L0.8000.53
163_I170_G0.7980.53
473_D510_S0.7960.53
110_E195_I0.7950.53
109_L145_L0.7900.52
401_R407_D0.7890.52
391_K400_L0.7860.52
241_M307_T0.7820.52
502_G506_K0.7780.51
321_A384_L0.7720.51
204_A279_E0.7720.51
303_H321_A0.7710.51
391_K397_Q0.7710.51
383_L388_P0.7700.51
278_D286_D0.7700.51
407_D438_H0.7680.50
240_L440_I0.7680.50
309_S314_K0.7630.50
281_D302_L0.7620.50
154_I166_R0.7610.50
397_Q406_V0.7600.50
509_L513_D0.7590.50
476_C503_E0.7570.49
182_G190_E0.7570.49
210_R237_R0.7550.49
266_G446_F0.7550.49
398_D401_R0.7550.49
391_K394_Q0.7540.49
305_I459_E0.7530.49
320_V387_A0.7520.49
248_Q496_Q0.7510.49
182_G185_R0.7500.49
108_L189_T0.7500.49
342_V440_I0.7490.49
123_T140_N0.7480.49
389_E394_Q0.7470.48
184_G187_T0.7420.48
231_S508_S0.7410.48
475_K510_S0.7390.48
493_P506_K0.7380.48
119_F317_S0.7380.48
299_E304_Q0.7370.48
491_T499_I0.7370.48
212_A435_G0.7370.48
491_T503_E0.7360.47
248_Q345_C0.7350.47
472_I476_C0.7350.47
419_G486_A0.7350.47
367_G386_F0.7340.47
212_A236_I0.7330.47
305_I433_V0.7320.47
110_E113_R0.7310.47
330_N428_E0.7310.47
115_I149_I0.7310.47
109_L112_I0.7310.47
288_Q305_I0.7290.47
98_G102_S0.7290.47
263_K270_A0.7290.47
389_E466_R0.7280.47
300_G303_H0.7280.47
393_D398_D0.7220.46
271_G274_K0.7210.46
102_S145_L0.7200.46
341_G348_C0.7180.46
239_G283_D0.7180.46
458_L464_R0.7160.46
424_V445_I0.7160.46
135_V502_G0.7150.45
368_V406_V0.7150.45
307_T458_L0.7150.45
431_D436_D0.7130.45
285_I309_S0.7110.45
452_L456_N0.7100.45
213_Y285_I0.7090.45
110_E114_H0.7090.45
317_S515_L0.7090.45
153_A262_P0.7080.45
173_A250_L0.7080.45
287_S418_K0.7070.45
303_H318_I0.7050.45
259_I501_T0.7040.44
367_G414_T0.7030.44
351_P502_G0.7020.44
110_E483_V0.7020.44
217_I383_L0.7010.44
128_S213_Y0.6990.44
158_T174_V0.6990.44
387_A467_M0.6940.44
460_G463_E0.6920.43
155_D261_V0.6900.43
124_Y175_F0.6890.43
472_I492_V0.6890.43
203_A279_E0.6880.43
292_K299_E0.6860.43
117_G123_T0.6850.43
231_S236_I0.6840.43
395_V399_K0.6840.43
124_Y505_A0.6830.43
368_V384_L0.6820.42
110_E463_E0.6820.42
139_L174_V0.6810.42
245_F286_D0.6800.42
307_T483_V0.6800.42
412_A438_H0.6800.42
174_V182_G0.6800.42
110_E217_I0.6790.42
261_V264_T0.6770.42
182_G191_I0.6750.42
116_D123_T0.6710.41
162_E171_V0.6700.41
326_W344_Y0.6700.41
225_A240_L0.6700.41
226_A306_E0.6680.41
464_R467_M0.6670.41
104_E192_V0.6660.41
346_P349_D0.6640.41
211_D237_R0.6630.41
303_H480_V0.6620.41
335_D428_E0.6620.41
213_Y316_R0.6620.41
145_L192_V0.6620.41
421_G427_L0.6610.41
391_K398_D0.6610.41
372_I402_S0.6600.40
335_D344_Y0.6580.40
477_E482_G0.6570.40
391_K402_S0.6570.40
227_A321_A0.6560.40
331_V342_V0.6560.40
195_I199_A0.6550.40
360_V385_E0.6550.40
383_L387_A0.6540.40
168_V497_I0.6540.40
113_R145_L0.6540.40
128_S168_V0.6490.39
144_V186_M0.6480.39
264_T496_Q0.6480.39
462_V483_V0.6480.39
328_N445_I0.6480.39
169_M238_T0.6460.39
395_V405_N0.6460.39
413_Q432_R0.6450.39
293_L318_I0.6430.39
150_K191_I0.6430.39
306_E309_S0.6420.39
412_A427_L0.6410.39
430_R436_D0.6410.39
216_L241_M0.6400.39
234_K512_F0.6390.39
263_K508_S0.6380.39
393_D402_S0.6380.39
120_E152_T0.6360.38
421_G441_E0.6360.38
417_V439_N0.6360.38
300_G481_K0.6350.38
464_R468_G0.6350.38
480_V484_F0.6340.38
303_H320_V0.6310.38
343_T353_F0.6310.38
126_S136_V0.6300.38
274_K286_D0.6280.38
384_L387_A0.6270.38
291_S302_L0.6260.37
394_Q477_E0.6240.37
262_P275_V0.6220.37
513_D516_I0.6210.37
172_P346_P0.6200.37
132_C488_D0.6170.37
130_H157_G0.6160.37
236_I376_G0.6130.36
472_I491_T0.6110.36
230_Y509_L0.6100.36
184_G502_G0.6100.36
244_R287_S0.6100.36
226_A275_V0.6090.36
170_G174_V0.6090.36
435_G494_Y0.6080.36
233_R326_W0.6060.36
383_L386_F0.6060.36
492_V506_K0.6040.36
415_T437_I0.6040.36
213_Y287_S0.6040.36
199_A202_R0.6020.35
168_V316_R0.6020.35
240_L415_T0.6020.35
161_N170_G0.6010.35
220_S512_F0.6000.35
385_E388_P0.6000.35
398_D402_S0.6000.35
219_G487_G0.5990.35
148_R445_I0.5990.35
286_D321_A0.5980.35
462_V479_N0.5970.35
283_D462_V0.5950.35
384_L411_N0.5940.35
303_H508_S0.5940.35
392_A395_V0.5940.35
306_E433_V0.5940.35
206_E389_E0.5920.35
360_V371_A0.5920.35
245_F427_L0.5900.34
319_I507_A0.5880.34
422_S425_V0.5880.34
278_D471_I0.5850.34
104_E188_L0.5850.34
365_N370_A0.5840.34
318_I321_A0.5830.34
355_G379_E0.5820.34
214_D231_S0.5810.34
315_A319_I0.5790.33
223_A319_I0.5780.33
98_G101_P0.5770.33
328_N339_T0.5770.33
285_I321_A0.5760.33
206_E428_E0.5750.33
221_G487_G0.5730.33
210_R213_Y0.5710.33
222_P364_G0.5710.33
229_I276_H0.5680.33
387_A415_T0.5680.33
101_P115_I0.5670.33
107_S301_G0.5670.33
313_L477_E0.5660.32
334_E342_V0.5650.32
219_G323_G0.5650.32
366_S369_E0.5650.32
312_V430_R0.5630.32
123_T139_L0.5620.32
341_G345_C0.5620.32
322_T453_P0.5610.32
341_G364_G0.5600.32
367_G497_I0.5600.32
114_H192_V0.5600.32
472_I485_A0.5590.32
123_T185_R0.5580.32
414_T427_L0.5580.32
263_K387_A0.5570.32
309_S481_K0.5560.32
343_T377_I0.5550.32
417_V421_G0.5540.31
230_Y363_G0.5530.31
105_A110_E0.5520.31
149_I470_I0.5510.31
137_Q140_N0.5510.31
427_L461_A0.5510.31
230_Y248_Q0.5510.31
385_E432_R0.5500.31
104_E189_T0.5490.31
234_K509_L0.5480.31
172_P248_Q0.5480.31
380_H443_A0.5480.31
430_R433_V0.5480.31
355_G363_G0.5480.31
212_A215_V0.5470.31
293_L483_V0.5470.31
341_G349_D0.5470.31
387_A500_A0.5460.31
186_M190_E0.5460.31
116_D120_E0.5450.31
265_E269_L0.5450.31
391_K395_V0.5440.31
140_N153_A0.5430.31
219_G247_G0.5420.31
162_E165_D0.5410.30
292_K301_G0.5400.30
221_G323_G0.5400.30
442_L445_I0.5390.30
323_G487_G0.5390.30
189_T192_V0.5390.30
264_T267_Q0.5380.30
360_V367_G0.5380.30
415_T418_K0.5370.30
277_V303_H0.5370.30
385_E390_M0.5360.30
128_S170_G0.5360.30
104_E145_L0.5360.30
123_T376_G0.5350.30
271_G508_S0.5350.30
196_D207_L0.5350.30
405_N408_I0.5340.30
331_V477_E0.5330.30
357_R382_T0.5330.30
264_T367_G0.5320.30
330_N459_E0.5310.30
301_G306_E0.5300.30
240_L277_V0.5300.30
108_L188_L0.5280.29
213_Y237_R0.5270.29
212_A315_A0.5260.29
268_K274_K0.5260.29
307_T310_G0.5250.29
478_T482_G0.5230.29
158_T176_V0.5230.29
340_K422_S0.5230.29
275_V299_E0.5210.29
105_A108_L0.5200.29
261_V273_L0.5190.29
279_E508_S0.5170.29
461_A484_F0.5170.29
330_N498_I0.5160.29
221_G247_G0.5160.29
434_S438_H0.5160.29
247_G487_G0.5150.28
194_K292_K0.5140.28
220_S245_F0.5120.28
326_W497_I0.5120.28
400_L405_N0.5120.28
394_Q404_K0.5110.28
244_R260_S0.5110.28
305_I308_A0.5100.28
292_K305_I0.5090.28
370_A373_D0.5090.28
303_H357_R0.5090.28
399_K500_A0.5080.28
119_F193_A0.5080.28
130_H145_L0.5070.28
277_V507_A0.5060.28
462_V500_A0.5060.28
196_D199_A0.5060.28
241_M290_A0.5050.28
433_V437_I0.5050.28
348_C370_A0.5050.28
462_V514_Y0.5040.28
491_T506_K0.5040.28
166_R175_F0.5040.28
292_K483_V0.5030.28
311_A316_R0.5030.28
132_C222_P0.5030.28
227_A231_S0.5020.27
208_N312_V0.5020.27
241_M270_A0.5010.27
123_T141_L0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1hyuA 2 1 100 0.42 Contact Map
2vdcG 1 0.762 100 0.556 Contact Map
1gteA 4 0.8676 100 0.557 Contact Map
4ylfB 1 0.7965 100 0.564 Contact Map
1fl2A 2 0.595 100 0.648 Contact Map
3ctyA 2 0.5816 100 0.667 Contact Map
2q7vA 2 0.595 100 0.667 Contact Map
2a87A 2 0.5931 100 0.669 Contact Map
4up3A 2 0.5797 100 0.669 Contact Map
2q0lA 2 0.5797 100 0.67 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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