GREMLIN Database
HOFQ - Putative DNA transport protein HofQ
UniProt: P34749 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12113
Length: 412 (387)
Sequences: 2666 (2015)
Seq/√Len: 102.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
374_S379_G7.2821.00
386_Q389_R6.5721.00
272_P305_E5.2741.00
374_S380_D5.1321.00
381_I384_F4.5011.00
280_E299_E3.7831.00
120_R168_E3.3131.00
321_H347_E3.2251.00
280_E298_K3.1111.00
357_T405_T3.0031.00
285_V296_E2.8151.00
124_L132_L2.6621.00
159_D163_A2.6421.00
320_L404_I2.6331.00
36_V74_V2.5981.00
276_K299_E2.5851.00
272_P307_T2.4821.00
353_K356_E2.4611.00
370_S393_K2.4251.00
157_L167_L2.4201.00
282_P297_F2.4001.00
62_L70_A2.2801.00
193_K396_E2.2561.00
188_V403_F2.2421.00
197_E392_G2.1991.00
30_D57_T2.1911.00
265_L346_I2.1871.00
315_R353_K2.1411.00
189_T344_Q2.1191.00
372_Q389_R2.1161.00
133_A137_E2.0981.00
31_V36_V2.0561.00
385_G389_R2.0281.00
321_H345_E2.0211.00
65_V70_A1.9961.00
181_V310_V1.9951.00
269_H310_V1.9721.00
280_E297_F1.9551.00
193_K255_Q1.9421.00
377_L381_I1.8931.00
352_V358_L1.8891.00
141_S159_D1.8881.00
366_R397_R1.8851.00
62_L65_V1.8461.00
161_K165_S1.8451.00
184_S407_R1.8331.00
66_P69_Q1.8271.00
122_I157_L1.8211.00
129_A153_N1.8101.00
366_R395_D1.7911.00
144_G159_D1.7771.00
277_Q363_I1.7631.00
303_G323_S1.7561.00
51_S96_W1.7461.00
386_Q391_D1.7441.00
130_G150_K1.7341.00
319_K349_Q1.7261.00
127_A151_R1.7251.00
328_G342_D1.7221.00
315_R351_E1.7181.00
300_A341_I1.7071.00
271_Q349_Q1.7041.00
184_S264_R1.6851.00
281_I327_P1.6581.00
323_S345_E1.6461.00
357_T403_F1.6201.00
153_N175_D1.6161.00
367_K396_E1.6151.00
189_T398_R1.6131.00
267_A308_P1.6121.00
283_Y339_L1.5971.00
352_V406_P1.5701.00
316_I408_L1.5591.00
21_P68_K1.5541.00
168_E172_A1.5461.00
160_N163_A1.5251.00
197_E249_S1.5241.00
377_L380_D1.5141.00
314_G354_S1.5081.00
280_E343_K1.5071.00
319_K347_E1.5071.00
284_Q336_G1.5061.00
141_S144_G1.4741.00
41_A48_L1.4671.00
159_D164_L1.4661.00
183_L306_V1.4611.00
287_S292_A1.4571.00
185_A404_I1.4481.00
283_Y297_F1.4451.00
282_P295_V1.4441.00
378_L381_I1.4431.00
32_P35_Q1.4421.00
136_G155_L1.4271.00
276_K345_E1.4231.00
327_P339_L1.4171.00
36_V58_V1.4141.00
72_Q82_T1.4091.00
179_G310_V1.3981.00
33_V74_V1.3951.00
374_S389_R1.3951.00
270_L309_T1.3881.00
128_D131_E1.3791.00
344_Q365_T1.3650.99
183_L318_L1.3570.99
263_P362_G1.3530.99
163_A166_A1.3500.99
269_H309_T1.3460.99
350_V358_L1.3440.99
329_Q340_A1.3420.99
379_G389_R1.3390.99
277_Q344_Q1.3360.99
326_V342_D1.3310.99
84_Q89_L1.3250.99
157_L164_L1.3240.99
75_V82_T1.3200.99
28_V36_V1.2930.99
182_E409_V1.2910.99
380_D389_R1.2900.99
368_N395_D1.2840.99
374_S377_L1.2830.99
75_V91_V1.2820.99
251_L257_L1.2700.99
280_E341_I1.2690.99
198_L250_A1.2640.99
165_S168_E1.2560.99
279_S342_D1.2440.99
318_L352_V1.2440.99
136_G167_L1.2440.99
118_E164_L1.2420.99
301_V325_N1.2400.99
284_Q295_V1.2400.99
99_N103_R1.2390.99
25_T63_T1.2210.99
120_R124_L1.2130.99
52_P78_A1.2070.99
106_A109_A1.2060.99
268_S317_R1.2020.99
267_A273_A1.1970.99
287_S294_S1.1930.99
27_M61_H1.1860.99
274_S305_E1.1860.99
359_A403_F1.1780.98
199_G202_W1.1750.98
46_L84_Q1.1700.98
249_S390_H1.1680.98
235_N239_I1.1650.98
274_S347_E1.1450.98
385_G388_F1.1410.98
216_V219_L1.1330.98
80_L91_V1.1270.98
276_K301_V1.1220.98
335_D338_V1.1190.98
213_V216_V1.1070.98
232_V238_R1.1060.98
83_R92_H1.1040.98
28_V31_V1.1030.98
106_A110_R1.1030.98
364_F397_R1.0970.98
146_M157_L1.0960.98
258_D397_R1.0940.98
266_L409_V1.0930.97
200_V248_L1.0880.97
26_L31_V1.0840.97
263_P273_A1.0820.97
116_P119_N1.0790.97
279_S328_G1.0740.97
383_W386_Q1.0740.97
334_A337_E1.0730.97
327_P340_A1.0720.97
32_P57_T1.0710.97
285_V295_V1.0710.97
354_S407_R1.0690.97
169_Q173_Q1.0690.97
169_Q172_A1.0610.97
298_K301_V1.0610.97
201_K247_E1.0520.97
159_D167_L1.0440.97
354_S408_L1.0430.97
127_A132_L1.0430.97
282_P340_A1.0380.97
265_L360_L1.0360.97
34_A38_Q1.0350.97
331_L337_E1.0270.96
37_L48_L1.0270.96
82_T89_L1.0230.96
190_I401_V1.0160.96
279_S340_A1.0100.96
266_L350_V1.0070.96
287_S293_T1.0070.96
323_S343_K1.0060.96
26_L70_A1.0060.96
252_E380_D1.0060.96
295_V338_V1.0020.96
46_L89_L0.9910.96
275_I361_G0.9790.95
233_G237_G0.9770.95
62_L69_Q0.9730.95
305_E321_H0.9710.95
192_E399_E0.9640.95
185_A304_M0.9630.95
379_G387_L0.9520.94
60_L70_A0.9480.94
73_T88_I0.9450.94
188_V248_L0.9440.94
279_S327_P0.9430.94
201_K249_S0.9410.94
290_S293_T0.9400.94
44_E48_L0.9390.94
33_V78_A0.9360.94
282_P298_K0.9300.94
204_L250_A0.9290.94
134_K137_E0.9290.94
109_A113_A0.9240.94
301_V324_Q0.9180.93
122_I171_V0.9180.93
180_Q322_I0.9170.93
299_E343_K0.9170.93
191_N396_E0.9140.93
124_L148_V0.9130.93
101_I105_E0.9120.93
286_S294_S0.9110.93
267_A306_V0.9100.93
209_H213_V0.9090.93
192_E364_F0.9050.93
284_Q338_V0.8960.92
222_D225_V0.8950.92
189_T324_Q0.8940.92
115_L160_N0.8930.92
50_V91_V0.8880.92
58_V78_A0.8820.92
267_A302_L0.8810.92
279_S341_I0.8800.92
232_V235_N0.8720.91
189_T360_L0.8710.91
265_L273_A0.8710.91
75_V80_L0.8680.91
376_P388_F0.8670.91
317_R351_E0.8650.91
370_S391_D0.8620.91
103_R106_A0.8590.91
302_L363_I0.8590.91
326_V367_K0.8570.91
286_S290_S0.8570.91
364_F399_E0.8560.91
300_A327_P0.8550.91
188_V257_L0.8550.91
191_N398_R0.8530.90
47_N88_I0.8460.90
278_G297_F0.8460.90
399_E406_P0.8430.90
107_E111_A0.8370.90
372_Q391_D0.8360.90
365_T398_R0.8350.90
322_I346_I0.8340.89
317_R349_Q0.8310.89
328_G340_A0.8300.89
42_E61_H0.8300.89
102_A106_A0.8280.89
346_I360_L0.8270.89
330_V340_A0.8250.89
311_L317_R0.8230.89
261_A277_Q0.8200.89
381_I389_R0.8200.89
164_L168_E0.8190.89
195_L394_E0.8190.89
23_K64_D0.8160.88
130_G134_K0.8140.88
166_A169_Q0.8140.88
37_L399_E0.8110.88
278_G282_P0.8090.88
178_V351_E0.8010.87
184_S399_E0.8010.87
375_V389_R0.8000.87
48_L89_L0.8000.87
68_K84_Q0.7990.87
99_N102_A0.7970.87
33_V37_L0.7960.87
231_H238_R0.7940.87
274_S321_H0.7930.87
182_E407_R0.7920.87
324_Q365_T0.7910.87
302_L324_Q0.7860.87
344_Q400_L0.7840.86
277_Q324_Q0.7810.86
285_V294_S0.7800.86
192_E397_R0.7800.86
302_L346_I0.7780.86
117_L120_R0.7780.86
129_A133_A0.7740.86
84_Q155_L0.7740.86
25_T66_P0.7740.86
306_V318_L0.7720.86
298_K341_I0.7710.85
187_I302_L0.7690.85
126_Y175_D0.7690.85
188_V401_V0.7670.85
215_Q219_L0.7670.85
208_Q241_G0.7640.85
284_Q296_E0.7630.85
32_P36_V0.7620.85
211_G219_L0.7580.84
307_T319_K0.7570.84
199_G339_L0.7510.84
330_V337_E0.7490.84
322_I363_I0.7480.84
276_K323_S0.7460.84
189_T258_D0.7440.83
156_L170_W0.7430.83
381_I388_F0.7430.83
223_L226_A0.7420.83
155_L167_L0.7400.83
196_R393_K0.7380.83
283_Y296_E0.7360.83
39_A42_E0.7360.83
133_A148_V0.7360.83
275_I359_A0.7360.83
109_A112_Q0.7300.82
263_P399_E0.7300.82
149_D152_T0.7290.82
278_G303_G0.7280.82
281_I339_L0.7270.82
277_Q325_N0.7270.82
81_I94_I0.7260.82
118_E121_S0.7260.82
183_L270_L0.7250.82
368_N393_K0.7240.82
130_G133_A0.7240.82
136_G171_V0.7220.81
191_N256_Q0.7130.81
371_G392_G0.7120.81
230_T233_G0.7110.80
35_Q38_Q0.7110.80
124_L129_A0.7100.80
378_L388_F0.7100.80
102_A110_R0.7070.80
233_G238_R0.7060.80
118_E122_I0.7060.80
139_L163_A0.7050.80
297_F325_N0.7050.80
132_L171_V0.7030.80
186_H262_S0.7000.79
129_A175_D0.6990.79
348_T407_R0.6980.79
24_V43_Q0.6960.79
58_V74_V0.6960.79
267_A316_I0.6940.79
26_L40_L0.6920.79
77_S91_V0.6850.78
51_S54_V0.6850.78
124_L153_N0.6850.78
263_P361_G0.6840.78
180_Q310_V0.6830.78
291_G294_S0.6820.78
375_V385_G0.6810.78
181_V267_A0.6800.77
258_D368_N0.6760.77
329_Q337_E0.6760.77
348_T360_L0.6760.77
119_N122_I0.6760.77
261_A365_T0.6740.77
382_P388_F0.6740.77
66_P70_A0.6710.77
58_V320_L0.6700.76
71_L82_T0.6690.76
38_Q74_V0.6660.76
108_Q113_A0.6630.76
99_N105_E0.6620.76
226_A230_T0.6600.75
89_L250_A0.6580.75
120_R164_L0.6580.75
306_V404_I0.6540.75
127_A149_D0.6540.75
180_Q402_V0.6530.75
110_R116_P0.6530.75
91_V100_N0.6530.75
101_I104_Q0.6500.74
158_R163_A0.6500.74
284_Q339_L0.6490.74
108_Q111_A0.6480.74
48_L91_V0.6480.74
318_L340_A0.6470.74
228_A231_H0.6460.74
67_W70_A0.6460.74
127_A174_M0.6460.74
277_Q322_I0.6440.74
123_T154_R0.6440.74
232_V239_I0.6440.74
29_D59_S0.6430.73
281_I341_I0.6430.73
135_A167_L0.6410.73
282_P338_V0.6400.73
263_P348_T0.6400.73
120_R127_A0.6390.73
117_L125_Q0.6380.73
302_L322_I0.6380.73
231_H236_I0.6370.73
297_F339_L0.6360.73
37_L52_P0.6360.73
89_L133_A0.6340.72
139_L316_I0.6340.72
331_L375_V0.6340.72
107_E112_Q0.6340.72
71_L75_V0.6310.72
180_Q186_H0.6300.72
200_V321_H0.6260.71
282_P300_A0.6260.71
28_V71_L0.6260.71
182_E264_R0.6240.71
182_E266_L0.6240.71
62_L184_S0.6240.71
380_D385_G0.6230.71
233_G240_N0.6230.71
122_I164_L0.6220.71
53_D96_W0.6210.71
129_A148_V0.6200.71
284_Q294_S0.6190.71
184_S405_T0.6190.71
187_I402_V0.6180.71
286_S292_A0.6160.70
278_G400_L0.6150.70
121_S154_R0.6140.70
211_G214_G0.6130.70
386_Q393_K0.6130.70
208_Q231_H0.6130.70
40_L70_A0.6110.70
251_L267_A0.6110.70
47_N87_N0.6100.70
279_S300_A0.6100.70
231_H237_G0.6090.69
178_V269_H0.6080.69
281_I298_K0.6080.69
156_L174_M0.6070.69
39_A70_A0.6070.69
51_S93_S0.6060.69
235_N238_R0.6060.69
369_K392_G0.6040.69
29_D38_Q0.6030.69
56_G80_L0.6020.69
195_L401_V0.6020.69
285_V339_L0.6020.69
344_Q363_I0.6010.68
300_A338_V0.6010.68
142_A172_A0.6010.68
124_L175_D0.6000.68
28_V39_A0.6000.68
186_H405_T0.5990.68
140_L159_D0.5980.68
159_D270_L0.5980.68
222_D226_A0.5970.68
273_A306_V0.5970.68
297_F341_I0.5970.68
211_G218_T0.5960.68
205_A242_R0.5950.68
308_P318_L0.5940.67
47_N62_L0.5940.67
180_Q266_L0.5940.67
190_I194_S0.5920.67
43_Q48_L0.5920.67
37_L50_V0.5900.67
302_L360_L0.5890.67
178_V271_Q0.5890.67
261_A348_T0.5870.67
276_K303_G0.5870.67
159_D405_T0.5870.67
159_D357_T0.5840.66
379_G382_P0.5840.66
116_P120_R0.5840.66
98_N108_Q0.5830.66
79_G94_I0.5830.66
128_D132_L0.5830.66
169_Q394_E0.5830.66
121_S156_L0.5820.66
303_G346_I0.5810.66
49_V73_T0.5790.66
191_N237_G0.5790.66
211_G215_Q0.5780.65
22_Q31_V0.5780.65
58_V91_V0.5780.65
224_S228_A0.5770.65
32_P56_G0.5760.65
259_I263_P0.5750.65
119_N402_V0.5740.65
214_G217_T0.5740.65
47_N65_V0.5730.65
327_P341_I0.5720.65
325_N345_E0.5710.64
58_V234_F0.5700.64
223_L227_T0.5690.64
194_S257_L0.5680.64
162_T165_S0.5680.64
285_V290_S0.5660.64
72_Q157_L0.5660.64
96_W158_R0.5640.64
283_Y323_S0.5630.63
53_D394_E0.5620.63
218_T383_W0.5600.63
265_L274_S0.5580.63
287_S295_V0.5580.63
71_L91_V0.5580.63
276_K280_E0.5570.63
248_L259_I0.5570.63
352_V356_E0.5570.63
132_L174_M0.5560.62
122_I175_D0.5540.62
382_P387_L0.5510.62
199_G249_S0.5510.62
201_K373_D0.5500.62
24_V66_P0.5500.62
98_N103_R0.5490.61
115_L162_T0.5490.61
93_S157_L0.5490.61
379_G388_F0.5480.61
261_A401_V0.5480.61
324_Q364_F0.5470.61
368_N391_D0.5470.61
330_V339_L0.5460.61
211_G217_T0.5440.61
75_V78_A0.5430.61
179_G269_H0.5430.61
218_T227_T0.5420.60
222_D228_A0.5410.60
53_D112_Q0.5400.60
65_V69_Q0.5400.60
327_P330_V0.5380.60
172_A210_A0.5370.60
83_R90_S0.5360.60
200_V243_L0.5360.60
255_Q371_G0.5340.59
227_T360_L0.5330.59
94_I98_N0.5310.59
42_E188_V0.5300.59
50_V59_S0.5290.59
179_G312_Q0.5290.59
200_V246_L0.5280.58
119_N158_R0.5280.58
346_I361_G0.5260.58
41_A46_L0.5240.58
139_L170_W0.5240.58
124_L127_A0.5230.58
122_I168_E0.5230.58
140_L163_A0.5220.58
92_H97_Q0.5210.57
271_Q319_K0.5200.57
336_G339_L0.5200.57
281_I297_F0.5200.57
169_Q371_G0.5180.57
324_Q344_Q0.5180.57
373_D390_H0.5180.57
130_G313_K0.5180.57
183_L275_I0.5170.57
150_K271_Q0.5170.57
231_H235_N0.5170.57
248_L273_A0.5160.57
72_Q95_A0.5130.56
328_G331_L0.5130.56
259_I367_K0.5130.56
212_G217_T0.5130.56
98_N101_I0.5130.56
65_V84_Q0.5110.56
24_V70_A0.5110.56
262_S277_Q0.5110.56
146_M270_L0.5090.56
72_Q139_L0.5070.55
261_A344_Q0.5070.55
367_K409_V0.5070.55
117_L158_R0.5060.55
236_I239_I0.5060.55
329_Q335_D0.5060.55
106_A111_A0.5060.55
234_F389_R0.5050.55
184_S262_S0.5040.55
210_A215_Q0.5030.55
36_V330_V0.5020.55
117_L121_S0.5020.55
378_L384_F0.5020.55
225_V228_A0.5020.55
384_F388_F0.5010.55
212_G215_Q0.5010.55
187_I336_G0.5010.55
183_L273_A0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4av2A 3 0.4175 100 0.184 Contact Map
2y3mA 2 0.3301 99.9 0.725 Contact Map
3gr5A 2 0.3641 99.9 0.734 Contact Map
3ossD 1 0.335 99.9 0.735 Contact Map
4e9jA 2 0.517 99.9 0.747 Contact Map
3ezjA 3 0.4684 99.8 0.759 Contact Map
4g08A 1 0.3325 99.8 0.763 Contact Map
4jtmA 2 0.1845 99.1 0.854 Contact Map
4ar0A 1 0.2864 99.1 0.854 Contact Map
4m0nA 1 0.2257 97.3 0.91 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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