NAPA - ECOLI - GREMLIN Contacts

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NAPA - Periplasmic nitrate reductase

UniProt:	P33937	Sequences: MKLSRRSFMKANAVAAAAAAAGLSVPGVARAVVGQQEAIKWDKAPCRFCGTGCGVLVGTQQGRVVACQGDPDAPVNRGLNCIKGYFLPKIMYGKDRLTQPLLRMKNGKYDKEGEFTPITWDQAFDVMEEKFKTALKEKGPESIGMFGSGQWTIWEGYAASKLFKAGFRSNNIDPNARHCMASAVVGFMRTFGMDEPMGCYDDIEQADAFVLWGANMAEMHPILWSRITNRRLSNQNVTVAVLSTYQHRSFELADNGIIFTPQSDLVILNYIANYIIQNNAINQDFFSKHVNLRKGATDIGYGLRPTHPLEKAAKNPGSDASEPMSFEDYKAFVAEYTLEKTAEMTGVPKDQLEQLAQLYADPNKKVISYWTMGFNQHTRGVWANNLVYNLHLLTGKISQPGCGPFSLTGQPSACGTAREVGTFAHRLPADMVVTNEKHRDICEKKWNIPSGTIPAKIGLHAVAQDRALKDGKLNVYWTMCTNNMQAGPNINEERMPGWRDPRNFIIVSDPYPTVSALAADLILPTAMWVEKEGAYGNAERRTQFWRQQVQAPGEAKSDLWQLVQFSRRFKTEEVWPEDLLAKKPELRGKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHDLAPFDDYHKARGLRWPVVNGKETQWRYSEGNDPYVKAGEGYKFYGKPDGKAVIFALPFEPAAEAPDEEYDLWLSTGRVLEHWHTGSMTRRVPELHRAFPEAVLFIHPLDAKARDLRRGDKVKVVSRRGEVISIVETRGRNRPPQGLVYMPFFDAAQLVNKLTLDATDPLSKETDFKKCAVKLEKV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12067
Length:	828 (765)
Sequences:	2808 (1623)
Seq/√Len:	58.7

ECOLI - NAPA YNFF FDOG FDNG DMSA YNFE TORA TORZ FDHF YDEP BISC NUOG NARZ NARG
BACSU - NASC YJGC YOAE FDHL YYAE NARG
HALSA - DMSA
SULSO - Q97XX8 Q97V13 Q97ZA1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
758_L	777_V	7.046	1.00
99_Q	117_P	5.635	1.00
339_E	349_K	5.526	1.00
273_N	277_Q	4.945	1.00
125_D	568_R	4.904	1.00
752_D	788_G	4.297	1.00
342_A	349_K	4.294	1.00
714_L	756_R	4.059	1.00
255_N	354_Q	3.855	1.00
768_S	823_V	3.743	1.00
764_V	777_V	3.654	1.00
748_I	777_V	3.608	1.00
507_V	519_A	3.576	1.00
765_K	772_E	3.531	1.00
127_M	521_L	3.479	1.00
274_Y	278_N	3.413	1.00
270_Y	341_T	3.302	1.00
547_Q	550_Q	3.225	1.00
278_N	357_Q	3.080	1.00
755_A	787_Q	3.030	1.00
267_I	355_L	3.020	1.00
337_T	340_K	2.934	1.00
691_D	695_V	2.902	1.00
133_T	137_E	2.887	1.00
119_T	122_Q	2.842	1.00
748_I	825_L	2.820	1.00
267_I	345_T	2.798	1.00
552_P	555_A	2.762	1.00
767_V	772_E	2.762	1.00
257_I	347_V	2.716	1.00
208_A	240_A	2.711	1.00
758_L	764_V	2.707	1.00
556_K	564_Q	2.659	1.00
751_L	787_Q	2.631	1.00
241_V	250_F	2.618	1.00
102_L	118_I	2.616	1.00
54_G	73_A	2.584	1.00
212_W	268_L	2.575	1.00
279_N	283_Q	2.549	1.00
348_P	351_Q	2.529	1.00
238_T	358_L	2.510	1.00
349_K	353_E	2.467	1.00
753_A	779_T	2.447	1.00
351_Q	354_Q	2.421	1.00
474_N	503_N	2.420	1.00
440_D	443_E	2.419	1.00
127_M	506_I	2.369	1.00
124_F	568_R	2.356	1.00
126_V	521_L	2.327	1.00
560_W	564_Q	2.308	1.00
478_T	515_S	2.300	1.00
439_R	446_W	2.294	1.00
102_L	116_T	2.290	1.00
564_Q	568_R	2.283	1.00
443_E	446_W	2.267	1.00
746_L	764_V	2.228	1.00
283_Q	287_S	2.203	1.00
765_K	774_I	2.200	1.00
341_T	352_L	2.190	1.00
104_M	116_T	2.185	1.00
342_A	352_L	2.158	1.00
439_R	443_E	2.153	1.00
760_R	779_T	2.130	1.00
118_I	521_L	2.125	1.00
763_K	774_I	2.103	1.00
272_A	393_L	2.073	1.00
695_V	698_A	2.062	1.00
280_A	357_Q	2.058	1.00
207_D	365_K	2.054	1.00
130_K	133_T	2.051	1.00
266_V	344_M	2.034	1.00
442_C	447_N	2.032	1.00
714_L	825_L	2.011	1.00
359_Y	366_V	2.006	1.00
701_F	704_A	1.998	1.00
100_P	120_W	1.993	1.00
342_A	348_P	1.991	1.00
98_T	553_G	1.987	1.00
442_C	446_W	1.975	1.00
134_A	475_V	1.974	1.00
440_D	447_N	1.953	1.00
102_L	521_L	1.947	1.00
263_S	344_M	1.942	1.00
440_D	444_K	1.930	1.00
206_A	209_F	1.928	1.00
64_V	91_M	1.896	1.00
118_I	122_Q	1.890	1.00
276_I	326_F	1.884	1.00
208_A	358_L	1.876	1.00
241_V	253_A	1.863	1.00
99_Q	554_E	1.861	1.00
255_N	351_Q	1.847	1.00
257_I	351_Q	1.838	1.00
274_Y	338_L	1.837	1.00
442_C	445_K	1.822	0.99
124_F	564_Q	1.818	0.99
257_I	355_L	1.818	0.99
56_L	71_P	1.816	0.99
440_D	446_W	1.809	0.99
122_Q	126_V	1.804	0.99
359_Y	394_T	1.776	0.99
120_W	523_L	1.773	0.99
748_I	758_L	1.770	0.99
271_I	359_Y	1.759	0.99
102_L	126_V	1.756	0.99
271_I	356_A	1.756	0.99
127_M	523_L	1.755	0.99
751_L	754_K	1.754	0.99
271_I	390_L	1.754	0.99
269_N	333_V	1.749	0.99
313_A	317_G	1.743	0.99
275_I	390_L	1.736	0.99
314_K	317_G	1.732	0.99
441_I	444_K	1.731	0.99
766_V	823_V	1.724	0.99
597_A	600_E	1.722	0.99
104_M	122_Q	1.714	0.99
750_P	781_G	1.709	0.99
122_Q	521_L	1.703	0.99
91_M	549_V	1.702	0.99
117_P	554_E	1.697	0.99
275_I	281_I	1.695	0.99
756_R	824_K	1.686	0.99
746_L	775_S	1.679	0.99
263_S	345_T	1.678	0.99
296_A	328_D	1.667	0.99
374_F	387_V	1.665	0.99
451_G	454_P	1.662	0.99
681_G	687_Y	1.661	0.99
314_K	318_S	1.645	0.99
780_R	784_R	1.639	0.99
315_N	318_S	1.636	0.99
714_L	752_D	1.626	0.99
312_A	317_G	1.624	0.99
118_I	126_V	1.623	0.99
274_Y	357_Q	1.611	0.99
459_L	467_A	1.609	0.99
447_N	451_G	1.606	0.99
211_L	249_S	1.598	0.99
439_R	444_K	1.593	0.99
767_V	824_K	1.590	0.99
743_E	776_I	1.590	0.99
331_A	334_A	1.588	0.99
746_L	792_M	1.582	0.99
126_V	130_K	1.575	0.99
104_M	114_E	1.573	0.99
284_D	287_S	1.569	0.98
798_A	802_N	1.549	0.98
340_K	343_E	1.545	0.98
556_K	560_W	1.544	0.98
443_E	449_P	1.542	0.98
280_A	360_A	1.535	0.98
362_P	366_V	1.533	0.98
281_I	326_F	1.530	0.98
509_D	513_T	1.506	0.98
121_D	568_R	1.505	0.98
278_N	353_E	1.502	0.98
261_P	789_L	1.502	0.98
131_F	475_V	1.497	0.98
689_K	695_V	1.494	0.98
441_I	446_W	1.494	0.98
439_R	447_N	1.489	0.98
590_T	593_E	1.486	0.98
684_Y	687_Y	1.485	0.98
125_D	129_E	1.476	0.98
691_D	696_I	1.465	0.98
242_L	267_I	1.462	0.98
719_G	791_Y	1.447	0.97
118_I	123_A	1.444	0.97
763_K	776_I	1.444	0.97
500_D	503_N	1.439	0.97
230_R	237_V	1.438	0.97
298_D	323_P	1.431	0.97
631_E	635_W	1.430	0.97
57_V	64_V	1.428	0.97
606_V	610_A	1.427	0.97
353_E	357_Q	1.418	0.97
443_E	447_N	1.418	0.97
441_I	449_P	1.418	0.97
746_L	766_V	1.416	0.97
276_I	281_I	1.416	0.97
440_D	445_K	1.415	0.97
98_T	101_L	1.408	0.97
207_D	362_P	1.403	0.97
268_L	387_V	1.391	0.97
694_A	698_A	1.391	0.97
714_L	749_H	1.390	0.97
329_Y	333_V	1.389	0.97
100_P	119_T	1.389	0.97
675_D	679_K	1.381	0.97
268_L	390_L	1.374	0.96
439_R	449_P	1.373	0.96
446_W	449_P	1.371	0.96
271_I	275_I	1.370	0.96
238_T	354_Q	1.367	0.96
132_K	136_K	1.363	0.96
312_A	315_N	1.359	0.96
753_A	758_L	1.359	0.96
300_G	303_L	1.358	0.96
284_D	288_K	1.357	0.96
272_A	333_V	1.357	0.96
523_L	561_Q	1.357	0.96
477_W	508_S	1.354	0.96
273_N	334_A	1.353	0.96
790_V	823_V	1.352	0.96
286_F	393_L	1.346	0.96
714_L	790_V	1.331	0.96
526_A	555_A	1.316	0.95
568_R	571_T	1.311	0.95
226_R	229_N	1.310	0.95
760_R	778_E	1.296	0.95
357_Q	361_D	1.296	0.95
452_T	455_A	1.295	0.95
671_S	674_N	1.290	0.95
275_I	360_A	1.285	0.95
101_L	117_P	1.284	0.95
255_N	355_L	1.282	0.95
444_K	448_I	1.278	0.95
441_I	447_N	1.276	0.95
444_K	449_P	1.266	0.94
792_M	801_V	1.264	0.94
255_N	358_L	1.260	0.94
464_Q	468_L	1.255	0.94
448_I	452_T	1.250	0.94
463_A	467_A	1.247	0.94
342_A	347_V	1.246	0.94
38_A	60_Q	1.246	0.94
208_A	355_L	1.243	0.94
441_I	445_K	1.241	0.94
134_A	142_S	1.241	0.94
711_E	824_K	1.238	0.94
313_A	316_P	1.238	0.94
272_A	329_Y	1.236	0.94
532_E	547_Q	1.236	0.94
179_C	182_S	1.231	0.93
210_V	368_S	1.231	0.93
244_T	258_I	1.229	0.93
606_V	609_L	1.224	0.93
339_E	353_E	1.223	0.93
592_Y	598_T	1.223	0.93
508_S	561_Q	1.223	0.93
238_T	255_N	1.222	0.93
775_S	792_M	1.218	0.93
102_L	122_Q	1.215	0.93
259_F	267_I	1.215	0.93
303_L	306_T	1.214	0.93
282_N	285_F	1.212	0.93
587_R	590_T	1.206	0.93
655_G	658_W	1.205	0.93
685_K	688_G	1.204	0.93
445_K	449_P	1.189	0.92
98_T	117_P	1.184	0.92
444_K	447_N	1.183	0.92
713_D	756_R	1.183	0.92
607_S	610_A	1.182	0.92
352_L	356_A	1.180	0.92
440_D	449_P	1.177	0.92
208_A	359_Y	1.172	0.92
691_D	694_A	1.168	0.92
588_G	595_L	1.162	0.91
298_D	321_S	1.161	0.91
646_P	649_D	1.156	0.91
456_K	461_A	1.155	0.91
639_G	643_D	1.151	0.91
202_D	205_Q	1.149	0.91
699_L	703_P	1.145	0.91
41_W	56_L	1.145	0.91
600_E	604_F	1.140	0.91
276_I	333_V	1.140	0.91
690_P	693_K	1.138	0.90
445_K	448_I	1.137	0.90
259_F	347_V	1.136	0.90
478_T	505_I	1.135	0.90
631_E	634_A	1.134	0.90
211_L	239_V	1.134	0.90
124_F	565_F	1.131	0.90
507_V	513_T	1.127	0.90
495_M	499_R	1.125	0.90
244_T	256_G	1.125	0.90
338_L	353_E	1.124	0.90
456_K	459_L	1.123	0.90
689_K	698_A	1.121	0.90
57_V	67_C	1.119	0.90
300_G	305_P	1.115	0.90
773_V	792_M	1.113	0.89
211_L	241_V	1.111	0.89
316_P	319_D	1.111	0.89
439_R	445_K	1.110	0.89
231_R	254_D	1.105	0.89
314_K	320_A	1.105	0.89
124_F	556_K	1.104	0.89
475_V	504_F	1.104	0.89
651_H	654_R	1.102	0.89
323_P	327_E	1.101	0.89
399_Q	402_C	1.099	0.89
681_G	684_Y	1.099	0.89
446_W	451_G	1.095	0.89
458_G	461_A	1.094	0.89
313_A	318_S	1.094	0.89
328_D	331_A	1.089	0.88
55_V	87_L	1.088	0.88
312_A	316_P	1.086	0.88
42_D	59_T	1.085	0.88
100_P	523_L	1.085	0.88
699_L	702_E	1.083	0.88
634_A	638_R	1.083	0.88
210_V	359_Y	1.079	0.88
56_L	70_D	1.079	0.88
640_H	644_L	1.079	0.88
592_Y	596_Y	1.079	0.88
381_V	810_D	1.076	0.88
703_P	707_A	1.074	0.88
694_A	697_F	1.073	0.88
87_L	528_W	1.068	0.87
510_P	527_M	1.067	0.87
210_V	242_L	1.066	0.87
432_V	437_K	1.064	0.87
44_A	57_V	1.063	0.87
598_T	604_F	1.062	0.87
571_T	576_P	1.058	0.87
681_G	686_F	1.058	0.87
655_G	659_P	1.058	0.87
228_T	231_R	1.057	0.87
691_D	698_A	1.056	0.87
449_P	452_T	1.056	0.87
274_Y	280_A	1.054	0.87
267_I	271_I	1.054	0.87
49_C	53_C	1.054	0.87
131_F	477_W	1.051	0.87
727_T	794_F	1.049	0.86
686_F	692_G	1.048	0.86
300_G	304_R	1.046	0.86
139_G	142_S	1.045	0.86
456_K	460_H	1.043	0.86
657_R	660_V	1.041	0.86
203_I	367_I	1.040	0.86
603_K	606_V	1.040	0.86
147_G	150_Q	1.038	0.86
468_L	471_G	1.036	0.86
396_K	402_C	1.032	0.86
625_L	628_G	1.031	0.86
323_P	331_A	1.031	0.86
300_G	306_T	1.031	0.86
599_P	602_S	1.030	0.85
699_L	704_A	1.029	0.85
507_V	516_A	1.027	0.85
292_L	393_L	1.027	0.85
689_K	694_A	1.027	0.85
589_K	593_E	1.025	0.85
221_P	224_W	1.023	0.85
502_R	505_I	1.023	0.85
488_P	818_F	1.023	0.85
339_E	342_A	1.020	0.85
631_E	637_G	1.018	0.85
257_I	267_I	1.017	0.85
208_A	366_V	1.016	0.85
734_V	737_L	1.015	0.85
379_R	383_A	1.012	0.84
594_V	598_T	1.011	0.84
338_L	342_A	1.008	0.84
376_Q	380_G	1.007	0.84
616_D	620_E	1.007	0.84
240_A	255_N	1.005	0.84
678_V	683_G	1.004	0.84
439_R	442_C	1.002	0.84
448_I	454_P	1.001	0.84
726_H	794_F	1.001	0.84
69_G	78_G	1.000	0.84
596_Y	601_V	0.998	0.84
641_G	644_L	0.994	0.83
594_V	597_A	0.992	0.83
746_L	790_V	0.992	0.83
445_K	451_G	0.992	0.83
185_V	812_L	0.989	0.83
211_L	227_I	0.989	0.83
689_K	692_G	0.988	0.83
733_R	737_L	0.987	0.83
207_D	235_Q	0.983	0.83
608_E	611_E	0.982	0.83
275_I	394_T	0.982	0.83
640_H	643_D	0.981	0.83
692_G	696_I	0.979	0.82
229_N	234_N	0.978	0.82
750_P	754_K	0.978	0.82
675_D	678_V	0.977	0.82
591_L	598_T	0.976	0.82
629_L	633_Y	0.974	0.82
286_F	292_L	0.974	0.82
699_L	705_A	0.973	0.82
683_G	686_F	0.972	0.82
689_K	693_K	0.967	0.82
482_N	515_S	0.965	0.82
736_E	739_R	0.964	0.81
703_P	708_P	0.964	0.81
290_V	392_L	0.962	0.81
105_K	112_E	0.961	0.81
704_A	707_A	0.958	0.81
63_R	92_Y	0.955	0.81
210_V	355_L	0.954	0.81
691_D	697_F	0.954	0.81
629_L	640_H	0.952	0.81
756_R	825_L	0.952	0.81
749_H	779_T	0.951	0.81
592_Y	595_L	0.951	0.81
274_Y	360_A	0.950	0.80
319_D	326_F	0.950	0.80
431_M	435_N	0.949	0.80
512_P	522_I	0.948	0.80
340_K	344_M	0.946	0.80
628_G	631_E	0.944	0.80
475_V	506_I	0.943	0.80
240_A	358_L	0.939	0.80
626_Q	629_L	0.938	0.80
259_F	263_S	0.937	0.80
573_E	576_P	0.936	0.79
656_L	661_V	0.936	0.79
365_K	399_Q	0.936	0.79
674_N	678_V	0.934	0.79
588_G	591_L	0.934	0.79
595_L	598_T	0.934	0.79
701_F	706_E	0.934	0.79
266_V	270_Y	0.933	0.79
601_V	604_F	0.931	0.79
273_N	338_L	0.930	0.79
624_Y	628_G	0.928	0.79
354_Q	358_L	0.928	0.79
127_M	477_W	0.926	0.79
190_T	385_N	0.924	0.79
508_S	525_T	0.924	0.79
594_V	601_V	0.921	0.78
674_N	677_Y	0.918	0.78
598_T	603_K	0.917	0.78
212_W	267_I	0.915	0.78
629_L	634_A	0.915	0.78
759_R	762_D	0.914	0.78
241_V	249_S	0.914	0.78
658_W	661_V	0.913	0.78
632_E	635_W	0.913	0.78
616_D	619_R	0.913	0.78
54_G	70_D	0.911	0.78
146_F	149_G	0.910	0.78
301_Y	306_T	0.908	0.77
572_E	575_W	0.906	0.77
157_Y	161_K	0.905	0.77
208_A	238_T	0.905	0.77
801_V	804_L	0.905	0.77
714_L	824_K	0.904	0.77
454_P	457_I	0.904	0.77
692_G	695_V	0.903	0.77
312_A	318_S	0.903	0.77
676_P	679_K	0.901	0.77
467_A	472_K	0.901	0.77
587_R	591_L	0.899	0.77
658_W	665_E	0.897	0.77
459_L	462_V	0.895	0.76
658_W	662_N	0.895	0.76
43_K	56_L	0.894	0.76
634_A	643_D	0.894	0.76
689_K	696_I	0.893	0.76
677_Y	680_A	0.891	0.76
579_L	582_K	0.891	0.76
628_G	632_E	0.888	0.76
350_D	353_E	0.887	0.76
218_E	248_R	0.886	0.76
573_E	577_E	0.881	0.75
599_P	604_F	0.880	0.75
644_L	649_D	0.880	0.75
338_L	341_T	0.879	0.75
458_G	462_V	0.875	0.75
274_Y	353_E	0.875	0.75
329_Y	332_F	0.872	0.74
566_S	570_K	0.872	0.74
641_G	645_A	0.872	0.74
572_E	576_P	0.871	0.74
275_I	359_Y	0.869	0.74
689_K	697_F	0.868	0.74
655_G	662_N	0.868	0.74
176_A	181_A	0.868	0.74
693_K	697_F	0.867	0.74
704_A	708_P	0.866	0.74
225_S	229_N	0.865	0.74
484_M	490_I	0.863	0.74
525_T	561_Q	0.863	0.74
105_K	116_T	0.863	0.74
281_I	393_L	0.863	0.74
645_A	648_D	0.863	0.74
295_G	321_S	0.863	0.74
497_G	500_D	0.863	0.74
127_M	504_F	0.862	0.74
39_I	60_Q	0.862	0.74
299_I	304_R	0.860	0.73
681_G	685_K	0.859	0.73
178_H	182_S	0.859	0.73
606_V	611_E	0.858	0.73
101_L	522_I	0.858	0.73
646_P	683_G	0.856	0.73
659_P	663_G	0.855	0.73
431_M	437_K	0.855	0.73
590_T	594_V	0.855	0.73
459_L	468_L	0.854	0.73
42_D	548_Q	0.854	0.73
684_Y	692_G	0.853	0.73
46_C	49_C	0.853	0.73
163_F	169_S	0.852	0.73
265_L	379_R	0.851	0.73
275_I	279_N	0.851	0.73
130_K	504_F	0.848	0.72
123_A	523_L	0.845	0.72
457_I	461_A	0.844	0.72
267_I	352_L	0.843	0.72
716_L	823_V	0.842	0.72
67_C	87_L	0.841	0.72
609_L	612_D	0.840	0.72
282_N	399_Q	0.840	0.72
693_K	696_I	0.839	0.72
799_Q	805_T	0.838	0.72
652_K	659_P	0.838	0.72
175_N	180_M	0.836	0.71
301_Y	304_R	0.836	0.71
432_V	438_H	0.834	0.71
653_A	657_R	0.834	0.71
632_E	637_G	0.832	0.71
270_Y	338_L	0.830	0.71
700_P	708_P	0.827	0.70
442_C	448_I	0.827	0.70
89_K	736_E	0.827	0.70
642_H	645_A	0.824	0.70
512_P	517_L	0.822	0.70
593_E	597_A	0.821	0.70
302_G	306_T	0.821	0.70
120_W	564_Q	0.820	0.70
638_R	642_H	0.819	0.70
690_P	698_A	0.819	0.70
639_G	642_H	0.819	0.70
632_E	640_H	0.818	0.70
634_A	642_H	0.818	0.70
477_W	565_F	0.816	0.69
321_S	324_M	0.814	0.69
629_L	637_G	0.810	0.69
56_L	68_Q	0.807	0.69
104_M	112_E	0.807	0.69
341_T	345_T	0.806	0.69
589_K	592_Y	0.806	0.69
475_V	521_L	0.805	0.68
635_W	639_G	0.805	0.68
120_W	561_Q	0.804	0.68
238_T	254_D	0.803	0.68
596_Y	599_P	0.803	0.68
302_G	305_P	0.803	0.68
343_E	754_K	0.803	0.68
514_V	797_A	0.801	0.68
637_G	640_H	0.801	0.68
315_N	319_D	0.800	0.68
276_I	330_K	0.798	0.68
275_I	393_L	0.798	0.68
242_L	355_L	0.796	0.68
463_A	466_R	0.796	0.68
714_L	755_A	0.796	0.68
748_I	764_V	0.795	0.67
296_A	323_P	0.794	0.67
272_A	276_I	0.791	0.67
655_G	660_V	0.790	0.67
499_R	505_I	0.789	0.67
634_A	639_G	0.788	0.67
594_V	599_P	0.788	0.67
212_W	242_L	0.788	0.67
748_I	790_V	0.787	0.67
680_A	685_K	0.787	0.67
458_G	468_L	0.787	0.67
779_T	784_R	0.786	0.67
681_G	688_G	0.786	0.67
314_K	319_D	0.786	0.67
596_Y	600_E	0.786	0.67
465_D	468_L	0.785	0.66
342_A	356_A	0.785	0.66
496_P	499_R	0.784	0.66
443_E	448_I	0.783	0.66
332_F	335_E	0.783	0.66
595_L	603_K	0.783	0.66
430_D	433_V	0.782	0.66
499_R	515_S	0.782	0.66
692_G	698_A	0.782	0.66
659_P	662_N	0.781	0.66
700_P	703_P	0.781	0.66
46_C	53_C	0.781	0.66
313_A	319_D	0.781	0.66
477_W	506_I	0.779	0.66
238_T	364_K	0.779	0.66
458_G	464_Q	0.778	0.66
204_E	229_N	0.778	0.66
628_G	635_W	0.778	0.66
571_T	575_W	0.777	0.66
368_S	387_V	0.775	0.65
280_A	361_D	0.775	0.65
60_Q	65_V	0.774	0.65
587_R	599_P	0.774	0.65
99_Q	119_T	0.774	0.65
633_Y	640_H	0.773	0.65
226_R	230_R	0.772	0.65
457_I	460_H	0.771	0.65
53_C	81_C	0.771	0.65
104_M	113_G	0.770	0.65
317_G	320_A	0.770	0.65
176_A	180_M	0.770	0.65
242_L	257_I	0.768	0.65
342_A	353_E	0.768	0.65
457_I	462_V	0.768	0.65
775_S	799_Q	0.768	0.65
647_F	651_H	0.766	0.65
460_H	463_A	0.765	0.64
179_C	731_T	0.765	0.64
187_F	194_D	0.765	0.64
654_R	662_N	0.764	0.64
675_D	682_E	0.763	0.64
292_L	326_F	0.761	0.64
346_G	786_P	0.760	0.64
77_R	229_N	0.760	0.64
591_L	594_V	0.759	0.64
636_F	642_H	0.759	0.64
654_R	658_W	0.757	0.64
430_D	435_N	0.757	0.64
636_F	641_G	0.757	0.64
587_R	593_E	0.757	0.64
259_F	345_T	0.755	0.63
204_E	235_Q	0.755	0.63
591_L	595_L	0.754	0.63
131_F	167_F	0.754	0.63
448_I	451_G	0.754	0.63
135_L	143_I	0.753	0.63
556_K	561_Q	0.753	0.63
576_P	581_A	0.752	0.63
720_R	726_H	0.749	0.63
57_V	548_Q	0.747	0.63
633_Y	637_G	0.747	0.63
645_A	649_D	0.747	0.63
580_L	583_K	0.747	0.63
607_S	611_E	0.746	0.63
487_G	490_I	0.745	0.62
335_E	700_P	0.744	0.62
680_A	687_Y	0.744	0.62
597_A	604_F	0.744	0.62
677_Y	682_E	0.743	0.62
588_G	596_Y	0.742	0.62
372_M	720_R	0.742	0.62
497_G	501_P	0.741	0.62
496_P	500_D	0.740	0.62
721_V	793_P	0.740	0.62
595_L	599_P	0.738	0.62
256_G	347_V	0.737	0.62
241_V	247_H	0.737	0.62
674_N	679_K	0.736	0.61
306_T	311_K	0.736	0.61
766_V	825_L	0.736	0.61
338_L	349_K	0.733	0.61
115_F	118_I	0.732	0.61
512_P	516_A	0.730	0.61
299_I	302_G	0.730	0.61
138_K	142_S	0.730	0.61
129_E	133_T	0.730	0.61
359_Y	368_S	0.729	0.61
680_A	686_F	0.729	0.61
318_S	321_S	0.729	0.61
128_E	569_F	0.729	0.61
683_G	690_P	0.728	0.61
598_T	601_V	0.728	0.61
186_G	190_T	0.727	0.61
700_P	704_A	0.727	0.61
453_I	714_L	0.726	0.60
270_Y	340_K	0.725	0.60
592_Y	601_V	0.724	0.60
202_D	373_G	0.724	0.60
263_S	766_V	0.723	0.60
53_C	84_G	0.723	0.60
138_K	474_N	0.722	0.60
206_A	367_I	0.722	0.60
40_K	62_G	0.722	0.60
459_L	465_D	0.722	0.60
597_A	602_S	0.721	0.60
744_A	796_D	0.720	0.60
754_K	759_R	0.718	0.60
605_P	609_L	0.717	0.59
463_A	468_L	0.717	0.59
657_R	661_V	0.717	0.59
295_G	324_M	0.717	0.59
345_T	352_L	0.716	0.59
456_K	462_V	0.715	0.59
588_G	594_V	0.712	0.59
322_E	325_S	0.712	0.59
661_V	664_K	0.711	0.59
635_W	638_R	0.711	0.59
609_L	614_L	0.711	0.59
674_N	680_A	0.711	0.59
193_M	670_Y	0.710	0.59
647_F	652_K	0.710	0.59
270_Y	274_Y	0.709	0.59
297_T	320_A	0.709	0.59
595_L	604_F	0.709	0.59
200_Y	538_A	0.708	0.58
182_S	815_E	0.708	0.58
324_M	327_E	0.707	0.58
246_Q	784_R	0.706	0.58
662_N	665_E	0.706	0.58
208_A	361_D	0.705	0.58
797_A	810_D	0.705	0.58
208_A	255_N	0.705	0.58
622_G	625_L	0.705	0.58
67_C	88_P	0.704	0.58
338_L	356_A	0.703	0.58
368_S	391_H	0.703	0.58
525_T	558_D	0.703	0.58
442_C	449_P	0.703	0.58
634_A	640_H	0.702	0.58
630_F	637_G	0.700	0.58
556_K	568_R	0.700	0.58
268_L	374_F	0.698	0.57
203_I	369_Y	0.697	0.57
361_D	364_K	0.697	0.57
625_L	641_G	0.696	0.57
804_L	808_A	0.696	0.57
701_F	708_P	0.695	0.57
258_I	261_P	0.694	0.57
731_T	737_L	0.693	0.57
655_G	664_K	0.693	0.57
588_G	603_K	0.692	0.57
487_G	727_T	0.691	0.57
613_Q	621_L	0.690	0.57
595_L	602_S	0.690	0.57
457_I	465_D	0.690	0.57
129_E	132_K	0.689	0.56
510_P	525_T	0.689	0.56
464_Q	476_Y	0.689	0.56
488_P	816_T	0.687	0.56
656_L	659_P	0.687	0.56
591_L	599_P	0.687	0.56
576_P	579_L	0.686	0.56
272_A	389_N	0.686	0.56
705_A	708_P	0.685	0.56
678_V	681_G	0.685	0.56
657_R	665_E	0.684	0.56
621_L	627_K	0.684	0.56
612_D	615_N	0.684	0.56
716_L	821_C	0.683	0.56
478_T	507_V	0.683	0.56
299_I	305_P	0.682	0.56
258_I	351_Q	0.681	0.56
683_G	687_Y	0.681	0.56
766_V	792_M	0.680	0.55
143_I	167_F	0.679	0.55
234_N	237_V	0.678	0.55
356_A	390_L	0.678	0.55
390_L	393_L	0.677	0.55
379_R	820_K	0.675	0.55
242_L	345_T	0.673	0.55
127_M	130_K	0.673	0.55
596_Y	602_S	0.673	0.55
656_L	660_V	0.672	0.55
175_N	182_S	0.671	0.54
660_V	665_E	0.671	0.54
102_L	105_K	0.671	0.54
258_I	786_P	0.671	0.54
300_G	311_K	0.671	0.54
653_A	656_L	0.669	0.54
441_I	448_I	0.668	0.54
372_M	376_Q	0.668	0.54
211_L	214_A	0.667	0.54
748_I	785_P	0.667	0.54
212_W	271_I	0.666	0.54
210_V	267_I	0.665	0.54
681_G	694_A	0.665	0.54
593_E	596_Y	0.665	0.54
732_R	737_L	0.664	0.54
504_F	521_L	0.663	0.54
591_L	600_E	0.663	0.54
316_P	320_A	0.663	0.54
69_G	80_N	0.662	0.53
724_H	731_T	0.662	0.53
481_T	487_G	0.661	0.53
644_L	647_F	0.661	0.53
634_A	637_G	0.661	0.53
457_I	463_A	0.661	0.53
526_A	551_A	0.660	0.53
657_R	662_N	0.658	0.53
785_P	791_Y	0.657	0.53
245_Y	717_S	0.656	0.53
672_E	683_G	0.656	0.53
608_E	613_Q	0.655	0.53
686_F	689_K	0.655	0.53
339_E	755_A	0.655	0.53
690_P	695_V	0.654	0.53
595_L	601_V	0.653	0.52
366_V	396_K	0.653	0.52
747_F	780_R	0.652	0.52
792_M	804_L	0.652	0.52
693_K	698_A	0.651	0.52
325_S	328_D	0.651	0.52
205_Q	400_P	0.650	0.52
383_A	387_V	0.650	0.52
669_R	672_E	0.650	0.52
632_E	639_G	0.648	0.52
68_Q	71_P	0.648	0.52
314_K	321_S	0.647	0.52
266_V	342_A	0.647	0.52
596_Y	603_K	0.647	0.52
605_P	608_E	0.646	0.52
637_G	641_G	0.646	0.52
628_G	634_A	0.646	0.52
137_E	503_N	0.646	0.52
185_V	381_V	0.645	0.52
625_L	629_L	0.645	0.52
128_E	568_R	0.644	0.51
676_P	683_G	0.642	0.51
629_L	636_F	0.641	0.51
301_Y	305_P	0.641	0.51
563_V	567_R	0.640	0.51
577_E	581_A	0.640	0.51
690_P	700_P	0.640	0.51
55_V	67_C	0.639	0.51
124_F	560_W	0.639	0.51
655_G	661_V	0.639	0.51
247_H	250_F	0.639	0.51
464_Q	467_A	0.636	0.51
276_I	293_R	0.636	0.51
49_C	81_C	0.636	0.51
702_E	707_A	0.634	0.50
119_T	123_A	0.634	0.50
266_V	330_K	0.634	0.50
122_Q	129_E	0.634	0.50
587_R	597_A	0.633	0.50
745_V	778_E	0.632	0.50
569_F	602_S	0.632	0.50
79_L	225_S	0.632	0.50
230_R	236_N	0.631	0.50
62_G	714_L	0.631	0.50
179_C	186_G	0.631	0.50
650_Y	655_G	0.630	0.50
461_A	464_Q	0.630	0.50
656_L	662_N	0.629	0.50
465_D	727_T	0.629	0.50
637_G	644_L	0.628	0.50
594_V	600_E	0.628	0.50
592_Y	602_S	0.627	0.50
269_N	386_L	0.627	0.50
579_L	583_K	0.627	0.50
462_V	468_L	0.622	0.49
320_A	324_M	0.622	0.49
635_W	640_H	0.620	0.49
269_N	336_Y	0.620	0.49
162_L	165_A	0.620	0.49
41_W	58_G	0.620	0.49
160_S	164_K	0.620	0.49
178_H	181_A	0.620	0.49
688_G	696_I	0.619	0.49
239_V	252_L	0.618	0.49
655_G	663_G	0.618	0.49
240_A	355_L	0.618	0.49
581_A	585_E	0.617	0.48
628_G	633_Y	0.616	0.48
686_F	693_K	0.616	0.48
268_L	386_L	0.615	0.48
284_D	579_L	0.615	0.48
592_Y	599_P	0.615	0.48
285_F	399_Q	0.614	0.48
478_T	481_T	0.614	0.48
354_Q	357_Q	0.614	0.48
590_T	599_P	0.613	0.48
588_G	593_E	0.613	0.48
611_E	615_N	0.613	0.48
586_L	595_L	0.612	0.48
444_K	451_G	0.611	0.48
176_A	179_C	0.611	0.48
606_V	613_Q	0.611	0.48
770_R	805_T	0.611	0.48
39_I	58_G	0.610	0.48
347_V	351_Q	0.609	0.48
372_M	375_N	0.609	0.48
43_K	72_D	0.609	0.48
63_R	825_L	0.608	0.47
660_V	663_G	0.608	0.47
587_R	598_T	0.607	0.47
161_K	164_K	0.606	0.47
451_G	455_A	0.605	0.47
488_P	794_F	0.605	0.47
590_T	598_T	0.605	0.47
432_V	435_N	0.604	0.47
660_V	664_K	0.604	0.47
261_P	820_K	0.604	0.47
448_I	453_I	0.603	0.47
714_L	753_A	0.602	0.47
126_V	504_F	0.602	0.47
748_I	779_T	0.601	0.47
592_Y	597_A	0.601	0.47
576_P	580_L	0.600	0.47
426_R	429_A	0.599	0.46
654_R	659_P	0.599	0.46
631_E	639_G	0.599	0.46
210_V	271_I	0.599	0.46
508_S	558_D	0.599	0.46
614_L	618_S	0.598	0.46
486_A	515_S	0.597	0.46
266_V	340_K	0.597	0.46
582_K	585_E	0.597	0.46
563_V	625_L	0.597	0.46
749_H	753_A	0.597	0.46
683_G	688_G	0.596	0.46
335_E	340_K	0.594	0.46
758_L	779_T	0.594	0.46
41_W	68_Q	0.594	0.46
677_Y	681_G	0.593	0.46
650_Y	654_R	0.592	0.46
629_L	635_W	0.591	0.46
658_W	664_K	0.591	0.46
684_Y	688_G	0.590	0.45
593_E	600_E	0.590	0.45
747_F	784_R	0.589	0.45
44_A	55_V	0.589	0.45
270_Y	352_L	0.589	0.45
458_G	463_A	0.588	0.45
682_E	685_K	0.588	0.45
587_R	595_L	0.588	0.45
576_P	582_K	0.587	0.45
375_N	383_A	0.586	0.45
679_K	685_K	0.586	0.45
617_E	621_L	0.586	0.45
688_G	698_A	0.586	0.45
245_Y	747_F	0.585	0.45
714_L	788_G	0.585	0.45
690_P	697_F	0.585	0.45
423_F	428_P	0.585	0.45
605_P	613_Q	0.584	0.45
214_A	369_Y	0.584	0.45
637_G	642_H	0.583	0.45
589_K	603_K	0.583	0.45
42_D	546_R	0.583	0.45
610_A	614_L	0.582	0.45
461_A	465_D	0.582	0.45
120_W	556_K	0.581	0.44
604_F	607_S	0.581	0.44
766_V	775_S	0.581	0.44
681_G	691_D	0.581	0.44
717_S	789_L	0.580	0.44
620_E	625_L	0.580	0.44
595_L	600_E	0.580	0.44
592_Y	600_E	0.579	0.44
624_Y	629_L	0.579	0.44
312_A	321_S	0.579	0.44
86_F	737_L	0.579	0.44
633_Y	636_F	0.579	0.44
599_P	603_K	0.578	0.44
105_K	113_G	0.577	0.44
283_Q	286_F	0.575	0.44
357_Q	360_A	0.575	0.44
243_S	250_F	0.574	0.44
605_P	610_A	0.574	0.44
477_W	505_I	0.573	0.44
272_A	390_L	0.573	0.44
474_N	502_R	0.573	0.44
605_P	611_E	0.571	0.43
453_I	748_I	0.571	0.43
175_N	179_C	0.568	0.43
755_A	788_G	0.568	0.43
638_R	643_D	0.568	0.43
601_V	607_S	0.568	0.43
242_L	492_E	0.568	0.43
448_I	455_A	0.567	0.43
657_R	663_G	0.567	0.43
578_D	582_K	0.567	0.43
342_A	350_D	0.567	0.43
69_G	73_A	0.567	0.43
625_L	630_F	0.567	0.43
279_N	790_V	0.566	0.43
460_H	468_L	0.566	0.43
177_R	181_A	0.566	0.43
744_A	801_V	0.566	0.43
591_L	596_Y	0.565	0.43
336_Y	344_M	0.565	0.43
732_R	739_R	0.564	0.43
680_A	683_G	0.564	0.43
353_E	746_L	0.563	0.43
625_L	633_Y	0.563	0.43
602_S	606_V	0.563	0.43
770_R	821_C	0.562	0.42
210_V	366_V	0.562	0.42
227_I	239_V	0.562	0.42
679_K	683_G	0.561	0.42
82_I	722_L	0.560	0.42
121_D	712_Y	0.560	0.42
613_Q	619_R	0.559	0.42
613_Q	617_E	0.558	0.42
578_D	581_A	0.558	0.42
173_D	178_H	0.558	0.42
798_A	801_V	0.558	0.42
799_Q	802_N	0.556	0.42
623_F	627_K	0.556	0.42
80_N	85_Y	0.556	0.42
627_K	631_E	0.555	0.42
467_A	474_N	0.555	0.42
701_F	705_A	0.555	0.42
673_G	677_Y	0.554	0.42
630_F	633_Y	0.554	0.42
135_L	167_F	0.553	0.41
211_L	242_L	0.552	0.41
248_R	784_R	0.551	0.41
373_G	810_D	0.551	0.41
270_Y	353_E	0.550	0.41
479_M	562_L	0.550	0.41
133_T	136_K	0.550	0.41
644_L	648_D	0.550	0.41
171_N	471_G	0.550	0.41
216_M	219_M	0.549	0.41
659_P	665_E	0.549	0.41
703_P	706_E	0.549	0.41
338_L	352_L	0.548	0.41
692_G	697_F	0.548	0.41
515_S	794_F	0.547	0.41
483_N	515_S	0.547	0.41
267_I	347_V	0.546	0.41
39_I	42_D	0.546	0.41
415_G	419_E	0.546	0.41
427_L	431_M	0.545	0.41
702_E	706_E	0.544	0.40
647_F	650_Y	0.544	0.40
509_D	565_F	0.544	0.40
125_D	560_W	0.544	0.40
140_P	143_I	0.543	0.40
116_T	122_Q	0.542	0.40
208_A	354_Q	0.542	0.40
242_L	820_K	0.541	0.40
46_C	84_G	0.541	0.40
680_A	684_Y	0.541	0.40
315_N	320_A	0.541	0.40
571_T	581_A	0.540	0.40
636_F	639_G	0.539	0.40
48_F	79_L	0.539	0.40
277_Q	281_I	0.539	0.40
658_W	663_G	0.539	0.40
590_T	607_S	0.538	0.40
676_P	681_G	0.538	0.40
603_K	607_S	0.538	0.40
702_E	708_P	0.537	0.40
100_P	556_K	0.537	0.40
58_G	68_Q	0.536	0.40
180_M	371_T	0.536	0.40
355_L	358_L	0.536	0.40
285_F	773_V	0.535	0.40
175_N	181_A	0.535	0.40
341_T	344_M	0.535	0.40
467_A	470_D	0.533	0.39
632_E	642_H	0.533	0.39
273_N	340_K	0.533	0.39
616_D	621_L	0.532	0.39
396_K	399_Q	0.532	0.39
102_L	130_K	0.531	0.39
326_F	393_L	0.531	0.39
598_T	602_S	0.531	0.39
686_F	690_P	0.530	0.39
59_T	116_T	0.530	0.39
83_K	795_F	0.528	0.39
148_S	154_W	0.528	0.39
269_N	272_A	0.528	0.39
597_A	603_K	0.527	0.39
590_T	601_V	0.527	0.39
751_L	781_G	0.527	0.39
744_A	793_P	0.527	0.39
273_N	337_T	0.527	0.39
619_R	624_Y	0.527	0.39
687_Y	691_D	0.527	0.39
330_K	334_A	0.526	0.39
613_Q	616_D	0.526	0.39
688_G	697_F	0.526	0.39
600_E	605_P	0.525	0.38
355_L	724_H	0.525	0.38
461_A	468_L	0.524	0.38
468_L	473_L	0.522	0.38
78_G	720_R	0.522	0.38
630_F	643_D	0.521	0.38
711_E	759_R	0.521	0.38
408_T	414_C	0.520	0.38
415_G	533_G	0.520	0.38
604_F	610_A	0.518	0.38
505_I	515_S	0.518	0.38
617_E	620_E	0.518	0.38
487_G	816_T	0.518	0.38
721_V	724_H	0.518	0.38
199_C	539_E	0.516	0.38
678_V	687_Y	0.516	0.38
626_Q	640_H	0.516	0.38
756_R	790_V	0.516	0.38
795_F	815_E	0.516	0.38
145_M	163_F	0.516	0.38
48_F	83_K	0.516	0.38
449_P	454_P	0.516	0.38
236_N	254_D	0.515	0.37
711_E	769_R	0.515	0.37
324_M	328_D	0.514	0.37
179_C	185_V	0.514	0.37
101_L	516_A	0.514	0.37
187_F	388_Y	0.514	0.37
423_F	436_E	0.514	0.37
604_F	608_E	0.513	0.37
428_P	438_H	0.513	0.37
713_D	758_L	0.513	0.37
125_D	128_E	0.513	0.37
131_F	506_I	0.512	0.37
656_L	663_G	0.512	0.37
654_R	661_V	0.511	0.37
631_E	642_H	0.511	0.37
578_D	583_K	0.511	0.37
439_R	448_I	0.511	0.37
418_R	423_F	0.510	0.37
588_G	592_Y	0.510	0.37
591_L	597_A	0.510	0.37
589_K	594_V	0.510	0.37
654_R	657_R	0.510	0.37
135_L	138_K	0.510	0.37
369_Y	746_L	0.509	0.37
805_T	821_C	0.509	0.37
594_V	603_K	0.509	0.37
590_T	595_L	0.509	0.37
178_H	818_F	0.508	0.37
43_K	54_G	0.508	0.37
229_N	825_L	0.508	0.37
55_V	80_N	0.508	0.37
277_Q	334_A	0.508	0.37
458_G	467_A	0.508	0.37
572_E	577_E	0.507	0.37
468_L	472_K	0.507	0.37
64_V	549_V	0.507	0.37
680_A	688_G	0.506	0.36
588_G	599_P	0.505	0.36
752_D	779_T	0.505	0.36
119_T	129_E	0.505	0.36
227_I	252_L	0.504	0.36
186_G	384_N	0.504	0.36
435_N	438_H	0.503	0.36
648_D	652_K	0.503	0.36
348_P	604_F	0.503	0.36
122_Q	133_T	0.503	0.36
610_A	613_Q	0.502	0.36
593_E	599_P	0.502	0.36
713_D	787_Q	0.502	0.36
347_V	355_L	0.502	0.36
118_I	789_L	0.502	0.36
749_H	787_Q	0.501	0.36
294_K	324_M	0.501	0.36
630_F	642_H	0.501	0.36
637_G	643_D	0.500	0.36
42_D	57_V	0.500	0.36
317_G	322_E	0.500	0.36

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1kqfA	3	0.942	100	0.216	Contact Map
3ml1A	1	0.9626	100	0.237	Contact Map
1h0hA	1	0.9457	100	0.249	Contact Map
1q16A	2	0.9867	100	0.254	Contact Map
2ivfA	1	0.9046	100	0.254	Contact Map
2vpzA	1	0.8164	100	0.278	Contact Map
2napA	1	0.8551	100	0.281	Contact Map
2iv2X	1	0.7983	100	0.284	Contact Map
2e7zA	1	0.8031	100	0.306	Contact Map
4aayA	6	0.8502	100	0.331	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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