GREMLIN Database
NAPA - Periplasmic nitrate reductase
UniProt: P33937 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12067
Length: 828 (765)
Sequences: 2808 (1623)
Seq/√Len: 58.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
758_L777_V7.0461.00
99_Q117_P5.6351.00
339_E349_K5.5261.00
273_N277_Q4.9451.00
125_D568_R4.9041.00
752_D788_G4.2971.00
342_A349_K4.2941.00
714_L756_R4.0591.00
255_N354_Q3.8551.00
768_S823_V3.7431.00
764_V777_V3.6541.00
748_I777_V3.6081.00
507_V519_A3.5761.00
765_K772_E3.5311.00
127_M521_L3.4791.00
274_Y278_N3.4131.00
270_Y341_T3.3021.00
547_Q550_Q3.2251.00
278_N357_Q3.0801.00
755_A787_Q3.0301.00
267_I355_L3.0201.00
337_T340_K2.9341.00
691_D695_V2.9021.00
133_T137_E2.8871.00
119_T122_Q2.8421.00
748_I825_L2.8201.00
267_I345_T2.7981.00
552_P555_A2.7621.00
767_V772_E2.7621.00
257_I347_V2.7161.00
208_A240_A2.7111.00
758_L764_V2.7071.00
556_K564_Q2.6591.00
751_L787_Q2.6311.00
241_V250_F2.6181.00
102_L118_I2.6161.00
54_G73_A2.5841.00
212_W268_L2.5751.00
279_N283_Q2.5491.00
348_P351_Q2.5291.00
238_T358_L2.5101.00
349_K353_E2.4671.00
753_A779_T2.4471.00
351_Q354_Q2.4211.00
474_N503_N2.4201.00
440_D443_E2.4191.00
127_M506_I2.3691.00
124_F568_R2.3561.00
126_V521_L2.3271.00
560_W564_Q2.3081.00
478_T515_S2.3001.00
439_R446_W2.2941.00
102_L116_T2.2901.00
564_Q568_R2.2831.00
443_E446_W2.2671.00
746_L764_V2.2281.00
283_Q287_S2.2031.00
765_K774_I2.2001.00
341_T352_L2.1901.00
104_M116_T2.1851.00
342_A352_L2.1581.00
439_R443_E2.1531.00
760_R779_T2.1301.00
118_I521_L2.1251.00
763_K774_I2.1031.00
272_A393_L2.0731.00
695_V698_A2.0621.00
280_A357_Q2.0581.00
207_D365_K2.0541.00
130_K133_T2.0511.00
266_V344_M2.0341.00
442_C447_N2.0321.00
714_L825_L2.0111.00
359_Y366_V2.0061.00
701_F704_A1.9981.00
100_P120_W1.9931.00
342_A348_P1.9911.00
98_T553_G1.9871.00
442_C446_W1.9751.00
134_A475_V1.9741.00
440_D447_N1.9531.00
102_L521_L1.9471.00
263_S344_M1.9421.00
440_D444_K1.9301.00
206_A209_F1.9281.00
64_V91_M1.8961.00
118_I122_Q1.8901.00
276_I326_F1.8841.00
208_A358_L1.8761.00
241_V253_A1.8631.00
99_Q554_E1.8611.00
255_N351_Q1.8471.00
257_I351_Q1.8381.00
274_Y338_L1.8371.00
442_C445_K1.8220.99
124_F564_Q1.8180.99
257_I355_L1.8180.99
56_L71_P1.8160.99
440_D446_W1.8090.99
122_Q126_V1.8040.99
359_Y394_T1.7760.99
120_W523_L1.7730.99
748_I758_L1.7700.99
271_I359_Y1.7590.99
102_L126_V1.7560.99
271_I356_A1.7560.99
127_M523_L1.7550.99
751_L754_K1.7540.99
271_I390_L1.7540.99
269_N333_V1.7490.99
313_A317_G1.7430.99
275_I390_L1.7360.99
314_K317_G1.7320.99
441_I444_K1.7310.99
766_V823_V1.7240.99
597_A600_E1.7220.99
104_M122_Q1.7140.99
750_P781_G1.7090.99
122_Q521_L1.7030.99
91_M549_V1.7020.99
117_P554_E1.6970.99
275_I281_I1.6950.99
756_R824_K1.6860.99
746_L775_S1.6790.99
263_S345_T1.6780.99
296_A328_D1.6670.99
374_F387_V1.6650.99
451_G454_P1.6620.99
681_G687_Y1.6610.99
314_K318_S1.6450.99
780_R784_R1.6390.99
315_N318_S1.6360.99
714_L752_D1.6260.99
312_A317_G1.6240.99
118_I126_V1.6230.99
274_Y357_Q1.6110.99
459_L467_A1.6090.99
447_N451_G1.6060.99
211_L249_S1.5980.99
439_R444_K1.5930.99
767_V824_K1.5900.99
743_E776_I1.5900.99
331_A334_A1.5880.99
746_L792_M1.5820.99
126_V130_K1.5750.99
104_M114_E1.5730.99
284_D287_S1.5690.98
798_A802_N1.5490.98
340_K343_E1.5450.98
556_K560_W1.5440.98
443_E449_P1.5420.98
280_A360_A1.5350.98
362_P366_V1.5330.98
281_I326_F1.5300.98
509_D513_T1.5060.98
121_D568_R1.5050.98
278_N353_E1.5020.98
261_P789_L1.5020.98
131_F475_V1.4970.98
689_K695_V1.4940.98
441_I446_W1.4940.98
439_R447_N1.4890.98
590_T593_E1.4860.98
684_Y687_Y1.4850.98
125_D129_E1.4760.98
691_D696_I1.4650.98
242_L267_I1.4620.98
719_G791_Y1.4470.97
118_I123_A1.4440.97
763_K776_I1.4440.97
500_D503_N1.4390.97
230_R237_V1.4380.97
298_D323_P1.4310.97
631_E635_W1.4300.97
57_V64_V1.4280.97
606_V610_A1.4270.97
353_E357_Q1.4180.97
443_E447_N1.4180.97
441_I449_P1.4180.97
746_L766_V1.4160.97
276_I281_I1.4160.97
440_D445_K1.4150.97
98_T101_L1.4080.97
207_D362_P1.4030.97
268_L387_V1.3910.97
694_A698_A1.3910.97
714_L749_H1.3900.97
329_Y333_V1.3890.97
100_P119_T1.3890.97
675_D679_K1.3810.97
268_L390_L1.3740.96
439_R449_P1.3730.96
446_W449_P1.3710.96
271_I275_I1.3700.96
238_T354_Q1.3670.96
132_K136_K1.3630.96
312_A315_N1.3590.96
753_A758_L1.3590.96
300_G303_L1.3580.96
284_D288_K1.3570.96
272_A333_V1.3570.96
523_L561_Q1.3570.96
477_W508_S1.3540.96
273_N334_A1.3530.96
790_V823_V1.3520.96
286_F393_L1.3460.96
714_L790_V1.3310.96
526_A555_A1.3160.95
568_R571_T1.3110.95
226_R229_N1.3100.95
760_R778_E1.2960.95
357_Q361_D1.2960.95
452_T455_A1.2950.95
671_S674_N1.2900.95
275_I360_A1.2850.95
101_L117_P1.2840.95
255_N355_L1.2820.95
444_K448_I1.2780.95
441_I447_N1.2760.95
444_K449_P1.2660.94
792_M801_V1.2640.94
255_N358_L1.2600.94
464_Q468_L1.2550.94
448_I452_T1.2500.94
463_A467_A1.2470.94
342_A347_V1.2460.94
38_A60_Q1.2460.94
208_A355_L1.2430.94
441_I445_K1.2410.94
134_A142_S1.2410.94
711_E824_K1.2380.94
313_A316_P1.2380.94
272_A329_Y1.2360.94
532_E547_Q1.2360.94
179_C182_S1.2310.93
210_V368_S1.2310.93
244_T258_I1.2290.93
606_V609_L1.2240.93
339_E353_E1.2230.93
592_Y598_T1.2230.93
508_S561_Q1.2230.93
238_T255_N1.2220.93
775_S792_M1.2180.93
102_L122_Q1.2150.93
259_F267_I1.2150.93
303_L306_T1.2140.93
282_N285_F1.2120.93
587_R590_T1.2060.93
655_G658_W1.2050.93
685_K688_G1.2040.93
445_K449_P1.1890.92
98_T117_P1.1840.92
444_K447_N1.1830.92
713_D756_R1.1830.92
607_S610_A1.1820.92
352_L356_A1.1800.92
440_D449_P1.1770.92
208_A359_Y1.1720.92
691_D694_A1.1680.92
588_G595_L1.1620.91
298_D321_S1.1610.91
646_P649_D1.1560.91
456_K461_A1.1550.91
639_G643_D1.1510.91
202_D205_Q1.1490.91
699_L703_P1.1450.91
41_W56_L1.1450.91
600_E604_F1.1400.91
276_I333_V1.1400.91
690_P693_K1.1380.90
445_K448_I1.1370.90
259_F347_V1.1360.90
478_T505_I1.1350.90
631_E634_A1.1340.90
211_L239_V1.1340.90
124_F565_F1.1310.90
507_V513_T1.1270.90
495_M499_R1.1250.90
244_T256_G1.1250.90
338_L353_E1.1240.90
456_K459_L1.1230.90
689_K698_A1.1210.90
57_V67_C1.1190.90
300_G305_P1.1150.90
773_V792_M1.1130.89
211_L241_V1.1110.89
316_P319_D1.1110.89
439_R445_K1.1100.89
231_R254_D1.1050.89
314_K320_A1.1050.89
124_F556_K1.1040.89
475_V504_F1.1040.89
651_H654_R1.1020.89
323_P327_E1.1010.89
399_Q402_C1.0990.89
681_G684_Y1.0990.89
446_W451_G1.0950.89
458_G461_A1.0940.89
313_A318_S1.0940.89
328_D331_A1.0890.88
55_V87_L1.0880.88
312_A316_P1.0860.88
42_D59_T1.0850.88
100_P523_L1.0850.88
699_L702_E1.0830.88
634_A638_R1.0830.88
210_V359_Y1.0790.88
56_L70_D1.0790.88
640_H644_L1.0790.88
592_Y596_Y1.0790.88
381_V810_D1.0760.88
703_P707_A1.0740.88
694_A697_F1.0730.88
87_L528_W1.0680.87
510_P527_M1.0670.87
210_V242_L1.0660.87
432_V437_K1.0640.87
44_A57_V1.0630.87
598_T604_F1.0620.87
571_T576_P1.0580.87
681_G686_F1.0580.87
655_G659_P1.0580.87
228_T231_R1.0570.87
691_D698_A1.0560.87
449_P452_T1.0560.87
274_Y280_A1.0540.87
267_I271_I1.0540.87
49_C53_C1.0540.87
131_F477_W1.0510.87
727_T794_F1.0490.86
686_F692_G1.0480.86
300_G304_R1.0460.86
139_G142_S1.0450.86
456_K460_H1.0430.86
657_R660_V1.0410.86
203_I367_I1.0400.86
603_K606_V1.0400.86
147_G150_Q1.0380.86
468_L471_G1.0360.86
396_K402_C1.0320.86
625_L628_G1.0310.86
323_P331_A1.0310.86
300_G306_T1.0310.86
599_P602_S1.0300.85
699_L704_A1.0290.85
507_V516_A1.0270.85
292_L393_L1.0270.85
689_K694_A1.0270.85
589_K593_E1.0250.85
221_P224_W1.0230.85
502_R505_I1.0230.85
488_P818_F1.0230.85
339_E342_A1.0200.85
631_E637_G1.0180.85
257_I267_I1.0170.85
208_A366_V1.0160.85
734_V737_L1.0150.85
379_R383_A1.0120.84
594_V598_T1.0110.84
338_L342_A1.0080.84
376_Q380_G1.0070.84
616_D620_E1.0070.84
240_A255_N1.0050.84
678_V683_G1.0040.84
439_R442_C1.0020.84
448_I454_P1.0010.84
726_H794_F1.0010.84
69_G78_G1.0000.84
596_Y601_V0.9980.84
641_G644_L0.9940.83
594_V597_A0.9920.83
746_L790_V0.9920.83
445_K451_G0.9920.83
185_V812_L0.9890.83
211_L227_I0.9890.83
689_K692_G0.9880.83
733_R737_L0.9870.83
207_D235_Q0.9830.83
608_E611_E0.9820.83
275_I394_T0.9820.83
640_H643_D0.9810.83
692_G696_I0.9790.82
229_N234_N0.9780.82
750_P754_K0.9780.82
675_D678_V0.9770.82
591_L598_T0.9760.82
629_L633_Y0.9740.82
286_F292_L0.9740.82
699_L705_A0.9730.82
683_G686_F0.9720.82
689_K693_K0.9670.82
482_N515_S0.9650.82
736_E739_R0.9640.81
703_P708_P0.9640.81
290_V392_L0.9620.81
105_K112_E0.9610.81
704_A707_A0.9580.81
63_R92_Y0.9550.81
210_V355_L0.9540.81
691_D697_F0.9540.81
629_L640_H0.9520.81
756_R825_L0.9520.81
749_H779_T0.9510.81
592_Y595_L0.9510.81
274_Y360_A0.9500.80
319_D326_F0.9500.80
431_M435_N0.9490.80
512_P522_I0.9480.80
340_K344_M0.9460.80
628_G631_E0.9440.80
475_V506_I0.9430.80
240_A358_L0.9390.80
626_Q629_L0.9380.80
259_F263_S0.9370.80
573_E576_P0.9360.79
656_L661_V0.9360.79
365_K399_Q0.9360.79
674_N678_V0.9340.79
588_G591_L0.9340.79
595_L598_T0.9340.79
701_F706_E0.9340.79
266_V270_Y0.9330.79
601_V604_F0.9310.79
273_N338_L0.9300.79
624_Y628_G0.9280.79
354_Q358_L0.9280.79
127_M477_W0.9260.79
190_T385_N0.9240.79
508_S525_T0.9240.79
594_V601_V0.9210.78
674_N677_Y0.9180.78
598_T603_K0.9170.78
212_W267_I0.9150.78
629_L634_A0.9150.78
759_R762_D0.9140.78
241_V249_S0.9140.78
658_W661_V0.9130.78
632_E635_W0.9130.78
616_D619_R0.9130.78
54_G70_D0.9110.78
146_F149_G0.9100.78
301_Y306_T0.9080.77
572_E575_W0.9060.77
157_Y161_K0.9050.77
208_A238_T0.9050.77
801_V804_L0.9050.77
714_L824_K0.9040.77
454_P457_I0.9040.77
692_G695_V0.9030.77
312_A318_S0.9030.77
676_P679_K0.9010.77
467_A472_K0.9010.77
587_R591_L0.8990.77
658_W665_E0.8970.77
459_L462_V0.8950.76
658_W662_N0.8950.76
43_K56_L0.8940.76
634_A643_D0.8940.76
689_K696_I0.8930.76
677_Y680_A0.8910.76
579_L582_K0.8910.76
628_G632_E0.8880.76
350_D353_E0.8870.76
218_E248_R0.8860.76
573_E577_E0.8810.75
599_P604_F0.8800.75
644_L649_D0.8800.75
338_L341_T0.8790.75
458_G462_V0.8750.75
274_Y353_E0.8750.75
329_Y332_F0.8720.74
566_S570_K0.8720.74
641_G645_A0.8720.74
572_E576_P0.8710.74
275_I359_Y0.8690.74
689_K697_F0.8680.74
655_G662_N0.8680.74
176_A181_A0.8680.74
693_K697_F0.8670.74
704_A708_P0.8660.74
225_S229_N0.8650.74
484_M490_I0.8630.74
525_T561_Q0.8630.74
105_K116_T0.8630.74
281_I393_L0.8630.74
645_A648_D0.8630.74
295_G321_S0.8630.74
497_G500_D0.8630.74
127_M504_F0.8620.74
39_I60_Q0.8620.74
299_I304_R0.8600.73
681_G685_K0.8590.73
178_H182_S0.8590.73
606_V611_E0.8580.73
101_L522_I0.8580.73
646_P683_G0.8560.73
659_P663_G0.8550.73
431_M437_K0.8550.73
590_T594_V0.8550.73
459_L468_L0.8540.73
42_D548_Q0.8540.73
684_Y692_G0.8530.73
46_C49_C0.8530.73
163_F169_S0.8520.73
265_L379_R0.8510.73
275_I279_N0.8510.73
130_K504_F0.8480.72
123_A523_L0.8450.72
457_I461_A0.8440.72
267_I352_L0.8430.72
716_L823_V0.8420.72
67_C87_L0.8410.72
609_L612_D0.8400.72
282_N399_Q0.8400.72
693_K696_I0.8390.72
799_Q805_T0.8380.72
652_K659_P0.8380.72
175_N180_M0.8360.71
301_Y304_R0.8360.71
432_V438_H0.8340.71
653_A657_R0.8340.71
632_E637_G0.8320.71
270_Y338_L0.8300.71
700_P708_P0.8270.70
442_C448_I0.8270.70
89_K736_E0.8270.70
642_H645_A0.8240.70
512_P517_L0.8220.70
593_E597_A0.8210.70
302_G306_T0.8210.70
120_W564_Q0.8200.70
638_R642_H0.8190.70
690_P698_A0.8190.70
639_G642_H0.8190.70
632_E640_H0.8180.70
634_A642_H0.8180.70
477_W565_F0.8160.69
321_S324_M0.8140.69
629_L637_G0.8100.69
56_L68_Q0.8070.69
104_M112_E0.8070.69
341_T345_T0.8060.69
589_K592_Y0.8060.69
475_V521_L0.8050.68
635_W639_G0.8050.68
120_W561_Q0.8040.68
238_T254_D0.8030.68
596_Y599_P0.8030.68
302_G305_P0.8030.68
343_E754_K0.8030.68
514_V797_A0.8010.68
637_G640_H0.8010.68
315_N319_D0.8000.68
276_I330_K0.7980.68
275_I393_L0.7980.68
242_L355_L0.7960.68
463_A466_R0.7960.68
714_L755_A0.7960.68
748_I764_V0.7950.67
296_A323_P0.7940.67
272_A276_I0.7910.67
655_G660_V0.7900.67
499_R505_I0.7890.67
634_A639_G0.7880.67
594_V599_P0.7880.67
212_W242_L0.7880.67
748_I790_V0.7870.67
680_A685_K0.7870.67
458_G468_L0.7870.67
779_T784_R0.7860.67
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42_D57_V0.5000.36
317_G322_E0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kqfA 3 0.942 100 0.216 Contact Map
3ml1A 1 0.9626 100 0.237 Contact Map
1h0hA 1 0.9457 100 0.249 Contact Map
1q16A 2 0.9867 100 0.254 Contact Map
2ivfA 1 0.9046 100 0.254 Contact Map
2vpzA 1 0.8164 100 0.278 Contact Map
2napA 1 0.8551 100 0.281 Contact Map
2iv2X 1 0.7983 100 0.284 Contact Map
2e7zA 1 0.8031 100 0.306 Contact Map
4aayA 6 0.8502 100 0.331 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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