NIKA - ECOLI - GREMLIN Contacts

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NIKA - Nickel-binding periplasmic protein

UniProt:	P33590	Sequences: MLSTLRRTLFALLACASFIVHAAAPDEITTAWPVNVGPLNPHLYTPNQMFAQSMVYEPLVKYQADGSVIPWLAKSWTHSEDGKTWTFTLRDDVKFSNGEPFDAEAAAENFRAVLDNRQRHAWLELANQIVDVKALSKTELQITLKSAYYPFLQELALPRPFRFIAPSQFKNHETMNGIKAPIGTGPWILQESKLNQYDVFVRNENYWGEKPAIKKITFNVIPDPTTRAVAFETGDIDLLYGNEGLLPLDTFARFSQNPAYHTQLSQPIETVMLALNTAKAPTNELAVREALNYAVNKKSLIDNALYGTQQVADTLFAPSVPYANLGLKPSQYDPQKAKALLEKAGWTLPAGKDIREKNGQPLRIELSFIGTDALSKSMAEIIQADMRQIGADVSLIGEEESSIYARQRDGRFGMIFHRTWGAPYDPHAFLSSMRVPSHADFQAQQGLADKPLIDKEIGEVLATHDETQRQALYRDILTRLHDEAVYLPISYISMMVVSKPELGNIPYAPIATEIPFEQIKPVKP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12075
Length:	524 (482)
Sequences:	22886 (17252)
Seq/√Len:	785.8

ECOLI - NIKA YEJA DPPA DDPA SAPA YGIS MPPA OPPA GSIB YBAE SGRR
BACSU - APPA OPPA DPPE YHJP
HALSA - Q9HMW4 Q9HMI3
SULSO - Q97UG7 Q97VF7 Q97UH5 Q97VK5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
190_Q	201_V	4.024	1.00
286_A	343_K	3.242	1.00
133_K	141_Q	3.212	1.00
135_L	141_Q	3.174	1.00
336_K	339_A	3.106	1.00
91_D	138_T	2.972	1.00
298_K	302_D	2.939	1.00
136_S	139_E	2.926	1.00
107_A	111_R	2.865	1.00
455_K	459_E	2.812	1.00
363_R	392_D	2.760	1.00
463_T	468_Q	2.720	1.00
188_I	201_V	2.712	1.00
107_A	134_A	2.596	1.00
280_A	283_N	2.539	1.00
293_Y	336_K	2.469	1.00
291_L	386_M	2.463	1.00
363_R	394_S	2.452	1.00
296_N	299_S	2.414	1.00
339_A	343_K	2.409	1.00
166_P	170_K	2.375	1.00
436_P	449_D	2.370	1.00
75_S	88_T	2.362	1.00
365_E	396_I	2.319	1.00
77_T	88_T	2.299	1.00
101_F	184_T	2.290	1.00
104_E	134_A	2.289	1.00
63_Q	67_S	2.288	1.00
452_L	455_K	2.285	1.00
27_E	215_K	2.280	1.00
448_A	483_E	2.202	1.00
133_K	143_T	2.191	1.00
84_T	141_Q	2.191	1.00
60_V	76_W	2.188	1.00
63_Q	69_I	2.182	1.00
365_E	394_S	2.151	1.00
286_A	289_E	2.147	1.00
79_S	83_K	2.146	1.00
285_L	289_E	2.144	1.00
96_S	203_N	2.140	1.00
286_A	340_L	2.121	1.00
99_E	167_S	2.121	1.00
86_T	141_Q	2.115	1.00
387_R	392_D	2.100	1.00
450_K	479_R	2.074	1.00
468_Q	471_A	2.072	1.00
94_K	100_P	2.063	1.00
436_P	454_D	2.007	1.00
93_V	101_F	2.000	1.00
130_V	145_K	1.997	1.00
199_V	215_K	1.989	1.00
459_E	472_L	1.962	1.00
84_T	143_T	1.956	1.00
450_K	483_E	1.955	1.00
78_H	85_W	1.948	1.00
94_K	205_N	1.940	1.00
465_D	468_Q	1.932	1.00
279_K	413_G	1.923	1.00
27_E	217_T	1.913	1.00
57_E	71_W	1.901	1.00
104_E	166_P	1.881	1.00
471_A	475_D	1.858	1.00
110_F	142_I	1.848	1.00
88_T	139_E	1.847	1.00
102_D	105_A	1.843	1.00
230_A	235_D	1.842	1.00
40_N	112_A	1.825	1.00
31_A	236_I	1.805	1.00
105_A	166_P	1.785	1.00
383_Q	387_R	1.782	1.00
74_K	91_D	1.778	1.00
452_L	475_D	1.772	1.00
188_I	204_E	1.768	1.00
106_A	140_L	1.767	1.00
453_I	476_I	1.763	1.00
460_V	473_Y	1.717	1.00
478_T	482_D	1.713	1.00
275_L	487_L	1.708	1.00
201_V	215_K	1.692	1.00
406_R	411_R	1.692	1.00
191_E	199_V	1.685	1.00
193_K	196_Q	1.685	1.00
312_A	491_Y	1.683	1.00
191_E	197_Y	1.681	1.00
29_T	217_T	1.675	1.00
130_V	143_T	1.661	1.00
285_L	483_E	1.655	1.00
294_A	389_I	1.655	1.00
456_E	475_D	1.650	1.00
74_K	88_T	1.622	1.00
460_V	472_L	1.619	1.00
97_N	165_A	1.619	1.00
92_D	100_P	1.618	1.00
452_L	479_R	1.599	1.00
26_D	214_K	1.599	1.00
342_E	347_T	1.594	1.00
289_E	336_K	1.584	1.00
79_S	84_T	1.579	1.00
399_E	402_S	1.575	1.00
190_Q	215_K	1.574	1.00
202_R	214_K	1.568	1.00
104_E	137_K	1.560	1.00
99_E	165_A	1.556	1.00
451_P	455_K	1.545	1.00
333_D	336_K	1.541	1.00
104_E	107_A	1.536	1.00
197_Y	217_T	1.529	1.00
275_L	414_M	1.512	1.00
60_V	87_F	1.505	1.00
475_D	478_T	1.502	1.00
252_A	255_S	1.488	1.00
74_K	90_R	1.483	1.00
456_E	472_L	1.479	1.00
295_V	382_I	1.479	1.00
103_A	134_A	1.472	1.00
232_E	253_R	1.468	1.00
102_D	137_K	1.468	1.00
361_P	392_D	1.465	1.00
187_W	213_I	1.460	1.00
193_K	197_Y	1.460	1.00
449_D	454_D	1.439	1.00
131_D	143_T	1.434	1.00
298_K	311_V	1.434	1.00
221_I	230_A	1.425	1.00
376_K	380_E	1.420	1.00
289_E	484_A	1.420	1.00
292_N	484_A	1.418	1.00
76_W	87_F	1.412	1.00
472_L	475_D	1.409	1.00
278_A	447_L	1.409	1.00
57_E	207_W	1.400	1.00
79_S	86_T	1.398	1.00
425_D	469_R	1.378	1.00
338_K	342_E	1.370	1.00
405_A	409_D	1.368	1.00
463_T	472_L	1.364	1.00
285_L	482_D	1.356	1.00
459_E	468_Q	1.346	1.00
259_A	500_P	1.346	1.00
470_Q	474_R	1.345	1.00
165_A	168_Q	1.341	1.00
86_T	139_E	1.341	1.00
57_E	184_T	1.339	1.00
282_T	364_I	1.331	1.00
199_V	217_T	1.317	1.00
291_L	391_A	1.311	1.00
396_I	406_R	1.310	1.00
96_S	188_I	1.310	1.00
94_K	203_N	1.309	1.00
335_Q	338_K	1.304	1.00
93_V	184_T	1.296	1.00
479_R	483_E	1.295	1.00
135_L	139_E	1.283	1.00
282_T	291_L	1.276	1.00
100_P	138_T	1.276	1.00
301_I	311_V	1.276	1.00
471_A	474_R	1.275	1.00
385_D	388_Q	1.270	1.00
29_T	237_D	1.268	1.00
287_V	341_L	1.260	1.00
468_Q	472_L	1.257	1.00
88_T	138_T	1.255	1.00
368_F	395_L	1.252	1.00
279_K	283_N	1.236	1.00
435_V	458_G	1.236	1.00
368_F	397_G	1.235	1.00
29_T	219_N	1.230	1.00
455_K	458_G	1.224	1.00
107_A	132_V	1.224	1.00
134_A	137_K	1.222	1.00
97_N	167_S	1.210	1.00
142_I	151_F	1.208	1.00
231_F	497_V	1.206	1.00
261_H	500_P	1.204	1.00
90_R	207_W	1.203	1.00
230_A	236_I	1.201	1.00
190_Q	199_V	1.201	1.00
459_E	463_T	1.187	1.00
28_I	238_L	1.182	1.00
200_F	218_F	1.178	1.00
318_P	491_Y	1.177	1.00
31_A	227_R	1.175	1.00
456_E	479_R	1.173	1.00
340_L	343_K	1.164	1.00
381_I	385_D	1.163	1.00
109_N	163_F	1.160	1.00
72_L	184_T	1.159	1.00
90_R	93_V	1.158	1.00
25_P	214_K	1.158	1.00
85_W	151_F	1.150	1.00
101_F	163_F	1.149	1.00
287_V	344_A	1.143	1.00
146_S	462_A	1.143	1.00
448_A	453_I	1.139	1.00
70_P	76_W	1.132	1.00
366_L	393_V	1.132	1.00
301_I	309_Q	1.132	1.00
96_S	205_N	1.127	1.00
339_A	342_E	1.126	1.00
452_L	456_E	1.126	1.00
384_A	388_Q	1.125	1.00
400_E	404_Y	1.124	1.00
111_R	115_D	1.123	1.00
7_R	10_F	1.120	1.00
197_Y	219_N	1.111	1.00
294_A	386_M	1.111	1.00
467_T	470_Q	1.107	1.00
61_K	69_I	1.097	1.00
383_Q	395_L	1.096	1.00
237_D	499_K	1.093	1.00
237_D	501_E	1.091	1.00
334_P	338_K	1.091	1.00
167_S	171_N	1.089	1.00
299_S	385_D	1.087	1.00
364_I	393_V	1.081	1.00
106_A	163_F	1.080	1.00
202_R	211_P	1.080	1.00
274_A	415_I	1.077	1.00
305_L	490_S	1.076	1.00
386_M	393_V	1.075	1.00
128_Q	148_Y	1.074	1.00
77_T	86_T	1.074	1.00
103_A	135_L	1.070	1.00
410_G	447_L	1.065	1.00
364_I	414_M	1.063	1.00
61_K	71_W	1.062	1.00
188_I	203_N	1.060	1.00
132_V	140_L	1.060	1.00
289_E	340_L	1.059	1.00
264_L	493_S	1.058	1.00
232_E	257_N	1.054	1.00
8_T	11_A	1.053	1.00
87_F	142_I	1.053	1.00
51_A	200_F	1.039	1.00
459_E	475_D	1.038	1.00
285_L	484_A	1.038	1.00
100_P	137_K	1.035	1.00
261_H	498_S	1.031	1.00
435_V	454_D	1.030	1.00
226_T	230_A	1.030	1.00
467_T	471_A	1.028	1.00
252_A	256_Q	1.028	1.00
74_K	138_T	1.025	1.00
96_S	182_I	1.018	1.00
292_N	297_K	1.016	1.00
334_P	389_I	1.014	1.00
105_A	108_E	1.012	1.00
263_Q	498_S	1.010	1.00
286_A	344_A	1.007	1.00
72_L	93_V	1.006	1.00
85_W	152_L	1.002	1.00
383_Q	393_V	1.001	1.00
151_F	155_L	0.993	1.00
15_C	18_F	0.993	1.00
335_Q	339_A	0.992	1.00
88_T	91_D	0.987	1.00
201_V	204_E	0.987	1.00
384_A	387_R	0.984	1.00
382_I	386_M	0.982	1.00
95_F	105_A	0.980	1.00
28_I	213_I	0.977	1.00
456_E	459_E	0.974	1.00
202_R	209_E	0.970	1.00
453_I	480_L	0.970	1.00
108_E	166_P	0.969	1.00
310_Q	493_S	0.968	1.00
456_E	476_I	0.968	1.00
275_L	291_L	0.967	1.00
479_R	482_D	0.967	1.00
72_L	106_A	0.964	1.00
302_D	307_G	0.963	1.00
427_H	461_L	0.957	1.00
168_Q	182_I	0.957	1.00
324_N	474_R	0.957	1.00
379_A	395_L	0.951	1.00
347_T	359_G	0.951	1.00
12_L	15_C	0.950	1.00
236_I	239_L	0.948	1.00
83_K	130_V	0.946	1.00
103_A	140_L	0.946	1.00
300_L	378_M	0.944	1.00
460_V	476_I	0.942	1.00
86_T	135_L	0.942	1.00
448_A	485_V	0.939	1.00
402_S	406_R	0.935	1.00
88_T	136_S	0.935	1.00
453_I	457_I	0.934	1.00
91_D	100_P	0.931	1.00
144_L	151_F	0.929	1.00
173_E	176_N	0.926	1.00
58_P	162_R	0.925	1.00
305_L	309_Q	0.925	1.00
458_G	462_A	0.924	1.00
336_K	340_L	0.923	1.00
60_V	152_L	0.922	1.00
85_W	144_L	0.922	1.00
58_P	71_W	0.919	1.00
111_R	114_L	0.914	1.00
148_Y	154_E	0.914	1.00
250_T	253_R	0.913	1.00
35_N	192_S	0.912	1.00
28_I	502_L	0.909	1.00
289_E	293_Y	0.907	1.00
96_S	189_L	0.905	1.00
229_V	232_E	0.903	1.00
96_S	183_G	0.897	1.00
255_S	264_L	0.893	1.00
81_D	84_T	0.892	1.00
134_A	140_L	0.891	1.00
247_P	250_T	0.890	1.00
289_E	482_D	0.887	1.00
292_N	487_L	0.887	1.00
324_N	478_T	0.886	1.00
398_E	406_R	0.885	1.00
377_S	380_E	0.884	1.00
57_E	206_Y	0.883	1.00
241_G	246_L	0.882	1.00
107_A	140_L	0.880	1.00
301_I	490_S	0.878	1.00
260_Y	497_V	0.875	1.00
104_E	108_E	0.873	1.00
60_V	73_A	0.873	1.00
254_F	260_Y	0.873	1.00
435_V	449_D	0.872	1.00
296_N	385_D	0.871	1.00
55_V	200_F	0.870	1.00
299_S	303_N	0.867	1.00
83_K	143_T	0.864	1.00
79_S	82_G	0.863	1.00
228_A	232_E	0.861	1.00
334_P	388_Q	0.861	1.00
346_W	359_G	0.859	1.00
73_A	87_F	0.858	1.00
257_N	260_Y	0.857	1.00
297_K	311_V	0.857	1.00
87_F	152_L	0.853	1.00
60_V	68_V	0.852	1.00
310_Q	318_P	0.852	1.00
221_I	236_I	0.850	1.00
367_S	406_R	0.847	1.00
466_E	470_Q	0.843	1.00
457_I	476_I	0.843	1.00
315_L	488_P	0.841	1.00
453_I	479_R	0.838	1.00
228_A	254_F	0.835	1.00
231_F	239_L	0.834	1.00
24_A	212_A	0.833	1.00
367_S	398_E	0.828	1.00
202_R	210_K	0.828	1.00
187_W	211_P	0.826	1.00
111_R	132_V	0.826	1.00
10_F	13_L	0.824	1.00
332_Y	388_Q	0.824	1.00
105_A	109_N	0.822	1.00
476_I	479_R	0.821	1.00
372_D	375_S	0.820	1.00
192_S	198_D	0.820	1.00
56_Y	183_G	0.818	1.00
11_A	14_A	0.818	1.00
274_A	446_G	0.817	1.00
407_Q	415_I	0.816	1.00
231_F	260_Y	0.815	1.00
15_C	19_I	0.814	1.00
35_N	220_V	0.812	1.00
97_N	182_I	0.812	1.00
93_V	138_T	0.811	1.00
72_L	101_F	0.808	1.00
93_V	207_W	0.804	1.00
431_S	461_L	0.803	1.00
368_F	379_A	0.803	1.00
78_H	82_G	0.803	1.00
115_D	118_Q	0.801	1.00
337_A	389_I	0.800	1.00
150_P	425_D	0.799	1.00
293_Y	330_S	0.798	1.00
362_L	391_A	0.796	1.00
252_A	306_Y	0.795	1.00
365_E	413_G	0.791	1.00
347_T	362_L	0.786	1.00
459_E	462_A	0.785	1.00
427_H	473_Y	0.785	1.00
273_L	382_I	0.783	1.00
108_E	169_F	0.783	1.00
474_R	478_T	0.783	1.00
109_N	164_I	0.781	1.00
296_N	332_Y	0.778	1.00
294_A	334_P	0.776	1.00
293_Y	332_Y	0.774	1.00
128_Q	146_S	0.774	1.00
23_A	26_D	0.774	1.00
475_D	479_R	0.774	1.00
92_D	138_T	0.773	1.00
427_H	431_S	0.772	1.00
189_L	198_D	0.771	1.00
134_A	141_Q	0.768	1.00
55_V	189_L	0.768	1.00
341_L	346_W	0.767	1.00
293_Y	340_L	0.766	1.00
202_R	213_I	0.766	1.00
83_K	146_S	0.766	1.00
290_A	341_L	0.764	1.00
41_P	164_I	0.763	1.00
284_E	346_W	0.763	1.00
387_R	391_A	0.762	1.00
314_T	477_L	0.761	1.00
451_P	454_D	0.759	1.00
42_H	112_A	0.757	1.00
87_F	155_L	0.756	1.00
26_D	213_I	0.755	1.00
89_L	101_F	0.754	1.00
9_L	12_L	0.754	1.00
227_R	239_L	0.754	1.00
30_T	238_L	0.753	1.00
54_M	200_F	0.753	1.00
431_S	435_V	0.750	1.00
22_A	212_A	0.744	1.00
444_Q	447_L	0.741	1.00
273_L	414_M	0.740	1.00
284_E	344_A	0.735	1.00
266_Q	493_S	0.733	1.00
386_M	414_M	0.732	1.00
386_M	389_I	0.732	1.00
277_T	485_V	0.732	1.00
71_W	207_W	0.730	1.00
366_L	379_A	0.726	1.00
108_E	170_K	0.726	1.00
287_V	346_W	0.724	1.00
367_S	396_I	0.724	1.00
295_V	300_L	0.723	1.00
204_E	214_K	0.722	1.00
340_L	344_A	0.722	1.00
238_L	502_L	0.721	1.00
177_G	181_P	0.719	1.00
380_E	395_L	0.718	1.00
448_A	479_R	0.718	1.00
128_Q	145_K	0.717	1.00
269_E	421_G	0.717	1.00
251_F	255_S	0.717	1.00
31_A	221_I	0.717	1.00
278_A	410_G	0.716	1.00
264_L	308_T	0.714	1.00
229_V	233_T	0.713	1.00
8_T	12_L	0.712	1.00
201_V	214_K	0.710	1.00
295_V	386_M	0.708	1.00
200_F	216_I	0.706	1.00
371_T	376_K	0.705	1.00
346_W	362_L	0.705	1.00
376_K	397_G	0.701	1.00
271_V	375_S	0.701	1.00
132_V	142_I	0.700	1.00
387_R	393_V	0.699	1.00
28_I	216_I	0.698	1.00
103_A	107_A	0.697	1.00
26_D	212_A	0.697	1.00
300_L	381_I	0.696	1.00
275_L	282_T	0.695	1.00
35_N	194_L	0.695	1.00
402_S	405_A	0.694	1.00
291_L	414_M	0.693	1.00
110_F	155_L	0.692	1.00
368_F	376_K	0.691	1.00
25_P	212_A	0.690	1.00
208_G	211_P	0.689	1.00
366_L	416_F	0.689	1.00
434_R	486_Y	0.688	1.00
76_W	152_L	0.688	1.00
398_E	402_S	0.688	1.00
64_A	506_P	0.687	1.00
7_R	11_A	0.687	1.00
293_Y	331_Q	0.686	1.00
338_K	348_L	0.685	1.00
254_F	497_V	0.685	1.00
324_N	327_L	0.684	1.00
54_M	216_I	0.683	1.00
168_Q	172_H	0.683	1.00
51_A	198_D	0.682	1.00
221_I	227_R	0.679	1.00
149_Y	469_R	0.679	1.00
165_A	182_I	0.678	1.00
321_P	466_E	0.678	1.00
129_I	132_V	0.677	1.00
291_L	487_L	0.677	1.00
189_L	192_S	0.676	1.00
348_L	361_P	0.675	1.00
129_I	142_I	0.674	1.00
101_F	138_T	0.673	1.00
348_L	359_G	0.673	1.00
95_F	183_G	0.673	1.00
423_P	428_A	0.673	1.00
59_L	73_A	0.671	1.00
380_E	383_Q	0.671	1.00
95_F	163_F	0.671	1.00
469_R	473_Y	0.669	1.00
77_T	80_E	0.668	1.00
95_F	101_F	0.666	1.00
219_N	230_A	0.664	1.00
264_L	495_M	0.663	1.00
291_L	364_I	0.662	1.00
55_V	183_G	0.660	1.00
62_Y	156_A	0.659	1.00
346_W	391_A	0.658	1.00
259_A	499_K	0.657	1.00
42_H	113_V	0.657	1.00
324_N	477_L	0.655	1.00
472_L	476_I	0.653	1.00
62_Y	68_V	0.651	1.00
56_Y	181_P	0.651	1.00
485_V	488_P	0.650	1.00
434_R	437_S	0.649	1.00
300_L	382_I	0.649	1.00
369_I	372_D	0.649	1.00
99_E	105_A	0.648	1.00
107_A	133_K	0.647	1.00
279_K	411_R	0.646	1.00
434_R	480_L	0.645	1.00
367_S	412_F	0.643	1.00
284_E	287_V	0.643	1.00
282_T	287_V	0.641	1.00
380_E	384_A	0.641	1.00
294_A	332_Y	0.640	1.00
435_V	457_I	0.639	1.00
498_S	505_I	0.638	1.00
382_I	393_V	0.637	1.00
239_L	246_L	0.636	1.00
322_Y	470_Q	0.636	1.00
37_G	46_P	0.636	1.00
341_L	389_I	0.636	1.00
231_F	499_K	0.632	1.00
188_I	205_N	0.631	1.00
198_D	220_V	0.631	1.00
341_L	344_A	0.631	1.00
279_K	282_T	0.630	1.00
58_P	184_T	0.629	1.00
213_I	502_L	0.629	1.00
78_H	152_L	0.628	1.00
403_I	415_I	0.628	1.00
101_F	109_N	0.627	1.00
167_S	170_K	0.626	1.00
89_L	138_T	0.624	1.00
95_F	184_T	0.623	1.00
83_K	147_A	0.622	1.00
108_E	112_A	0.622	1.00
341_L	391_A	0.621	1.00
6_R	9_L	0.621	1.00
187_W	215_K	0.619	1.00
102_D	138_T	0.617	1.00
277_T	446_G	0.615	1.00
466_E	469_R	0.614	1.00
323_A	326_G	0.612	1.00
378_M	382_I	0.610	1.00
146_S	458_G	0.609	1.00
499_K	502_L	0.608	1.00
82_G	86_T	0.607	1.00
95_F	167_S	0.605	1.00
223_D	226_T	0.603	1.00
44_Y	48_Q	0.603	1.00
44_Y	52_Q	0.603	1.00
458_G	461_L	0.601	1.00
76_W	88_T	0.600	1.00
400_E	418_R	0.600	1.00
369_I	375_S	0.599	1.00
334_P	341_L	0.597	1.00
373_A	377_S	0.597	1.00
22_A	26_D	0.597	1.00
114_L	145_K	0.596	1.00
103_A	138_T	0.596	1.00
386_M	391_A	0.596	1.00
87_F	140_L	0.595	1.00
298_K	301_I	0.595	1.00
369_I	403_I	0.590	1.00
68_V	152_L	0.590	1.00
463_T	469_R	0.589	1.00
39_L	192_S	0.589	1.00
111_R	134_A	0.588	1.00
29_T	236_I	0.588	1.00
37_G	48_Q	0.587	1.00
116_N	119_R	0.587	1.00
55_V	181_P	0.587	1.00
181_P	189_L	0.585	1.00
453_I	456_E	0.585	1.00
398_E	403_I	0.585	1.00
484_A	487_L	0.584	1.00
308_T	495_M	0.583	1.00
49_M	158_P	0.583	1.00
326_G	478_T	0.582	1.00
196_Q	219_N	0.582	1.00
460_V	469_R	0.582	1.00
89_L	93_V	0.581	1.00
326_G	474_R	0.581	1.00
292_N	330_S	0.580	1.00
295_V	489_I	0.580	1.00
82_G	464_H	0.580	1.00
482_D	485_V	0.579	1.00
454_D	458_G	0.579	1.00
277_T	283_N	0.578	1.00
270_T	312_A	0.577	1.00
257_N	500_P	0.577	1.00
342_E	348_L	0.575	1.00
56_Y	184_T	0.575	1.00
187_W	202_R	0.573	1.00
341_L	362_L	0.573	1.00
278_A	283_N	0.572	1.00
327_L	330_S	0.572	1.00
272_M	486_Y	0.571	1.00
261_H	503_G	0.571	1.00
102_D	166_P	0.571	1.00
22_A	25_P	0.570	1.00
295_V	487_L	0.570	1.00
373_A	376_K	0.570	1.00
108_E	167_S	0.570	1.00
329_P	481_H	0.569	1.00
332_Y	385_D	0.567	1.00
80_E	84_T	0.567	1.00
169_F	172_H	0.566	1.00
112_A	169_F	0.566	1.00
287_V	362_L	0.564	1.00
172_H	180_A	0.563	1.00
103_A	136_S	0.561	1.00
338_K	389_I	0.561	1.00
284_E	345_G	0.559	1.00
189_L	200_F	0.557	1.00
84_T	133_K	0.557	1.00
342_E	346_W	0.557	1.00
271_V	378_M	0.555	1.00
203_N	206_Y	0.553	1.00
359_G	362_L	0.552	1.00
385_D	389_I	0.552	1.00
333_D	339_A	0.551	1.00
275_L	292_N	0.551	1.00
96_S	184_T	0.551	1.00
476_I	480_L	0.551	1.00
430_L	433_M	0.549	1.00
39_L	198_D	0.549	1.00
293_Y	337_A	0.548	1.00
434_R	458_G	0.547	1.00
209_E	212_A	0.546	1.00
371_T	399_E	0.545	1.00
15_C	20_V	0.544	1.00
378_M	490_S	0.543	1.00
301_I	305_L	0.542	1.00
238_L	498_S	0.542	1.00
273_L	489_I	0.541	1.00
21_H	24_A	0.541	1.00
59_L	106_A	0.540	1.00
89_L	103_A	0.540	1.00
298_K	331_Q	0.539	1.00
287_V	291_L	0.539	1.00
420_W	423_P	0.539	1.00
450_K	453_I	0.538	1.00
70_P	75_S	0.536	1.00
58_P	87_F	0.536	1.00
231_F	236_I	0.536	1.00
345_G	359_G	0.536	1.00
174_T	177_G	0.535	1.00
74_K	89_L	0.535	1.00
25_P	215_K	0.534	1.00
291_L	389_I	0.533	1.00
173_E	177_G	0.533	1.00
124_E	127_N	0.533	1.00
405_A	408_R	0.531	1.00
95_F	109_N	0.531	1.00
219_N	235_D	0.531	1.00
403_I	407_Q	0.530	1.00
111_R	131_D	0.529	1.00
111_R	166_P	0.529	1.00
430_L	476_I	0.528	1.00
341_L	345_G	0.528	1.00
276_N	413_G	0.528	1.00
99_E	166_P	0.527	1.00
116_N	120_H	0.527	1.00
300_L	489_I	0.527	1.00
251_F	262_T	0.527	1.00
6_R	10_F	0.526	1.00
32_W	218_F	0.526	1.00
304_A	381_I	0.526	1.00
103_A	139_E	0.526	1.00
456_E	460_V	0.526	1.00
225_T	229_V	0.525	1.00
464_H	468_Q	0.525	1.00
258_P	500_P	0.525	1.00
234_G	499_K	0.524	1.00
308_T	311_V	0.524	1.00
246_L	497_V	0.524	1.00
266_Q	310_Q	0.524	1.00
281_P	362_L	0.524	1.00
224_P	227_R	0.523	1.00
425_D	428_A	0.522	1.00
179_K	194_L	0.521	1.00
27_E	199_V	0.520	1.00
281_P	413_G	0.519	1.00
393_V	414_M	0.518	1.00
502_L	505_I	0.518	1.00
273_L	487_L	0.518	1.00
364_I	368_F	0.516	1.00
213_I	216_I	0.514	1.00
134_A	139_E	0.513	1.00
431_S	458_G	0.513	1.00
286_A	339_A	0.511	1.00
313_D	329_P	0.511	1.00
126_A	161_F	0.511	1.00
6_R	11_A	0.510	1.00
14_A	17_S	0.510	1.00
300_L	304_A	0.509	1.00
46_P	400_E	0.509	1.00
54_M	218_F	0.509	1.00
321_P	470_Q	0.509	1.00
366_L	414_M	0.509	1.00
344_A	347_T	0.507	1.00
32_W	36_V	0.507	1.00
293_Y	333_D	0.506	1.00
424_Y	428_A	0.506	1.00
101_F	106_A	0.506	1.00
36_V	198_D	0.506	1.00
57_E	93_V	0.505	1.00
255_S	308_T	0.504	1.00
123_L	127_N	0.504	1.00
52_Q	56_Y	0.504	1.00
74_K	93_V	0.503	1.00
299_S	381_I	0.501	1.00
368_F	371_T	0.501	1.00
101_F	183_G	0.500	1.00
450_K	485_V	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1xocA	2	0.9408	100	0.121	Contact Map
4oevA	1	0.9218	100	0.129	Contact Map
2nooA	1	0.9408	100	0.131	Contact Map
4wedA	1	0.9141	100	0.133	Contact Map
4oerA	1	0.9504	100	0.135	Contact Map
4qflA	1	0.9122	100	0.142	Contact Map
2grvA	1	0.9179	100	0.157	Contact Map
3drfA	1	0.9218	100	0.16	Contact Map
4fajA	1	0.9027	100	0.165	Contact Map
3t66A	1	0.8969	100	0.165	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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