GREMLIN Database
NUOG - NADH-quinone oxidoreductase subunit G
UniProt: P33602 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12087
Length: 908 (690)
Sequences: 1070 (523)
Seq/√Len: 19.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
338_Y342_A4.6121.00
300_Q658_T4.5741.00
281_Q292_T4.4921.00
333_G342_A4.4341.00
333_G338_Y4.3281.00
333_G340_G4.3191.00
627_A686_I4.3101.00
286_R291_I4.2741.00
333_G336_N4.1311.00
335_E338_Y3.9851.00
335_E342_A3.9191.00
333_G337_F3.8741.00
337_F342_A3.8501.00
306_L591_M3.8481.00
587_A590_V3.7841.00
336_N340_G3.5131.00
336_N342_A3.5061.00
337_F340_G3.4681.00
342_A345_E3.4591.00
335_E340_G3.3561.00
299_M658_T3.3051.00
224_A241_E3.2951.00
305_I308_Q3.1821.00
340_G345_E3.1580.99
333_G343_H3.1180.99
333_G341_I3.1070.99
342_A346_Q3.0710.99
17_D25_S3.0590.99
285_R290_F3.0230.99
431_V483_I2.9030.99
340_G343_H2.8950.99
293_L301_G2.8640.99
338_Y341_I2.8380.99
51_K81_D2.8140.99
331_L659_L2.7730.99
445_W448_R2.7430.99
650_R654_S2.7190.98
301_G305_I2.6920.98
597_R607_V2.6840.98
333_G345_E2.6700.98
341_I345_E2.5500.98
338_Y343_H2.5440.98
198_V206_F2.5140.97
321_S630_F2.4960.97
338_Y345_E2.4760.97
646_L654_S2.4630.97
5_H76_F2.4620.97
335_E341_I2.4290.97
103_C112_C2.4100.97
340_G346_Q2.4090.97
337_F341_I2.4020.97
336_N341_I2.4000.96
454_Q457_L2.3880.96
103_C106_C2.3860.96
562_D588_P2.3720.96
3_T12_E2.3320.96
24_L32_Y2.3230.96
377_V413_W2.2950.95
365_A698_R2.2790.95
702_L706_P2.2330.95
446_T449_A2.2270.95
373_D495_K2.2090.94
435_D519_A2.2070.94
482_K485_V2.2060.94
106_C112_C2.1900.94
338_Y346_Q2.1640.94
336_N343_H2.1560.94
13_V17_D2.1410.93
180_Y186_D2.1340.93
337_F345_E2.1330.93
172_V181_F2.1310.93
566_V590_V2.1300.93
304_D308_Q2.1180.93
284_Q293_L2.1000.93
333_G346_Q2.0570.92
657_S663_E2.0460.92
334_E338_Y2.0440.92
443_A447_Y2.0170.91
336_N345_E1.9980.91
421_I486_I1.9980.91
406_A431_V1.9850.90
459_F462_A1.9770.90
343_H346_Q1.9700.90
51_K83_E1.9680.90
673_I676_V1.9660.90
337_F343_H1.9580.90
341_I346_Q1.9570.90
447_Y454_Q1.9490.90
638_Y644_V1.9470.89
453_D456_R1.9150.89
467_N480_Q1.9100.89
470_P476_E1.9020.88
335_E343_H1.8980.88
377_V380_E1.8920.88
18_N21_E1.8830.88
335_E346_Q1.8790.88
334_E337_F1.8670.87
182_G186_D1.8670.87
132_K135_H1.8670.87
7_D80_D1.8630.87
324_S327_A1.8460.87
544_M676_V1.8400.87
454_Q458_G1.8400.87
649_W672_V1.8220.86
393_V499_I1.8200.86
334_E342_A1.8190.86
113_H156_R1.8160.86
439_L454_Q1.7980.85
504_A509_V1.7810.85
443_A454_Q1.7550.84
493_A496_P1.7350.83
316_G325_N1.7290.83
99_H103_C1.7260.83
552_A561_A1.7220.83
22_A26_L1.7220.83
306_L563_A1.7190.83
337_F346_Q1.7150.82
375_V401_A1.7080.82
6_V23_C1.7050.82
93_E127_R1.7010.82
514_A523_R1.6800.81
78_S81_D1.6530.80
335_E345_E1.6420.79
30_I66_S1.6390.79
564_V587_A1.6260.79
431_V475_I1.6240.79
4_I11_Y1.6070.78
475_I483_I1.6030.78
99_H112_C1.5990.78
99_H106_C1.5960.77
638_Y645_M1.5950.77
309_S563_A1.5950.77
450_P524_G1.5940.77
656_H664_V1.5920.77
141_G193_F1.5910.77
480_Q484_D1.5870.77
470_P473_D1.5870.77
442_I491_A1.5850.77
222_Q241_E1.5840.77
369_I499_I1.5830.77
283_V607_V1.5780.77
457_L460_A1.5770.77
673_I677_V1.5550.76
92_V118_T1.5480.75
290_F607_V1.5460.75
336_N346_Q1.5380.75
106_C115_Q1.5380.75
369_I393_V1.5340.75
617_D632_Q1.5220.74
439_L458_G1.5090.73
617_D629_R1.4960.73
439_L443_A1.4930.72
632_Q635_D1.4910.72
697_I701_K1.4870.72
29_D120_M1.4860.72
345_E348_R1.4850.72
376_L406_A1.4850.72
196_N261_F1.4840.72
334_E340_G1.4700.71
3_T10_E1.4660.71
432_T513_A1.4580.71
565_V593_V1.4420.70
308_Q312_V1.4390.70
365_A368_E1.4360.69
7_D88_R1.4340.69
313_I562_D1.4310.69
19_L30_I1.4280.69
146_H180_Y1.4270.69
165_A391_L1.4120.68
14_N17_D1.4060.68
571_L581_N1.4050.68
103_C115_Q1.4000.67
281_Q644_V1.3990.67
6_V28_L1.3980.67
281_Q293_L1.3870.67
637_A645_M1.3680.66
647_E650_R1.3660.65
490_L517_A1.3620.65
131_T134_T1.3590.65
7_D78_S1.3580.65
199_E251_N1.3560.65
465_L470_P1.3480.64
394_R412_D1.3450.64
428_P509_V1.3440.64
701_K708_R1.3400.64
470_P481_S1.3330.63
112_C115_Q1.3320.63
632_Q636_P1.3310.63
104_P150_R1.3300.63
316_G385_T1.3240.63
343_H347_E1.3180.63
481_S485_V1.3170.63
238_S252_R1.3160.62
13_V22_A1.3160.62
567_L652_L1.3150.62
374_A404_M1.3150.62
429_L433_N1.3110.62
176_H186_D1.3100.62
457_L461_I1.3070.62
7_D22_A1.3050.62
556_L587_A1.3030.62
259_H392_A1.3000.61
436_D465_L1.2980.61
557_E586_K1.2980.61
371_S526_D1.2920.61
63_L84_A1.2880.61
436_D466_D1.2870.61
334_E341_I1.2860.61
257_V325_N1.2800.60
162_K168_T1.2790.60
470_P480_Q1.2760.60
673_I686_I1.2720.60
131_T135_H1.2700.60
431_V473_D1.2660.59
11_Y26_L1.2660.59
92_V121_T1.2640.59
319_R502_T1.2630.59
238_S694_T1.2620.59
674_D687_K1.2560.59
284_Q301_G1.2550.59
402_R489_A1.2550.59
160_Y196_N1.2550.59
246_L273_V1.2540.59
455_A458_G1.2520.59
23_C30_I1.2490.58
667_T671_H1.2470.58
63_L87_F1.2420.58
15_G71_A1.2370.58
378_L432_T1.2320.57
327_A331_L1.2280.57
476_E480_Q1.2230.57
242_R246_L1.2220.57
366_L389_V1.2180.56
113_H117_M1.2160.56
117_M121_T1.2150.56
374_A489_A1.2130.56
39_L159_R1.2120.56
495_K527_V1.2120.56
442_I488_Q1.2070.56
339_T345_E1.2010.55
328_L567_L1.1990.55
565_V652_L1.1960.55
476_E482_K1.1890.55
208_D268_F1.1850.54
677_V704_R1.1820.54
225_P252_R1.1820.54
105_V116_D1.1810.54
4_I71_A1.1760.54
47_Q117_M1.1750.54
221_M242_R1.1740.54
82_E86_Q1.1740.54
217_R220_D1.1700.53
259_H367_R1.1700.53
110_G115_Q1.1690.53
299_M654_S1.1660.53
46_R94_W1.1640.53
502_T570_D1.1590.53
301_G591_M1.1570.52
302_A591_M1.1510.52
571_L603_N1.1470.52
569_N574_H1.1450.52
102_D150_R1.1440.52
330_E675_A1.1390.51
404_M486_I1.1310.51
299_M646_L1.1300.51
690_A700_Q1.1290.51
627_A673_I1.1220.50
46_R65_M1.1150.50
565_V648_S1.1140.50
239_P249_I1.1080.49
239_P614_A1.1060.49
584_L590_V1.1010.49
410_V415_I1.0990.49
284_Q606_L1.0900.48
19_L52_Q1.0860.48
670_D677_V1.0850.48
24_L37_P1.0840.48
47_Q84_A1.0770.47
339_T346_Q1.0770.47
556_L586_K1.0750.47
654_S658_T1.0720.47
498_I517_A1.0710.47
414_Q420_N1.0670.47
240_G250_E1.0660.47
325_N567_L1.0620.46
19_L66_S1.0610.46
102_D106_C1.0600.46
357_R518_K1.0590.46
397_V403_E1.0560.46
502_T623_N1.0550.46
653_H664_V1.0540.46
373_D493_A1.0510.46
99_H102_D1.0500.46
306_L589_L1.0480.45
51_K78_S1.0470.45
6_V15_G1.0470.45
325_N331_L1.0450.45
327_A652_L1.0440.45
270_Y292_T1.0440.45
585_A603_N1.0430.45
581_N603_N1.0420.45
668_Q671_H1.0410.45
281_Q654_S1.0410.45
419_L482_K1.0400.45
13_V25_S1.0360.45
68_M77_I1.0350.45
130_F133_R1.0350.45
357_R529_I1.0350.45
339_T343_H1.0340.45
463_H468_S1.0280.44
17_D21_E1.0280.44
544_M683_L1.0280.44
36_H39_L1.0270.44
653_H665_D1.0270.44
46_R175_A1.0220.44
279_P607_V1.0180.43
332_V336_N1.0110.43
199_E267_R1.0100.43
49_A84_A1.0080.43
327_A669_L1.0060.43
502_T548_S1.0060.43
14_N25_S1.0060.43
94_W176_H1.0050.43
60_R175_A1.0050.43
145_S212_S1.0030.43
102_D112_C1.0010.42
110_G217_R0.9980.42
522_G527_V0.9980.42
98_N391_L0.9940.42
23_C77_I0.9910.42
305_I588_P0.9880.42
104_P115_Q0.9870.42
103_C110_G0.9820.41
533_A539_M0.9810.41
582_A586_K0.9780.41
454_Q460_A0.9770.41
303_A655_L0.9760.41
90_S128_Y0.9760.41
339_T342_A0.9750.41
182_G185_E0.9660.40
71_A617_D0.9650.40
92_V117_M0.9640.40
227_I630_F0.9640.40
302_A305_I0.9630.40
676_V680_I0.9630.40
320_A567_L0.9590.40
373_D494_K0.9500.39
36_H156_R0.9500.39
476_E481_S0.9480.39
421_I475_I0.9430.39
11_Y27_G0.9420.39
306_L655_L0.9380.38
638_Y648_S0.9330.38
106_C110_G0.9320.38
43_G93_E0.9310.38
17_D22_A0.9310.38
2_A71_A0.9280.38
130_F135_H0.9270.38
351_L507_L0.9230.38
102_D115_Q0.9210.37
101_H106_C0.9210.37
46_R176_H0.9130.37
236_N252_R0.9100.37
669_L688_D0.9090.37
555_E558_T0.9080.37
109_G115_Q0.9060.37
65_M68_M0.9050.36
343_H570_D0.9040.36
560_R588_P0.9030.36
370_E395_Q0.9010.36
273_V614_A0.8990.36
225_P238_S0.8960.36
357_R523_R0.8960.36
4_I19_L0.8920.36
322_V621_I0.8920.36
285_R605_H0.8910.36
14_N22_A0.8880.35
553_L584_L0.8870.35
4_I17_D0.8860.35
20_L32_Y0.8860.35
555_E561_A0.8850.35
18_N131_T0.8850.35
128_Y175_A0.8840.35
342_A348_R0.8840.35
482_K486_I0.8830.35
536_V620_V0.8810.35
385_T573_R0.8770.35
222_Q244_G0.8770.35
597_R601_M0.8770.35
293_L297_Q0.8760.35
432_T509_V0.8750.35
343_H348_R0.8730.35
84_A87_F0.8690.34
446_T560_R0.8690.34
7_D499_I0.8670.34
341_I348_R0.8670.34
52_Q64_V0.8670.34
223_F240_G0.8660.34
43_G46_R0.8650.34
670_D674_D0.8650.34
239_P246_L0.8640.34
96_M101_H0.8640.34
159_R163_D0.8630.34
298_A608_L0.8620.34
96_M118_T0.8620.34
341_I347_E0.8620.34
307_R310_K0.8600.34
100_P159_R0.8560.34
377_V393_V0.8540.33
22_A77_I0.8540.33
380_E501_G0.8540.33
301_G304_D0.8520.33
591_M659_L0.8510.33
419_L485_V0.8460.33
117_M120_M0.8450.33
460_A463_H0.8430.33
465_L468_S0.8420.33
656_H663_E0.8410.33
304_D576_S0.8410.33
223_F238_S0.8390.33
77_I467_N0.8390.33
356_L515_N0.8380.33
307_R659_L0.8380.33
5_H10_E0.8370.33
29_D566_V0.8370.33
466_D470_P0.8370.33
342_A347_E0.8360.32
392_A626_R0.8360.32
443_A458_G0.8360.32
9_K26_L0.8340.32
166_D416_A0.8330.32
4_I12_E0.8320.32
470_P483_I0.8320.32
32_Y84_A0.8300.32
10_E476_E0.8280.32
613_F620_V0.8270.32
68_M93_E0.8250.32
374_A493_A0.8250.32
96_M112_C0.8210.32
573_R594_D0.8210.32
559_G562_D0.8200.32
114_L203_T0.8190.32
106_C109_G0.8170.31
139_D209_K0.8170.31
43_G159_R0.8160.31
616_S648_S0.8160.31
343_H509_V0.8140.31
214_R245_E0.8110.31
304_D654_S0.8100.31
223_F249_I0.8100.31
484_D491_A0.8090.31
466_D469_A0.8070.31
325_N328_L0.8060.31
144_I198_V0.8050.31
366_L623_N0.8050.31
382_V393_V0.8010.31
410_V485_V0.7980.30
333_G348_R0.7970.30
369_I389_V0.7950.30
669_L673_I0.7940.30
586_K590_V0.7910.30
456_R459_F0.7900.30
652_L655_L0.7890.30
101_H150_R0.7880.30
318_P343_H0.7880.30
4_I13_V0.7880.30
301_G308_Q0.7880.30
101_H115_Q0.7880.30
336_N563_A0.7870.30
328_L332_V0.7850.30
437_T440_D0.7850.30
146_H193_F0.7850.30
458_G461_I0.7820.29
91_V95_L0.7820.29
101_H105_V0.7800.29
94_W175_A0.7780.29
674_D689_A0.7780.29
588_P608_L0.7770.29
11_Y23_C0.7750.29
309_S314_G0.7740.29
378_L504_A0.7720.29
364_P685_G0.7690.29
312_V588_P0.7690.29
138_Q209_K0.7680.29
592_V601_M0.7680.29
454_Q459_F0.7670.29
451_V518_K0.7660.29
99_H115_Q0.7660.29
106_C116_D0.7650.29
369_I647_E0.7640.29
103_C116_D0.7630.28
335_E348_R0.7620.28
156_R368_E0.7590.28
293_L606_L0.7580.28
304_D307_R0.7570.28
107_E207_T0.7570.28
237_I251_N0.7560.28
428_P504_A0.7550.28
118_T277_D0.7540.28
331_L336_N0.7530.28
450_P685_G0.7510.28
93_E159_R0.7510.28
566_V632_Q0.7510.28
189_L192_E0.7490.28
155_Y268_F0.7480.28
386_G539_M0.7480.28
15_G186_D0.7480.28
118_T579_R0.7470.28
500_S542_G0.7460.28
334_E343_H0.7460.28
441_D602_E0.7460.28
437_T483_I0.7450.28
211_H250_E0.7450.28
444_A476_E0.7450.28
138_Q193_F0.7450.28
91_V94_W0.7450.28
293_L654_S0.7440.27
114_L118_T0.7440.27
76_F470_P0.7430.27
348_R502_T0.7430.27
191_S194_S0.7400.27
348_R570_D0.7400.27
281_Q294_N0.7390.27
285_R597_R0.7380.27
284_Q297_Q0.7380.27
594_D633_V0.7360.27
254_N671_H0.7360.27
690_A697_I0.7350.27
325_N648_S0.7330.27
439_L463_H0.7320.27
244_G635_D0.7310.27
410_V414_Q0.7310.27
331_L611_A0.7310.27
555_E560_R0.7310.27
339_T347_E0.7300.27
454_Q461_I0.7300.27
490_L520_L0.7300.27
283_V604_A0.7290.27
634_Y637_A0.7260.27
471_A558_T0.7250.27
361_I524_G0.7250.27
654_S657_S0.7240.26
132_K137_N0.7220.26
22_A71_A0.7220.26
19_L60_R0.7210.26
96_M103_C0.7210.26
286_R305_I0.7190.26
112_C624_E0.7190.26
92_V123_H0.7180.26
115_Q150_R0.7170.26
653_H662_R0.7170.26
601_M648_S0.7160.26
66_S91_V0.7150.26
240_G248_R0.7150.26
130_F134_T0.7140.26
404_M421_I0.7140.26
102_D124_S0.7140.26
101_H110_G0.7140.26
384_Q412_D0.7140.26
598_T607_V0.7110.26
233_I388_R0.7110.26
655_L659_L0.7100.26
490_L496_P0.7100.26
301_G589_L0.7100.26
603_N607_V0.7060.26
137_N145_S0.7030.25
33_F114_L0.7030.25
279_P598_T0.7020.25
289_D597_R0.7020.25
144_I148_M0.7010.25
684_A701_K0.7010.25
46_R91_V0.7010.25
239_P374_A0.6990.25
375_V393_V0.6990.25
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270_Y274_N0.5200.18
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632_Q647_E0.5200.18
476_E659_L0.5190.17
80_D655_L0.5180.17
434_V438_R0.5170.17
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230_Q275_L0.5170.17
290_F605_H0.5160.17
701_K707_H0.5150.17
331_L608_L0.5150.17
385_T553_L0.5150.17
333_G347_E0.5150.17
533_A538_S0.5140.17
129_R456_R0.5140.17
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610_A683_L0.5140.17
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230_Q237_I0.5120.17
80_D560_R0.5120.17
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553_L562_D0.5110.17
399_G421_I0.5110.17
451_V454_Q0.5100.17
553_L632_Q0.5090.17
230_Q324_S0.5090.17
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76_F87_F0.5090.17
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265_R360_G0.5080.17
453_D489_A0.5080.17
254_N493_A0.5080.17
80_D120_M0.5080.17
670_D673_I0.5070.17
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382_V499_I0.5060.17
557_E582_A0.5060.17
5_H12_E0.5050.17
225_P237_I0.5050.17
14_N136_R0.5040.17
143_F268_F0.5040.17
509_V513_A0.5040.17
66_S697_I0.5030.17
80_D617_D0.5030.17
319_R623_N0.5030.17
443_A674_D0.5030.17
247_R431_V0.5030.17
92_V315_I0.5020.17
344_G503_N0.5020.17
304_D404_M0.5020.17
448_R591_M0.5020.17
509_V512_A0.5010.17
580_V604_A0.5010.17
303_A524_G0.5010.17
364_P411_A0.5010.17
71_A89_E0.5010.17
60_R76_F0.5010.17
41_S434_V0.5010.17
234_G323_E0.5000.17
30_I246_L0.5000.17
7_D455_A0.5000.17
438_R447_Y0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3i9v3 1 0.7819 100 0.548 Contact Map
1h0hA 1 0.7434 100 0.625 Contact Map
2iv2X 1 0.6531 100 0.634 Contact Map
1kqfA 3 0.7434 100 0.634 Contact Map
2napA 1 0.6872 100 0.642 Contact Map
3ml1A 1 0.707 100 0.658 Contact Map
4aayA 6 0.6905 100 0.661 Contact Map
2e7zA 1 0.6663 100 0.662 Contact Map
1g8kA 3 0.6861 100 0.667 Contact Map
2vpzA 1 0.6762 100 0.669 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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