GREMLIN Database
YFIE - Uncharacterized HTH-type transcriptional regulator YfiE
UniProt: P33634 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11785
Length: 293 (283)
Sequences: 79611 (58113)
Seq/√Len: 3454.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_E74_V3.7361.00
15_E24_K3.4511.00
157_R287_E2.6811.00
67_H81_A2.5671.00
11_T24_K2.5561.00
95_V140_A2.5251.00
158_E264_T2.3311.00
91_E122_S2.2621.00
158_E161_E2.2591.00
45_V60_E2.2551.00
161_E264_T2.2401.00
228_V235_S2.2001.00
10_K69_Y2.1681.00
8_T35_H2.1581.00
10_K14_E2.1251.00
91_E120_R2.1071.00
67_H74_V2.1021.00
165_V239_R2.0841.00
163_S239_R2.0681.00
161_E262_T2.0621.00
111_R285_C2.0391.00
11_T15_E2.0161.00
20_R23_Q1.9961.00
93_R122_S1.9891.00
179_E182_R1.9711.00
11_T14_E1.9521.00
13_V57_L1.9301.00
10_K65_L1.9251.00
8_T32_V1.8981.00
229_A250_E1.8921.00
71_L75_M1.8891.00
14_E69_Y1.8821.00
65_L69_Y1.8751.00
168_A254_L1.8731.00
189_I233_G1.8661.00
165_V253_E1.8381.00
187_S215_T1.7981.00
13_V65_L1.7561.00
156_R266_M1.7481.00
63_K81_A1.7171.00
49_E56_C1.7161.00
134_A139_E1.6991.00
64_L78_L1.6871.00
15_E20_R1.6761.00
67_H70_E1.6301.00
155_N271_A1.5911.00
18_F36_I1.5881.00
10_K68_I1.5811.00
17_S20_R1.5721.00
157_R269_H1.5651.00
14_E24_K1.5451.00
5_R35_H1.5411.00
5_R42_E1.5351.00
133_D137_N1.5081.00
5_R38_Q1.5011.00
102_S222_E1.4971.00
28_T31_T1.4901.00
112_F282_F1.4761.00
269_H283_I1.4721.00
67_H77_T1.4641.00
11_T25_L1.4591.00
9_L65_L1.4551.00
145_F268_A1.4501.00
155_N269_H1.4491.00
46_Q49_E1.4461.00
51_I56_C1.4441.00
283_I287_E1.4361.00
74_V77_T1.4291.00
8_T27_C1.4241.00
19_L29_Q1.4111.00
134_A140_A1.4101.00
198_R202_E1.4011.00
175_V182_R1.4001.00
112_F119_V1.3971.00
71_L78_L1.3921.00
135_L143_G1.3921.00
147_R266_M1.3911.00
93_R124_Q1.3891.00
115_R285_C1.3861.00
87_D118_K1.3821.00
186_C234_V1.3771.00
275_V279_M1.3621.00
281_T284_Q1.3581.00
66_P70_E1.3561.00
59_R62_K1.3561.00
89_D118_K1.3521.00
64_L79_R1.3511.00
10_K72_T1.3491.00
267_C283_I1.3421.00
162_Q240_F1.3221.00
224_I235_S1.3201.00
136_L153_A1.3051.00
142_V267_C1.3041.00
67_H78_L1.2991.00
226_R229_A1.2921.00
111_R115_R1.2811.00
27_C31_T1.2791.00
158_E266_M1.2751.00
113_R215_T1.2651.00
142_V279_M1.2561.00
63_K66_P1.2541.00
170_P250_E1.2531.00
113_R187_S1.2521.00
170_P252_I1.2481.00
239_R253_E1.2401.00
34_F38_Q1.2391.00
3_L75_M1.2321.00
42_E79_R1.2311.00
110_Q230_A1.2291.00
110_Q114_Q1.2141.00
9_L48_F1.2121.00
63_K67_H1.2091.00
9_L13_V1.1991.00
168_A234_V1.1901.00
156_R268_A1.1801.00
239_R243_A1.1711.00
177_F257_G1.1671.00
107_Q230_A1.1671.00
126_L134_A1.1651.00
34_F37_Q1.1491.00
253_E256_F1.1451.00
70_E77_T1.1421.00
62_K66_P1.1371.00
176_D252_I1.1231.00
187_S213_E1.1191.00
122_S217_E1.1161.00
6_F68_I1.1151.00
116_A281_T1.1091.00
178_T182_R1.1091.00
11_T21_A1.1081.00
226_R230_A1.1081.00
157_R283_I1.1041.00
37_Q41_Q1.0951.00
243_A247_E1.0831.00
71_L74_V1.0761.00
101_L125_S1.0751.00
18_F55_M1.0741.00
167_V253_E1.0731.00
136_L151_D1.0691.00
35_H38_Q1.0591.00
284_Q287_E1.0591.00
33_T37_Q1.0541.00
244_K248_C1.0521.00
79_R83_K1.0521.00
9_L47_L1.0471.00
124_Q134_A1.0451.00
112_F285_C1.0361.00
280_H284_Q1.0331.00
108_V286_V1.0301.00
12_V21_A1.0231.00
163_S262_T1.0231.00
169_S231_N1.0221.00
92_L282_F1.0221.00
111_R114_Q1.0201.00
73_R77_T1.0171.00
64_L68_I1.0071.00
189_I224_I1.0071.00
12_V18_F1.0051.00
270_H273_K1.0041.00
218_L224_I1.0001.00
4_R7_I1.0001.00
199_Q202_E0.9981.00
285_C288_E0.9971.00
225_K229_A0.9871.00
112_F116_A0.9841.00
38_Q41_Q0.9821.00
57_L61_G0.9811.00
190_I214_N0.9721.00
21_A32_V0.9701.00
168_A172_I0.9691.00
167_V242_V0.9691.00
205_L210_I0.9591.00
76_D79_R0.9581.00
7_I76_D0.9571.00
27_C32_V0.9561.00
13_V48_F0.9561.00
8_T25_L0.9551.00
70_E73_R0.9511.00
9_L39_L0.9421.00
20_R24_K0.9391.00
180_P258_E0.9361.00
75_M79_R0.9341.00
9_L57_L0.9331.00
218_L227_C0.9331.00
199_Q203_S0.9301.00
134_A137_N0.9301.00
98_E220_S0.9241.00
166_L234_V0.9171.00
276_S279_M0.9091.00
76_D80_E0.9071.00
115_R288_E0.9021.00
108_V285_C0.9011.00
16_G56_C0.9011.00
95_V143_G0.8981.00
45_V82_A0.8941.00
48_F55_M0.8871.00
204_T208_R0.8851.00
188_F212_V0.8851.00
155_N158_E0.8811.00
51_I54_R0.8791.00
60_E63_K0.8791.00
110_Q232_I0.8781.00
66_P69_Y0.8741.00
60_E82_A0.8661.00
19_L23_Q0.8661.00
147_R264_T0.8641.00
77_T81_A0.8581.00
140_A143_G0.8541.00
25_L32_V0.8531.00
75_M78_L0.8491.00
29_Q33_T0.8471.00
90_G278_A0.8461.00
277_P281_T0.8371.00
113_R232_I0.8361.00
187_S214_N0.8341.00
119_V278_A0.8311.00
14_E65_L0.8301.00
15_E21_A0.8291.00
95_V145_F0.8291.00
7_I11_T0.8241.00
94_V142_V0.8241.00
120_R213_E0.8221.00
9_L64_L0.8191.00
74_V78_L0.8181.00
16_G54_R0.8181.00
124_Q140_A0.8181.00
275_V280_H0.8171.00
169_S232_I0.8171.00
13_V61_G0.8141.00
13_V16_G0.8061.00
12_V48_F0.8041.00
246_L249_G0.8011.00
16_G62_K0.8001.00
179_E257_G0.7991.00
4_R35_H0.7991.00
154_L268_A0.7991.00
181_G184_N0.7971.00
62_K65_L0.7921.00
229_A248_C0.7891.00
37_Q46_Q0.7861.00
69_Y73_R0.7851.00
182_R185_A0.7841.00
167_V235_S0.7811.00
78_L82_A0.7801.00
163_S260_S0.7771.00
227_C232_I0.7761.00
68_I71_L0.7761.00
132_R136_L0.7731.00
5_R8_T0.7691.00
12_V32_V0.7681.00
96_S101_L0.7671.00
201_F205_L0.7651.00
49_E58_T0.7641.00
18_F32_V0.7621.00
90_G119_V0.7621.00
204_T207_Q0.7591.00
7_I10_K0.7581.00
3_L72_T0.7581.00
220_S223_S0.7571.00
284_Q288_E0.7541.00
12_V36_I0.7531.00
138_D270_H0.7521.00
168_A252_I0.7491.00
112_F281_T0.7461.00
163_S255_P0.7461.00
167_V237_L0.7441.00
200_I204_T0.7431.00
171_Q231_N0.7401.00
172_I186_C0.7381.00
281_T285_C0.7371.00
273_K276_S0.7351.00
59_R63_K0.7341.00
142_V282_F0.7271.00
60_E64_L0.7261.00
115_R281_T0.7191.00
136_L154_L0.7181.00
141_D279_M0.7121.00
153_A271_A0.7111.00
192_E217_E0.7101.00
102_S226_R0.7051.00
203_S207_Q0.7031.00
93_R141_D0.7001.00
167_V246_L0.7001.00
238_P241_A0.6941.00
177_F255_P0.6931.00
88_P116_A0.6931.00
31_T35_H0.6921.00
67_H71_L0.6901.00
64_L82_A0.6901.00
184_N210_I0.6891.00
57_L62_K0.6821.00
93_R140_A0.6821.00
179_E258_E0.6791.00
191_N224_I0.6761.00
202_E206_R0.6751.00
56_C62_K0.6731.00
49_E54_R0.6731.00
107_Q110_Q0.6731.00
7_I72_T0.6711.00
244_K247_E0.6681.00
181_G208_R0.6671.00
242_V246_L0.6661.00
9_L61_G0.6651.00
23_Q26_C0.6631.00
40_E50_K0.6621.00
166_L236_Y0.6611.00
188_F234_V0.6601.00
80_E84_K0.6581.00
246_L253_E0.6551.00
125_S219_I0.6541.00
77_T80_E0.6531.00
200_I203_S0.6451.00
216_I227_C0.6391.00
277_P280_H0.6371.00
4_R38_Q0.6361.00
203_S206_R0.6341.00
201_F204_T0.6311.00
120_R217_E0.6311.00
146_Y263_I0.6291.00
36_I40_E0.6261.00
73_R76_D0.6211.00
105_M108_V0.6181.00
166_L183_H0.6171.00
72_T76_D0.6171.00
12_V17_S0.6161.00
43_F64_L0.6161.00
142_V283_I0.6161.00
172_I176_D0.6141.00
197_F201_F0.6111.00
198_R217_E0.6101.00
192_E219_I0.6101.00
13_V62_K0.6081.00
40_E45_V0.6071.00
96_S105_M0.6041.00
111_R288_E0.6031.00
4_R8_T0.6031.00
92_L142_V0.6011.00
45_V49_E0.5971.00
218_L223_S0.5961.00
107_Q111_R0.5961.00
185_A213_E0.5961.00
68_I72_T0.5951.00
21_A25_L0.5941.00
84_K88_P0.5931.00
98_E127_N0.5881.00
116_A119_V0.5871.00
269_H280_H0.5871.00
92_L278_A0.5871.00
197_F200_I0.5851.00
171_Q252_I0.5851.00
170_P249_G0.5841.00
282_F286_V0.5831.00
89_D120_R0.5821.00
135_L154_L0.5791.00
199_Q204_T0.5791.00
31_T34_F0.5721.00
162_Q263_I0.5721.00
63_K82_A0.5701.00
48_F57_L0.5701.00
95_V124_Q0.5681.00
164_L236_Y0.5681.00
18_F29_Q0.5661.00
147_R156_R0.5661.00
43_F82_A0.5651.00
104_R108_V0.5641.00
95_V126_L0.5601.00
125_S220_S0.5561.00
27_C35_H0.5551.00
28_T34_F0.5551.00
224_I228_V0.5541.00
166_L188_F0.5541.00
159_L267_C0.5521.00
30_S34_F0.5501.00
90_G118_K0.5491.00
43_F46_Q0.5481.00
80_E83_K0.5481.00
160_G265_A0.5471.00
173_A252_I0.5471.00
100_L104_R0.5461.00
45_V85_E0.5431.00
175_V178_T0.5411.00
16_G55_M0.5411.00
110_Q113_R0.5401.00
193_P217_E0.5381.00
106_P110_Q0.5381.00
221_I238_P0.5361.00
181_G210_I0.5361.00
107_Q226_R0.5361.00
96_S123_L0.5351.00
237_L242_V0.5351.00
102_S220_S0.5341.00
57_L65_L0.5341.00
136_L139_E0.5341.00
202_E205_L0.5341.00
198_R204_T0.5331.00
135_L268_A0.5321.00
46_Q60_E0.5321.00
78_L81_A0.5311.00
222_E226_R0.5291.00
278_A281_T0.5281.00
6_F64_L0.5281.00
227_C233_G0.5271.00
205_L212_V0.5271.00
8_T36_I0.5261.00
250_E253_E0.5241.00
18_F50_K0.5231.00
269_H275_V0.5181.00
196_V199_Q0.5181.00
18_F54_R0.5151.00
279_M283_I0.5141.00
155_N272_G0.5141.00
71_L79_R0.5131.00
38_Q42_E0.5131.00
43_F79_R0.5111.00
191_N221_I0.5111.00
8_T21_A0.5101.00
30_S33_T0.5101.00
120_R215_T0.5091.00
109_L121_L0.5081.00
198_R201_F0.5081.00
10_K76_D0.5071.00
66_P81_A0.5071.00
280_H283_I0.5011.00
144_V286_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fxqA 3 0.9932 100 0.083 Contact Map
1uthA 2 0.7577 100 0.087 Contact Map
2esnA 3 0.9932 100 0.088 Contact Map
2h98A 2 0.6894 100 0.096 Contact Map
1ixcA 4 0.9863 100 0.099 Contact Map
4x6gA 4 1 100 0.1 Contact Map
2h9bA 2 0.6894 100 0.1 Contact Map
1al3A 1 0.7065 100 0.105 Contact Map
3fzvA 4 0.9693 100 0.106 Contact Map
3szpA 3 0.9795 100 0.123 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0112 seconds.