GREMLIN Database
YEJF - Uncharacterized ABC transporter ATP-binding protein YejF
UniProt: P33916 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12041
Length: 529 (455)
Sequences: 181 (151)
Seq/√Len: 7.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
483_S489_V7.8561.00
36_E226_R5.2600.99
316_G483_S5.2390.99
250_H253_T5.0940.99
39_A212_F4.8920.99
316_G489_V4.3480.98
44_S330_L3.9360.96
448_I482_I3.7480.94
196_L219_I3.7290.94
387_E392_H3.4340.91
9_E70_D3.1550.87
381_V387_E2.9830.83
111_L165_V2.9250.82
52_A179_I2.9050.82
375_L387_E2.8770.81
25_V51_T2.8010.79
316_G326_S2.7360.77
46_S230_M2.6350.75
186_A431_R2.5840.73
329_G448_I2.4830.70
8_I30_L2.4800.70
316_G493_C2.4690.69
411_E470_S2.4460.69
376_N387_E2.4170.68
227_V439_A2.3980.67
227_V241_A2.2430.62
25_V230_M2.2380.61
388_G392_H2.2360.61
25_V43_E2.2110.60
283_V286_P2.2110.60
26_N234_R2.1640.59
141_V167_I2.1580.58
170_A180_A2.1360.58
229_V237_E2.1290.57
115_L169_M2.0890.56
259_S342_I2.0400.54
289_K292_L1.9840.52
372_N447_I1.9390.50
44_S316_G1.9280.50
52_A213_I1.9250.50
313_E495_Q1.9180.49
191_V452_P1.8720.48
237_E248_P1.8190.46
437_A483_S1.7940.45
108_L257_L1.7590.43
200_R254_Q1.7590.43
25_V40_L1.7560.43
106_N169_M1.7550.43
465_L488_V1.7420.43
171_L436_I1.7400.43
25_V46_S1.7230.42
169_M198_L1.7180.42
214_T220_V1.7160.42
44_S437_A1.7150.42
199_L441_I1.7130.41
309_L315_L1.6960.41
327_T331_A1.6920.41
306_S489_V1.6800.40
229_V253_T1.6710.40
56_L96_M1.6680.40
52_A214_T1.6550.39
331_A342_I1.6530.39
287_I290_G1.6400.39
27_D326_S1.6330.39
330_L483_S1.6240.38
342_I473_Q1.6240.38
326_S405_V1.6210.38
218_S436_I1.6140.38
71_I287_I1.6100.38
152_D191_V1.5800.37
229_V311_A1.5780.37
7_A12_S1.5580.36
64_V299_N1.5550.36
285_F289_K1.5410.35
143_I447_I1.5380.35
90_R455_S1.5300.35
258_N403_Q1.5130.34
60_P180_A1.5090.34
382_L387_E1.5020.34
98_F186_A1.5010.34
482_I488_V1.4960.34
385_I388_G1.4940.34
191_V483_S1.4890.33
17_H177_L1.4800.33
366_V370_D1.4800.33
257_L481_F1.4800.33
367_V488_V1.4750.33
46_S64_V1.4750.33
171_L202_L1.4710.33
26_N327_T1.4600.32
192_Q478_A1.4550.32
294_R338_S1.4390.32
367_V370_D1.4290.31
445_S482_I1.4260.31
326_S483_S1.4260.31
449_L452_P1.4210.31
27_D437_A1.4190.31
167_I464_I1.4100.31
226_R238_Q1.4020.31
90_R430_Q1.3910.30
316_G437_A1.3880.30
192_Q430_Q1.3850.30
296_V437_A1.3820.30
175_P329_G1.3760.30
404_Q443_K1.3690.29
155_H452_P1.3640.29
316_G330_L1.3630.29
106_N472_Q1.3570.29
178_L377_P1.3550.29
185_T455_S1.3420.29
323_S367_V1.3410.29
230_M467_L1.3410.29
8_I445_S1.3390.28
219_I462_A1.3360.28
89_V293_K1.3360.28
366_V371_P1.3360.28
75_G495_Q1.3350.28
384_I387_E1.3260.28
253_T260_E1.3200.28
363_R445_S1.3180.28
165_V381_V1.3180.28
178_L339_Q1.3150.28
383_Q387_E1.3100.28
100_E114_Q1.3080.28
50_V214_T1.3070.27
129_A473_Q1.3060.27
409_M446_L1.3050.27
327_T336_I1.2970.27
40_L305_I1.2870.27
381_V472_Q1.2790.27
296_V330_L1.2790.27
207_N375_L1.2780.27
241_A257_L1.2750.27
100_E185_T1.2740.26
367_V426_F1.2730.26
166_M333_L1.2720.26
90_R185_T1.2670.26
175_P412_V1.2550.26
280_Q291_I1.2470.26
156_Q436_I1.2400.25
327_T385_I1.2360.25
375_L392_H1.2330.25
193_A323_S1.2320.25
23_T494_H1.2260.25
54_S453_T1.2200.25
50_V220_V1.2130.25
10_N317_L1.2080.25
227_V257_L1.2050.24
445_S448_I1.2050.24
97_I301_V1.1930.24
159_G215_H1.1880.24
66_Y380_N1.1860.24
489_V493_C1.1810.24
39_A90_R1.1740.24
236_V253_T1.1700.23
72_R197_Q1.1690.23
387_E390_R1.1670.23
72_R79_L1.1660.23
46_S473_Q1.1640.23
6_L11_L1.1630.23
228_A235_C1.1600.23
161_E449_L1.1600.23
291_I332_L1.1600.23
467_L499_L1.1600.23
171_L230_M1.1580.23
208_M483_S1.1570.23
405_V459_T1.1540.23
381_V426_F1.1520.23
162_R220_V1.1450.23
240_Y337_N1.1400.23
376_N385_I1.1380.23
116_Y134_I1.1370.23
141_V436_I1.1350.23
285_F292_L1.1300.22
411_E467_L1.1280.22
50_V185_T1.1260.22
483_S493_C1.1230.22
320_E364_I1.1210.22
170_A453_T1.1170.22
302_V426_F1.1120.22
217_L491_A1.1070.22
96_M426_F1.1050.22
178_L194_Q1.1040.22
8_I11_L1.0980.22
381_V388_G1.0960.21
171_L439_A1.0940.21
383_Q390_R1.0870.21
301_V482_I1.0870.21
376_N388_G1.0850.21
285_F308_T1.0810.21
381_V385_I1.0760.21
461_Q488_V1.0760.21
30_L425_E1.0740.21
368_F371_P1.0700.21
30_L133_E1.0700.21
98_F431_R1.0670.21
375_L388_G1.0660.21
209_G489_V1.0660.21
71_I251_P1.0620.21
143_I412_V1.0610.21
142_G482_I1.0610.21
90_R175_P1.0610.21
179_I465_L1.0590.21
58_L96_M1.0480.20
230_M413_G1.0460.20
154_P211_L1.0450.20
90_R100_E1.0430.20
376_N390_R1.0380.20
141_V461_Q1.0360.20
205_E494_H1.0340.20
114_Q252_Y1.0250.20
201_E411_E1.0230.20
53_L366_V1.0170.20
317_L422_Y1.0150.19
413_G463_Q1.0120.19
99_Q182_E1.0080.19
25_V155_H1.0080.19
93_K176_E1.0070.19
285_F293_K1.0030.19
385_I392_H1.0030.19
309_L426_F1.0010.19
105_L428_G1.0000.19
412_V431_R1.0000.19
375_L383_Q0.9940.19
384_I388_G0.9910.19
185_T225_H0.9870.19
174_R412_V0.9850.19
234_R279_E0.9850.19
56_L424_A0.9840.19
10_N29_S0.9770.19
339_Q342_I0.9760.19
242_A342_I0.9750.19
333_L364_I0.9710.18
56_L179_I0.9680.18
197_Q343_I0.9650.18
15_F25_V0.9630.18
162_R452_P0.9590.18
144_R381_V0.9590.18
169_M472_Q0.9570.18
114_Q387_E0.9570.18
92_N344_F0.9560.18
292_L295_I0.9550.18
90_R224_A0.9540.18
422_Y425_E0.9490.18
71_I443_K0.9490.18
54_S161_E0.9480.18
31_Q498_I0.9420.18
380_N388_G0.9410.18
82_S85_T0.9390.18
376_N381_V0.9380.18
28_V295_I0.9360.18
157_L296_V0.9360.18
385_I389_L0.9350.18
175_P431_R0.9350.18
294_R331_A0.9330.18
32_I173_T0.9300.17
102_M191_V0.9300.17
41_V372_N0.9290.17
434_I446_L0.9260.17
53_L172_L0.9260.17
315_L479_Y0.9210.17
366_V448_I0.9210.17
405_V497_I0.9190.17
137_C178_L0.9150.17
134_I412_V0.9120.17
304_N389_L0.9110.17
51_T477_L0.9110.17
87_R482_I0.9100.17
241_A467_L0.9090.17
321_S340_G0.9080.17
448_I488_V0.9080.17
439_A447_I0.9080.17
249_T406_I0.9070.17
126_R436_I0.9070.17
328_T493_C0.9070.17
13_V28_V0.9010.17
367_V371_P0.8940.17
99_Q181_D0.8930.17
31_Q280_Q0.8920.17
106_N198_L0.8910.17
36_E64_V0.8870.17
235_C439_A0.8860.17
54_S229_V0.8850.17
236_V466_T0.8850.17
160_G182_E0.8840.16
182_E433_R0.8840.16
50_V455_S0.8830.16
431_R441_I0.8820.16
99_Q160_G0.8800.16
99_Q433_R0.8800.16
97_I166_M0.8800.16
417_E480_L0.8790.16
152_D452_P0.8790.16
212_F442_L0.8760.16
181_D433_R0.8760.16
160_G181_D0.8760.16
232_N236_V0.8760.16
135_L417_E0.8760.16
289_K307_F0.8750.16
302_V499_L0.8720.16
199_L431_R0.8710.16
287_I292_L0.8700.16
30_L72_R0.8680.16
117_E446_L0.8670.16
160_G433_R0.8670.16
320_E423_P0.8640.16
53_L482_I0.8630.16
32_I214_T0.8620.16
376_N392_H0.8600.16
65_E97_I0.8580.16
239_N245_F0.8570.16
44_S483_S0.8570.16
154_P435_A0.8570.16
257_L260_E0.8570.16
50_V100_E0.8550.16
185_T449_L0.8550.16
454_S481_F0.8520.16
30_L485_D0.8510.16
50_V161_E0.8510.16
50_V330_L0.8500.16
199_L408_V0.8500.16
290_G294_R0.8490.16
483_S494_H0.8480.16
84_Q478_A0.8470.16
162_R185_T0.8450.16
177_L425_E0.8450.16
318_V489_V0.8450.16
66_Y410_H0.8410.16
309_L434_I0.8410.16
161_E455_S0.8400.16
41_V458_K0.8400.16
311_A415_D0.8380.16
381_V392_H0.8380.16
210_M494_H0.8380.16
281_L291_I0.8350.15
133_E236_V0.8330.15
28_V94_I0.8300.15
10_N244_L0.8300.15
104_S331_A0.8260.15
437_A467_L0.8220.15
99_Q215_H0.8210.15
40_L51_T0.8200.15
159_G163_Q0.8190.15
244_L248_P0.8180.15
163_Q215_H0.8170.15
40_L483_S0.8170.15
248_P454_S0.8170.15
213_I220_V0.8140.15
185_T329_G0.8110.15
168_A461_Q0.8100.15
90_R186_A0.8090.15
142_G254_Q0.8070.15
44_S196_L0.8060.15
111_L178_L0.8040.15
291_I306_S0.8040.15
91_G180_A0.8040.15
53_L329_G0.8030.15
409_M443_K0.8020.15
345_D405_V0.8020.15
318_V486_L0.8010.15
88_G136_N0.7990.15
118_V152_D0.7990.15
228_A309_L0.7990.15
479_Y497_I0.7950.15
100_E186_A0.7950.15
41_V437_A0.7920.15
50_V114_Q0.7890.15
300_V311_A0.7890.15
165_V460_V0.7870.15
186_A430_Q0.7860.15
209_G465_L0.7840.14
44_S296_V0.7830.14
94_I177_L0.7810.14
153_Y465_L0.7800.14
50_V90_R0.7790.14
96_M111_L0.7780.14
144_R460_V0.7730.14
109_H166_M0.7730.14
331_A462_A0.7720.14
392_H434_I0.7720.14
99_Q159_G0.7720.14
221_R260_E0.7700.14
365_Q370_D0.7690.14
288_R467_L0.7690.14
440_L446_L0.7680.14
169_M452_P0.7660.14
92_N304_N0.7630.14
73_F95_A0.7620.14
53_L185_T0.7580.14
162_R330_L0.7570.14
117_E478_A0.7530.14
301_V367_V0.7520.14
90_R431_R0.7520.14
51_T162_R0.7510.14
208_M316_G0.7510.14
401_R459_T0.7490.14
71_I459_T0.7480.14
472_Q479_Y0.7440.14
100_E213_I0.7430.14
257_L462_A0.7410.14
248_P261_P0.7410.14
90_R225_H0.7410.14
107_P321_S0.7400.14
173_T244_L0.7390.14
331_A338_S0.7390.14
165_V483_S0.7380.14
162_R191_V0.7370.14
379_L384_I0.7370.14
114_Q185_T0.7360.14
367_V449_L0.7350.14
64_V327_T0.7320.14
191_V489_V0.7320.14
32_I208_M0.7310.13
449_L455_S0.7270.13
239_N244_L0.7270.13
152_D168_A0.7260.13
40_L44_S0.7250.13
58_L222_K0.7230.13
88_G380_N0.7230.13
37_T203_Q0.7230.13
280_Q415_D0.7230.13
71_I81_A0.7210.13
159_G164_R0.7200.13
473_Q494_H0.7170.13
211_L317_L0.7160.13
9_E145_Q0.7150.13
250_H417_E0.7110.13
100_E109_H0.7110.13
294_R327_T0.7100.13
86_L257_L0.7100.13
199_L261_P0.7100.13
37_T78_L0.7090.13
24_V315_L0.7080.13
367_V372_N0.7080.13
213_I449_L0.7070.13
129_A282_Q0.7030.13
193_A298_H0.7010.13
285_F290_G0.7000.13
161_E259_S0.6970.13
179_I461_Q0.6970.13
50_V162_R0.6970.13
72_R305_I0.6970.13
100_E431_R0.6920.13
282_Q317_L0.6910.13
65_E90_R0.6900.13
217_L477_L0.6900.13
188_D432_Q0.6900.13
141_V210_M0.6900.13
67_L149_R0.6860.13
50_V449_L0.6850.13
164_R215_H0.6840.13
196_L200_R0.6820.13
208_M289_K0.6800.13
41_V245_F0.6800.13
175_P430_Q0.6800.13
37_T202_L0.6790.13
212_F477_L0.6770.13
218_S380_N0.6760.13
100_E455_S0.6720.12
300_V497_I0.6720.12
301_V464_I0.6700.12
182_E215_H0.6690.12
124_G480_L0.6680.12
6_L178_L0.6680.12
236_V309_L0.6650.12
127_R478_A0.6640.12
61_S222_K0.6630.12
134_I478_A0.6630.12
330_L449_L0.6620.12
161_E213_I0.6610.12
128_E403_Q0.6610.12
138_L210_M0.6560.12
86_L327_T0.6550.12
36_E71_I0.6540.12
326_S404_Q0.6520.12
225_H455_S0.6480.12
25_V36_E0.6480.12
12_S15_F0.6480.12
134_I455_S0.6460.12
50_V213_I0.6460.12
24_V403_Q0.6450.12
124_G326_S0.6440.12
192_Q219_I0.6440.12
12_S28_V0.6440.12
344_F364_I0.6430.12
403_Q410_H0.6430.12
410_H470_S0.6430.12
377_P462_A0.6420.12
434_I474_K0.6400.12
233_G256_L0.6400.12
75_G94_I0.6390.12
162_R455_S0.6390.12
346_G405_V0.6380.12
249_T474_K0.6360.12
364_I446_L0.6320.12
278_V281_L0.6310.12
6_L259_S0.6310.12
50_V65_E0.6310.12
330_L367_V0.6270.12
254_Q487_H0.6260.12
274_T277_D0.6260.12
7_A308_T0.6250.12
181_D215_H0.6230.12
128_E132_G0.6230.12
50_V225_H0.6230.12
33_E402_E0.6220.12
161_E185_T0.6210.12
215_H433_R0.6210.12
160_G215_H0.6210.12
169_M478_A0.6210.12
78_L81_A0.6180.12
36_E108_L0.6180.12
221_R434_I0.6180.12
159_G181_D0.6160.12
105_L321_S0.6160.12
194_Q465_L0.6140.12
27_D44_S0.6130.12
200_R209_G0.6120.11
30_L424_A0.6110.11
73_F492_L0.6100.11
91_G313_E0.6080.11
159_G182_E0.6080.11
278_V405_V0.6080.11
177_L480_L0.6070.11
300_V341_S0.6070.11
191_V316_G0.6070.11
314_T381_V0.6070.11
296_V316_G0.6060.11
205_E476_Q0.6060.11
42_G48_K0.6060.11
45_G48_K0.6060.11
42_G47_G0.6060.11
42_G45_G0.6060.11
49_S461_Q0.6040.11
39_A50_V0.6030.11
58_L425_E0.6020.11
186_A329_G0.6020.11
153_Y461_Q0.6000.11
70_D116_Y0.5990.11
166_M187_L0.5980.11
229_V248_P0.5980.11
121_L219_I0.5980.11
104_S192_Q0.5960.11
58_L141_V0.5950.11
175_P244_L0.5910.11
255_K497_I0.5910.11
366_V426_F0.5900.11
171_L449_L0.5870.11
327_T489_V0.5870.11
198_L326_S0.5860.11
90_R130_A0.5860.11
52_A228_A0.5860.11
103_V320_E0.5850.11
103_V171_L0.5840.11
97_I431_R0.5840.11
159_G433_R0.5830.11
143_I186_A0.5820.11
262_S411_E0.5810.11
289_K293_K0.5790.11
65_E225_H0.5790.11
244_L341_S0.5780.11
185_T430_Q0.5780.11
479_Y493_C0.5770.11
283_V287_I0.5740.11
109_H185_T0.5730.11
114_Q162_R0.5710.11
115_L189_V0.5700.11
326_S493_C0.5700.11
177_L346_G0.5690.11
362_H434_I0.5680.11
33_E238_Q0.5670.11
243_T471_L0.5660.11
106_N482_I0.5660.11
219_I313_E0.5660.11
100_E225_H0.5650.11
382_L420_H0.5650.11
51_T452_P0.5650.11
79_L82_S0.5650.11
177_L290_G0.5640.11
329_G431_R0.5640.11
258_N478_A0.5630.11
203_Q471_L0.5630.11
442_L488_V0.5630.11
114_Q418_T0.5630.11
8_I86_L0.5630.11
39_A224_A0.5630.11
250_H255_K0.5610.11
65_E114_Q0.5610.11
185_T301_V0.5600.11
295_I307_F0.5590.11
230_M249_T0.5580.11
469_K489_V0.5580.11
275_L287_I0.5580.11
83_D304_N0.5560.11
187_L220_V0.5540.11
107_P229_V0.5530.11
13_V60_P0.5520.11
236_V440_L0.5510.11
279_E285_F0.5510.11
191_V208_M0.5510.11
97_I186_A0.5500.11
201_E439_A0.5500.11
49_S261_P0.5500.11
421_R453_T0.5500.11
219_I327_T0.5500.11
379_L387_E0.5490.11
210_M437_A0.5480.11
111_L311_A0.5470.11
136_N341_S0.5460.10
29_S319_G0.5460.10
111_L434_I0.5430.10
375_L390_R0.5430.10
169_M482_I0.5420.10
333_L426_F0.5410.10
49_S161_E0.5410.10
142_G198_L0.5410.10
101_P186_A0.5410.10
115_L168_A0.5410.10
486_L493_C0.5410.10
250_H422_Y0.5400.10
78_L94_I0.5390.10
250_H294_R0.5370.10
27_D257_L0.5360.10
218_S315_L0.5360.10
66_Y132_G0.5360.10
231_Q413_G0.5350.10
386_E424_A0.5350.10
190_S493_C0.5340.10
69_G143_I0.5340.10
155_H464_I0.5330.10
462_A488_V0.5320.10
250_H260_E0.5320.10
70_D497_I0.5310.10
330_L455_S0.5310.10
136_N255_K0.5310.10
186_A455_S0.5300.10
165_V464_I0.5290.10
13_V228_A0.5280.10
141_V169_M0.5270.10
102_M385_I0.5260.10
118_V141_V0.5260.10
314_T331_A0.5240.10
437_A477_L0.5240.10
27_D296_V0.5230.10
412_V418_T0.5230.10
43_E299_N0.5220.10
97_I455_S0.5220.10
118_V482_I0.5210.10
16_R246_A0.5210.10
176_E281_L0.5200.10
111_L494_H0.5200.10
364_I479_Y0.5180.10
296_V483_S0.5170.10
230_M497_I0.5170.10
260_E310_R0.5160.10
255_K462_A0.5160.10
153_Y435_A0.5150.10
34_A372_N0.5150.10
157_L428_G0.5140.10
431_R454_S0.5130.10
262_S327_T0.5120.10
9_E305_I0.5120.10
129_A305_I0.5120.10
169_M175_P0.5120.10
286_P298_H0.5100.10
293_K306_S0.5090.10
381_V384_I0.5080.10
90_R330_L0.5070.10
173_T285_F0.5060.10
230_M414_L0.5060.10
7_A416_P0.5050.10
116_Y333_L0.5050.10
133_E243_T0.5040.10
46_S307_F0.5030.10
37_T464_I0.5020.10
375_L431_R0.5020.10
84_Q300_V0.5020.10
114_Q455_S0.5010.10
8_I140_R0.5010.10
157_L168_A0.5010.10
6_L294_R0.5000.10
242_A441_I0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4finA 2 0.8885 100 0.495 Contact Map
4q9hA 1 0.9206 100 0.497 Contact Map
4f4cA 1 0.8922 100 0.508 Contact Map
1yqtA 1 0.8847 100 0.524 Contact Map
3ux8A 2 0.8091 100 0.527 Contact Map
2iw3A 2 0.8412 100 0.528 Contact Map
3bk7A 1 0.8828 100 0.529 Contact Map
3ozxA 1 0.8677 100 0.534 Contact Map
3j16B 1 0.8866 100 0.535 Contact Map
2vf7A 2 0.9112 100 0.593 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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