GREMLIN Database
YFIH - Laccase domain protein YfiH
UniProt: P33644 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12097
Length: 243 (228)
Sequences: 3479 (2634)
Seq/√Len: 174.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
161_A216_C3.1371.00
139_V149_I3.0931.00
161_A219_T3.0341.00
111_L122_A2.8361.00
123_A138_T2.7121.00
49_E52_K2.6431.00
104_T238_S2.6131.00
220_E223_T2.5591.00
90_A138_T2.3981.00
29_P32_D2.3321.00
28_L46_H2.3181.00
112_F123_A2.3061.00
166_G170_E2.2841.00
49_E53_R2.2451.00
160_R219_T2.2371.00
110_V135_L2.2331.00
73_K137_E2.2261.00
116_A148_N2.1881.00
68_E87_R2.1731.00
136_E201_R2.1661.00
108_L156_A2.1231.00
90_A123_A2.0411.00
112_F151_A2.0411.00
196_Q199_R2.0351.00
156_A195_Y1.9781.00
119_E142_F1.9121.00
162_F192_A1.8971.00
43_N46_H1.8671.00
20_S54_L1.8611.00
158_G161_A1.8111.00
34_L54_L1.7951.00
158_G216_C1.7611.00
186_H189_K1.7591.00
215_R220_E1.7561.00
112_F149_I1.7531.00
112_F138_T1.7421.00
130_L198_A1.7301.00
38_A48_E1.7121.00
144_D149_I1.6761.00
108_L198_A1.6571.00
157_I218_Y1.6521.00
215_R224_F1.6031.00
137_E140_S1.5891.00
133_G136_E1.5731.00
151_A202_L1.5681.00
199_R203_A1.5361.00
73_K132_A1.5221.00
114_N118_T1.5031.00
67_L88_A1.4881.00
215_R223_T1.4661.00
139_V205_V1.4581.00
74_D87_R1.4511.00
125_A198_A1.4471.00
165_G168_V1.4441.00
19_S238_S1.4401.00
195_Y212_G1.4361.00
199_R212_G1.4361.00
26_V46_H1.4331.00
26_V49_E1.4241.00
101_A237_A1.4231.00
169_R173_M1.4041.00
115_R148_N1.4021.00
169_R190_Y1.3971.00
122_A240_I1.3841.00
99_V241_W1.3821.00
111_L238_S1.3641.00
91_S100_C1.3641.00
120_V240_I1.3471.00
163_E189_K1.3401.00
115_R150_L1.3381.00
119_E144_D1.3151.00
131_C172_F1.3111.00
76_L88_A1.3051.00
123_A135_L1.3021.00
77_K94_N1.2871.00
44_P48_E1.2801.00
67_L91_S1.2731.00
111_L240_I1.2691.00
33_S225_F1.2641.00
161_A218_Y1.2521.00
70_V87_R1.2331.00
196_Q200_Q1.2181.00
64_P101_A1.2181.00
117_G144_D1.2171.00
80_G95_T1.2131.00
75_V137_E1.2091.00
158_G219_T1.2071.00
109_P154_G1.2041.00
216_C219_T1.2001.00
31_Y232_T1.1991.00
121_A138_T1.1901.00
26_V53_R1.1881.00
92_Y121_A1.1721.00
135_L198_A1.1711.00
60_L99_V1.1541.00
66_W101_A1.1351.00
92_Y142_F1.1241.00
36_L54_L1.1231.00
128_R132_A1.1211.00
195_Y213_G1.1171.00
23_I223_T1.1111.00
115_R209_Q1.1021.00
54_L239_F1.0961.00
114_N144_D1.0961.00
182_A196_Q1.0841.00
78_L91_S1.0831.00
19_S236_M1.0821.00
67_L102_V1.0711.00
193_D196_Q1.0561.00
150_L209_Q1.0551.00
36_L237_A1.0471.00
99_V239_F1.0461.00
114_N142_F1.0461.00
144_D148_N1.0450.99
100_C120_V1.0440.99
90_A134_V1.0430.99
139_V207_V1.0420.99
93_S98_T1.0400.99
227_Y233_T1.0390.99
170_E174_A1.0360.99
114_N119_E1.0290.99
218_Y229_R1.0190.99
140_S205_V1.0100.99
102_V122_A1.0050.99
55_F64_P1.0050.99
125_A130_L0.9990.99
159_P193_D0.9930.99
108_L153_L0.9840.99
113_C150_L0.9820.99
151_A207_V0.9780.99
20_S239_F0.9750.99
40_C233_T0.9660.99
117_G148_N0.9650.99
131_C171_A0.9650.99
230_D233_T0.9600.99
110_V123_A0.9560.99
92_Y141_C0.9510.99
93_S100_C0.9410.99
39_H68_E0.9310.99
131_C168_V0.9300.99
77_K92_Y0.9240.99
74_D88_A0.9230.99
65_V98_T0.9230.99
145_N148_N0.9230.99
108_L194_I0.9210.99
178_K200_Q0.9210.99
14_G113_C0.8970.98
24_G27_S0.8930.98
34_L53_R0.8880.98
79_T95_T0.8660.98
96_P118_T0.8620.98
194_I218_Y0.8520.98
221_N229_R0.8510.98
182_A200_Q0.8510.98
19_S152_W0.8410.98
179_A197_L0.8400.98
103_M237_A0.8400.98
166_G190_Y0.8380.98
79_T82_P0.8360.98
133_G201_R0.8340.98
77_K141_C0.8300.97
104_T122_A0.8300.97
92_Y119_E0.8210.97
168_V171_A0.8140.97
94_N119_E0.8120.97
65_V82_P0.8060.97
75_V138_T0.8030.97
112_F135_L0.7980.97
163_E191_L0.7960.97
198_A201_R0.7960.97
78_L98_T0.7920.97
95_T98_T0.7910.97
39_H103_M0.7900.97
151_A205_V0.7870.96
159_P184_I0.7860.96
78_L100_C0.7840.96
75_V92_Y0.7840.96
134_V137_E0.7840.96
66_W103_M0.7780.96
119_E149_I0.7780.96
200_Q204_N0.7750.96
18_C239_F0.7750.96
130_L197_L0.7710.96
37_G40_C0.7690.96
15_V113_C0.7680.96
52_K56_A0.7660.96
114_N117_G0.7620.96
92_Y138_T0.7610.96
221_N230_D0.7600.96
172_F176_D0.7560.96
24_G33_S0.7560.96
113_C118_T0.7560.96
67_L103_M0.7490.95
157_I162_F0.7480.95
169_R183_F0.7440.95
63_K83_Y0.7420.95
160_R184_I0.7370.95
128_R171_A0.7350.95
25_G42_D0.7330.95
192_A197_L0.7320.95
110_V151_A0.7300.95
114_N143_A0.7260.95
133_G204_N0.7260.95
227_Y230_D0.7250.94
195_Y215_R0.7240.94
220_E224_F0.7230.94
168_V192_A0.7210.94
60_L241_W0.7210.94
61_P99_V0.7200.94
199_R210_I0.7190.94
162_F218_Y0.7170.94
46_H49_E0.7120.94
72_G132_A0.7090.94
133_G175_V0.7040.94
212_G215_R0.7040.94
136_E140_S0.7000.93
40_C235_R0.6980.93
164_V168_V0.6960.93
40_C47_V0.6930.93
159_P195_Y0.6920.93
27_S50_N0.6900.93
203_A210_I0.6890.93
104_T236_M0.6850.93
125_A134_V0.6830.93
114_N148_N0.6800.92
20_S36_L0.6780.92
157_I164_V0.6760.92
73_K134_V0.6750.92
23_I33_S0.6730.92
179_A201_R0.6720.92
165_G190_Y0.6630.91
19_S155_P0.6620.91
100_C121_A0.6620.91
200_Q203_A0.6620.91
68_E86_K0.6610.91
225_F233_T0.6610.91
166_G169_R0.6560.91
16_A241_W0.6560.91
18_C58_G0.6560.91
30_P232_T0.6550.91
201_R205_V0.6530.91
55_F60_L0.6510.91
156_A212_G0.6470.90
125_A129_G0.6460.90
79_T94_N0.6460.90
176_D201_R0.6450.90
153_L212_G0.6430.90
171_A174_A0.6430.90
166_G188_D0.6400.90
53_R56_A0.6400.90
158_G218_Y0.6390.90
35_N42_D0.6360.90
39_H51_R0.6360.90
66_W237_A0.6360.90
25_G50_N0.6320.89
38_A68_E0.6310.89
136_E204_N0.6280.89
130_L135_L0.6260.89
155_P217_T0.6240.89
38_A44_P0.6220.89
42_D47_V0.6190.88
55_F63_K0.6190.88
102_V238_S0.6160.88
72_G87_R0.6150.88
159_P162_F0.6150.88
152_W211_F0.6140.88
159_P191_L0.6120.88
48_E52_K0.6110.88
119_E143_A0.6090.88
17_A152_W0.6090.88
127_W168_V0.6070.87
166_G187_G0.6060.87
136_E205_V0.6050.87
108_L130_L0.6020.87
153_L195_Y0.5980.87
185_Q188_D0.5950.86
64_P99_V0.5910.86
65_V78_L0.5870.86
165_G189_K0.5850.85
178_K204_N0.5840.85
167_E171_A0.5800.85
142_F149_I0.5780.85
122_A238_S0.5760.85
90_A104_T0.5750.84
54_L237_A0.5750.84
51_R235_R0.5740.84
111_L236_M0.5740.84
101_A239_F0.5730.84
160_R191_L0.5700.84
207_V210_I0.5690.84
179_A200_Q0.5680.84
75_V90_A0.5680.84
132_A171_A0.5670.84
85_S88_A0.5650.83
104_T109_P0.5620.83
158_G212_G0.5610.83
185_Q190_Y0.5610.83
173_M179_A0.5590.83
168_V172_F0.5580.83
28_L43_N0.5580.83
139_V146_P0.5580.83
70_V74_D0.5550.82
30_P233_T0.5540.82
172_F192_A0.5490.82
77_K119_E0.5480.82
21_T224_F0.5460.81
19_S34_L0.5440.81
112_F121_A0.5400.81
93_S120_V0.5400.81
90_A137_E0.5370.80
125_A194_I0.5370.80
162_F189_K0.5350.80
162_F191_L0.5340.80
153_L199_R0.5340.80
187_G191_L0.5340.80
77_K95_T0.5320.80
196_Q203_A0.5310.79
24_G50_N0.5300.79
167_E172_F0.5280.79
74_D77_K0.5220.78
60_L63_K0.5220.78
25_G33_S0.5210.78
127_W191_L0.5210.78
58_G239_F0.5190.78
163_E187_G0.5170.78
160_R218_Y0.5150.77
150_L211_F0.5140.77
127_W189_K0.5130.77
51_R66_W0.5110.77
146_P207_V0.5100.77
55_F239_F0.5100.77
114_N150_L0.5090.77
162_F165_G0.5090.77
38_A51_R0.5080.76
60_L239_F0.5040.76
45_D49_E0.5040.76
169_R192_A0.5030.76
13_K16_A0.5030.76
23_I222_E0.5020.76
218_Y230_D0.5020.76
20_S58_G0.5010.75
173_M178_K0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z9tA 1 0.9877 100 0.028 Contact Map
1rv9A 1 0.9877 100 0.055 Contact Map
1t8hA 1 1 100 0.075 Contact Map
1xfjA 1 1 100 0.081 Contact Map
2f9zC 1 0.5391 30.7 0.962 Contact Map
1np7A 1 0.642 21 0.965 Contact Map
4h31A 3 0.7572 15.3 0.967 Contact Map
1jaeA 1 0.2881 14.5 0.967 Contact Map
4x9yA 1 0.284 13.8 0.968 Contact Map
1g94A 1 0.2551 12.8 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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