TKT2 - ECOLI - GREMLIN Contacts

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TKT2 - Transketolase 2

UniProt:	P33570	Sequences: MSRKDLANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPTDPTWYDRDRFILSNGHASMLLYSLLHLTGYDLPLEELKNFRQLHSKTPGHPEIGYTPGVETTTGPLGQGLANAVGLAIAERTLAAQFNQPDHEIVDHFTYVFMGDGCLMEGISHEVCSLAGTLGLGKLIGFYDHNGISIDGETEGWFTDDTAKRFEAYHWHVIHEIDGHDPQAVKEAILEAQSVKDKPSLIICRTVIGFGSPNKAGKEEAHGAPLGEEEVALARQKLGWHHPPFEIPKEIYHAWDAREKGEKAQQSWNEKFAAYKKAHPQLAEEFTRRMSGGLPKDWEKTTQKYINELQANPAKIATRKASQNTLNAYGPMLPELLGGSADLAPSNLTIWKGSVSLKEDPAGNYIHYGVREFGMTAIANGIAHHGGFVPYTATFLMFVEYARNAARMAALMKARQIMVYTHDSIGLGEDGPTHQAVEQLASLRLTPNFSTWRPCDQVEAAVGWKLAVERHNGPTALILSRQNLAQVERTPDQVKEIARGGYVLKDSGGKPDIILIATGSEMEITLQAAEKLAGEGRNVRVVSLPSTDIFDAQDEEYRESVLPSNVAARVAVEAGIADYWYKYVGLKGAIVGMTGYGESAPADKLFPFFGFTAENIVAKAHKVLGVKGA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12100
Length:	667 (592)
Sequences:	9233 (5061)
Seq/√Len:	208.0

ECOLI - TKT2 TKT1 DXS ODP1
BACSU - TKT DXS

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
573_E	659_H	4.434	1.00
551_I	658_A	4.249	1.00
202_K	205_E	4.224	1.00
417_A	430_T	3.439	1.00
212_I	238_S	3.352	1.00
550_D	576_N	3.184	1.00
43_F	224_K	3.141	1.00
219_D	222_A	3.112	1.00
82_P	85_E	3.105	1.00
539_G	582_L	2.983	1.00
597_E	602_S	2.851	1.00
508_R	511_G	2.813	1.00
543_K	567_A	2.780	1.00
233_V	236_K	2.759	1.00
651_A	655_V	2.720	1.00
589_D	621_Y	2.710	1.00
199_D	202_K	2.665	1.00
210_H	238_S	2.586	1.00
147_F	178_I	2.584	1.00
281_P	284_E	2.541	1.00
314_K	325_T	2.536	1.00
228_L	232_S	2.475	1.00
593_E	597_E	2.422	1.00
569_K	655_V	2.412	1.00
427_V	453_R	2.400	1.00
609_A	628_I	2.348	1.00
303_Q	307_N	2.340	1.00
210_H	233_V	2.299	1.00
490_W	501_G	2.277	1.00
212_I	226_A	2.242	1.00
166_C	204_F	2.235	1.00
163_H	207_Y	2.226	1.00
568_E	572_G	2.222	1.00
566_A	570_L	2.217	1.00
627_A	657_K	2.194	1.00
554_I	582_L	2.175	1.00
615_A	630_G	2.175	1.00
551_I	577_V	2.156	1.00
627_A	660_K	2.127	1.00
565_Q	568_E	2.116	1.00
642_K	645_P	2.094	1.00
307_N	311_A	2.077	1.00
84_E	87_K	2.055	1.00
152_M	179_G	2.009	1.00
435_M	477_Q	2.004	1.00
297_E	301_K	1.998	1.00
126_A	148_T	1.984	1.00
287_K	291_H	1.961	1.00
488_S	584_S	1.960	1.00
175_G	210_H	1.947	1.00
504_L	507_E	1.936	1.00
444_A	487_F	1.933	1.00
653_N	657_K	1.929	1.00
304_Q	308_E	1.924	1.00
153_G	156_C	1.923	1.00
553_L	563_T	1.922	1.00
420_I	426_F	1.891	1.00
518_S	522_L	1.880	1.00
212_I	229_E	1.874	1.00
110_T	121_N	1.874	1.00
582_L	585_T	1.869	1.00
593_E	596_R	1.851	1.00
270_A	274_Q	1.848	1.00
487_F	514_A	1.845	1.00
301_K	305_S	1.840	1.00
224_K	228_L	1.834	1.00
488_S	511_G	1.828	1.00
589_D	620_K	1.809	1.00
533_K	536_A	1.793	1.00
201_A	205_E	1.793	1.00
308_E	312_A	1.792	1.00
217_G	244_T	1.789	1.00
533_K	537_R	1.782	1.00
451_K	510_N	1.780	1.00
595_Y	600_L	1.766	1.00
389_W	392_S	1.762	1.00
569_K	651_A	1.751	1.00
421_A	453_R	1.750	1.00
477_Q	516_I	1.734	1.00
354_I	359_A	1.732	1.00
447_A	456_M	1.715	1.00
75_H	290_Y	1.712	1.00
141_H	309_K	1.688	1.00
291_H	294_D	1.687	1.00
391_G	394_S	1.685	1.00
43_F	231_Q	1.682	1.00
539_G	543_K	1.675	1.00
147_F	231_Q	1.671	1.00
326_R	373_E	1.663	1.00
183_H	241_I	1.661	1.00
622_V	628_I	1.659	1.00
97_P	105_T	1.654	1.00
596_R	600_L	1.652	1.00
171_T	197_T	1.651	1.00
175_G	235_D	1.649	1.00
538_G	541_V	1.647	1.00
245_V	254_A	1.644	1.00
656_A	660_K	1.643	1.00
252_N	271_L	1.639	1.00
54_Y	324_F	1.639	1.00
563_T	610_V	1.638	1.00
144_V	324_F	1.634	1.00
339_T	342_K	1.632	1.00
166_C	207_Y	1.623	1.00
92_L	642_K	1.620	1.00
74_L	107_G	1.587	1.00
645_P	652_E	1.576	1.00
503_K	507_E	1.575	1.00
569_K	652_E	1.573	1.00
544_D	578_R	1.571	1.00
569_K	572_G	1.569	1.00
173_G	396_K	1.557	1.00
245_V	255_G	1.547	1.00
561_E	565_Q	1.543	1.00
180_F	227_I	1.533	1.00
633_G	637_S	1.526	1.00
92_L	638_A	1.525	1.00
225_E	229_E	1.516	1.00
201_A	241_I	1.512	1.00
168_L	172_L	1.506	1.00
475_V	631_M	1.505	1.00
653_N	656_A	1.502	1.00
615_A	619_Y	1.502	1.00
421_A	428_P	1.493	1.00
478_L	516_I	1.493	1.00
83_L	87_K	1.489	1.00
441_R	480_S	1.485	1.00
592_D	595_Y	1.485	1.00
555_A	563_T	1.480	1.00
564_L	579_V	1.480	1.00
201_A	211_V	1.477	1.00
484_T	487_F	1.471	1.00
250_S	272_A	1.468	1.00
335_D	339_T	1.466	1.00
421_A	452_A	1.465	1.00
518_S	558_S	1.456	1.00
562_I	651_A	1.453	1.00
146_H	423_H	1.453	1.00
391_G	395_L	1.446	1.00
592_D	596_R	1.446	1.00
504_L	508_R	1.441	1.00
488_S	508_R	1.441	1.00
642_K	646_F	1.437	1.00
543_K	568_E	1.437	1.00
280_H	284_E	1.434	1.00
354_I	362_N	1.425	1.00
571_A	577_V	1.424	1.00
417_A	431_A	1.423	1.00
331_G	334_K	1.417	1.00
300_E	304_Q	1.413	1.00
336_W	339_T	1.412	1.00
549_P	576_N	1.409	1.00
388_I	393_V	1.407	1.00
142_E	145_D	1.406	1.00
488_S	587_I	1.406	1.00
417_A	454_Q	1.403	1.00
534_E	537_R	1.401	1.00
555_A	560_M	1.400	1.00
565_Q	651_A	1.388	1.00
161_I	411_F	1.381	1.00
493_C	560_M	1.378	1.00
437_V	480_S	1.378	1.00
122_A	179_G	1.369	1.00
282_P	286_P	1.369	1.00
389_W	395_L	1.363	1.00
122_A	150_V	1.361	1.00
185_G	243_R	1.359	1.00
256_K	259_A	1.359	1.00
366_A	369_P	1.355	1.00
615_A	632_T	1.350	1.00
553_L	658_A	1.349	1.00
292_A	296_R	1.345	1.00
434_L	481_L	1.342	1.00
563_T	579_V	1.339	1.00
358_K	386_L	1.336	1.00
376_G	429_Y	1.334	1.00
446_M	487_F	1.334	1.00
358_K	521_N	1.325	1.00
640_A	644_F	1.322	1.00
414_T	440_A	1.319	1.00
308_E	311_A	1.318	1.00
628_I	631_M	1.310	1.00
498_A	517_L	1.298	1.00
353_K	521_N	1.298	1.00
643_L	647_F	1.297	1.00
531_Q	537_R	1.296	1.00
253_K	258_E	1.293	1.00
644_F	649_F	1.288	1.00
60_I	125_L	1.288	1.00
105_T	108_V	1.278	1.00
531_Q	536_A	1.273	1.00
553_L	601_P	1.272	1.00
539_G	542_L	1.270	1.00
43_F	228_L	1.269	1.00
531_Q	534_E	1.268	1.00
639_P	642_K	1.262	1.00
210_H	229_E	1.259	1.00
85_E	88_N	1.257	1.00
575_R	659_H	1.253	1.00
92_L	646_F	1.251	1.00
569_K	573_E	1.249	1.00
414_T	457_V	1.248	1.00
311_A	314_K	1.243	1.00
354_I	358_K	1.241	1.00
294_D	297_E	1.236	1.00
123_V	174_L	1.235	1.00
511_G	590_A	1.234	1.00
328_M	331_G	1.232	1.00
501_G	515_L	1.231	1.00
534_E	538_G	1.230	1.00
247_G	259_A	1.229	1.00
585_T	589_D	1.218	1.00
98_G	101_E	1.217	1.00
228_L	231_Q	1.215	1.00
305_S	308_E	1.214	1.00
434_L	516_I	1.212	1.00
336_W	340_T	1.210	1.00
652_E	656_A	1.208	1.00
155_G	187_S	1.205	1.00
593_E	602_S	1.203	1.00
148_T	176_K	1.201	1.00
93_H	646_F	1.201	1.00
180_F	242_C	1.198	1.00
296_R	300_E	1.198	1.00
120_A	165_V	1.194	1.00
181_Y	201_A	1.191	1.00
96_T	99_H	1.190	1.00
479_A	613_G	1.188	1.00
567_A	579_V	1.187	1.00
127_I	172_L	1.185	1.00
130_R	399_P	1.184	1.00
305_S	309_K	1.174	1.00
167_S	196_F	1.174	1.00
131_T	375_L	1.174	1.00
594_E	597_E	1.171	1.00
539_G	545_S	1.171	1.00
444_A	458_Y	1.170	1.00
335_D	338_K	1.168	1.00
490_W	513_T	1.165	1.00
540_Y	543_K	1.161	1.00
388_I	391_G	1.159	1.00
536_A	539_G	1.157	1.00
500_V	535_I	1.155	1.00
634_Y	637_S	1.154	1.00
657_K	660_K	1.147	1.00
175_G	234_K	1.144	1.00
120_A	412_G	1.143	1.00
212_I	230_A	1.135	1.00
545_S	576_N	1.134	1.00
376_G	403_Y	1.133	1.00
623_G	626_G	1.128	1.00
204_F	239_L	1.127	1.00
97_P	101_E	1.125	1.00
532_V	536_A	1.122	1.00
359_A	495_Q	1.121	1.00
263_P	269_V	1.119	1.00
523_A	561_E	1.119	1.00
309_K	312_A	1.117	1.00
608_V	629_V	1.116	1.00
81_L	85_E	1.116	1.00
545_S	549_P	1.115	1.00
142_E	309_K	1.113	1.00
555_A	559_E	1.111	1.00
367_Y	374_L	1.111	1.00
325_T	329_S	1.105	1.00
382_A	405_H	1.104	1.00
358_K	362_N	1.103	1.00
441_R	457_V	1.102	1.00
640_A	643_L	1.102	1.00
63_N	153_G	1.097	1.00
149_Y	178_I	1.097	1.00
119_L	179_G	1.094	1.00
559_E	562_I	1.093	1.00
338_K	342_K	1.092	1.00
324_F	328_M	1.092	1.00
457_V	517_L	1.090	1.00
392_S	395_L	1.089	1.00
538_G	542_L	1.088	1.00
268_E	271_L	1.084	1.00
129_E	148_T	1.080	1.00
619_Y	628_I	1.076	1.00
479_A	617_Y	1.074	1.00
120_A	415_A	1.074	1.00
505_A	508_R	1.071	1.00
414_T	456_M	1.070	1.00
211_V	241_I	1.068	1.00
150_V	179_G	1.068	1.00
488_S	586_D	1.065	1.00
539_G	599_V	1.054	1.00
550_D	575_R	1.053	1.00
541_V	544_D	1.053	1.00
565_Q	569_K	1.049	1.00
119_L	166_C	1.049	1.00
385_N	431_A	1.048	1.00
595_Y	599_V	1.046	1.00
96_T	101_E	1.046	1.00
619_Y	622_V	1.046	1.00
608_V	657_K	1.045	1.00
336_W	342_K	1.040	1.00
609_A	615_A	1.039	1.00
356_T	522_L	1.036	1.00
566_A	655_V	1.033	1.00
595_Y	598_S	1.032	1.00
546_G	576_N	1.032	1.00
479_A	483_L	1.032	1.00
389_W	393_V	1.032	1.00
389_W	394_S	1.029	1.00
314_K	321_A	1.029	1.00
187_S	408_V	1.027	1.00
388_I	394_S	1.026	1.00
464_G	644_F	1.026	1.00
229_E	233_V	1.024	1.00
592_D	598_S	1.023	1.00
253_K	268_E	1.022	1.00
390_K	395_L	1.019	1.00
360_S	502_W	1.014	1.00
421_A	454_Q	1.014	1.00
271_L	274_Q	1.013	1.00
175_G	238_S	1.011	1.00
537_R	541_V	1.005	1.00
119_L	150_V	1.004	1.00
488_S	513_T	1.001	1.00
534_E	539_G	0.997	1.00
54_Y	144_V	0.997	1.00
147_F	176_K	0.994	1.00
549_P	604_V	0.993	1.00
323_E	326_R	0.991	1.00
585_T	621_Y	0.990	1.00
160_G	164_E	0.990	1.00
552_I	601_P	0.985	1.00
173_G	235_D	0.981	1.00
571_A	576_N	0.980	1.00
288_E	291_H	0.980	1.00
339_T	370_M	0.980	1.00
254_A	275_K	0.979	1.00
550_D	596_R	0.978	1.00
420_I	423_H	0.978	1.00
566_A	569_K	0.978	1.00
538_G	543_K	0.977	1.00
375_L	420_I	0.974	1.00
54_Y	328_M	0.970	1.00
481_L	514_A	0.968	1.00
444_A	456_M	0.963	1.00
203_R	207_Y	0.962	1.00
317_H	320_L	0.960	1.00
480_S	484_T	0.960	1.00
323_E	327_R	0.959	1.00
295_A	298_K	0.959	1.00
267_E	271_L	0.959	1.00
552_I	580_V	0.958	1.00
364_L	429_Y	0.957	1.00
503_K	536_A	0.957	1.00
351_P	524_Q	0.955	0.99
63_N	151_F	0.955	0.99
594_E	598_S	0.955	0.99
131_T	426_F	0.953	0.99
252_N	268_E	0.953	0.99
266_E	270_A	0.950	0.99
606_A	612_A	0.948	0.99
440_A	444_A	0.946	0.99
330_G	333_P	0.944	0.99
84_E	88_N	0.942	0.99
361_Q	386_L	0.942	0.99
638_A	643_L	0.941	0.99
119_L	162_S	0.937	0.99
326_R	331_G	0.935	0.99
608_V	612_A	0.933	0.99
649_F	653_N	0.932	0.99
229_E	232_S	0.931	0.99
358_K	361_Q	0.930	0.99
633_G	646_F	0.929	0.99
94_S	97_P	0.928	0.99
272_A	275_K	0.927	0.99
478_L	483_L	0.925	0.99
505_A	513_T	0.924	0.99
543_K	564_L	0.923	0.99
311_A	315_K	0.921	0.99
277_G	282_P	0.918	0.99
390_K	394_S	0.916	0.99
123_V	165_V	0.913	0.99
227_I	231_Q	0.907	0.99
543_K	571_A	0.904	0.99
553_L	610_V	0.902	0.99
215_I	222_A	0.902	0.99
597_E	601_P	0.900	0.99
442_N	447_A	0.900	0.99
504_L	536_A	0.897	0.99
81_L	105_T	0.896	0.99
609_A	622_V	0.892	0.99
158_M	187_S	0.890	0.99
609_A	612_A	0.888	0.99
128_A	420_I	0.887	0.99
545_S	571_A	0.886	0.99
594_E	600_L	0.886	0.99
97_P	100_P	0.885	0.99
333_P	339_T	0.885	0.99
533_K	539_G	0.878	0.99
525_V	564_L	0.877	0.99
597_E	600_L	0.877	0.99
531_Q	539_G	0.873	0.99
355_A	358_K	0.871	0.99
527_R	530_D	0.871	0.99
378_S	385_N	0.870	0.99
152_M	157_L	0.870	0.99
270_A	280_H	0.869	0.99
552_I	600_L	0.869	0.99
130_R	176_K	0.868	0.99
481_L	484_T	0.867	0.99
531_Q	538_G	0.866	0.99
549_P	578_R	0.864	0.99
210_H	234_K	0.863	0.99
479_A	616_D	0.863	0.99
532_V	539_G	0.863	0.99
362_N	390_K	0.862	0.99
68_M	86_L	0.861	0.99
250_S	271_L	0.861	0.99
338_K	341_Q	0.861	0.99
597_E	603_N	0.859	0.99
629_V	654_I	0.856	0.99
129_E	423_H	0.854	0.99
331_G	336_W	0.853	0.99
584_S	587_I	0.851	0.99
334_K	339_T	0.850	0.99
201_A	214_E	0.850	0.99
458_Y	514_A	0.847	0.99
181_Y	239_L	0.847	0.99
480_S	483_L	0.847	0.99
367_Y	371_L	0.847	0.99
383_P	405_H	0.847	0.99
129_E	176_K	0.846	0.99
278_W	286_P	0.845	0.99
406_Y	417_A	0.845	0.99
416_I	419_G	0.845	0.99
221_Q	225_E	0.845	0.99
335_D	342_K	0.844	0.99
110_T	422_H	0.839	0.99
161_I	415_A	0.839	0.99
632_T	637_S	0.837	0.99
608_V	658_A	0.837	0.99
610_V	654_I	0.833	0.99
210_H	235_D	0.833	0.99
210_H	236_K	0.832	0.99
411_F	443_A	0.831	0.99
375_L	426_F	0.831	0.99
488_S	590_A	0.831	0.99
537_R	540_Y	0.828	0.99
548_K	576_N	0.827	0.99
616_D	619_Y	0.827	0.99
117_Q	415_A	0.827	0.99
477_Q	610_V	0.825	0.99
565_Q	652_E	0.823	0.99
129_E	146_H	0.823	0.99
585_T	617_Y	0.823	0.99
444_A	514_A	0.819	0.98
96_T	100_P	0.819	0.98
609_A	613_G	0.818	0.98
633_G	636_E	0.817	0.98
541_V	578_R	0.816	0.98
601_P	604_V	0.816	0.98
531_Q	535_I	0.816	0.98
321_A	325_T	0.814	0.98
283_F	287_K	0.813	0.98
438_E	477_Q	0.813	0.98
267_E	270_A	0.813	0.98
545_S	548_K	0.812	0.98
553_L	577_V	0.811	0.98
133_A	141_H	0.808	0.98
224_K	231_Q	0.808	0.98
638_A	642_K	0.806	0.98
337_E	341_Q	0.803	0.98
304_Q	307_N	0.802	0.98
633_G	647_F	0.799	0.98
320_L	323_E	0.798	0.98
490_W	584_S	0.798	0.98
406_Y	412_G	0.798	0.98
140_D	143_I	0.797	0.98
141_H	316_A	0.795	0.98
582_L	614_I	0.792	0.98
132_L	423_H	0.792	0.98
438_E	441_R	0.791	0.98
552_I	604_V	0.791	0.98
127_I	416_I	0.791	0.98
437_V	458_Y	0.791	0.98
650_T	653_N	0.789	0.98
572_G	576_N	0.789	0.98
641_D	645_P	0.787	0.98
151_F	180_F	0.786	0.98
377_G	413_M	0.786	0.98
555_A	579_V	0.782	0.98
552_I	595_Y	0.781	0.98
332_L	335_D	0.780	0.98
144_V	235_D	0.779	0.98
322_E	326_R	0.776	0.98
185_G	191_E	0.775	0.98
130_R	175_G	0.774	0.98
313_Y	317_H	0.773	0.98
654_I	657_K	0.773	0.98
152_M	156_C	0.773	0.98
68_M	72_S	0.772	0.98
336_W	341_Q	0.771	0.98
281_P	285_I	0.770	0.98
299_G	302_A	0.769	0.98
655_V	659_H	0.769	0.98
535_I	538_G	0.768	0.98
645_P	650_T	0.767	0.98
546_G	571_A	0.762	0.98
589_D	596_R	0.761	0.98
214_E	241_I	0.759	0.97
388_I	392_S	0.759	0.97
532_V	537_R	0.758	0.97
94_S	98_G	0.757	0.97
189_D	383_P	0.757	0.97
215_I	242_C	0.754	0.97
484_T	489_T	0.748	0.97
163_H	166_C	0.748	0.97
60_I	122_A	0.748	0.97
501_G	535_I	0.747	0.97
63_N	66_A	0.747	0.97
556_T	582_L	0.746	0.97
222_A	226_A	0.744	0.97
608_V	627_A	0.743	0.97
99_H	102_I	0.743	0.97
331_G	509_H	0.743	0.97
61_L	70_L	0.741	0.97
364_L	389_W	0.741	0.97
333_P	336_W	0.740	0.97
626_G	629_V	0.739	0.97
117_Q	411_F	0.738	0.97
254_A	257_E	0.738	0.97
328_M	338_K	0.738	0.97
417_A	456_M	0.736	0.97
265_G	268_E	0.736	0.97
618_W	621_Y	0.736	0.97
302_A	305_S	0.736	0.97
289_I	293_W	0.735	0.97
600_L	604_V	0.734	0.97
331_G	335_D	0.734	0.97
416_I	420_I	0.734	0.97
522_L	558_S	0.731	0.97
615_A	628_I	0.731	0.97
600_L	607_R	0.730	0.97
376_G	381_L	0.730	0.97
447_A	454_Q	0.730	0.97
233_V	238_S	0.729	0.97
55_D	309_K	0.729	0.97
414_T	458_Y	0.727	0.97
334_K	337_E	0.726	0.97
567_A	577_V	0.724	0.97
548_K	604_V	0.723	0.97
550_D	577_V	0.723	0.97
554_I	585_T	0.721	0.97
149_Y	231_Q	0.720	0.97
626_G	631_M	0.719	0.96
466_G	473_Q	0.719	0.96
417_A	428_P	0.718	0.96
548_K	603_N	0.717	0.96
128_A	423_H	0.717	0.96
363_T	499_A	0.716	0.96
394_S	405_H	0.715	0.96
566_A	658_A	0.715	0.96
563_T	654_I	0.715	0.96
117_Q	444_A	0.714	0.96
284_E	287_K	0.713	0.96
495_Q	524_Q	0.713	0.96
273_R	282_P	0.712	0.96
644_F	648_G	0.712	0.96
181_Y	241_I	0.712	0.96
299_G	303_Q	0.711	0.96
310_F	321_A	0.708	0.96
349_A	352_A	0.707	0.96
337_E	507_E	0.705	0.96
567_A	571_A	0.704	0.96
622_V	626_G	0.704	0.96
631_M	649_F	0.703	0.96
365_N	390_K	0.702	0.96
596_R	599_V	0.702	0.96
442_N	446_M	0.702	0.96
77_T	295_A	0.701	0.96
216_D	219_D	0.701	0.96
443_A	447_A	0.699	0.96
507_E	536_A	0.699	0.96
273_R	278_W	0.698	0.96
348_Q	351_P	0.698	0.96
614_I	617_Y	0.693	0.96
617_Y	622_V	0.693	0.96
592_D	600_L	0.692	0.96
539_G	585_T	0.692	0.96
547_G	576_N	0.691	0.96
227_I	240_I	0.690	0.96
117_Q	440_A	0.689	0.96
551_I	608_V	0.687	0.95
175_G	233_V	0.685	0.95
364_L	368_G	0.684	0.95
596_R	601_P	0.684	0.95
299_G	304_Q	0.683	0.95
478_L	613_G	0.681	0.95
334_K	342_K	0.680	0.95
127_I	420_I	0.679	0.95
536_A	541_V	0.678	0.95
553_L	579_V	0.676	0.95
613_G	616_D	0.674	0.95
492_P	501_G	0.672	0.95
615_A	618_W	0.670	0.95
266_E	282_P	0.670	0.95
178_I	230_A	0.669	0.95
554_I	607_R	0.668	0.95
656_A	659_H	0.668	0.95
102_I	450_M	0.667	0.95
500_V	503_K	0.666	0.95
168_L	407_G	0.666	0.95
634_Y	638_A	0.666	0.95
556_T	585_T	0.665	0.95
102_I	422_H	0.663	0.95
463_I	647_F	0.663	0.95
414_T	444_A	0.662	0.94
283_F	286_P	0.662	0.94
631_M	634_Y	0.662	0.94
559_E	601_P	0.662	0.94
141_H	317_H	0.661	0.94
390_K	393_V	0.659	0.94
629_V	657_K	0.659	0.94
298_K	302_A	0.655	0.94
230_A	238_S	0.654	0.94
127_I	404_I	0.654	0.94
494_D	564_L	0.654	0.94
310_F	313_Y	0.653	0.94
617_Y	621_Y	0.652	0.94
290_Y	295_A	0.652	0.94
191_E	257_E	0.651	0.94
312_A	316_A	0.651	0.94
254_A	259_A	0.649	0.94
488_S	504_L	0.648	0.94
455_I	502_W	0.648	0.94
460_H	558_S	0.647	0.94
562_I	644_F	0.646	0.94
317_H	321_A	0.646	0.94
339_T	343_Y	0.644	0.94
440_A	456_M	0.644	0.94
440_A	443_A	0.643	0.94
489_T	516_I	0.643	0.94
525_V	561_E	0.642	0.94
253_K	259_A	0.641	0.93
503_K	532_V	0.639	0.93
365_N	369_P	0.639	0.93
248_F	254_A	0.639	0.93
367_Y	506_V	0.639	0.93
255_G	258_E	0.637	0.93
577_V	658_A	0.636	0.93
310_F	314_K	0.635	0.93
440_A	458_Y	0.632	0.93
282_P	285_I	0.630	0.93
94_S	100_P	0.629	0.93
113_G	116_G	0.629	0.93
337_E	340_T	0.628	0.93
298_K	301_K	0.627	0.93
626_G	630_G	0.627	0.93
551_I	597_E	0.627	0.93
465_L	640_A	0.625	0.93
417_A	420_I	0.624	0.93
121_N	450_M	0.624	0.93
328_M	334_K	0.624	0.93
285_I	292_A	0.624	0.93
453_R	509_H	0.623	0.93
307_N	316_A	0.623	0.93
168_L	412_G	0.622	0.92
64_G	182_D	0.621	0.92
329_S	333_P	0.621	0.92
328_M	339_T	0.621	0.92
272_A	276_L	0.619	0.92
615_A	631_M	0.618	0.92
214_E	218_H	0.618	0.92
566_A	610_V	0.617	0.92
368_G	389_W	0.617	0.92
411_F	442_N	0.617	0.92
127_I	131_T	0.616	0.92
427_V	455_I	0.616	0.92
444_A	481_L	0.615	0.92
593_E	600_L	0.614	0.92
554_I	600_L	0.613	0.92
359_A	498_A	0.613	0.92
117_Q	439_Y	0.612	0.92
157_L	239_L	0.611	0.92
444_A	484_T	0.611	0.92
382_A	388_I	0.610	0.92
222_A	225_E	0.608	0.92
631_M	643_L	0.607	0.92
504_L	587_I	0.607	0.92
226_A	230_A	0.606	0.91
273_R	276_L	0.606	0.91
223_V	227_I	0.605	0.91
541_V	545_S	0.605	0.91
191_E	194_G	0.605	0.91
329_S	339_T	0.605	0.91
215_I	218_H	0.605	0.91
73_L	77_T	0.604	0.91
493_C	522_L	0.604	0.91
329_S	334_K	0.603	0.91
334_K	340_T	0.602	0.91
285_I	290_Y	0.601	0.91
329_S	342_K	0.601	0.91
253_K	256_K	0.601	0.91
427_V	506_V	0.600	0.91
285_I	291_H	0.600	0.91
354_I	521_N	0.597	0.91
209_W	239_L	0.596	0.91
251_P	268_E	0.594	0.91
434_L	478_L	0.594	0.91
526_E	568_E	0.594	0.91
608_V	611_E	0.593	0.91
504_L	513_T	0.593	0.91
494_D	542_L	0.592	0.90
343_Y	348_Q	0.592	0.90
393_V	398_D	0.591	0.90
460_H	518_S	0.591	0.90
648_G	653_N	0.590	0.90
183_H	243_R	0.589	0.90
212_I	233_V	0.589	0.90
549_P	552_I	0.589	0.90
284_E	288_E	0.589	0.90
334_K	338_K	0.589	0.90
296_R	299_G	0.589	0.90
312_A	315_K	0.588	0.90
500_V	532_V	0.587	0.90
604_V	607_R	0.586	0.90
612_A	644_F	0.584	0.90
504_L	511_G	0.584	0.90
340_T	499_A	0.583	0.90
629_V	632_T	0.581	0.90
335_D	341_Q	0.577	0.89
266_E	269_V	0.577	0.89
359_A	363_T	0.576	0.89
655_V	658_A	0.576	0.89
328_M	335_D	0.575	0.89
388_I	395_L	0.574	0.89
329_S	335_D	0.573	0.89
636_E	643_L	0.573	0.89
380_D	384_S	0.573	0.89
167_S	407_G	0.572	0.89
332_L	338_K	0.572	0.89
477_Q	556_T	0.572	0.89
319_Q	322_E	0.572	0.89
125_L	148_T	0.570	0.89
54_Y	312_A	0.570	0.89
538_G	545_S	0.570	0.89
441_R	477_Q	0.569	0.89
75_H	82_P	0.569	0.89
571_A	575_R	0.567	0.89
606_A	613_G	0.566	0.88
75_H	83_L	0.566	0.88
495_Q	528_T	0.566	0.88
560_M	579_V	0.564	0.88
586_D	589_D	0.563	0.88
607_R	624_L	0.562	0.88
534_E	540_Y	0.561	0.88
545_S	567_A	0.561	0.88
120_A	161_I	0.558	0.88
490_W	504_L	0.558	0.88
214_E	242_C	0.557	0.88
593_E	601_P	0.557	0.88
639_P	643_L	0.556	0.88
378_S	382_A	0.556	0.88
466_G	520_Q	0.554	0.87
427_V	430_T	0.554	0.87
328_M	332_L	0.553	0.87
98_G	102_I	0.553	0.87
559_E	654_I	0.553	0.87
415_A	440_A	0.552	0.87
274_Q	277_G	0.552	0.87
435_M	438_E	0.552	0.87
157_L	163_H	0.550	0.87
337_E	342_K	0.549	0.87
484_T	586_D	0.549	0.87
451_K	486_N	0.548	0.87
103_G	451_K	0.548	0.87
343_Y	362_N	0.548	0.87
490_W	515_L	0.548	0.87
127_I	375_L	0.548	0.87
329_S	336_W	0.548	0.87
420_I	428_P	0.547	0.87
368_G	374_L	0.546	0.87
513_T	584_S	0.545	0.87
131_T	134_A	0.545	0.87
328_M	336_W	0.545	0.87
335_D	340_T	0.544	0.86
596_R	621_Y	0.544	0.86
537_R	542_L	0.542	0.86
600_L	609_A	0.542	0.86
478_L	489_T	0.541	0.86
63_N	152_M	0.541	0.86
365_N	368_G	0.541	0.86
430_T	456_M	0.539	0.86
365_N	389_W	0.539	0.86
435_M	465_L	0.539	0.86
214_E	243_R	0.539	0.86
361_Q	365_N	0.538	0.86
179_G	239_L	0.538	0.86
87_K	293_W	0.538	0.86
567_A	576_N	0.538	0.86
532_V	538_G	0.537	0.86
383_P	386_L	0.537	0.86
592_D	597_E	0.537	0.86
223_V	242_C	0.537	0.86
331_G	342_K	0.537	0.86
554_I	598_S	0.537	0.86
165_V	412_G	0.536	0.86
194_G	405_H	0.536	0.86
373_E	399_P	0.536	0.86
500_V	511_G	0.536	0.86
333_P	342_K	0.535	0.86
552_I	578_R	0.535	0.86
127_I	168_L	0.534	0.85
74_L	315_K	0.534	0.85
133_A	143_I	0.534	0.85
163_H	203_R	0.534	0.85
323_E	328_M	0.534	0.85
92_L	636_E	0.534	0.85
223_V	244_T	0.532	0.85
149_Y	227_I	0.530	0.85
143_I	310_F	0.530	0.85
140_D	317_H	0.530	0.85
352_A	362_N	0.529	0.85
293_W	297_E	0.529	0.85
205_E	210_H	0.529	0.85
591_Q	595_Y	0.529	0.85
490_W	587_I	0.529	0.85
216_D	222_A	0.529	0.85
163_H	379_A	0.528	0.85
498_A	501_G	0.527	0.85
98_G	103_G	0.527	0.85
606_A	610_V	0.526	0.85
93_H	101_E	0.526	0.85
627_A	631_M	0.526	0.85
134_A	400_A	0.525	0.84
606_A	609_A	0.525	0.84
301_K	304_Q	0.525	0.84
269_V	272_A	0.524	0.84
367_Y	370_M	0.524	0.84
81_L	106_P	0.524	0.84
148_T	423_H	0.524	0.84
93_H	98_G	0.523	0.84
614_I	632_T	0.523	0.84
643_L	648_G	0.523	0.84
601_P	606_A	0.523	0.84
218_H	242_C	0.522	0.84
82_P	88_N	0.520	0.84
322_E	325_T	0.520	0.84
618_W	622_V	0.518	0.84
102_I	105_T	0.516	0.83
615_A	622_V	0.516	0.83
119_L	152_M	0.515	0.83
121_N	418_N	0.515	0.83
645_P	653_N	0.514	0.83
532_V	535_I	0.514	0.83
535_I	540_Y	0.514	0.83
128_A	426_F	0.513	0.83
431_A	457_V	0.512	0.83
563_T	601_P	0.512	0.83
123_V	169_A	0.512	0.83
611_E	618_W	0.512	0.83
419_G	422_H	0.512	0.83
371_L	506_V	0.512	0.83
606_A	625_K	0.512	0.83
445_R	457_V	0.511	0.83
133_A	142_E	0.511	0.83
544_D	547_G	0.511	0.83
163_H	412_G	0.510	0.83
500_V	504_L	0.510	0.83
458_Y	517_L	0.510	0.83
121_N	411_F	0.509	0.83
297_E	300_E	0.509	0.83
616_D	620_K	0.509	0.83
96_T	105_T	0.508	0.83
600_L	603_N	0.507	0.82
458_Y	515_L	0.506	0.82
329_S	332_L	0.506	0.82
333_P	338_K	0.505	0.82
382_A	431_A	0.505	0.82
328_M	342_K	0.504	0.82
224_K	227_I	0.504	0.82
205_E	211_V	0.504	0.82
110_T	125_L	0.503	0.82
97_P	108_V	0.503	0.82
562_I	565_Q	0.502	0.82
276_L	295_A	0.502	0.82
264_L	268_E	0.501	0.82
616_D	621_Y	0.501	0.82
318_P	322_E	0.501	0.82
585_T	616_D	0.500	0.82

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2r8oA	2	0.9985	100	0.215	Contact Map
1r9jA	2	0.9715	100	0.222	Contact Map
3komA	2	0.9775	100	0.227	Contact Map
3uk1A	2	0.988	100	0.23	Contact Map
1itzA	2	0.9775	100	0.231	Contact Map
3m49A	2	0.9835	100	0.239	Contact Map
3rimA	2	0.9835	100	0.241	Contact Map
4c7vA	2	0.979	100	0.244	Contact Map
1gpuA	2	0.976	100	0.247	Contact Map
2e6kA	2	0.9655	100	0.253	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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