GREMLIN Database
SELU - tRNA 2-selenouridine synthase
UniProt: P33667 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11768
Length: 364 (305)
Sequences: 958 (722)
Seq/√Len: 41.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_A96_C4.8331.00
27_I45_N4.8301.00
49_A53_T4.1121.00
283_H306_D3.7581.00
320_G323_A3.3971.00
326_V330_E3.2331.00
50_A66_L3.1841.00
157_L252_R3.0811.00
191_S195_L3.0691.00
146_L214_L3.0411.00
64_L102_Q3.0271.00
54_C66_L2.9161.00
105_H120_L2.8411.00
251_E322_L2.8251.00
283_H302_A2.7541.00
150_C338_R2.7471.00
46_D50_A2.7441.00
128_L194_N2.6651.00
162_Q213_V2.5591.00
58_Q62_A2.4841.00
247_E326_V2.4641.00
199_E202_K2.3981.00
157_L255_E2.3901.00
219_R228_E2.3711.00
166_V214_L2.3411.00
26_P44_N2.2941.00
51_V66_L2.2271.00
60_S102_Q2.1480.99
226_L231_R2.1450.99
31_H190_A2.1190.99
153_S244_D2.1030.99
60_S64_L2.0930.99
50_A70_L2.0930.99
245_P248_I2.0540.99
325_L329_L2.0400.99
126_K130_Q2.0260.99
250_L325_L2.0030.99
148_G239_I1.9800.99
30_E45_N1.9740.99
154_G252_R1.9410.99
29_F39_N1.9190.99
154_G256_E1.9150.99
290_K295_L1.8930.99
44_N47_E1.8260.98
108_Q120_L1.7740.98
254_N322_L1.7620.98
171_L199_E1.7590.98
297_R331_E1.7500.98
303_A307_A1.7500.98
173_R184_Q1.7360.97
321_H324_W1.7180.97
179_F286_L1.7030.97
336_M340_Q1.6600.97
287_S302_A1.6590.97
146_L234_M1.6540.97
93_G118_Y1.6240.96
199_E203_T1.6130.96
26_P45_N1.5990.96
290_K299_N1.5990.96
77_Q81_D1.5980.96
289_I298_Y1.5970.96
46_D49_A1.5840.96
296_Q300_E1.5750.95
53_T57_Q1.5640.95
108_Q118_Y1.5540.95
163_P199_E1.5500.95
133_I193_E1.5490.95
158_L242_V1.5440.95
160_Q167_D1.5430.95
251_E255_E1.5260.95
98_A190_A1.5160.94
137_I229_C1.4870.94
25_A49_A1.4850.94
43_M47_E1.4600.93
74_E78_Q1.4590.93
214_L234_M1.4320.92
68_H110_W1.4090.92
295_L299_N1.4070.92
304_R320_G1.4050.92
173_R183_L1.3920.91
77_Q82_A1.3840.91
244_D248_I1.3760.91
244_D252_R1.3760.91
197_A201_L1.3710.91
307_A320_G1.3620.90
302_A306_D1.3610.90
43_M68_H1.3130.89
296_Q299_N1.3070.89
47_E73_G1.3030.88
80_M221_I1.2950.88
75_I106_I1.2720.87
280_E284_H1.2710.87
51_V323_A1.2660.87
175_R259_L1.2650.87
250_L322_L1.2490.86
72_A109_S1.2440.86
220_M225_H1.2380.86
43_M51_V1.1970.84
39_N49_A1.1920.83
66_L70_L1.1840.83
283_H305_L1.1670.82
327_P331_E1.1530.81
80_M114_A1.1460.81
59_G294_G1.1440.81
73_G81_D1.1430.81
246_F250_L1.1380.80
84_R116_I1.1350.80
280_E306_D1.1340.80
68_H106_I1.1300.80
293_L298_Y1.1260.80
221_I226_L1.1230.80
252_R256_E1.1120.79
110_W325_L1.1060.78
125_Y186_Q1.1060.78
173_R195_L1.0980.78
221_I224_N1.0900.77
32_G194_N1.0900.77
144_I212_W1.0750.76
132_A197_A1.0680.76
144_I234_M1.0680.76
43_M74_E1.0680.76
182_T286_L1.0600.75
108_Q112_H1.0590.75
160_Q170_G1.0590.75
109_S294_G1.0550.75
14_L198_A1.0510.75
323_A326_V1.0450.74
175_R183_L1.0380.74
18_T94_I1.0380.74
304_R323_A1.0320.73
132_A190_A1.0280.73
85_A88_L1.0280.73
123_G127_A1.0250.73
128_L198_A1.0250.73
18_T92_Q1.0220.73
102_Q113_A1.0140.72
344_K347_K1.0010.71
324_W328_L1.0010.71
153_S246_F0.9970.71
182_T264_D0.9870.70
148_G216_D0.9850.70
250_L254_N0.9780.69
178_A289_I0.9770.69
21_I40_L0.9760.69
284_H288_A0.9730.69
192_F221_I0.9710.69
308_A320_G0.9680.69
183_L256_E0.9620.68
253_L325_L0.9610.68
34_M237_A0.9530.67
111_L116_I0.9490.67
59_G62_A0.9470.67
255_E307_A0.9390.66
66_L69_K0.9380.66
220_M223_S0.9330.66
216_D341_L0.9330.66
43_M71_V0.9310.65
130_Q133_I0.9300.65
23_V44_N0.9280.65
47_E75_I0.9270.65
171_L195_L0.9240.65
189_Q193_E0.9230.65
68_H72_A0.9220.65
20_I299_N0.9200.65
300_E303_A0.9180.64
287_S298_Y0.9170.64
241_V341_L0.9130.64
42_L293_L0.9110.64
109_S156_T0.9100.64
179_F336_M0.9070.63
167_D170_G0.9060.63
121_V128_L0.8950.62
300_E323_A0.8940.62
47_E74_E0.8910.62
144_I166_V0.8900.62
130_Q240_A0.8900.62
121_V160_Q0.8870.62
40_L84_R0.8870.62
294_G298_Y0.8820.61
216_D340_Q0.8810.61
147_I213_V0.8810.61
308_A321_H0.8810.61
196_L226_L0.8740.61
127_A130_Q0.8710.60
285_G288_A0.8680.60
21_I38_I0.8660.60
154_G242_V0.8660.60
246_F326_V0.8650.60
120_L253_L0.8600.59
154_G244_D0.8590.59
147_I250_L0.8580.59
144_I233_R0.8540.59
141_Q284_H0.8530.59
65_A75_I0.8500.58
126_K133_I0.8470.58
188_S191_S0.8470.58
179_F285_G0.8450.58
61_D102_Q0.8430.58
48_R98_A0.8400.57
246_F330_E0.8380.57
246_F251_E0.8350.57
71_V110_W0.8340.57
254_N258_F0.8340.57
56_K126_K0.8300.57
121_V182_T0.8270.56
196_L224_N0.8240.56
82_A200_M0.8220.56
247_E307_A0.8220.56
156_T170_G0.8120.55
96_C239_I0.8080.55
61_D65_A0.8060.54
188_S193_E0.8050.54
147_I325_L0.8010.54
231_R235_T0.8010.54
17_D202_K0.7980.54
130_Q134_Q0.7960.53
23_V49_A0.7940.53
32_G332_Y0.7930.53
189_Q340_Q0.7930.53
74_E116_I0.7900.53
196_L203_T0.7890.53
183_L264_D0.7780.52
239_I347_K0.7780.52
32_G191_S0.7760.52
160_Q251_E0.7740.51
228_E232_E0.7710.51
73_G76_R0.7710.51
166_V171_L0.7700.51
112_H118_Y0.7680.51
81_D85_A0.7630.50
62_A65_A0.7570.50
112_H117_D0.7570.50
52_G67_G0.7570.50
178_A336_M0.7540.50
26_P176_G0.7430.48
31_H213_V0.7420.48
178_A344_K0.7420.48
234_M294_G0.7400.48
20_I37_A0.7400.48
14_L128_L0.7400.48
261_M281_Y0.7370.48
29_F338_R0.7370.48
287_S290_K0.7350.48
291_R294_G0.7340.48
32_G125_Y0.7320.47
226_L229_C0.7310.47
54_C58_Q0.7300.47
47_E50_A0.7300.47
94_I289_I0.7290.47
114_A166_V0.7270.47
301_L332_Y0.7260.47
135_A201_L0.7260.47
19_P91_P0.7260.47
221_I347_K0.7250.47
94_I121_V0.7210.46
225_H256_E0.7200.46
34_M96_C0.7200.46
75_I109_S0.7200.46
286_L324_W0.7120.46
81_D88_L0.7120.46
40_L83_W0.7110.46
84_R221_I0.7080.45
33_A335_P0.7060.45
181_R288_A0.7060.45
121_V234_M0.7050.45
194_N289_I0.7050.45
248_I251_E0.7040.45
50_A58_Q0.7030.45
56_K59_G0.7020.45
109_S113_A0.6990.44
171_L187_L0.6980.44
297_R300_E0.6970.44
128_L282_L0.6940.44
42_L107_V0.6940.44
47_E51_V0.6920.44
251_E254_N0.6920.44
221_I343_K0.6900.44
40_L61_D0.6900.44
96_C191_S0.6850.43
43_M324_W0.6850.43
27_I30_E0.6810.43
23_V39_N0.6810.43
221_I225_H0.6790.43
121_V305_L0.6780.42
282_L305_L0.6780.42
67_G226_L0.6750.42
43_M102_Q0.6740.42
255_E284_H0.6720.42
50_A251_E0.6720.42
302_A305_L0.6710.42
150_C153_S0.6710.42
150_C218_S0.6680.42
45_N302_A0.6660.41
216_D294_G0.6650.41
216_D339_Y0.6650.41
199_E247_E0.6630.41
80_M174_H0.6630.41
110_W243_E0.6620.41
160_Q240_A0.6610.41
284_H306_D0.6600.41
147_I196_L0.6590.41
126_K234_M0.6590.41
148_G329_L0.6580.41
68_H114_A0.6580.41
293_L332_Y0.6560.40
133_I137_I0.6540.40
51_V282_L0.6500.40
144_I237_A0.6500.40
25_A120_L0.6460.40
122_E170_G0.6450.40
93_G107_V0.6450.40
128_L197_A0.6420.39
143_P232_E0.6410.39
32_G253_L0.6400.39
145_V153_S0.6380.39
163_P242_V0.6370.39
186_Q221_I0.6370.39
145_V235_T0.6310.38
70_L167_D0.6290.38
105_H253_L0.6260.38
77_Q166_V0.6240.38
35_P195_L0.6220.37
182_T185_P0.6210.37
216_D221_I0.6210.37
60_S121_V0.6210.37
285_G332_Y0.6170.37
144_I214_L0.6160.37
85_A95_L0.6130.37
43_M78_Q0.6130.37
134_Q170_G0.6130.37
45_N300_E0.6120.37
59_G107_V0.6120.37
30_E185_P0.6110.37
57_Q170_G0.6100.36
189_Q301_L0.6090.36
145_V213_V0.6070.36
26_P42_L0.6040.36
30_E92_Q0.6030.36
198_A202_K0.6020.36
42_L285_G0.6000.36
161_Q306_D0.6000.36
21_I164_N0.6000.36
260_R264_D0.5990.35
25_A108_Q0.5980.35
44_N49_A0.5980.35
98_A132_A0.5960.35
140_A229_C0.5950.35
251_E284_H0.5940.35
75_I80_M0.5940.35
299_N302_A0.5910.35
289_I301_L0.5890.35
166_V210_R0.5860.34
203_T212_W0.5860.34
109_S159_V0.5850.34
21_I89_Q0.5840.34
178_A341_L0.5830.34
189_Q328_L0.5830.34
112_H255_E0.5820.34
166_V226_L0.5790.34
25_A45_N0.5790.34
19_P87_C0.5790.34
27_I44_N0.5780.34
336_M339_Y0.5760.34
68_H324_W0.5740.33
289_I305_L0.5730.33
166_V199_E0.5710.33
199_E243_E0.5710.33
42_L71_V0.5710.33
40_L259_L0.5700.33
77_Q137_I0.5700.33
214_L230_L0.5700.33
159_V165_G0.5690.33
130_Q136_T0.5690.33
148_G234_M0.5660.33
71_V136_T0.5660.33
39_N95_L0.5660.33
188_S303_A0.5660.33
137_I159_V0.5630.32
31_H175_R0.5590.32
178_A237_A0.5590.32
81_D138_E0.5580.32
137_I140_A0.5580.32
64_L106_I0.5570.32
159_V242_V0.5570.32
144_I230_L0.5560.32
223_S236_Q0.5560.32
166_V196_L0.5550.32
258_F325_L0.5540.32
234_M282_L0.5540.32
301_L335_P0.5540.32
23_V107_V0.5530.32
294_G336_M0.5500.31
88_L116_I0.5490.31
68_H73_G0.5490.31
68_H74_E0.5470.31
242_V321_H0.5470.31
321_H336_M0.5450.31
16_A161_Q0.5450.31
294_G297_R0.5440.31
130_Q157_L0.5430.31
171_L196_L0.5430.31
261_M329_L0.5430.31
136_T343_K0.5420.31
221_I339_Y0.5420.31
135_A197_A0.5390.31
157_L213_V0.5390.31
254_N325_L0.5390.31
138_E141_Q0.5380.30
65_A220_M0.5350.30
20_I94_I0.5350.30
140_A158_L0.5350.30
284_H287_S0.5350.30
195_L199_E0.5340.30
234_M253_L0.5340.30
199_E283_H0.5340.30
248_I303_A0.5330.30
57_Q67_G0.5330.30
157_L161_Q0.5320.30
65_A81_D0.5320.30
111_L186_Q0.5320.30
19_P93_G0.5310.30
68_H332_Y0.5300.30
68_H75_I0.5300.30
59_G73_G0.5300.30
26_P118_Y0.5290.30
128_L190_A0.5270.30
146_L218_S0.5260.30
261_M321_H0.5250.29
131_T197_A0.5250.29
113_A121_V0.5240.29
14_L34_M0.5230.29
87_C122_E0.5230.29
198_A212_W0.5220.29
34_M347_K0.5220.29
244_D328_L0.5210.29
67_G340_Q0.5200.29
245_P327_P0.5190.29
157_L256_E0.5180.29
56_K329_L0.5180.29
55_Y71_V0.5180.29
212_W253_L0.5160.29
174_H178_A0.5150.29
16_A307_A0.5150.29
216_D239_I0.5120.28
21_I83_W0.5110.28
236_Q300_E0.5090.28
60_S214_L0.5080.28
145_V240_A0.5080.28
292_R339_Y0.5070.28
16_A342_E0.5060.28
179_F289_I0.5050.28
219_R232_E0.5050.28
193_E335_P0.5040.28
102_Q248_I0.5030.28
143_P280_E0.5030.28
119_P308_A0.5010.28
235_T254_N0.5010.28
29_F236_Q0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1okgA 1 0.5275 100 0.796 Contact Map
3g5jA 1 0.3516 99.9 0.811 Contact Map
3icsA 2 0.2802 99.8 0.851 Contact Map
3ntdA 2 0.261 99.8 0.857 Contact Map
3gk5A 1 0.2747 99.8 0.858 Contact Map
3fojA 1 0.2692 99.7 0.862 Contact Map
3flhA 3 0.2857 99.7 0.862 Contact Map
3nhvA 3 0.3324 99.7 0.864 Contact Map
1gmxA 1 0.2857 99.7 0.864 Contact Map
1tq1A 1 0.3104 99.7 0.864 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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