GREMLIN Database
YEJE - Inner membrane ABC transporter permease protein YejE
UniProt: P33915 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12040
Length: 341 (327)
Sequences: 2514 (1649)
Seq/√Len: 91.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_G330_A4.9951.00
161_A176_G4.2511.00
12_W16_R4.0051.00
243_V247_S3.9971.00
35_S140_T3.3201.00
229_T253_M3.1221.00
126_D130_G2.8491.00
168_Y245_D2.7991.00
293_L320_L2.7681.00
175_W179_F2.6981.00
133_L137_L2.6571.00
25_L29_L2.5691.00
123_L136_I2.5421.00
15_F327_I2.4521.00
132_V296_L2.3661.00
167_Y245_D2.3491.00
110_N113_F2.2921.00
311_I315_L2.2391.00
19_R22_Y2.2311.00
226_F253_M2.2291.00
171_K175_W2.1131.00
233_D236_R2.0981.00
123_L133_L2.0771.00
81_P84_K2.0641.00
165_Q177_Q2.0541.00
276_L292_S2.0501.00
28_F327_I2.0491.00
33_G37_C2.0371.00
79_Q82_W2.0061.00
109_T113_F2.0001.00
168_Y172_V1.9881.00
132_V309_L1.9471.00
293_L316_S1.9461.00
13_A16_R1.9101.00
195_L199_V1.9051.00
123_L312_T1.8981.00
50_R53_G1.8941.00
235_I253_M1.8731.00
39_E141_R1.8621.00
114_P117_P1.8361.00
27_I319_I1.8271.00
244_S247_S1.7991.00
45_K48_L1.7971.00
247_S250_L1.7871.00
83_L87_L1.7351.00
184_S216_M1.7141.00
37_C40_L1.6691.00
23_W26_W1.6671.00
229_T234_Y1.6591.00
9_Q13_A1.6551.00
79_Q84_K1.6421.00
330_A334_A1.6201.00
30_V34_L1.6081.00
202_N205_W1.6061.00
277_T298_L1.6041.00
24_S323_L1.5761.00
130_G135_R1.5731.00
329_E336_D1.5691.00
16_R26_W1.5661.00
246_R250_L1.5641.00
131_D134_A1.5521.00
173_D223_R1.5351.00
111_K114_P1.5331.00
111_K115_S1.5241.00
157_M161_A1.5071.00
106_N121_N1.5041.00
16_R22_Y1.4911.00
140_T293_L1.4911.00
112_P116_P1.4891.00
332_R336_D1.4861.00
79_Q83_L1.4781.00
178_R181_E1.4671.00
145_L149_M1.4591.00
83_L88_E1.4561.00
110_N114_P1.4500.99
25_L327_I1.4380.99
150_L272_S1.4260.99
82_W86_R1.4200.99
315_L319_I1.4140.99
83_L86_R1.4100.99
163_A226_F1.3980.99
84_K87_L1.3860.99
84_K88_E1.3760.99
26_W30_V1.3710.99
158_G162_G1.3680.99
96_A100_F1.3570.99
38_S42_A1.3560.99
80_D83_L1.3410.99
104_S107_F1.3380.99
97_P100_F1.3370.99
76_A80_D1.3330.99
56_Y67_D1.3220.99
70_G73_A1.3130.99
63_Y68_F1.3090.99
78_Y83_L1.3020.99
166_G230_R1.2990.99
140_T320_L1.2950.99
207_L211_V1.2940.99
143_S147_G1.2930.99
97_P102_A1.2900.99
75_Q79_Q1.2860.99
229_T232_F1.2760.99
147_G272_S1.2760.99
150_L211_V1.2720.99
145_L207_L1.2690.99
101_G104_S1.2660.99
82_W87_L1.2600.99
79_Q87_L1.2560.99
110_N116_P1.2540.98
234_Y256_N1.2500.98
177_Q219_V1.2440.98
29_L33_G1.2430.98
34_L137_L1.2370.98
239_Q248_I1.2320.98
243_V251_R1.2200.98
167_Y248_I1.2170.98
165_Q176_G1.2140.98
157_M160_L1.2130.98
155_S265_L1.2110.98
310_G314_F1.2040.98
162_G166_G1.2020.98
163_A249_I1.2010.98
18_N21_G1.1980.98
100_F104_S1.1940.98
102_A106_N1.1860.98
82_W85_Q1.1840.98
74_S80_D1.1810.98
138_Y141_R1.1800.98
168_Y249_I1.1790.98
31_L319_I1.1770.98
103_T106_N1.1600.97
20_R24_S1.1590.97
136_I316_S1.1520.97
98_I101_G1.1510.97
333_D336_D1.1500.97
67_D70_G1.1490.97
46_P51_Y1.1310.97
12_W25_L1.1290.97
42_A134_A1.1250.97
28_F323_L1.1190.97
195_L209_I1.1130.97
158_G218_L1.1130.97
50_R55_W1.1090.97
115_S118_S1.0940.96
9_Q12_W1.0930.96
96_A99_R1.0900.96
239_Q245_D1.0860.96
87_L90_N1.0850.96
77_D83_L1.0750.96
75_Q82_W1.0690.96
164_L168_Y1.0670.96
109_T112_P1.0650.96
221_V260_A1.0630.96
68_F71_P1.0600.96
108_A113_F1.0580.96
156_V160_L1.0570.96
136_I312_T1.0550.96
155_S218_L1.0470.95
74_S77_D1.0420.95
77_D82_W1.0250.95
258_M261_T1.0240.95
58_P61_K1.0210.95
238_A243_V1.0170.95
183_W216_M1.0100.94
76_A79_Q1.0100.94
33_G41_I1.0020.94
74_S83_L1.0010.94
199_V284_F1.0010.94
257_A260_A1.0000.94
36_L141_R0.9990.94
172_V176_G0.9980.94
71_P74_S0.9940.94
80_D88_E0.9900.94
27_I31_L0.9900.94
60_L64_S0.9880.94
245_D249_I0.9870.94
110_N115_S0.9850.94
185_G188_T0.9840.94
117_P120_Q0.9830.94
81_P86_R0.9780.93
132_V299_Q0.9740.93
102_A105_I0.9740.93
226_F257_A0.9720.93
76_A81_P0.9710.93
114_P118_S0.9710.93
108_A111_K0.9680.93
38_S138_Y0.9660.93
180_I216_M0.9620.93
236_R240_A0.9610.93
19_R251_R0.9590.93
82_W90_N0.9580.93
297_L313_A0.9560.93
329_E332_R0.9550.93
64_S70_G0.9510.92
238_A248_I0.9480.92
10_A14_R0.9460.92
74_S81_P0.9460.92
285_G329_E0.9430.92
225_E228_R0.9410.92
69_G72_L0.9370.92
75_Q83_L0.9330.92
12_W22_Y0.9280.91
126_D135_R0.9270.91
63_Y67_D0.9240.91
102_A107_F0.9230.91
85_Q89_N0.9210.91
52_D90_N0.9140.91
140_T144_V0.9140.91
278_S282_L0.9100.91
48_L57_F0.9090.91
289_G336_D0.9080.91
50_R54_S0.9050.90
79_Q86_R0.9040.90
75_Q80_D0.8950.90
108_A112_P0.8820.89
97_P103_T0.8730.89
32_F144_V0.8720.89
149_M203_F0.8720.89
26_W37_C0.8660.88
80_D84_K0.8650.88
144_V331_V0.8650.88
154_S214_G0.8590.88
76_A83_L0.8560.88
291_P295_E0.8540.88
266_P325_I0.8540.88
99_R103_T0.8520.88
82_W89_N0.8520.88
42_A138_Y0.8510.88
112_P115_S0.8480.87
111_K118_S0.8470.87
62_N65_E0.8470.87
80_D87_L0.8460.87
82_W88_E0.8430.87
80_D85_Q0.8400.87
64_S67_D0.8400.87
160_L250_L0.8380.87
286_L289_G0.8380.87
81_P85_Q0.8370.87
58_P64_S0.8350.87
53_G60_L0.8340.86
150_L276_L0.8240.86
270_C297_L0.8200.86
32_F145_L0.8190.85
10_A15_F0.8170.85
79_Q89_N0.8170.85
238_A252_H0.8170.85
56_Y60_L0.8170.85
22_Y25_L0.8120.85
189_L211_V0.8110.85
77_D81_P0.8110.85
172_V175_W0.8070.85
63_Y69_G0.8070.85
29_L32_F0.8060.85
171_K174_L0.8020.84
220_G224_A0.7990.84
153_C211_V0.7960.84
216_M317_V0.7950.84
78_Y81_P0.7940.84
22_Y26_W0.7940.84
85_Q88_E0.7910.83
212_L302_N0.7880.83
267_F325_I0.7880.83
16_R19_R0.7870.83
270_C325_I0.7860.83
79_Q90_N0.7850.83
18_N333_D0.7840.83
196_S284_F0.7810.83
177_Q180_I0.7770.82
109_T114_P0.7760.82
214_G275_T0.7740.82
33_G88_E0.7720.82
56_Y59_L0.7710.82
185_G301_K0.7710.82
123_L132_V0.7630.81
65_E69_G0.7620.81
221_V265_L0.7560.81
169_G230_R0.7540.80
164_L176_G0.7520.80
276_L280_D0.7510.80
38_S137_L0.7510.80
192_I284_F0.7500.80
117_P121_N0.7490.80
74_S78_Y0.7470.80
201_P205_W0.7440.79
24_S27_I0.7420.79
71_P80_D0.7400.79
199_V202_N0.7390.79
57_F61_K0.7380.79
32_F36_L0.7360.79
191_L213_F0.7350.79
154_S268_I0.7310.78
16_R23_W0.7290.78
313_A317_V0.7240.78
60_L63_Y0.7230.78
23_W27_I0.7230.78
56_Y125_T0.7210.77
135_R296_L0.7180.77
217_S271_S0.7170.77
215_W282_L0.7130.77
278_S288_L0.7120.76
218_L222_V0.7110.76
97_P101_G0.7100.76
55_W309_L0.7060.76
108_A115_S0.7040.76
78_Y89_N0.7010.75
225_E260_A0.7000.75
24_S330_A0.7000.75
44_D49_V0.6990.75
108_A114_P0.6960.75
135_R289_G0.6950.75
99_R102_A0.6940.75
79_Q88_E0.6930.75
63_Y66_S0.6930.75
81_P88_E0.6880.74
266_P328_G0.6870.74
41_I133_L0.6860.74
160_L246_R0.6850.74
53_G121_N0.6840.74
19_R23_W0.6810.73
233_D237_A0.6750.73
78_Y82_W0.6730.72
199_V205_W0.6700.72
99_R106_N0.6690.72
98_I106_N0.6690.72
210_T275_T0.6660.72
37_C41_I0.6630.71
46_P134_A0.6610.71
62_N75_Q0.6590.71
280_D285_G0.6580.71
274_T307_P0.6540.70
60_L65_E0.6530.70
244_S250_L0.6510.70
263_T332_R0.6510.70
81_P89_N0.6500.70
221_V264_F0.6470.69
181_E233_D0.6460.69
83_L89_N0.6440.69
98_I105_I0.6440.69
76_A90_N0.6430.69
236_R239_Q0.6420.69
86_R90_N0.6410.69
205_W209_I0.6390.68
78_Y86_R0.6380.68
83_L90_N0.6360.68
181_E255_P0.6350.68
125_T131_D0.6350.68
227_L284_F0.6330.68
234_Y238_A0.6320.68
139_G282_L0.6310.67
98_I104_S0.6310.67
20_R23_W0.6300.67
228_R232_F0.6290.67
77_D80_D0.6270.67
66_S73_A0.6260.67
11_R14_R0.6260.67
220_G223_R0.6250.67
307_P311_I0.6240.67
60_L67_D0.6230.66
147_G196_S0.6220.66
75_Q78_Y0.6220.66
257_A263_T0.6210.66
286_L295_E0.6200.66
270_C313_A0.6200.66
80_D89_N0.6200.66
15_F18_N0.6170.66
97_P106_N0.6150.65
209_I222_V0.6150.65
33_G86_R0.6140.65
269_L273_I0.6140.65
85_Q90_N0.6140.65
304_L307_P0.6140.65
198_V232_F0.6100.65
72_L78_Y0.6100.65
188_T192_I0.6080.65
61_K64_S0.6080.65
186_M191_L0.6060.64
254_L258_M0.6060.64
96_A102_A0.6020.64
232_F256_N0.6010.64
21_G25_L0.6010.64
121_N125_T0.6010.64
159_V336_D0.6000.64
229_T257_A0.6000.64
112_P117_P0.5980.63
72_L84_K0.5980.63
155_S269_L0.5980.63
111_K116_P0.5970.63
215_W219_V0.5930.63
106_N120_Q0.5910.62
317_V325_I0.5900.62
263_T321_L0.5900.62
325_I329_E0.5890.62
28_F36_L0.5880.62
195_L200_Q0.5870.62
68_F72_L0.5870.62
12_W234_Y0.5860.62
99_R104_S0.5840.62
196_S201_P0.5840.62
100_F105_I0.5830.61
75_Q87_L0.5810.61
77_D87_L0.5800.61
172_V227_L0.5790.61
262_L335_F0.5780.61
81_P87_L0.5780.61
220_G329_E0.5750.60
53_G57_F0.5740.60
167_Y230_R0.5720.60
247_S251_R0.5690.60
156_V250_L0.5680.59
55_W306_A0.5670.59
275_T284_F0.5670.59
155_S210_T0.5660.59
96_A101_G0.5650.59
17_H29_L0.5650.59
37_C42_A0.5640.59
28_F144_V0.5630.59
166_G256_N0.5630.59
216_M219_V0.5620.59
223_R285_G0.5620.59
75_Q86_R0.5610.58
289_G329_E0.5610.58
292_S332_R0.5600.58
192_I207_L0.5600.58
164_L172_V0.5590.58
102_A175_W0.5590.58
79_Q85_Q0.5590.58
76_A82_W0.5580.58
165_Q220_G0.5570.58
98_I113_F0.5550.58
74_S82_W0.5540.58
120_Q133_L0.5540.58
129_G261_T0.5530.57
316_S320_L0.5520.57
276_L285_G0.5520.57
155_S159_V0.5510.57
217_S264_F0.5500.57
84_K90_N0.5470.57
111_K117_P0.5460.56
165_Q276_L0.5460.56
182_V301_K0.5460.56
146_F263_T0.5460.56
46_P290_S0.5450.56
197_S284_F0.5440.56
145_L198_V0.5430.56
34_L37_C0.5420.56
9_Q22_Y0.5410.56
328_G332_R0.5410.56
261_T335_F0.5400.56
166_G215_W0.5400.56
98_I103_T0.5380.55
9_Q16_R0.5360.55
237_A252_H0.5340.55
15_F22_Y0.5330.55
46_P138_Y0.5330.55
51_Y137_L0.5310.54
13_A120_Q0.5300.54
126_D222_V0.5280.54
77_D85_Q0.5280.54
87_L91_G0.5280.54
159_V250_L0.5260.54
88_E92_W0.5260.54
218_L268_I0.5250.54
84_K327_I0.5240.53
246_R254_L0.5230.53
273_I306_A0.5230.53
53_G58_P0.5210.53
109_T115_S0.5190.53
88_E91_G0.5190.53
165_Q304_L0.5190.53
13_A17_H0.5180.53
157_M172_V0.5170.52
96_A118_S0.5160.52
206_L210_T0.5150.52
221_V284_F0.5150.52
232_F253_M0.5140.52
159_V311_I0.5130.52
59_L62_N0.5120.52
261_T325_I0.5100.51
190_F196_S0.5090.51
281_F321_L0.5080.51
147_G297_L0.5070.51
297_L301_K0.5060.51
101_G105_I0.5060.51
317_V324_L0.5040.51
113_F116_P0.5030.51
183_W261_T0.5030.51
33_G75_Q0.5020.50
127_A309_L0.5020.50
190_F259_V0.5000.50
45_K52_D0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tquM 1 0.7419 99.9 0.694 Contact Map
3tuiA 2 0.5953 99.9 0.7 Contact Map
3d31C 2 0.6804 99.9 0.724 Contact Map
2onkC 2 0.695 99.9 0.732 Contact Map
4ymuD 2 0.6129 99.8 0.743 Contact Map
3rlfF 1 0.8504 99.8 0.745 Contact Map
3rlfG 1 0.7507 99.8 0.75 Contact Map
4tquN 1 0.7683 99.8 0.755 Contact Map
4djkA 2 0.2405 12.4 0.966 Contact Map
3j9pD 4 0.6481 11.4 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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