GREMLIN Database
G3P3 - Putative glyceraldehyde-3-phosphate dehydrogenase C
UniProt: P33898 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12103
Length: 333 (321)
Sequences: 5413 (2420)
Seq/√Len: 135.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
163_H221_E4.2401.00
77_E82_N3.5811.00
169_E248_G3.3931.00
160_K164_D3.1611.00
271_G287_F3.0671.00
135_D329_K2.7991.00
250_K305_Q2.7641.00
203_N280_S2.7521.00
107_Q111_D2.7411.00
79_E82_N2.6611.00
260_L291_F2.5331.00
166_F259_A2.4931.00
179_Y201_A2.4751.00
56_W68_D2.4531.00
3_K28_D2.4401.00
165_S262_Q2.4121.00
289_S311_A2.3651.00
145_V330_F2.3371.00
105_K108_A2.2991.00
61_T71_S2.2091.00
170_V246_I2.2021.00
288_G322_Q2.1871.00
102_S105_K2.1821.00
231_Q240_V2.1621.00
64_S71_S2.1501.00
237_T283_I2.0901.00
249_K255_E2.0181.00
131_Y135_D2.0101.00
127_K142_D1.9931.00
256_V307_V1.9931.00
178_A235_V1.9421.00
46_K275_E1.9381.00
21_L54_F1.9221.00
80_A100_Y1.9031.00
258_N262_Q1.9001.00
40_I194_L1.8771.00
51_Y237_T1.8651.00
216_G223_S1.8581.00
28_D70_K1.8561.00
20_L29_V1.8551.00
204_I231_Q1.8531.00
103_A107_Q1.8441.00
238_G282_I1.8381.00
61_T64_S1.8271.00
159_A222_L1.7801.00
9_F45_L1.7741.00
84_P87_A1.7731.00
17_L29_V1.7731.00
261_K265_T1.7691.00
261_K274_D1.7251.00
116_K143_T1.7201.00
81_K111_D1.7131.00
81_K108_A1.6971.00
247_L307_V1.6891.00
272_Y293_A1.6781.00
322_Q325_R1.6441.00
271_G285_S1.6431.00
96_C120_S1.6431.00
127_K137_T1.6361.00
118_L327_L1.6211.00
17_L45_L1.6141.00
19_R321_T1.6051.00
17_L67_V1.6041.00
257_N296_T1.6001.00
120_S323_L1.5931.00
169_E305_Q1.5921.00
94_V327_L1.5791.00
182_T190_R1.5631.00
159_A168_I1.5611.00
276_E294_T1.5601.00
169_E246_I1.5591.00
250_K303_D1.5451.00
49_S202_E1.5411.00
101_T119_I1.5301.00
73_A87_A1.5181.00
3_K89_G1.4901.00
64_S73_A1.4661.00
102_S124_G1.4541.00
43_Y197_S1.4351.00
166_F247_L1.4241.00
38_P74_V1.4141.00
273_T282_I1.3971.00
107_Q110_L1.3931.00
53_P285_S1.3931.00
43_Y194_L1.3771.00
185_L200_A1.3741.00
49_S280_S1.3701.00
158_M311_A1.3581.00
285_S290_V1.3491.00
22_E55_P1.3461.00
202_E236_K1.3421.00
123_A126_M1.3401.00
75_Y88_K1.3241.00
217_L223_S1.3221.00
253_A296_T1.3211.00
94_V323_L1.3141.00
252_T255_E1.3141.00
158_M289_S1.3091.00
24_K328_E1.3011.00
181_G186_V1.2961.00
31_A75_Y1.2891.00
96_C323_L1.2891.00
246_I305_Q1.2851.00
196_A207_H1.2771.00
106_S119_I1.2621.00
161_A270_F1.2581.00
287_F290_V1.2541.00
171_G226_L1.2511.00
162_L260_L1.2351.00
277_I282_I1.2341.00
199_A202_E1.2311.00
288_G325_R1.2191.00
83_I88_K1.2111.00
92_I327_L1.2061.00
193_D196_A1.2011.00
273_T277_I1.1931.00
161_A259_A1.1931.00
170_V305_Q1.1911.00
17_L72_I1.1860.99
261_K272_Y1.1790.99
274_D293_A1.1740.99
79_E108_A1.1710.99
163_H219_I1.1700.99
38_P60_F1.1660.99
61_T66_I1.1480.99
280_S283_I1.1450.99
184_S188_G1.1440.99
165_S259_A1.1440.99
247_L251_V1.1370.99
162_L309_T1.1340.99
54_F68_D1.1310.99
181_G188_G1.1280.99
317_Y321_T1.1240.99
165_S169_E1.1130.99
15_L51_Y1.1120.99
295_Q310_V1.1030.99
16_V323_L1.1010.99
158_M260_L1.0890.99
5_G83_I1.0870.99
262_Q266_N1.0830.99
42_A58_V1.0820.99
16_V320_V1.0800.99
319_F323_L1.0800.99
167_G247_L1.0790.99
176_I231_Q1.0760.99
119_I126_M1.0760.99
16_V94_V1.0750.99
286_H317_Y1.0710.99
166_F251_V1.0590.99
258_N261_K1.0540.99
22_E284_G1.0530.99
92_I118_L1.0470.99
66_I69_G1.0470.99
138_L145_V1.0440.99
66_I71_S1.0440.99
229_H310_V1.0420.99
119_I123_A1.0390.99
138_L143_T1.0370.99
26_N328_E1.0370.99
158_M309_T1.0350.99
251_V255_E1.0310.99
128_T217_L1.0270.99
240_V310_V1.0260.98
47_H275_E1.0260.98
37_S40_I1.0240.98
139_D142_D1.0230.98
50_N236_K1.0150.98
123_A128_T1.0150.98
83_I112_A1.0120.98
137_T221_E1.0110.98
235_V238_G1.0110.98
195_R292_D1.0090.98
162_L247_L1.0090.98
163_H248_G1.0070.98
253_A257_N1.0060.98
118_L145_V0.9980.98
45_L56_W0.9960.98
5_G90_A0.9950.98
103_A126_M0.9890.98
170_V306_L0.9850.98
166_F256_V0.9780.98
41_L74_V0.9780.98
155_L173_M0.9700.98
254_E258_N0.9680.98
286_H321_T0.9630.98
182_T196_A0.9590.98
116_K138_L0.9560.98
108_A112_A0.9490.98
21_L70_K0.9480.97
231_Q310_V0.9480.97
270_F289_S0.9420.97
251_V259_A0.9400.97
104_E107_Q0.9390.97
129_I142_D0.9360.97
273_T294_T0.9360.97
259_A262_Q0.9320.97
129_I138_L0.9280.97
272_Y291_F0.9260.97
130_V148_A0.9200.97
51_Y284_G0.9200.97
251_V256_V0.9180.97
284_G317_Y0.9170.97
162_L245_S0.9160.97
91_E115_K0.9120.97
90_A93_I0.9110.97
271_G290_V0.9050.97
63_D73_A0.9010.97
131_Y326_T0.8990.97
50_N237_T0.8930.96
2_S27_I0.8920.96
73_A88_K0.8890.96
154_C241_T0.8860.96
31_A90_A0.8840.96
102_S108_A0.8750.96
46_K53_P0.8740.96
257_N291_F0.8710.96
190_R196_A0.8690.96
75_Y84_P0.8690.96
238_G283_I0.8630.96
131_Y329_K0.8610.96
273_T293_A0.8550.95
51_Y283_I0.8500.95
181_G205_I0.8490.95
92_I330_F0.8420.95
20_L324_I0.8410.95
50_N186_V0.8350.95
39_K60_F0.8340.95
103_A125_E0.8320.95
27_I328_E0.8300.95
9_F32_I0.8290.95
34_D189_P0.8250.94
158_M291_F0.8210.94
5_G112_A0.8190.94
107_Q144_I0.8160.94
118_L326_T0.8060.94
41_L189_P0.8050.94
57_S68_D0.8030.94
32_I65_L0.8000.93
30_V90_A0.7990.93
31_A88_K0.7990.93
60_F66_I0.7950.93
101_T105_K0.7930.93
50_N202_E0.7930.93
199_A236_K0.7850.93
102_S107_Q0.7840.93
16_V324_I0.7840.93
172_T229_H0.7820.93
43_Y47_H0.7810.93
242_E308_K0.7800.93
75_Y83_I0.7740.92
179_Y185_L0.7740.92
84_P88_K0.7730.92
36_T189_P0.7690.92
136_D329_K0.7650.92
173_M241_T0.7650.92
184_S197_S0.7630.92
255_E258_N0.7610.92
148_A319_F0.7610.92
190_R197_S0.7580.92
99_F105_K0.7530.91
251_V307_V0.7520.91
215_I219_I0.7490.91
165_S263_A0.7480.91
35_L189_P0.7470.91
155_L159_A0.7470.91
108_A111_D0.7460.91
131_Y269_S0.7450.91
204_I310_V0.7450.91
45_L54_F0.7430.91
59_D66_I0.7430.91
38_P42_A0.7400.91
259_A263_A0.7350.90
194_L197_S0.7350.90
6_I17_L0.7350.90
78_K99_F0.7340.90
158_M241_T0.7330.90
229_H308_K0.7310.90
181_G184_S0.7290.90
195_R295_Q0.7290.90
46_K57_S0.7280.90
138_L329_K0.7270.90
103_A144_I0.7250.90
174_T244_V0.7200.89
327_L330_F0.7180.89
166_F249_K0.7170.89
126_M142_D0.7170.89
31_A73_A0.7150.89
245_S309_T0.7150.89
32_I74_V0.7150.89
50_N199_A0.7140.89
208_T213_K0.7140.89
36_T41_L0.7130.89
35_L41_L0.7110.89
291_F294_T0.7090.89
127_K139_D0.7070.88
35_L99_F0.7060.88
179_Y236_K0.7040.88
129_I137_T0.7030.88
57_S69_G0.7030.88
167_G248_G0.7020.88
3_K91_E0.7010.88
261_K264_T0.7000.88
104_E125_E0.6980.88
130_V133_V0.6950.88
35_L77_E0.6950.88
27_I92_I0.6890.87
35_L78_K0.6870.87
34_D99_F0.6860.87
49_S236_K0.6860.87
271_G289_S0.6850.87
245_S307_V0.6800.86
238_G241_T0.6800.86
247_L256_V0.6760.86
215_I226_L0.6750.86
103_A143_T0.6730.86
21_L68_D0.6730.86
2_S92_I0.6720.86
63_D71_S0.6700.86
60_F64_S0.6690.86
42_A60_F0.6670.85
75_Y87_A0.6650.85
77_E83_I0.6630.85
172_T299_T0.6620.85
155_L241_T0.6610.85
147_V320_V0.6600.85
159_A226_L0.6600.85
119_I144_I0.6590.85
118_L330_F0.6590.85
93_I114_A0.6570.84
107_Q143_T0.6550.84
140_G143_T0.6550.84
2_S26_N0.6540.84
260_L270_F0.6540.84
58_V67_V0.6530.84
174_T231_Q0.6520.84
210_G239_S0.6500.84
96_C327_L0.6470.84
35_L76_A0.6470.84
86_K112_A0.6450.83
165_S249_K0.6440.83
62_E66_I0.6440.83
45_L67_V0.6430.83
22_E56_W0.6420.83
201_A236_K0.6410.83
102_S125_E0.6400.83
125_E217_L0.6390.83
129_I326_T0.6370.83
138_L330_F0.6370.83
19_R324_I0.6370.83
244_V306_L0.6370.83
172_T227_K0.6330.82
127_K145_V0.6330.82
39_K194_L0.6310.82
106_S144_I0.6280.82
55_P68_D0.6280.82
17_L21_L0.6260.82
131_Y147_V0.6230.81
14_R18_G0.6230.81
193_D207_H0.6220.81
162_L243_L0.6220.81
43_Y277_I0.6210.81
39_K62_E0.6200.81
5_G88_K0.6200.81
104_E111_D0.6190.81
43_Y193_D0.6170.81
265_T272_Y0.6170.81
24_K324_I0.6170.81
256_V260_L0.6150.80
35_L97_T0.6150.80
101_T106_S0.6140.80
257_N293_A0.6130.80
159_A219_I0.6110.80
45_L58_V0.6100.80
159_A243_L0.6090.80
194_L276_E0.6080.80
246_I306_L0.6070.80
110_L144_I0.6060.79
235_V282_I0.6020.79
101_T124_G0.6020.79
32_I72_I0.6010.79
22_E25_S0.6000.79
142_D145_V0.5990.79
193_D197_S0.5990.79
78_K81_K0.5990.79
148_A214_A0.5990.79
110_L143_T0.5960.78
204_I233_V0.5940.78
103_A108_A0.5940.78
202_E283_I0.5930.78
176_I204_I0.5930.78
238_G277_I0.5900.78
35_L83_I0.5890.78
5_G31_A0.5870.77
154_C311_A0.5850.77
91_E114_A0.5830.77
19_R317_Y0.5830.77
131_Y325_R0.5820.77
2_S5_G0.5820.77
15_L317_Y0.5790.76
46_K58_V0.5790.76
132_N269_S0.5780.76
215_I227_K0.5780.76
261_K293_A0.5770.76
4_V27_I0.5770.76
260_L309_T0.5770.76
179_Y202_E0.5770.76
262_Q265_T0.5750.76
85_W109_H0.5750.76
65_L72_I0.5750.76
39_K43_Y0.5740.76
204_I235_V0.5720.75
166_F245_S0.5710.75
161_A263_A0.5700.75
164_D219_I0.5700.75
173_M228_G0.5700.75
5_G89_G0.5690.75
174_T242_E0.5630.74
245_S260_L0.5630.74
38_P63_D0.5620.74
86_K114_A0.5610.74
159_A245_S0.5610.74
171_G245_S0.5610.74
326_T329_K0.5610.74
229_H295_Q0.5610.74
163_H222_L0.5600.74
88_K112_A0.5580.74
173_M243_L0.5580.74
174_T308_K0.5570.74
4_V327_L0.5570.74
91_E113_G0.5560.73
323_L327_L0.5550.73
179_Y200_A0.5540.73
275_E282_I0.5530.73
320_V325_R0.5530.73
165_S247_L0.5520.73
251_V305_Q0.5520.73
40_I197_S0.5510.73
47_H53_P0.5500.73
147_V325_R0.5500.73
288_G320_V0.5490.72
254_E257_N0.5480.72
40_I189_P0.5480.72
36_T40_I0.5470.72
109_H114_A0.5450.72
3_K30_V0.5450.72
83_I109_H0.5440.72
62_E65_L0.5430.72
38_P64_S0.5430.72
16_V20_L0.5430.72
171_G243_L0.5420.72
42_A65_L0.5380.71
269_S288_G0.5360.71
175_T239_S0.5360.71
171_G216_G0.5350.71
326_T330_F0.5330.70
151_T175_T0.5320.70
5_G75_Y0.5300.70
182_T197_S0.5300.70
258_N265_T0.5300.70
319_F326_T0.5290.70
19_R22_E0.5270.69
119_I125_E0.5270.69
7_N33_N0.5260.69
30_V33_N0.5240.69
53_P275_E0.5240.69
84_P112_A0.5230.69
260_L272_Y0.5220.69
229_H240_V0.5170.68
165_S260_L0.5170.68
154_C289_S0.5140.68
159_A163_H0.5130.67
5_G85_W0.5130.67
66_I70_K0.5120.67
168_I245_S0.5120.67
2_S91_E0.5110.67
14_R44_L0.5080.67
36_T76_A0.5080.67
25_S328_E0.5060.66
273_T290_V0.5050.66
15_L19_R0.5040.66
209_T239_S0.5030.66
60_F63_D0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4boyA 4 0.985 100 0.219 Contact Map
3idsC 4 0.991 100 0.228 Contact Map
1rm4O 4 0.985 100 0.23 Contact Map
3docA 4 0.985 100 0.233 Contact Map
4lsmA 4 0.985 100 0.235 Contact Map
1obfO 4 0.979 100 0.238 Contact Map
2ep7A 4 0.982 100 0.241 Contact Map
4o59O 4 0.985 100 0.241 Contact Map
2x5jO 4 0.967 100 0.242 Contact Map
3pymA 4 0.988 100 0.244 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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