GREMLIN Database
SGRR - HTH-type transcriptional regulator SgrR
UniProt: P33595 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12094
Length: 551 (431)
Sequences: 19161 (14147)
Seq/√Len: 681.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
274_I284_Q4.2241.00
351_Q403_S3.4501.00
223_P229_D3.3451.00
221_V229_D3.3361.00
396_E399_A3.2321.00
186_P226_W3.2101.00
363_T367_Y3.0741.00
202_I206_K2.9951.00
224_T227_T2.9941.00
272_A284_Q2.9501.00
490_A495_G2.8621.00
345_H348_A2.7431.00
202_I222_S2.6901.00
121_I298_E2.5661.00
358_Y396_E2.5101.00
356_V426_L2.4951.00
361_S364_N2.4871.00
196_L268_T2.4561.00
253_R256_E2.4431.00
173_Q183_F2.4411.00
399_A403_S2.4301.00
171_H183_F2.4131.00
158_N163_E2.3961.00
427_A432_T2.3471.00
221_V231_H2.3131.00
158_N165_E2.3051.00
179_H229_D2.2951.00
194_R254_E2.2841.00
155_T172_W2.2811.00
351_Q354_D2.2511.00
350_Q354_D2.2471.00
191_H286_F2.2341.00
199_D222_S2.2311.00
405_T434_K2.2191.00
351_Q400_G2.2021.00
344_T451_D2.1461.00
188_V196_L2.1391.00
492_W495_G2.1311.00
179_H231_H2.1291.00
181_R229_D2.1251.00
189_H195_E2.1231.00
175_I178_L2.1211.00
189_H288_D2.0991.00
495_G498_N2.0881.00
152_S167_D2.0711.00
282_K298_E2.0651.00
174_Q180_W2.0591.00
121_I300_N2.0291.00
498_N501_N2.0111.00
205_L230_I2.0051.00
134_L207_R1.9941.00
197_E200_D1.9621.00
183_F227_T1.9331.00
218_A233_T1.9261.00
201_V228_L1.8911.00
478_Q482_P1.8781.00
405_T436_K1.8591.00
272_A287_D1.8581.00
199_D253_R1.8501.00
158_N161_N1.8481.00
275_R282_K1.8411.00
423_Q427_A1.8181.00
350_Q509_S1.8181.00
380_A517_H1.8151.00
123_R300_N1.8141.00
340_F513_V1.8031.00
170_H186_P1.7951.00
275_R280_Q1.7571.00
252_P255_W1.7551.00
504_Q508_A1.7381.00
446_G449_E1.7321.00
199_D225_P1.7301.00
200_D253_R1.7231.00
505_Q509_S1.7111.00
487_A499_L1.6991.00
359_V429_H1.6781.00
192_H252_P1.6671.00
284_Q298_E1.6621.00
170_H183_F1.6611.00
194_R252_P1.6571.00
175_I179_H1.6491.00
187_G195_E1.6351.00
354_D396_E1.6321.00
120_H297_D1.6311.00
501_N504_Q1.6261.00
199_D202_I1.6241.00
280_Q300_N1.5931.00
219_D231_H1.5921.00
274_I298_E1.5831.00
271_Y296_I1.5801.00
198_M222_S1.5801.00
170_H185_R1.5791.00
285_A297_D1.5781.00
155_T182_F1.5601.00
354_D510_K1.5561.00
398_P402_E1.5531.00
340_F452_I1.5511.00
197_E225_P1.5471.00
416_R420_G1.5291.00
350_Q508_A1.5281.00
277_S280_Q1.5251.00
172_W182_F1.5161.00
393_I396_E1.5161.00
352_V401_L1.5071.00
357_S510_K1.4981.00
360_L422_M1.4971.00
181_R227_T1.4851.00
439_D442_Q1.4851.00
395_S398_P1.4751.00
324_E526_R1.4741.00
175_I181_R1.4701.00
140_R143_E1.4681.00
363_T379_P1.4421.00
497_M500_A1.4391.00
152_S268_T1.4271.00
356_V431_V1.4221.00
152_S290_F1.4121.00
191_H272_A1.4061.00
366_V379_P1.3991.00
192_H254_E1.3961.00
282_K300_N1.3861.00
482_P509_S1.3821.00
195_E226_W1.3611.00
274_I282_K1.3611.00
188_V268_T1.3481.00
326_E526_R1.3441.00
486_Q495_G1.3421.00
436_K446_G1.3311.00
425_I428_S1.3231.00
123_R302_W1.3181.00
119_R297_D1.3041.00
189_H286_F1.2991.00
202_I220_I1.2971.00
230_I239_L1.2951.00
223_P227_T1.2901.00
408_F435_I1.2741.00
168_I268_T1.2691.00
347_G356_V1.2681.00
183_F226_W1.2651.00
473_E483_I1.2601.00
472_C485_W1.2561.00
366_V377_W1.2551.00
386_R517_H1.2351.00
222_S225_P1.2331.00
440_Y444_H1.2281.00
283_I301_V1.2261.00
339_L453_W1.2251.00
146_I283_I1.2191.00
280_Q302_W1.2171.00
421_I425_I1.2151.00
206_K210_T1.1991.00
220_I228_L1.1931.00
494_N497_M1.1891.00
218_A231_H1.1781.00
424_Q428_S1.1771.00
166_A172_W1.1761.00
359_V426_L1.1751.00
344_T348_A1.1731.00
394_K429_H1.1721.00
185_R290_F1.1701.00
180_W239_L1.1691.00
400_G403_S1.1641.00
185_R188_V1.1621.00
125_L310_E1.1561.00
191_H288_D1.1511.00
347_G404_L1.1441.00
201_V250_I1.1401.00
326_E524_G1.1381.00
272_A286_F1.1371.00
426_L433_L1.1361.00
285_A294_A1.1341.00
486_Q490_A1.1321.00
156_R167_D1.1281.00
399_A402_E1.1241.00
423_Q435_I1.1161.00
204_S250_I1.1141.00
354_D400_G1.1101.00
394_K398_P1.1091.00
182_F230_I1.1091.00
408_F437_E1.1081.00
486_Q501_N1.1051.00
540_D543_S1.1051.00
463_L496_E1.0971.00
203_A253_R1.0931.00
350_Q510_K1.0881.00
505_Q508_A1.0791.00
255_W266_I1.0771.00
234_Q489_A1.0761.00
406_L433_L1.0751.00
364_N425_I1.0751.00
329_S519_W1.0741.00
370_E516_L1.0731.00
156_R165_E1.0691.00
200_D203_A1.0631.00
170_H226_W1.0611.00
284_Q287_D1.0601.00
423_Q433_L1.0531.00
122_L296_I1.0501.00
285_A293_R1.0501.00
442_Q446_G1.0481.00
328_E524_G1.0471.00
196_L250_I1.0471.00
168_I201_V1.0471.00
191_H266_I1.0451.00
494_N498_N1.0411.00
478_Q481_I1.0391.00
198_M223_P1.0371.00
176_S179_H1.0341.00
180_W240_P1.0321.00
541_F544_A1.0291.00
173_Q181_R1.0281.00
180_W232_L1.0271.00
190_F200_D1.0261.00
261_F265_P1.0251.00
422_M426_L1.0201.00
311_P314_G1.0191.00
502_W505_Q1.0181.00
407_T436_K1.0171.00
357_S513_V1.0111.00
168_I188_V1.0101.00
392_T500_A1.0091.00
424_Q427_A1.0041.00
357_S362_P0.9981.00
378_F519_W0.9981.00
129_P276_N0.9931.00
118_G295_L0.9901.00
186_P195_E0.9891.00
479_H482_P0.9871.00
370_E377_W0.9861.00
394_K428_S0.9841.00
417_V420_G0.9841.00
340_F356_V0.9821.00
396_E400_G0.9811.00
206_K209_N0.9761.00
183_F186_P0.9711.00
354_D358_Y0.9701.00
419_A435_I0.9691.00
365_L418_I0.9681.00
239_L243_L0.9671.00
325_K523_Q0.9631.00
354_D508_A0.9621.00
195_E225_P0.9621.00
395_S399_A0.9551.00
427_A431_V0.9481.00
364_N368_F0.9461.00
366_V516_L0.9451.00
485_W489_A0.9421.00
200_D204_S0.9421.00
122_L528_M0.9381.00
202_I228_L0.9351.00
153_S249_M0.9341.00
362_P379_P0.9301.00
168_I196_L0.9271.00
153_S167_D0.9241.00
181_R223_P0.9241.00
198_M228_L0.9231.00
135_P251_L0.9151.00
378_F386_R0.9151.00
191_H267_G0.9131.00
404_L452_I0.9111.00
199_D203_A0.9101.00
232_L239_L0.9101.00
291_G542_K0.9091.00
150_I283_I0.9081.00
315_L321_Q0.9071.00
438_I446_G0.9061.00
155_T169_A0.9041.00
271_Y294_A0.8971.00
493_R497_M0.8961.00
151_F267_G0.8951.00
367_Y375_Q0.8951.00
361_S425_I0.8911.00
192_H266_I0.8891.00
355_W401_L0.8891.00
501_N505_Q0.8871.00
177_P181_R0.8871.00
117_Q120_H0.8861.00
182_F240_P0.8841.00
183_F224_T0.8831.00
359_V394_K0.8801.00
222_S228_L0.8771.00
236_D242_L0.8771.00
155_T240_P0.8721.00
334_G458_N0.8661.00
178_L231_H0.8651.00
216_H236_D0.8621.00
206_K220_I0.8591.00
204_S251_L0.8561.00
149_Q283_I0.8561.00
152_S289_F0.8561.00
260_N263_S0.8551.00
486_Q489_A0.8541.00
155_T164_L0.8491.00
178_L218_A0.8491.00
216_H234_Q0.8431.00
412_H415_H0.8421.00
150_I273_V0.8421.00
447_E453_W0.8401.00
191_H273_V0.8391.00
322_G325_K0.8381.00
120_H296_I0.8351.00
392_T504_Q0.8331.00
475_P478_Q0.8331.00
468_F472_C0.8311.00
129_P303_V0.8291.00
342_S511_A0.8281.00
285_A296_I0.8241.00
500_A504_Q0.8221.00
531_L544_A0.8211.00
188_V226_W0.8201.00
174_Q177_P0.8191.00
401_L431_V0.8191.00
169_A182_F0.8181.00
485_W488_D0.8181.00
487_A502_W0.8181.00
261_F264_H0.8131.00
331_L519_W0.8081.00
136_G208_I0.8081.00
116_R295_L0.8081.00
360_L365_L0.8051.00
257_T260_N0.8051.00
283_I299_V0.8041.00
188_V290_F0.8031.00
136_G207_R0.8031.00
187_G226_W0.8021.00
125_L304_L0.8021.00
338_L452_I0.7981.00
383_L514_P0.7971.00
149_Q299_V0.7971.00
260_N264_H0.7971.00
405_T451_D0.7951.00
358_Y400_G0.7951.00
397_K429_H0.7931.00
404_L433_L0.7911.00
182_F243_L0.7901.00
336_Y415_H0.7851.00
276_N281_L0.7831.00
120_H295_L0.7801.00
349_N352_V0.7791.00
220_I230_I0.7781.00
222_S229_D0.7761.00
172_W240_P0.7761.00
178_L234_Q0.7741.00
273_V281_L0.7731.00
190_F250_I0.7711.00
122_L299_V0.7691.00
160_E532_R0.7681.00
420_G435_I0.7681.00
203_A256_E0.7651.00
150_I267_G0.7611.00
196_L204_S0.7571.00
138_A147_A0.7571.00
194_R200_D0.7561.00
365_L421_I0.7561.00
338_L422_M0.7551.00
217_I220_I0.7541.00
205_L243_L0.7541.00
382_G503_C0.7531.00
190_F254_E0.7521.00
356_V452_I0.7501.00
190_F267_G0.7501.00
129_P278_T0.7491.00
416_R437_E0.7471.00
107_L110_H0.7431.00
167_D290_F0.7421.00
340_F347_G0.7411.00
420_G423_Q0.7391.00
106_M109_S0.7391.00
329_S376_L0.7391.00
184_L196_L0.7351.00
360_L426_L0.7341.00
209_N233_T0.7341.00
443_W453_W0.7341.00
511_A514_P0.7341.00
154_L169_A0.7331.00
426_L452_I0.7311.00
525_Q528_M0.7311.00
119_R295_L0.7291.00
252_P266_I0.7271.00
291_G294_A0.7251.00
178_L235_P0.7251.00
198_M202_I0.7241.00
196_L226_W0.7161.00
356_V513_V0.7111.00
442_Q445_T0.7091.00
284_Q297_D0.7071.00
190_F268_T0.7061.00
157_I244_G0.7061.00
329_S521_I0.7011.00
237_R496_E0.6971.00
440_Y455_N0.6941.00
151_F265_P0.6911.00
287_D297_D0.6901.00
418_I422_M0.6901.00
271_Y298_E0.6901.00
413_S417_V0.6901.00
472_C475_P0.6881.00
311_P322_G0.6881.00
197_E226_W0.6841.00
184_L226_W0.6831.00
272_A288_D0.6821.00
407_T410_Q0.6821.00
146_I281_L0.6801.00
427_A433_L0.6791.00
273_V276_N0.6771.00
306_E309_D0.6771.00
496_E499_L0.6771.00
202_I221_V0.6761.00
172_W183_F0.6751.00
299_V541_F0.6731.00
344_T347_G0.6711.00
407_T446_G0.6711.00
422_M433_L0.6711.00
144_T246_V0.6701.00
408_F416_R0.6691.00
177_P491_R0.6691.00
304_L310_E0.6661.00
347_G352_V0.6661.00
153_S268_T0.6611.00
401_L429_H0.6611.00
190_F196_L0.6581.00
426_L429_H0.6571.00
418_I516_L0.6561.00
157_I164_L0.6561.00
296_I528_M0.6541.00
323_E526_R0.6521.00
131_R140_R0.6521.00
203_A207_R0.6511.00
460_T466_S0.6491.00
465_F488_D0.6481.00
234_Q485_W0.6461.00
138_A143_E0.6461.00
438_I443_W0.6461.00
151_F268_T0.6441.00
216_H233_T0.6431.00
438_I442_Q0.6421.00
365_L422_M0.6411.00
524_G531_L0.6391.00
390_A497_M0.6391.00
116_R120_H0.6381.00
407_T438_I0.6371.00
151_F261_F0.6361.00
203_A251_L0.6361.00
206_K219_D0.6351.00
335_C380_A0.6351.00
360_L513_V0.6341.00
376_L521_I0.6341.00
179_H221_V0.6331.00
154_L201_V0.6331.00
343_R348_A0.6331.00
326_E529_R0.6331.00
152_S291_G0.6321.00
420_G424_Q0.6311.00
326_E525_Q0.6301.00
474_V483_I0.6291.00
407_T450_S0.6281.00
389_H493_R0.6281.00
166_A171_H0.6241.00
203_A254_E0.6231.00
426_L431_V0.6211.00
338_L515_L0.6211.00
408_F419_A0.6181.00
174_Q240_P0.6161.00
398_P429_H0.6161.00
344_T449_E0.6141.00
363_T366_V0.6141.00
413_S416_R0.6141.00
392_T503_C0.6141.00
461_L465_F0.6141.00
238_W463_L0.6141.00
409_Y415_H0.6121.00
156_R291_G0.6101.00
444_H448_I0.6081.00
471_L512_M0.6081.00
324_E525_Q0.6071.00
394_K401_L0.6071.00
198_M224_T0.6071.00
411_D416_R0.6071.00
285_A292_Y0.6051.00
281_L303_V0.6051.00
124_V541_F0.6041.00
360_L515_L0.6031.00
149_Q301_V0.6031.00
273_V283_I0.6021.00
406_L419_A0.6021.00
336_Y418_I0.6001.00
404_L407_T0.6001.00
184_L201_V0.6001.00
346_R451_D0.5991.00
192_H255_W0.5941.00
126_Y130_L0.5941.00
249_M252_P0.5931.00
279_N302_W0.5921.00
493_R496_E0.5911.00
147_A151_F0.5911.00
433_L452_I0.5911.00
342_S348_A0.5901.00
206_K253_R0.5891.00
490_A496_E0.5891.00
347_G452_I0.5881.00
337_Y512_M0.5881.00
133_L276_N0.5881.00
340_F357_S0.5861.00
126_Y301_V0.5861.00
276_N303_V0.5831.00
262_A265_P0.5831.00
206_K216_H0.5811.00
337_Y455_N0.5791.00
164_L240_P0.5791.00
487_A496_E0.5791.00
198_M226_W0.5781.00
476_L482_P0.5771.00
251_L255_W0.5761.00
383_L512_M0.5751.00
271_Y285_A0.5741.00
217_I230_I0.5731.00
251_L254_E0.5731.00
258_L261_F0.5731.00
444_H447_E0.5731.00
510_K513_V0.5721.00
121_I282_K0.5721.00
105_Q108_V0.5711.00
388_H391_R0.5711.00
131_R143_E0.5711.00
136_G204_S0.5651.00
155_T243_L0.5651.00
259_S263_S0.5641.00
191_H268_T0.5631.00
150_I265_P0.5631.00
190_F194_R0.5621.00
133_L281_L0.5621.00
404_L408_F0.5611.00
415_H454_L0.5601.00
287_D293_R0.5591.00
465_F469_A0.5581.00
132_N262_A0.5581.00
540_D544_A0.5581.00
122_L544_A0.5571.00
415_H456_S0.5571.00
366_V370_E0.5571.00
473_E476_L0.5561.00
190_F204_S0.5561.00
200_D254_E0.5551.00
304_L309_D0.5531.00
197_E253_R0.5531.00
155_T244_G0.5531.00
425_I429_H0.5511.00
365_L369_A0.5511.00
182_F228_L0.5501.00
352_V356_V0.5501.00
307_I310_E0.5501.00
194_R253_R0.5491.00
468_F488_D0.5491.00
351_Q399_A0.5481.00
522_I531_L0.5481.00
119_R298_E0.5481.00
222_S227_T0.5471.00
296_I299_V0.5471.00
539_F544_A0.5471.00
200_D251_L0.5461.00
457_A470_H0.5461.00
462_P496_E0.5451.00
331_L378_F0.5451.00
474_V478_Q0.5441.00
198_M227_T0.5431.00
206_K222_S0.5431.00
507_V510_K0.5431.00
356_V404_L0.5431.00
405_T432_T0.5411.00
265_P273_V0.5411.00
196_L267_G0.5381.00
115_F118_G0.5371.00
465_F499_L0.5371.00
196_L201_V0.5371.00
184_L188_V0.5371.00
407_T434_K0.5361.00
477_L482_P0.5361.00
196_L200_D0.5351.00
323_E326_E0.5351.00
457_A460_T0.5351.00
140_R440_Y0.5351.00
195_E200_D0.5351.00
190_F197_E0.5331.00
132_N137_S0.5321.00
464_D468_F0.5321.00
347_G451_D0.5321.00
198_M225_P0.5321.00
508_A511_A0.5311.00
285_A295_L0.5301.00
524_G528_M0.5301.00
336_Y518_H0.5301.00
358_Y429_H0.5291.00
443_W447_E0.5291.00
322_G526_R0.5291.00
208_I247_P0.5281.00
343_R481_I0.5281.00
263_S278_T0.5281.00
184_L198_M0.5281.00
134_L262_A0.5271.00
215_S233_T0.5271.00
358_Y397_K0.5271.00
365_L515_L0.5271.00
286_F289_F0.5271.00
147_A150_I0.5271.00
476_L479_H0.5271.00
383_L506_L0.5261.00
141_R458_N0.5251.00
338_L454_L0.5251.00
116_R119_R0.5241.00
152_S196_L0.5231.00
445_T448_I0.5221.00
401_L430_Q0.5200.99
490_A493_R0.5200.99
471_L506_L0.5190.99
168_I184_L0.5180.99
146_I301_V0.5170.99
174_Q178_L0.5170.99
130_L281_L0.5170.99
332_E520_L0.5160.99
393_I399_A0.5160.99
404_L431_V0.5150.99
409_Y412_H0.5140.99
292_Y295_L0.5140.99
141_R144_T0.5140.99
271_Y544_A0.5130.99
491_R495_G0.5130.99
502_W506_L0.5120.99
364_N421_I0.5110.99
202_I223_P0.5110.99
422_M454_L0.5100.99
454_L515_L0.5100.99
380_A514_P0.5090.99
161_N165_E0.5070.99
423_Q432_T0.5070.99
294_A542_K0.5060.99
503_C507_V0.5050.99
421_I424_Q0.5050.99
113_R116_R0.5040.99
347_G431_V0.5040.99
220_I223_P0.5020.99
389_H497_M0.5020.99
325_K526_R0.5010.99
477_L480_C0.5010.99
205_L220_I0.5010.99
302_W314_G0.5000.99
472_C478_Q0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zs6A 1 0.7768 100 0.402 Contact Map
4tozA 1 0.7967 100 0.405 Contact Map
1xocA 2 0.775 100 0.405 Contact Map
2wolA 1 0.8149 100 0.406 Contact Map
1jetA 1 0.7931 100 0.406 Contact Map
4qflA 1 0.7713 100 0.407 Contact Map
3m8uA 1 0.775 100 0.408 Contact Map
1dpeA 1 0.7713 100 0.412 Contact Map
3tpaA 1 0.7731 100 0.414 Contact Map
4wedA 1 0.7568 100 0.416 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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