GREMLIN Database
NAPH - Ferredoxin-type protein NapH
UniProt: P33934 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12062
Length: 287 (242)
Sequences: 2775 (1749)
Seq/√Len: 112.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
131_A135_R5.0621.00
130_S135_R3.6191.00
133_I137_I3.4641.00
131_A134_P3.3551.00
142_L186_L3.2181.00
227_N272_E2.9921.00
121_L148_G2.9831.00
214_G217_T2.9721.00
130_S134_P2.9711.00
131_A136_H2.9431.00
225_K274_V2.9041.00
196_W200_I2.8921.00
120_W124_R2.8461.00
34_F38_M2.7121.00
183_A187_F2.6141.00
132_T135_R2.5641.00
106_S261_M2.5061.00
235_V269_V2.3811.00
30_L34_F2.3471.00
154_T157_W2.3391.00
126_D141_L2.2051.00
125_F144_V2.1471.00
222_D225_K2.1261.00
237_P265_R2.1201.00
210_L215_V2.0361.00
28_R32_Q2.0051.00
61_D64_P1.9961.00
23_R26_V1.9861.00
211_G214_G1.9511.00
104_F108_V1.9461.00
231_D235_V1.9391.00
214_G218_V1.8681.00
29_R32_Q1.8661.00
137_I140_V1.8601.00
125_F140_V1.7731.00
158_E163_V1.7591.00
100_G103_L1.7421.00
165_L169_S1.7411.00
130_S133_I1.7181.00
227_N231_D1.6971.00
132_T136_H1.6781.00
176_S180_L1.6571.00
131_A199_H1.6541.00
68_P73_Q1.6301.00
211_G215_V1.6081.00
192_V195_G1.5741.00
138_R259_D1.5711.00
210_L214_G1.5521.00
158_E161_N1.5431.00
146_L182_L1.5401.00
168_R171_V1.5331.00
213_K216_I1.5131.00
227_N271_S1.5011.00
67_D70_M1.4941.00
210_L216_I1.4841.00
27_L31_C1.4591.00
211_G218_V1.4491.00
89_A92_I1.4291.00
170_L173_G1.4291.00
63_V66_T1.4241.00
231_D269_V1.4211.00
235_V265_R1.4071.00
176_S179_L1.3841.00
142_L205_A1.3821.00
163_V167_G1.3801.00
164_S168_R1.3771.00
233_F242_L1.3761.00
134_P137_I1.3581.00
24_W27_L1.3301.00
215_V218_V1.3301.00
131_A137_I1.3291.00
273_D276_T1.3251.00
40_L43_P1.3131.00
195_G199_H1.2910.99
26_V30_L1.2900.99
130_S136_H1.2860.99
38_M42_G1.2560.99
29_R33_F1.2440.99
140_V143_V1.2330.99
121_L124_R1.2130.99
240_H243_R1.2110.99
162_P165_L1.2080.99
31_C107_W1.2060.99
179_L183_A1.2020.99
221_T275_F1.1980.99
46_G164_S1.1960.99
142_L191_V1.1820.99
58_L62_T1.1590.99
238_E261_M1.1560.99
210_L217_T1.1550.99
218_V221_T1.1410.99
37_G41_S1.1270.98
210_L213_K1.1270.98
117_L121_L1.1220.98
102_R259_D1.1160.98
233_F241_V1.1050.98
23_R27_L1.1050.98
40_L151_L1.1020.98
97_A207_Y1.1010.98
87_T94_V1.0890.98
46_G162_P1.0600.98
116_D198_G1.0400.97
212_S216_I1.0390.97
115_T189_L1.0390.97
121_L144_V1.0370.97
183_A192_V1.0360.97
187_F191_V1.0320.97
93_T264_G1.0270.97
158_E166_M1.0230.97
169_S172_M1.0150.97
67_D74_S1.0110.97
32_Q40_L1.0110.97
161_N164_S1.0060.97
227_N230_M1.0020.97
272_E275_F0.9980.97
210_L218_V0.9940.97
59_L62_T0.9910.97
124_R128_N0.9810.96
180_L184_L0.9740.96
212_S215_V0.9730.96
178_A182_L0.9650.96
114_I181_I0.9640.96
58_L61_D0.9570.96
198_G238_E0.9550.96
32_Q36_L0.9540.96
139_Y142_L0.9530.96
25_L33_F0.9460.96
140_V144_V0.9400.95
189_L195_G0.9380.95
265_R268_D0.9310.95
101_K262_T0.9270.95
56_S59_L0.9270.95
168_R172_M0.9250.95
63_V92_I0.9180.95
123_R128_N0.9140.95
237_P261_M0.9020.94
231_D273_D0.8950.94
216_I221_T0.8930.94
222_D277_I0.8900.94
233_F243_R0.8830.94
28_R110_P0.8800.93
260_C266_C0.8800.93
104_F209_V0.8760.93
33_F41_S0.8750.93
119_N208_G0.8740.93
172_M175_G0.8630.93
31_C35_V0.8630.93
142_L146_L0.8610.93
230_M234_H0.8580.93
143_V147_V0.8570.93
25_L29_R0.8570.93
28_R37_G0.8530.92
275_F278_T0.8440.92
80_L83_T0.8370.92
57_S61_D0.8360.92
97_A101_K0.8260.91
27_L30_L0.8250.91
145_I160_I0.8240.91
150_A182_L0.8220.91
91_I99_A0.8190.91
28_R107_W0.8140.91
231_D272_E0.8030.90
177_G181_I0.8000.90
81_P84_V0.8000.90
194_H238_E0.8000.90
21_S34_F0.7960.90
26_V29_R0.7930.89
144_V148_G0.7930.89
102_R208_G0.7920.89
29_R35_V0.7920.89
230_M233_F0.7910.89
236_C260_C0.7900.89
236_C266_C0.7900.89
198_G259_D0.7840.89
32_Q37_G0.7840.89
231_D234_H0.7840.89
238_E265_R0.7830.89
31_C34_F0.7820.89
188_D191_V0.7810.89
133_I136_H0.7780.88
227_N261_M0.7770.88
184_L188_D0.7710.88
55_S59_L0.7710.88
208_G259_D0.7690.88
81_P85_A0.7690.88
104_F188_D0.7650.88
216_I219_A0.7620.87
67_D161_N0.7610.87
140_V170_L0.7610.87
263_C266_C0.7610.87
260_C263_C0.7610.87
46_G49_I0.7590.87
67_D76_A0.7540.87
273_D278_T0.7510.87
65_L73_Q0.7510.87
136_H140_V0.7510.87
34_F37_G0.7510.87
139_Y150_A0.7460.86
75_L95_L0.7410.86
158_E167_G0.7410.86
217_T221_T0.7400.86
255_V258_R0.7380.86
89_A93_T0.7330.85
193_E261_M0.7320.85
23_R139_Y0.7320.85
97_A262_T0.7300.85
211_G216_I0.7270.85
66_T73_Q0.7240.85
118_A149_S0.7230.85
165_L168_R0.7180.84
146_L150_A0.7180.84
226_C232_C0.7120.84
23_R30_L0.7110.84
161_N174_F0.7050.83
69_L72_L0.7010.83
154_T170_L0.6940.82
264_G267_V0.6910.82
32_Q35_V0.6880.81
76_A80_L0.6810.81
74_S77_S0.6790.81
174_F178_A0.6780.81
185_F189_L0.6750.80
105_C109_C0.6730.80
218_V277_I0.6730.80
91_I95_L0.6710.80
236_C263_C0.6710.80
56_S61_D0.6690.80
33_F37_G0.6680.80
158_E164_S0.6670.79
113_P117_L0.6660.79
86_L90_V0.6650.79
107_W264_G0.6640.79
66_T71_T0.6630.79
102_R110_P0.6630.79
66_T75_L0.6600.79
134_P140_V0.6590.79
29_R36_L0.6590.79
111_L115_T0.6580.79
105_C201_C0.6570.78
109_C201_C0.6570.78
106_S269_V0.6540.78
125_F128_N0.6530.78
64_P78_G0.6520.78
55_S58_L0.6520.78
260_C270_C0.6470.77
266_C270_C0.6470.77
41_S45_F0.6460.77
224_Q234_H0.6460.77
259_D262_T0.6410.77
92_I96_Y0.6410.77
188_D192_V0.6360.76
74_S80_L0.6360.76
67_D73_Q0.6330.76
48_W55_S0.6320.76
143_V191_V0.6310.76
138_R198_G0.6310.76
162_P167_G0.6260.75
114_I186_L0.6260.75
163_V169_S0.6240.75
142_L209_V0.6230.75
63_V104_F0.6190.74
225_K273_D0.6170.74
79_H157_W0.6160.74
122_R127_L0.6160.74
241_V255_V0.6120.73
146_L183_A0.6120.73
226_C270_C0.6090.73
114_I166_M0.6080.73
139_Y205_A0.6070.73
23_R31_C0.6060.73
33_F38_M0.6060.73
70_M73_Q0.6050.73
120_W204_G0.6040.72
105_C197_C0.6010.72
109_C197_C0.6010.72
27_L183_A0.5980.72
154_T158_E0.5930.71
25_L116_D0.5930.71
109_C260_C0.5900.71
105_C260_C0.5900.71
105_C266_C0.5900.71
109_C266_C0.5900.71
150_A154_T0.5900.71
68_P81_P0.5900.71
125_F184_L0.5900.71
170_L175_G0.5890.71
218_V275_F0.5880.70
226_C229_C0.5880.70
32_Q113_P0.5880.70
90_V93_T0.5860.70
197_C201_C0.5850.70
38_M41_S0.5850.70
224_Q227_N0.5840.70
134_P139_Y0.5810.70
23_R38_M0.5770.69
63_V70_M0.5750.69
201_C266_C0.5740.69
201_C260_C0.5740.69
219_A276_T0.5740.69
152_T185_F0.5720.68
70_M74_S0.5720.68
99_A198_G0.5700.68
39_F43_P0.5700.68
261_M265_R0.5680.68
55_S60_F0.5670.68
66_T84_V0.5670.68
68_P71_T0.5650.67
41_S47_V0.5610.67
21_S169_S0.5610.67
121_L127_L0.5580.66
87_T91_I0.5570.66
228_R243_R0.5560.66
232_C270_C0.5530.66
30_L37_G0.5520.66
240_H259_D0.5510.65
229_C232_C0.5510.65
28_R162_P0.5500.65
236_C270_C0.5480.65
30_L33_F0.5470.65
85_A94_V0.5470.65
164_S171_V0.5460.65
94_V206_L0.5450.65
152_T156_I0.5410.64
80_L184_L0.5390.64
65_L70_M0.5390.64
21_S30_L0.5360.63
55_S143_V0.5350.63
181_I185_F0.5350.63
27_L37_G0.5340.63
30_L178_A0.5340.63
66_T69_L0.5320.63
108_V168_R0.5310.63
96_Y103_L0.5310.63
98_L213_K0.5270.62
195_G198_G0.5270.62
243_R255_V0.5250.62
83_T89_A0.5240.62
57_S60_F0.5240.62
99_A278_T0.5220.61
37_G43_P0.5200.61
197_C260_C0.5190.61
197_C266_C0.5190.61
211_G217_T0.5170.61
161_N168_R0.5150.60
36_L40_L0.5150.60
242_L255_V0.5150.60
263_C270_C0.5140.60
111_L203_V0.5130.60
28_R116_D0.5130.60
123_R129_Q0.5120.60
240_H254_Q0.5110.60
145_I206_L0.5100.60
127_L254_Q0.5100.60
31_C38_M0.5100.60
102_R238_E0.5090.59
146_L175_G0.5050.59
224_Q228_R0.5040.59
109_C236_C0.5030.59
105_C236_C0.5030.59
39_F42_G0.5010.58
169_S173_G0.5010.58
59_L66_T0.5000.58
119_N238_E0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p6vA 1 0.6585 99.1 0.821 Contact Map
7fd1A 1 0.223 99 0.826 Contact Map
3gyxB 1 0.2369 99 0.827 Contact Map
1jnrB 1 0.2369 99 0.828 Contact Map
1hfeL 2 0.3171 99 0.828 Contact Map
1iqzA 1 0.2334 98.9 0.831 Contact Map
2fgoA 1 0.223 98.9 0.831 Contact Map
4z3xE 2 0.3589 98.9 0.832 Contact Map
2v2kA 1 0.223 98.9 0.833 Contact Map
3eunA 1 0.223 98.9 0.833 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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