G3P3 - ECOLI - GREMLIN Contacts

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G3P3 - Putative glyceraldehyde-3-phosphate dehydrogenase C

UniProt:	P33898	Sequences: MSKVGINGFGRIGRLVLGRLLEVKSNIDVVAINDLTSPKILAYLLKHDSNYGPFPWSVDFTEDSLIVDGKSIAVYAEKEAKNIPWKAKGAEIIVECTGFYTSAEKSQAHLDAGAKKVLISAPAGEMKTIVYNVNDDTLDGNDTIVSVASCTTNCLAPMAKALHDSFGIEVGTMTTIHAYTGTQSLVDGPRGKDLRASRAAAENIIPHTTGAAKAIGLVIPELSGKLKGHAQRVPVKTGSVTELVSILGKKVTAEEVNNALKQATTNNESFGYTDEEIVSSDIIGSHFGSVFDATQTEITAVGDLQLVKTVAWYDNEYGFVTQLIRTLEKFAKL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12103
Length:	333 (321)
Sequences:	5413 (2420)
Seq/√Len:	135.1

ECOLI - G3P3 E4PD G3P1
BACSU - G3P2 G3P1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
163_H	221_E	4.240	1.00
77_E	82_N	3.581	1.00
169_E	248_G	3.393	1.00
160_K	164_D	3.161	1.00
271_G	287_F	3.067	1.00
135_D	329_K	2.799	1.00
250_K	305_Q	2.764	1.00
203_N	280_S	2.752	1.00
107_Q	111_D	2.741	1.00
79_E	82_N	2.661	1.00
260_L	291_F	2.533	1.00
166_F	259_A	2.493	1.00
179_Y	201_A	2.475	1.00
56_W	68_D	2.453	1.00
3_K	28_D	2.440	1.00
165_S	262_Q	2.412	1.00
289_S	311_A	2.365	1.00
145_V	330_F	2.337	1.00
105_K	108_A	2.299	1.00
61_T	71_S	2.209	1.00
170_V	246_I	2.202	1.00
288_G	322_Q	2.187	1.00
102_S	105_K	2.182	1.00
231_Q	240_V	2.162	1.00
64_S	71_S	2.150	1.00
237_T	283_I	2.090	1.00
249_K	255_E	2.018	1.00
131_Y	135_D	2.010	1.00
127_K	142_D	1.993	1.00
256_V	307_V	1.993	1.00
178_A	235_V	1.942	1.00
46_K	275_E	1.938	1.00
21_L	54_F	1.922	1.00
80_A	100_Y	1.903	1.00
258_N	262_Q	1.900	1.00
40_I	194_L	1.877	1.00
51_Y	237_T	1.865	1.00
216_G	223_S	1.858	1.00
28_D	70_K	1.856	1.00
20_L	29_V	1.855	1.00
204_I	231_Q	1.853	1.00
103_A	107_Q	1.844	1.00
238_G	282_I	1.838	1.00
61_T	64_S	1.827	1.00
159_A	222_L	1.780	1.00
9_F	45_L	1.774	1.00
84_P	87_A	1.773	1.00
17_L	29_V	1.773	1.00
261_K	265_T	1.769	1.00
261_K	274_D	1.725	1.00
116_K	143_T	1.720	1.00
81_K	111_D	1.713	1.00
81_K	108_A	1.697	1.00
247_L	307_V	1.689	1.00
272_Y	293_A	1.678	1.00
322_Q	325_R	1.644	1.00
271_G	285_S	1.643	1.00
96_C	120_S	1.643	1.00
127_K	137_T	1.636	1.00
118_L	327_L	1.621	1.00
17_L	45_L	1.614	1.00
19_R	321_T	1.605	1.00
17_L	67_V	1.604	1.00
257_N	296_T	1.600	1.00
120_S	323_L	1.593	1.00
169_E	305_Q	1.592	1.00
94_V	327_L	1.579	1.00
182_T	190_R	1.563	1.00
159_A	168_I	1.561	1.00
276_E	294_T	1.560	1.00
169_E	246_I	1.559	1.00
250_K	303_D	1.545	1.00
49_S	202_E	1.541	1.00
101_T	119_I	1.530	1.00
73_A	87_A	1.518	1.00
3_K	89_G	1.490	1.00
64_S	73_A	1.466	1.00
102_S	124_G	1.454	1.00
43_Y	197_S	1.435	1.00
166_F	247_L	1.424	1.00
38_P	74_V	1.414	1.00
273_T	282_I	1.397	1.00
107_Q	110_L	1.393	1.00
53_P	285_S	1.393	1.00
43_Y	194_L	1.377	1.00
185_L	200_A	1.374	1.00
49_S	280_S	1.370	1.00
158_M	311_A	1.358	1.00
285_S	290_V	1.349	1.00
22_E	55_P	1.346	1.00
202_E	236_K	1.342	1.00
123_A	126_M	1.340	1.00
75_Y	88_K	1.324	1.00
217_L	223_S	1.322	1.00
253_A	296_T	1.321	1.00
94_V	323_L	1.314	1.00
252_T	255_E	1.314	1.00
158_M	289_S	1.309	1.00
24_K	328_E	1.301	1.00
181_G	186_V	1.296	1.00
31_A	75_Y	1.289	1.00
96_C	323_L	1.289	1.00
246_I	305_Q	1.285	1.00
196_A	207_H	1.277	1.00
106_S	119_I	1.262	1.00
161_A	270_F	1.258	1.00
287_F	290_V	1.254	1.00
171_G	226_L	1.251	1.00
162_L	260_L	1.235	1.00
277_I	282_I	1.234	1.00
199_A	202_E	1.231	1.00
288_G	325_R	1.219	1.00
83_I	88_K	1.211	1.00
92_I	327_L	1.206	1.00
193_D	196_A	1.201	1.00
273_T	277_I	1.193	1.00
161_A	259_A	1.193	1.00
170_V	305_Q	1.191	1.00
17_L	72_I	1.186	0.99
261_K	272_Y	1.179	0.99
274_D	293_A	1.174	0.99
79_E	108_A	1.171	0.99
163_H	219_I	1.170	0.99
38_P	60_F	1.166	0.99
61_T	66_I	1.148	0.99
280_S	283_I	1.145	0.99
184_S	188_G	1.144	0.99
165_S	259_A	1.144	0.99
247_L	251_V	1.137	0.99
162_L	309_T	1.134	0.99
54_F	68_D	1.131	0.99
181_G	188_G	1.128	0.99
317_Y	321_T	1.124	0.99
165_S	169_E	1.113	0.99
15_L	51_Y	1.112	0.99
295_Q	310_V	1.103	0.99
16_V	323_L	1.101	0.99
158_M	260_L	1.089	0.99
5_G	83_I	1.087	0.99
262_Q	266_N	1.083	0.99
42_A	58_V	1.082	0.99
16_V	320_V	1.080	0.99
319_F	323_L	1.080	0.99
167_G	247_L	1.079	0.99
176_I	231_Q	1.076	0.99
119_I	126_M	1.076	0.99
16_V	94_V	1.075	0.99
286_H	317_Y	1.071	0.99
166_F	251_V	1.059	0.99
258_N	261_K	1.054	0.99
22_E	284_G	1.053	0.99
92_I	118_L	1.047	0.99
66_I	69_G	1.047	0.99
138_L	145_V	1.044	0.99
66_I	71_S	1.044	0.99
229_H	310_V	1.042	0.99
119_I	123_A	1.039	0.99
138_L	143_T	1.037	0.99
26_N	328_E	1.037	0.99
158_M	309_T	1.035	0.99
251_V	255_E	1.031	0.99
128_T	217_L	1.027	0.99
240_V	310_V	1.026	0.98
47_H	275_E	1.026	0.98
37_S	40_I	1.024	0.98
139_D	142_D	1.023	0.98
50_N	236_K	1.015	0.98
123_A	128_T	1.015	0.98
83_I	112_A	1.012	0.98
137_T	221_E	1.011	0.98
235_V	238_G	1.011	0.98
195_R	292_D	1.009	0.98
162_L	247_L	1.009	0.98
163_H	248_G	1.007	0.98
253_A	257_N	1.006	0.98
118_L	145_V	0.998	0.98
45_L	56_W	0.996	0.98
5_G	90_A	0.995	0.98
103_A	126_M	0.989	0.98
170_V	306_L	0.985	0.98
166_F	256_V	0.978	0.98
41_L	74_V	0.978	0.98
155_L	173_M	0.970	0.98
254_E	258_N	0.968	0.98
286_H	321_T	0.963	0.98
182_T	196_A	0.959	0.98
116_K	138_L	0.956	0.98
108_A	112_A	0.949	0.98
21_L	70_K	0.948	0.97
231_Q	310_V	0.948	0.97
270_F	289_S	0.942	0.97
251_V	259_A	0.940	0.97
104_E	107_Q	0.939	0.97
129_I	142_D	0.936	0.97
273_T	294_T	0.936	0.97
259_A	262_Q	0.932	0.97
129_I	138_L	0.928	0.97
272_Y	291_F	0.926	0.97
130_V	148_A	0.920	0.97
51_Y	284_G	0.920	0.97
251_V	256_V	0.918	0.97
284_G	317_Y	0.917	0.97
162_L	245_S	0.916	0.97
91_E	115_K	0.912	0.97
90_A	93_I	0.911	0.97
271_G	290_V	0.905	0.97
63_D	73_A	0.901	0.97
131_Y	326_T	0.899	0.97
50_N	237_T	0.893	0.96
2_S	27_I	0.892	0.96
73_A	88_K	0.889	0.96
154_C	241_T	0.886	0.96
31_A	90_A	0.884	0.96
102_S	108_A	0.875	0.96
46_K	53_P	0.874	0.96
257_N	291_F	0.871	0.96
190_R	196_A	0.869	0.96
75_Y	84_P	0.869	0.96
238_G	283_I	0.863	0.96
131_Y	329_K	0.861	0.96
273_T	293_A	0.855	0.95
51_Y	283_I	0.850	0.95
181_G	205_I	0.849	0.95
92_I	330_F	0.842	0.95
20_L	324_I	0.841	0.95
50_N	186_V	0.835	0.95
39_K	60_F	0.834	0.95
103_A	125_E	0.832	0.95
27_I	328_E	0.830	0.95
9_F	32_I	0.829	0.95
34_D	189_P	0.825	0.94
158_M	291_F	0.821	0.94
5_G	112_A	0.819	0.94
107_Q	144_I	0.816	0.94
118_L	326_T	0.806	0.94
41_L	189_P	0.805	0.94
57_S	68_D	0.803	0.94
32_I	65_L	0.800	0.93
30_V	90_A	0.799	0.93
31_A	88_K	0.799	0.93
60_F	66_I	0.795	0.93
101_T	105_K	0.793	0.93
50_N	202_E	0.793	0.93
199_A	236_K	0.785	0.93
102_S	107_Q	0.784	0.93
16_V	324_I	0.784	0.93
172_T	229_H	0.782	0.93
43_Y	47_H	0.781	0.93
242_E	308_K	0.780	0.93
75_Y	83_I	0.774	0.92
179_Y	185_L	0.774	0.92
84_P	88_K	0.773	0.92
36_T	189_P	0.769	0.92
136_D	329_K	0.765	0.92
173_M	241_T	0.765	0.92
184_S	197_S	0.763	0.92
255_E	258_N	0.761	0.92
148_A	319_F	0.761	0.92
190_R	197_S	0.758	0.92
99_F	105_K	0.753	0.91
251_V	307_V	0.752	0.91
215_I	219_I	0.749	0.91
165_S	263_A	0.748	0.91
35_L	189_P	0.747	0.91
155_L	159_A	0.747	0.91
108_A	111_D	0.746	0.91
131_Y	269_S	0.745	0.91
204_I	310_V	0.745	0.91
45_L	54_F	0.743	0.91
59_D	66_I	0.743	0.91
38_P	42_A	0.740	0.91
259_A	263_A	0.735	0.90
194_L	197_S	0.735	0.90
6_I	17_L	0.735	0.90
78_K	99_F	0.734	0.90
158_M	241_T	0.733	0.90
229_H	308_K	0.731	0.90
181_G	184_S	0.729	0.90
195_R	295_Q	0.729	0.90
46_K	57_S	0.728	0.90
138_L	329_K	0.727	0.90
103_A	144_I	0.725	0.90
174_T	244_V	0.720	0.89
327_L	330_F	0.718	0.89
166_F	249_K	0.717	0.89
126_M	142_D	0.717	0.89
31_A	73_A	0.715	0.89
245_S	309_T	0.715	0.89
32_I	74_V	0.715	0.89
50_N	199_A	0.714	0.89
208_T	213_K	0.714	0.89
36_T	41_L	0.713	0.89
35_L	41_L	0.711	0.89
291_F	294_T	0.709	0.89
127_K	139_D	0.707	0.88
35_L	99_F	0.706	0.88
179_Y	236_K	0.704	0.88
129_I	137_T	0.703	0.88
57_S	69_G	0.703	0.88
167_G	248_G	0.702	0.88
3_K	91_E	0.701	0.88
261_K	264_T	0.700	0.88
104_E	125_E	0.698	0.88
130_V	133_V	0.695	0.88
35_L	77_E	0.695	0.88
27_I	92_I	0.689	0.87
35_L	78_K	0.687	0.87
34_D	99_F	0.686	0.87
49_S	236_K	0.686	0.87
271_G	289_S	0.685	0.87
245_S	307_V	0.680	0.86
238_G	241_T	0.680	0.86
247_L	256_V	0.676	0.86
215_I	226_L	0.675	0.86
103_A	143_T	0.673	0.86
21_L	68_D	0.673	0.86
2_S	92_I	0.672	0.86
63_D	71_S	0.670	0.86
60_F	64_S	0.669	0.86
42_A	60_F	0.667	0.85
75_Y	87_A	0.665	0.85
77_E	83_I	0.663	0.85
172_T	299_T	0.662	0.85
155_L	241_T	0.661	0.85
147_V	320_V	0.660	0.85
159_A	226_L	0.660	0.85
119_I	144_I	0.659	0.85
118_L	330_F	0.659	0.85
93_I	114_A	0.657	0.84
107_Q	143_T	0.655	0.84
140_G	143_T	0.655	0.84
2_S	26_N	0.654	0.84
260_L	270_F	0.654	0.84
58_V	67_V	0.653	0.84
174_T	231_Q	0.652	0.84
210_G	239_S	0.650	0.84
96_C	327_L	0.647	0.84
35_L	76_A	0.647	0.84
86_K	112_A	0.645	0.83
165_S	249_K	0.644	0.83
62_E	66_I	0.644	0.83
45_L	67_V	0.643	0.83
22_E	56_W	0.642	0.83
201_A	236_K	0.641	0.83
102_S	125_E	0.640	0.83
125_E	217_L	0.639	0.83
129_I	326_T	0.637	0.83
138_L	330_F	0.637	0.83
19_R	324_I	0.637	0.83
244_V	306_L	0.637	0.83
172_T	227_K	0.633	0.82
127_K	145_V	0.633	0.82
39_K	194_L	0.631	0.82
106_S	144_I	0.628	0.82
55_P	68_D	0.628	0.82
17_L	21_L	0.626	0.82
131_Y	147_V	0.623	0.81
14_R	18_G	0.623	0.81
193_D	207_H	0.622	0.81
162_L	243_L	0.622	0.81
43_Y	277_I	0.621	0.81
39_K	62_E	0.620	0.81
5_G	88_K	0.620	0.81
104_E	111_D	0.619	0.81
43_Y	193_D	0.617	0.81
265_T	272_Y	0.617	0.81
24_K	324_I	0.617	0.81
256_V	260_L	0.615	0.80
35_L	97_T	0.615	0.80
101_T	106_S	0.614	0.80
257_N	293_A	0.613	0.80
159_A	219_I	0.611	0.80
45_L	58_V	0.610	0.80
159_A	243_L	0.609	0.80
194_L	276_E	0.608	0.80
246_I	306_L	0.607	0.80
110_L	144_I	0.606	0.79
235_V	282_I	0.602	0.79
101_T	124_G	0.602	0.79
32_I	72_I	0.601	0.79
22_E	25_S	0.600	0.79
142_D	145_V	0.599	0.79
193_D	197_S	0.599	0.79
78_K	81_K	0.599	0.79
148_A	214_A	0.599	0.79
110_L	143_T	0.596	0.78
204_I	233_V	0.594	0.78
103_A	108_A	0.594	0.78
202_E	283_I	0.593	0.78
176_I	204_I	0.593	0.78
238_G	277_I	0.590	0.78
35_L	83_I	0.589	0.78
5_G	31_A	0.587	0.77
154_C	311_A	0.585	0.77
91_E	114_A	0.583	0.77
19_R	317_Y	0.583	0.77
131_Y	325_R	0.582	0.77
2_S	5_G	0.582	0.77
15_L	317_Y	0.579	0.76
46_K	58_V	0.579	0.76
132_N	269_S	0.578	0.76
215_I	227_K	0.578	0.76
261_K	293_A	0.577	0.76
4_V	27_I	0.577	0.76
260_L	309_T	0.577	0.76
179_Y	202_E	0.577	0.76
262_Q	265_T	0.575	0.76
85_W	109_H	0.575	0.76
65_L	72_I	0.575	0.76
39_K	43_Y	0.574	0.76
204_I	235_V	0.572	0.75
166_F	245_S	0.571	0.75
161_A	263_A	0.570	0.75
164_D	219_I	0.570	0.75
173_M	228_G	0.570	0.75
5_G	89_G	0.569	0.75
174_T	242_E	0.563	0.74
245_S	260_L	0.563	0.74
38_P	63_D	0.562	0.74
86_K	114_A	0.561	0.74
159_A	245_S	0.561	0.74
171_G	245_S	0.561	0.74
326_T	329_K	0.561	0.74
229_H	295_Q	0.561	0.74
163_H	222_L	0.560	0.74
88_K	112_A	0.558	0.74
173_M	243_L	0.558	0.74
174_T	308_K	0.557	0.74
4_V	327_L	0.557	0.74
91_E	113_G	0.556	0.73
323_L	327_L	0.555	0.73
179_Y	200_A	0.554	0.73
275_E	282_I	0.553	0.73
320_V	325_R	0.553	0.73
165_S	247_L	0.552	0.73
251_V	305_Q	0.552	0.73
40_I	197_S	0.551	0.73
47_H	53_P	0.550	0.73
147_V	325_R	0.550	0.73
288_G	320_V	0.549	0.72
254_E	257_N	0.548	0.72
40_I	189_P	0.548	0.72
36_T	40_I	0.547	0.72
109_H	114_A	0.545	0.72
3_K	30_V	0.545	0.72
83_I	109_H	0.544	0.72
62_E	65_L	0.543	0.72
38_P	64_S	0.543	0.72
16_V	20_L	0.543	0.72
171_G	243_L	0.542	0.72
42_A	65_L	0.538	0.71
269_S	288_G	0.536	0.71
175_T	239_S	0.536	0.71
171_G	216_G	0.535	0.71
326_T	330_F	0.533	0.70
151_T	175_T	0.532	0.70
5_G	75_Y	0.530	0.70
182_T	197_S	0.530	0.70
258_N	265_T	0.530	0.70
319_F	326_T	0.529	0.70
19_R	22_E	0.527	0.69
119_I	125_E	0.527	0.69
7_N	33_N	0.526	0.69
30_V	33_N	0.524	0.69
53_P	275_E	0.524	0.69
84_P	112_A	0.523	0.69
260_L	272_Y	0.522	0.69
229_H	240_V	0.517	0.68
165_S	260_L	0.517	0.68
154_C	289_S	0.514	0.68
159_A	163_H	0.513	0.67
5_G	85_W	0.513	0.67
66_I	70_K	0.512	0.67
168_I	245_S	0.512	0.67
2_S	91_E	0.511	0.67
14_R	44_L	0.508	0.67
36_T	76_A	0.508	0.67
25_S	328_E	0.506	0.66
273_T	290_V	0.505	0.66
15_L	19_R	0.504	0.66
209_T	239_S	0.503	0.66
60_F	63_D	0.500	0.65

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4boyA	4	0.985	100	0.219	Contact Map
3idsC	4	0.991	100	0.228	Contact Map
1rm4O	4	0.985	100	0.23	Contact Map
3docA	4	0.985	100	0.233	Contact Map
4lsmA	4	0.985	100	0.235	Contact Map
1obfO	4	0.979	100	0.238	Contact Map
2ep7A	4	0.982	100	0.241	Contact Map
4o59O	4	0.985	100	0.241	Contact Map
2x5jO	4	0.967	100	0.242	Contact Map
3pymA	4	0.988	100	0.244	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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