GREMLIN Database
RECX - Regulatory protein RecX
UniProt: P33596 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12080
Length: 166 (144)
Sequences: 3336 (2700)
Seq/√Len: 225.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_E64_H3.9481.00
145_R149_Y2.6921.00
33_R57_E2.5681.00
30_Q34_R2.5561.00
26_D73_R2.3051.00
87_Y91_R2.2831.00
97_N103_R2.2561.00
17_R39_P2.2221.00
15_L62_W2.2121.00
62_W66_H2.0061.00
11_Y58_R1.9681.00
67_G70_D1.9561.00
141_V145_R1.9381.00
118_C159_E1.9031.00
91_R95_E1.8421.00
40_I51_A1.8031.00
72_S108_K1.7751.00
90_A93_R1.7571.00
29_E33_R1.6631.00
153_L156_D1.6571.00
14_L51_A1.6481.00
25_R31_E1.6331.00
89_P117_W1.6191.00
122_R163_N1.5261.00
125_A143_I1.5001.00
77_R80_A1.4951.00
144_Q157_I1.4501.00
18_A63_C1.4391.00
29_E60_I1.4181.00
148_L157_I1.4181.00
82_R95_E1.4161.00
140_K144_Q1.4111.00
74_F78_F1.4091.00
14_L59_V1.3971.00
27_H31_E1.3841.00
94_Q98_Q1.3681.00
102_S105_A1.3621.00
34_R38_A1.3441.00
27_H35_K1.3231.00
21_I35_K1.3221.00
121_A156_D1.3151.00
78_F82_R1.3061.00
72_S76_A1.2941.00
93_R97_N1.2621.00
75_V101_I1.2481.00
14_L40_I1.2451.00
37_A56_Y1.2451.00
137_F140_K1.2441.00
24_V27_H1.2361.00
95_E98_Q1.2231.00
103_R107_E1.2041.00
93_R107_E1.2021.00
21_I27_H1.1971.00
158_Q162_R1.1971.00
146_F150_R1.1911.00
129_Y143_I1.1551.00
105_A109_A1.1541.00
70_D73_R1.1471.00
118_C122_R1.1441.00
128_K146_F1.1401.00
156_D160_I1.1291.00
30_Q100_G1.1251.00
154_M158_Q1.1191.00
121_A160_I1.1151.00
75_V109_A1.1121.00
76_A112_E1.1011.00
125_A160_I1.0911.00
75_V79_I1.0901.00
29_E61_A1.0811.00
122_R126_T1.0801.00
87_Y95_E1.0761.00
35_K38_A1.0751.00
144_Q154_M1.0731.00
33_R37_A1.0731.00
29_E69_L1.0461.00
51_A56_Y1.0351.00
64_H69_L1.0341.00
31_E99_K1.0321.00
26_D77_R1.0301.00
55_D59_V1.0261.00
101_I106_T1.0261.00
33_R56_Y1.0231.00
79_I109_A1.0161.00
128_K131_E1.0141.00
61_A65_E1.0101.00
93_R106_T1.0071.00
15_L19_V1.0041.00
76_A80_A1.0041.00
79_I92_I0.9921.00
17_R35_K0.9851.00
53_A57_E0.9791.00
73_R76_A0.9731.00
21_I32_L0.9711.00
78_F95_E0.9611.00
16_D20_R0.9441.00
121_A125_A0.9401.00
15_L59_V0.9391.00
17_R21_I0.9361.00
90_A94_Q0.9301.00
72_S105_A0.9301.00
118_C156_D0.9221.00
124_Q146_F0.9191.00
148_L154_M0.9181.00
122_R160_I0.9181.00
144_Q158_Q0.9060.99
59_V63_C0.8850.99
36_L56_Y0.8720.99
78_F96_L0.8720.99
121_A147_L0.8660.99
96_L101_I0.8660.99
123_D126_T0.8590.99
125_A147_L0.8510.99
120_L152_Y0.8480.99
117_W156_D0.8420.99
125_A129_Y0.8400.99
15_L66_H0.8390.99
89_P93_R0.8350.99
138_S141_V0.8350.99
60_I64_H0.8330.99
10_A13_R0.8200.99
75_V105_A0.8200.99
14_L55_D0.8180.99
39_P51_A0.8180.99
106_T110_M0.8050.99
155_E158_Q0.8020.99
19_V68_Y0.8020.99
28_S74_F0.7900.98
77_R81_S0.7880.98
20_R24_V0.7860.98
79_I110_M0.7840.98
11_Y55_D0.7830.98
28_S31_E0.7820.98
132_P139_E0.7720.98
28_S101_I0.7630.98
25_R74_F0.7530.98
140_K162_R0.7460.98
28_S78_F0.7430.98
16_D19_V0.7350.98
29_E71_D0.7350.98
52_T55_D0.7260.97
144_Q148_L0.7260.97
17_R51_A0.7210.97
120_L123_D0.7190.97
82_R87_Y0.7160.97
15_L63_C0.7160.97
91_R149_Y0.7080.97
37_A53_A0.6990.97
136_V139_E0.6980.97
55_D58_R0.6950.97
135_T139_E0.6910.97
62_W65_E0.6890.96
91_R94_Q0.6870.96
30_Q33_R0.6870.96
137_F141_V0.6860.96
18_A32_L0.6820.96
31_E34_R0.6750.96
129_Y139_E0.6720.96
17_R20_R0.6690.96
28_S100_G0.6670.96
20_R23_A0.6590.95
107_E111_R0.6540.95
74_F99_K0.6520.95
63_C66_H0.6520.95
106_T109_A0.6450.95
73_R77_R0.6450.95
138_S142_K0.6400.95
94_Q97_N0.6220.94
51_A59_V0.6110.93
132_P143_I0.6010.93
11_Y15_L0.6000.93
74_F95_E0.5980.92
32_L63_C0.5980.92
88_G148_L0.5960.92
81_S85_K0.5950.92
140_K158_Q0.5880.92
78_F99_K0.5860.92
157_I161_W0.5850.92
88_G117_W0.5850.92
18_A59_V0.5770.91
78_F81_S0.5770.91
86_G120_L0.5760.91
34_R37_A0.5740.91
137_F142_K0.5700.91
83_S113_C0.5680.90
63_C68_Y0.5670.90
67_G73_R0.5660.90
10_A52_T0.5650.90
80_A84_R0.5640.90
57_E61_A0.5640.90
109_A112_E0.5610.90
93_R110_M0.5590.90
17_R27_H0.5590.90
91_R150_R0.5520.89
128_K132_P0.5460.89
97_N106_T0.5440.88
116_D119_A0.5420.88
96_L106_T0.5390.88
124_Q150_R0.5360.88
40_I52_T0.5360.88
87_Y92_I0.5340.88
19_V23_A0.5340.88
12_A16_D0.5310.87
136_V140_K0.5290.87
160_I163_N0.5250.87
95_E99_K0.5240.87
24_V35_K0.5230.87
155_E159_E0.5170.86
74_F101_I0.5160.86
61_A64_H0.5140.86
17_R36_L0.5120.85
81_S84_R0.5100.85
117_W121_A0.5070.85
54_E58_R0.5020.84
88_G91_R0.5010.84
159_E162_R0.5010.84
11_Y62_W0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3e3vA 1 0.9036 100 0.122 Contact Map
3c1dA 2 0.9277 100 0.125 Contact Map
3dfgA 1 0.8554 100 0.131 Contact Map
3d5lA 1 0.9217 100 0.138 Contact Map
4eqqA 2 0.6024 85.2 0.876 Contact Map
2fbkA 2 0.6205 78 0.886 Contact Map
4ejoA 2 0.5783 77 0.886 Contact Map
3deuA 2 0.6687 75.3 0.888 Contact Map
2g9wA 2 0.6687 74.5 0.889 Contact Map
3cjnA 2 0.6687 74.3 0.889 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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