GREMLIN Database
NIKB - Nickel transport system permease protein NikB
UniProt: P33591 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12076
Length: 314 (298)
Sequences: 20059 (13016)
Seq/√Len: 754.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_Q66_V3.3391.00
62_Q70_T3.2331.00
28_R67_Q3.1791.00
73_W77_H2.8391.00
69_G73_W2.7821.00
199_M226_I2.7481.00
56_T61_D2.6681.00
48_P52_A2.6641.00
20_S68_Y2.5941.00
107_A180_A2.4671.00
212_R218_D2.4501.00
220_Q224_R2.4131.00
33_D55_R2.3901.00
100_A258_W2.3811.00
263_R267_S2.3541.00
208_V226_I2.2721.00
202_V207_H2.2491.00
119_L135_V2.2341.00
21_V68_Y2.1681.00
202_V205_Q2.1281.00
93_D264_Y2.1171.00
65_Y69_G2.0671.00
239_G295_V2.0651.00
217_N220_Q2.0651.00
219_K223_R2.0461.00
89_P92_D2.0391.00
50_M53_S1.9791.00
19_A285_V1.9591.00
132_D196_R1.9491.00
51_L55_R1.9331.00
203_A226_I1.9181.00
86_S93_D1.9091.00
111_L184_A1.8961.00
114_L118_P1.8891.00
47_T50_M1.8621.00
216_L220_Q1.8581.00
165_L174_Q1.8431.00
53_S57_M1.8031.00
126_H129_R1.8011.00
208_V221_T1.7491.00
88_R92_D1.7451.00
66_V70_T1.7391.00
159_S167_A1.7361.00
165_L177_I1.7091.00
122_W126_H1.7071.00
90_V279_C1.7021.00
91_L95_L1.6971.00
52_A55_R1.6841.00
130_L134_A1.6801.00
235_I302_L1.6711.00
52_A56_T1.6611.00
74_K79_D1.6571.00
124_A199_M1.6511.00
121_I199_M1.5951.00
126_H131_P1.5871.00
170_Y258_W1.5871.00
210_W214_R1.5811.00
125_R222_E1.5721.00
206_R209_T1.5661.00
122_W131_P1.5621.00
156_M161_Y1.5611.00
180_A184_A1.5511.00
115_T118_P1.5431.00
70_T73_W1.5351.00
131_P135_V1.5301.00
202_V230_A1.5231.00
298_L301_A1.5141.00
265_A280_F1.5071.00
236_T299_N1.5051.00
112_I187_S1.5011.00
12_L289_V1.4591.00
115_T188_L1.4331.00
6_L10_L1.4301.00
149_W153_L1.4271.00
70_T74_K1.4261.00
88_R96_N1.4251.00
202_V208_V1.4091.00
207_H229_N1.3991.00
17_L68_Y1.3941.00
268_A276_V1.3911.00
16_V286_V1.3881.00
103_E170_Y1.3871.00
157_A161_Y1.3831.00
75_A80_F1.3771.00
10_L14_P1.3751.00
202_V226_I1.3601.00
154_L182_S1.3581.00
100_A170_Y1.3571.00
54_T57_M1.3521.00
80_F279_C1.3511.00
17_L21_V1.3371.00
120_G124_A1.3361.00
103_E107_A1.3221.00
128_D132_D1.3211.00
96_N99_P1.3151.00
88_R93_D1.3011.00
113_L238_V1.3001.00
54_T58_L1.2931.00
125_R218_D1.2901.00
35_A51_L1.2841.00
116_S195_L1.2831.00
214_R225_H1.2811.00
116_S191_N1.2731.00
93_D276_V1.2711.00
191_N241_H1.2661.00
33_D36_L1.2631.00
59_G62_Q1.2511.00
109_L238_V1.2471.00
194_L237_A1.2471.00
66_V69_G1.2431.00
264_Y276_V1.2431.00
62_Q65_Y1.2401.00
80_F91_L1.2371.00
184_A188_L1.2361.00
82_I89_P1.2351.00
142_G189_A1.2241.00
100_A103_E1.2151.00
196_R200_L1.2021.00
63_P66_V1.2011.00
124_A203_A1.1961.00
126_H218_D1.1961.00
20_S71_W1.1941.00
76_L79_D1.1831.00
145_M150_L1.1811.00
195_L234_M1.1711.00
120_G195_L1.1701.00
135_V192_A1.1611.00
157_A162_L1.1541.00
297_L301_A1.1441.00
280_F284_M1.1381.00
36_L51_L1.1341.00
119_L192_A1.1311.00
232_L299_N1.1301.00
103_E176_I1.1281.00
123_A135_V1.1221.00
59_G70_T1.1071.00
53_S56_T1.1001.00
130_L133_F1.0991.00
266_V270_F1.0831.00
172_G175_H1.0821.00
243_G288_F1.0761.00
92_D96_N1.0711.00
74_K77_H1.0701.00
173_W177_I1.0661.00
21_V25_L1.0631.00
171_G175_H1.0601.00
182_S186_M1.0601.00
139_A192_A1.0481.00
291_C295_V1.0441.00
16_V289_V1.0311.00
93_D96_N1.0301.00
9_F293_L1.0241.00
95_L99_P1.0231.00
158_F162_L1.0221.00
5_V297_L1.0201.00
18_A22_I1.0141.00
124_A200_L1.0101.00
153_L157_A1.0071.00
17_L72_L0.9851.00
177_I181_V0.9841.00
28_R64_L0.9821.00
108_A184_A0.9811.00
195_L199_M0.9801.00
154_L178_L0.9791.00
165_L178_L0.9771.00
83_S273_D0.9741.00
151_A182_S0.9711.00
83_S88_R0.9631.00
92_D95_L0.9621.00
118_P121_I0.9561.00
218_D221_T0.9561.00
199_M230_A0.9551.00
211_A216_L0.9541.00
12_L293_L0.9511.00
132_D200_L0.9491.00
121_I222_E0.9481.00
39_L54_T0.9451.00
14_P17_L0.9391.00
166_P169_G0.9361.00
242_I291_C0.9341.00
56_T62_Q0.9341.00
105_A245_L0.9331.00
147_N252_I0.9271.00
128_D133_F0.9261.00
35_A39_L0.9221.00
25_L28_R0.9201.00
82_I87_Q0.9191.00
211_A221_T0.9091.00
136_R192_A0.9071.00
216_L221_T0.9051.00
9_F13_I0.9041.00
97_F264_Y0.9011.00
108_A112_I0.8991.00
69_G72_L0.8951.00
267_S271_N0.8931.00
300_A306_I0.8921.00
220_Q223_R0.8921.00
138_I142_G0.8901.00
176_I180_A0.8891.00
49_E53_S0.8891.00
117_V195_L0.8851.00
212_R221_T0.8841.00
294_I298_L0.8831.00
235_I295_V0.8801.00
290_V294_I0.8791.00
274_Y278_Q0.8751.00
116_S120_G0.8751.00
25_L64_L0.8721.00
75_A282_L0.8701.00
111_L180_A0.8691.00
103_E106_G0.8681.00
299_N306_I0.8671.00
73_W76_L0.8651.00
48_P51_L0.8621.00
181_V184_A0.8601.00
21_V64_L0.8551.00
158_F165_L0.8511.00
106_G110_V0.8501.00
188_L192_A0.8441.00
20_S282_L0.8441.00
221_T226_I0.8441.00
267_S270_F0.8371.00
230_A233_P0.8331.00
133_F136_R0.8331.00
28_R274_Y0.8301.00
108_A183_I0.8271.00
32_G272_R0.8251.00
223_R226_I0.8241.00
118_P122_W0.8171.00
120_G199_M0.8171.00
243_G291_C0.8141.00
201_D205_Q0.8121.00
134_A138_I0.8091.00
211_A225_H0.8091.00
72_L75_A0.8061.00
264_Y268_A0.8051.00
94_M279_C0.8041.00
49_E52_A0.7931.00
150_L185_F0.7901.00
113_L118_P0.7881.00
297_L300_A0.7881.00
71_W75_A0.7861.00
101_T105_A0.7781.00
39_L46_P0.7751.00
299_N303_D0.7751.00
46_P51_L0.7751.00
151_A255_I0.7731.00
198_S202_V0.7691.00
177_I180_A0.7681.00
109_L242_I0.7661.00
254_N263_R0.7641.00
68_Y72_L0.7631.00
107_A258_W0.7621.00
286_V290_V0.7621.00
125_R223_R0.7621.00
119_L188_L0.7591.00
195_L230_A0.7541.00
23_I281_T0.7531.00
218_D222_E0.7531.00
84_F275_P0.7521.00
115_T119_L0.7471.00
143_V189_A0.7471.00
198_S230_A0.7461.00
72_L76_L0.7461.00
121_I227_L0.7451.00
117_V234_M0.7431.00
94_M280_F0.7421.00
95_L98_L0.7371.00
198_S201_D0.7361.00
187_S190_I0.7351.00
35_A55_R0.7351.00
104_L180_A0.7341.00
249_T252_I0.7331.00
131_P134_A0.7291.00
90_V276_V0.7291.00
147_N185_F0.7291.00
116_S192_A0.7271.00
90_V264_Y0.7251.00
106_G242_I0.7241.00
155_V167_A0.7211.00
161_Y164_W0.7171.00
254_N266_V0.7161.00
35_A54_T0.7161.00
300_A307_R0.7101.00
264_Y280_F0.7081.00
182_S252_I0.7071.00
73_W78_L0.7031.00
284_M288_F0.6991.00
99_P102_L0.6991.00
279_C283_M0.6991.00
158_F178_L0.6991.00
112_I184_A0.6981.00
99_P103_E0.6941.00
15_M289_V0.6891.00
265_A268_A0.6891.00
38_Y54_T0.6861.00
158_F164_W0.6861.00
142_G185_F0.6841.00
278_Q281_T0.6811.00
156_M160_V0.6781.00
211_A214_R0.6771.00
102_L106_G0.6771.00
139_A189_A0.6651.00
173_W176_I0.6621.00
50_M54_T0.6611.00
27_L30_G0.6601.00
268_A277_I0.6591.00
123_A132_D0.6571.00
259_P263_R0.6551.00
134_A137_F0.6551.00
36_L40_R0.6511.00
288_F292_N0.6491.00
115_T184_A0.6491.00
137_F140_F0.6481.00
195_L198_S0.6481.00
25_L29_L0.6461.00
135_V139_A0.6461.00
170_Y176_I0.6451.00
21_V65_Y0.6421.00
107_A173_W0.6401.00
132_D136_R0.6391.00
168_M257_A0.6381.00
55_R61_D0.6351.00
184_A187_S0.6301.00
14_P18_A0.6301.00
235_I298_L0.6291.00
147_N151_A0.6241.00
46_P50_M0.6231.00
93_D97_F0.6171.00
133_F137_F0.6161.00
10_L13_I0.6151.00
189_A192_A0.6121.00
98_L102_L0.6091.00
104_L253_E0.6091.00
265_A284_M0.6071.00
209_T212_R0.6061.00
278_Q282_L0.6031.00
190_I237_A0.5991.00
254_N267_S0.5991.00
126_H132_D0.5971.00
147_N150_L0.5961.00
101_T249_T0.5941.00
55_R60_L0.5931.00
8_R296_D0.5921.00
97_F263_R0.5911.00
137_F141_L0.5901.00
195_L227_L0.5891.00
231_S234_M0.5891.00
113_L191_N0.5881.00
216_L225_H0.5871.00
13_I17_L0.5861.00
110_V114_L0.5861.00
266_V269_I0.5841.00
239_G291_C0.5791.00
191_N195_L0.5791.00
205_Q209_T0.5761.00
295_V299_N0.5761.00
57_M87_Q0.5751.00
32_G35_A0.5751.00
78_L82_I0.5751.00
190_I241_H0.5751.00
237_A241_H0.5741.00
198_S233_P0.5701.00
165_L169_G0.5701.00
83_S86_S0.5701.00
34_P37_D0.5691.00
108_A249_T0.5691.00
178_L182_S0.5691.00
145_M149_W0.5691.00
107_A177_I0.5681.00
147_N186_M0.5661.00
114_L117_V0.5661.00
191_N237_A0.5661.00
107_A111_L0.5651.00
64_L67_Q0.5641.00
149_W152_F0.5641.00
277_I281_T0.5641.00
232_L306_I0.5621.00
129_R133_F0.5611.00
27_L277_I0.5611.00
219_K222_E0.5601.00
47_T51_L0.5571.00
154_L181_V0.5571.00
35_A58_L0.5571.00
24_F28_R0.5551.00
175_H178_L0.5551.00
250_M254_N0.5551.00
208_V212_R0.5551.00
250_M266_V0.5541.00
223_R227_L0.5531.00
7_R11_L0.5511.00
7_R10_L0.5511.00
223_R228_R0.5471.00
241_H244_E0.5471.00
12_L15_M0.5461.00
125_R203_A0.5431.00
293_L297_L0.5431.00
174_Q177_I0.5431.00
194_L198_S0.5421.00
52_A61_D0.5421.00
105_A242_I0.5411.00
123_A136_R0.5411.00
129_R134_A0.5401.00
209_T213_L0.5391.00
217_N221_T0.5381.00
191_N234_M0.5381.00
113_L117_V0.5381.00
105_A249_T0.5381.00
80_F94_M0.5381.00
75_A78_L0.5371.00
28_R278_Q0.5361.00
105_A109_L0.5351.00
107_A110_V0.5351.00
11_L15_M0.5331.00
35_A38_Y0.5311.00
186_M189_A0.5291.00
199_M227_L0.5291.00
181_V185_F0.5261.00
222_E226_I0.5241.00
166_P174_Q0.5221.00
231_S235_I0.5211.00
187_S241_H0.5211.00
190_I194_L0.5201.00
27_L31_T0.5201.00
287_V291_C0.5181.00
124_A132_D0.5171.00
121_I223_R0.5171.00
168_M171_G0.5171.00
111_L181_V0.5141.00
151_A155_V0.5131.00
107_A176_I0.5131.00
103_E258_W0.5131.00
178_L181_V0.5131.00
19_A23_I0.5121.00
11_L14_P0.5121.00
275_P278_Q0.5111.00
207_H211_A0.5111.00
166_P175_H0.5101.00
276_V280_F0.5091.00
20_S72_L0.5091.00
12_L16_V0.5071.00
149_W182_S0.5061.00
169_G175_H0.5061.00
101_T253_E0.5031.00
173_W180_A0.5021.00
216_L219_K0.5021.00
159_S178_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tuiA 2 0.6656 99.9 0.65 Contact Map
4tquM 1 0.8312 99.9 0.665 Contact Map
3rlfF 1 0.8376 99.9 0.674 Contact Map
4ymuD 2 0.6688 99.8 0.69 Contact Map
2onkC 2 0.7739 99.8 0.694 Contact Map
3d31C 2 0.7771 99.8 0.696 Contact Map
4tquN 1 0.8217 99.8 0.71 Contact Map
3rlfG 1 0.8408 99.7 0.72 Contact Map
2yevC 1 0.1083 14.3 0.958 Contact Map
4ltoA 3 0.3344 7 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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