GREMLIN Database
CHPB - mRNA interferase ChpB
UniProt: P33647 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12096
Length: 116 (102)
Sequences: 1550 (1030)
Seq/√Len: 102.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_L107_A3.2931.00
64_S81_N3.1981.00
100_A103_V2.9461.00
17_F32_A2.9211.00
49_A78_V2.5751.00
74_V97_G2.4611.00
11_D98_L2.4291.00
49_A80_V2.4241.00
14_L96_I2.1931.00
53_Q75_H2.1491.00
78_V107_A2.1081.00
20_A26_Q2.1071.00
9_R108_L2.0541.00
10_G104_V1.8971.00
103_V106_E1.6981.00
35_L49_A1.6921.00
15_V32_A1.6691.00
33_L99_A1.5841.00
48_V86_M1.5791.00
106_E110_R1.5741.00
25_Q79_L1.5501.00
8_E38_Q1.5441.00
21_S90_A1.4731.00
18_D26_Q1.4101.00
15_V86_M1.3680.99
95_R98_L1.3490.99
25_Q30_R1.3300.99
87_D90_A1.3020.99
20_A84_R1.2740.99
16_G28_A1.2170.99
73_D97_G1.2040.99
14_L94_K1.2030.99
45_M85_M1.1890.99
13_V92_L1.1890.99
24_E91_R1.1860.99
36_S40_F1.1850.99
58_A77_V1.1840.98
17_F84_R1.1840.98
99_A104_V1.1760.98
61_A64_S1.1520.98
11_D95_R1.1410.98
65_V103_V1.1310.98
78_V103_V1.1250.98
28_A94_K1.1200.98
40_F45_M1.0800.97
14_L31_P1.0150.96
14_L28_A1.0090.96
101_D106_E1.0050.96
59_R66_P0.9990.96
12_I72_G0.9920.95
101_D105_E0.9900.95
54_G59_R0.9840.95
32_A86_M0.9640.95
60_Y64_S0.9620.95
17_F20_A0.9590.95
17_F48_V0.9550.94
40_F43_L0.9550.94
68_H72_G0.9520.94
68_H100_A0.9510.94
64_S77_V0.9430.94
38_Q41_N0.9420.94
23_H44_G0.9390.94
18_D28_A0.9210.93
18_D27_G0.9120.93
53_Q74_V0.9080.93
16_G92_L0.9080.93
34_V48_V0.9070.93
47_L85_M0.9000.93
35_L111_L0.8960.92
105_E109_L0.8790.92
14_L93_A0.8760.91
51_I67_L0.8730.91
13_V93_A0.8660.91
37_V64_S0.8660.91
13_V34_V0.8520.90
61_A81_N0.8210.89
32_A48_V0.8170.88
19_P91_R0.8150.88
25_Q64_S0.8130.88
63_F81_N0.7950.87
50_P53_Q0.7890.87
12_I51_I0.7870.86
36_S46_T0.7710.85
40_F81_N0.7680.85
64_S79_L0.7630.85
104_V107_A0.7610.85
37_V81_N0.7500.84
59_R62_G0.7480.84
12_I74_V0.7360.83
67_L72_G0.7330.82
36_S77_V0.7300.82
105_E112_Q0.7230.81
66_P77_V0.7110.80
98_L101_D0.7030.80
99_A103_V0.6990.79
19_P24_E0.6940.79
83_V111_L0.6880.78
18_D94_K0.6880.78
34_V68_H0.6860.78
72_G97_G0.6780.77
54_G79_L0.6710.76
15_V92_L0.6700.76
45_M80_V0.6650.76
47_L79_L0.6550.75
66_P70_E0.6450.74
10_G63_F0.6440.73
52_T82_Q0.6360.72
13_V46_T0.6320.72
51_I76_G0.6230.71
73_D100_A0.6220.71
35_L65_V0.6220.71
63_F80_V0.6210.71
40_F63_F0.6160.70
94_K109_L0.6150.70
33_L50_P0.6150.70
108_L112_Q0.6140.70
49_A83_V0.6130.70
47_L83_V0.6120.70
38_Q42_Q0.6110.69
23_H86_M0.6020.68
48_V97_G0.6000.68
41_N111_L0.5980.68
10_G108_L0.5880.67
16_G93_A0.5770.65
12_I97_G0.5760.65
20_A49_A0.5760.65
49_A107_A0.5760.65
40_F47_L0.5710.64
37_V40_F0.5640.63
21_S38_Q0.5610.63
12_I99_A0.5590.63
11_D89_H0.5510.62
7_F95_R0.5490.61
25_Q81_N0.5420.60
27_G64_S0.5420.60
39_A109_L0.5420.60
108_L111_L0.5400.60
16_G21_S0.5340.59
63_F79_L0.5300.59
54_G64_S0.5270.58
54_G77_V0.5250.58
21_S42_Q0.5170.57
44_G90_A0.5150.56
50_P59_R0.5150.56
27_G79_L0.5140.56
23_H45_M0.5100.56
22_G90_A0.5080.55
80_V107_A0.5080.55
21_S102_E0.5050.55
41_N84_R0.5050.55
43_L47_L0.5010.54
39_A94_K0.5010.54
10_G79_L0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ub4A 2 0.8793 100 0.275 Contact Map
4mzmA 2 0.9397 100 0.282 Contact Map
1m1fA 2 0.9138 100 0.29 Contact Map
4mdxA 2 0.9483 100 0.319 Contact Map
2kmtA 2 0.8621 99.1 0.679 Contact Map
3vubA 2 0.8362 98.9 0.704 Contact Map
4eyzA 1 0.5862 25.3 0.922 Contact Map
3pmiA 4 0.6638 19.8 0.926 Contact Map
3nr7A 2 0.319 16.2 0.928 Contact Map
2l89A 1 0.8103 15 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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