GREMLIN Database
TKT2 - Transketolase 2
UniProt: P33570 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12100
Length: 667 (592)
Sequences: 9233 (5061)
Seq/√Len: 208.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
573_E659_H4.4341.00
551_I658_A4.2491.00
202_K205_E4.2241.00
417_A430_T3.4391.00
212_I238_S3.3521.00
550_D576_N3.1841.00
43_F224_K3.1411.00
219_D222_A3.1121.00
82_P85_E3.1051.00
539_G582_L2.9831.00
597_E602_S2.8511.00
508_R511_G2.8131.00
543_K567_A2.7801.00
233_V236_K2.7591.00
651_A655_V2.7201.00
589_D621_Y2.7101.00
199_D202_K2.6651.00
210_H238_S2.5861.00
147_F178_I2.5841.00
281_P284_E2.5411.00
314_K325_T2.5361.00
228_L232_S2.4751.00
593_E597_E2.4221.00
569_K655_V2.4121.00
427_V453_R2.4001.00
609_A628_I2.3481.00
303_Q307_N2.3401.00
210_H233_V2.2991.00
490_W501_G2.2771.00
212_I226_A2.2421.00
166_C204_F2.2351.00
163_H207_Y2.2261.00
568_E572_G2.2221.00
566_A570_L2.2171.00
627_A657_K2.1941.00
554_I582_L2.1751.00
615_A630_G2.1751.00
551_I577_V2.1561.00
627_A660_K2.1271.00
565_Q568_E2.1161.00
642_K645_P2.0941.00
307_N311_A2.0771.00
84_E87_K2.0551.00
152_M179_G2.0091.00
435_M477_Q2.0041.00
297_E301_K1.9981.00
126_A148_T1.9841.00
287_K291_H1.9611.00
488_S584_S1.9601.00
175_G210_H1.9471.00
504_L507_E1.9361.00
444_A487_F1.9331.00
653_N657_K1.9291.00
304_Q308_E1.9241.00
153_G156_C1.9231.00
553_L563_T1.9221.00
420_I426_F1.8911.00
518_S522_L1.8801.00
212_I229_E1.8741.00
110_T121_N1.8741.00
582_L585_T1.8691.00
593_E596_R1.8511.00
270_A274_Q1.8481.00
487_F514_A1.8451.00
301_K305_S1.8401.00
224_K228_L1.8341.00
488_S511_G1.8281.00
589_D620_K1.8091.00
533_K536_A1.7931.00
201_A205_E1.7931.00
308_E312_A1.7921.00
217_G244_T1.7891.00
533_K537_R1.7821.00
451_K510_N1.7801.00
595_Y600_L1.7661.00
389_W392_S1.7621.00
569_K651_A1.7511.00
421_A453_R1.7501.00
477_Q516_I1.7341.00
354_I359_A1.7321.00
447_A456_M1.7151.00
75_H290_Y1.7121.00
141_H309_K1.6881.00
291_H294_D1.6871.00
391_G394_S1.6851.00
43_F231_Q1.6821.00
539_G543_K1.6751.00
147_F231_Q1.6711.00
326_R373_E1.6631.00
183_H241_I1.6611.00
622_V628_I1.6591.00
97_P105_T1.6541.00
596_R600_L1.6521.00
171_T197_T1.6511.00
175_G235_D1.6491.00
538_G541_V1.6471.00
245_V254_A1.6441.00
656_A660_K1.6431.00
252_N271_L1.6391.00
54_Y324_F1.6391.00
563_T610_V1.6381.00
144_V324_F1.6341.00
339_T342_K1.6321.00
166_C207_Y1.6231.00
92_L642_K1.6201.00
74_L107_G1.5871.00
645_P652_E1.5761.00
503_K507_E1.5751.00
569_K652_E1.5731.00
544_D578_R1.5711.00
569_K572_G1.5691.00
173_G396_K1.5571.00
245_V255_G1.5471.00
561_E565_Q1.5431.00
180_F227_I1.5331.00
633_G637_S1.5261.00
92_L638_A1.5251.00
225_E229_E1.5161.00
201_A241_I1.5121.00
168_L172_L1.5061.00
475_V631_M1.5051.00
653_N656_A1.5021.00
615_A619_Y1.5021.00
421_A428_P1.4931.00
478_L516_I1.4931.00
83_L87_K1.4891.00
441_R480_S1.4851.00
592_D595_Y1.4851.00
555_A563_T1.4801.00
564_L579_V1.4801.00
201_A211_V1.4771.00
484_T487_F1.4711.00
250_S272_A1.4681.00
335_D339_T1.4661.00
421_A452_A1.4651.00
518_S558_S1.4561.00
562_I651_A1.4531.00
146_H423_H1.4531.00
391_G395_L1.4461.00
592_D596_R1.4461.00
504_L508_R1.4411.00
488_S508_R1.4411.00
642_K646_F1.4371.00
543_K568_E1.4371.00
280_H284_E1.4341.00
354_I362_N1.4251.00
571_A577_V1.4241.00
417_A431_A1.4231.00
331_G334_K1.4171.00
300_E304_Q1.4131.00
336_W339_T1.4121.00
549_P576_N1.4091.00
388_I393_V1.4071.00
142_E145_D1.4061.00
488_S587_I1.4061.00
417_A454_Q1.4031.00
534_E537_R1.4011.00
555_A560_M1.4001.00
565_Q651_A1.3881.00
161_I411_F1.3811.00
493_C560_M1.3781.00
437_V480_S1.3781.00
122_A179_G1.3691.00
282_P286_P1.3691.00
389_W395_L1.3631.00
122_A150_V1.3611.00
185_G243_R1.3591.00
256_K259_A1.3591.00
366_A369_P1.3551.00
615_A632_T1.3501.00
553_L658_A1.3491.00
292_A296_R1.3451.00
434_L481_L1.3421.00
563_T579_V1.3391.00
358_K386_L1.3361.00
376_G429_Y1.3341.00
446_M487_F1.3341.00
358_K521_N1.3251.00
640_A644_F1.3221.00
414_T440_A1.3191.00
308_E311_A1.3181.00
628_I631_M1.3101.00
498_A517_L1.2981.00
353_K521_N1.2981.00
643_L647_F1.2971.00
531_Q537_R1.2961.00
253_K258_E1.2931.00
644_F649_F1.2881.00
60_I125_L1.2881.00
105_T108_V1.2781.00
531_Q536_A1.2731.00
553_L601_P1.2721.00
539_G542_L1.2701.00
43_F228_L1.2691.00
531_Q534_E1.2681.00
639_P642_K1.2621.00
210_H229_E1.2591.00
85_E88_N1.2571.00
575_R659_H1.2531.00
92_L646_F1.2511.00
569_K573_E1.2491.00
414_T457_V1.2481.00
311_A314_K1.2431.00
354_I358_K1.2411.00
294_D297_E1.2361.00
123_V174_L1.2351.00
511_G590_A1.2341.00
328_M331_G1.2321.00
501_G515_L1.2311.00
534_E538_G1.2301.00
247_G259_A1.2291.00
585_T589_D1.2181.00
98_G101_E1.2171.00
228_L231_Q1.2151.00
305_S308_E1.2141.00
434_L516_I1.2121.00
336_W340_T1.2101.00
652_E656_A1.2081.00
155_G187_S1.2051.00
593_E602_S1.2031.00
148_T176_K1.2011.00
93_H646_F1.2011.00
180_F242_C1.1981.00
296_R300_E1.1981.00
120_A165_V1.1941.00
181_Y201_A1.1911.00
96_T99_H1.1901.00
479_A613_G1.1881.00
567_A579_V1.1871.00
127_I172_L1.1851.00
130_R399_P1.1841.00
305_S309_K1.1741.00
167_S196_F1.1741.00
131_T375_L1.1741.00
594_E597_E1.1711.00
539_G545_S1.1711.00
444_A458_Y1.1701.00
335_D338_K1.1681.00
490_W513_T1.1651.00
540_Y543_K1.1611.00
388_I391_G1.1591.00
536_A539_G1.1571.00
500_V535_I1.1551.00
634_Y637_S1.1541.00
657_K660_K1.1471.00
175_G234_K1.1441.00
120_A412_G1.1431.00
212_I230_A1.1351.00
545_S576_N1.1341.00
376_G403_Y1.1331.00
623_G626_G1.1281.00
204_F239_L1.1271.00
97_P101_E1.1251.00
532_V536_A1.1221.00
359_A495_Q1.1211.00
263_P269_V1.1191.00
523_A561_E1.1191.00
309_K312_A1.1171.00
608_V629_V1.1161.00
81_L85_E1.1161.00
545_S549_P1.1151.00
142_E309_K1.1131.00
555_A559_E1.1111.00
367_Y374_L1.1111.00
325_T329_S1.1051.00
382_A405_H1.1041.00
358_K362_N1.1031.00
441_R457_V1.1021.00
640_A643_L1.1021.00
63_N153_G1.0971.00
149_Y178_I1.0971.00
119_L179_G1.0941.00
559_E562_I1.0931.00
338_K342_K1.0921.00
324_F328_M1.0921.00
457_V517_L1.0901.00
392_S395_L1.0891.00
538_G542_L1.0881.00
268_E271_L1.0841.00
129_E148_T1.0801.00
619_Y628_I1.0761.00
479_A617_Y1.0741.00
120_A415_A1.0741.00
505_A508_R1.0711.00
414_T456_M1.0701.00
211_V241_I1.0681.00
150_V179_G1.0681.00
488_S586_D1.0651.00
539_G599_V1.0541.00
550_D575_R1.0531.00
541_V544_D1.0531.00
565_Q569_K1.0491.00
119_L166_C1.0491.00
385_N431_A1.0481.00
595_Y599_V1.0461.00
96_T101_E1.0461.00
619_Y622_V1.0461.00
608_V657_K1.0451.00
336_W342_K1.0401.00
609_A615_A1.0391.00
356_T522_L1.0361.00
566_A655_V1.0331.00
595_Y598_S1.0321.00
546_G576_N1.0321.00
479_A483_L1.0321.00
389_W393_V1.0321.00
389_W394_S1.0291.00
314_K321_A1.0291.00
187_S408_V1.0271.00
388_I394_S1.0261.00
464_G644_F1.0261.00
229_E233_V1.0241.00
592_D598_S1.0231.00
253_K268_E1.0221.00
390_K395_L1.0191.00
360_S502_W1.0141.00
421_A454_Q1.0141.00
271_L274_Q1.0131.00
175_G238_S1.0111.00
537_R541_V1.0051.00
119_L150_V1.0041.00
488_S513_T1.0011.00
534_E539_G0.9971.00
54_Y144_V0.9971.00
147_F176_K0.9941.00
549_P604_V0.9931.00
323_E326_R0.9911.00
585_T621_Y0.9901.00
160_G164_E0.9901.00
552_I601_P0.9851.00
173_G235_D0.9811.00
571_A576_N0.9801.00
288_E291_H0.9801.00
339_T370_M0.9801.00
254_A275_K0.9791.00
550_D596_R0.9781.00
420_I423_H0.9781.00
566_A569_K0.9781.00
538_G543_K0.9771.00
375_L420_I0.9741.00
54_Y328_M0.9701.00
481_L514_A0.9681.00
444_A456_M0.9631.00
203_R207_Y0.9621.00
317_H320_L0.9601.00
480_S484_T0.9601.00
323_E327_R0.9591.00
295_A298_K0.9591.00
267_E271_L0.9591.00
552_I580_V0.9581.00
364_L429_Y0.9571.00
503_K536_A0.9571.00
351_P524_Q0.9550.99
63_N151_F0.9550.99
594_E598_S0.9550.99
131_T426_F0.9530.99
252_N268_E0.9530.99
266_E270_A0.9500.99
606_A612_A0.9480.99
440_A444_A0.9460.99
330_G333_P0.9440.99
84_E88_N0.9420.99
361_Q386_L0.9420.99
638_A643_L0.9410.99
119_L162_S0.9370.99
326_R331_G0.9350.99
608_V612_A0.9330.99
649_F653_N0.9320.99
229_E232_S0.9310.99
358_K361_Q0.9300.99
633_G646_F0.9290.99
94_S97_P0.9280.99
272_A275_K0.9270.99
478_L483_L0.9250.99
505_A513_T0.9240.99
543_K564_L0.9230.99
311_A315_K0.9210.99
277_G282_P0.9180.99
390_K394_S0.9160.99
123_V165_V0.9130.99
227_I231_Q0.9070.99
543_K571_A0.9040.99
553_L610_V0.9020.99
215_I222_A0.9020.99
597_E601_P0.9000.99
442_N447_A0.9000.99
504_L536_A0.8970.99
81_L105_T0.8960.99
609_A622_V0.8920.99
158_M187_S0.8900.99
609_A612_A0.8880.99
128_A420_I0.8870.99
545_S571_A0.8860.99
594_E600_L0.8860.99
97_P100_P0.8850.99
333_P339_T0.8850.99
533_K539_G0.8780.99
525_V564_L0.8770.99
597_E600_L0.8770.99
531_Q539_G0.8730.99
355_A358_K0.8710.99
527_R530_D0.8710.99
378_S385_N0.8700.99
152_M157_L0.8700.99
270_A280_H0.8690.99
552_I600_L0.8690.99
130_R176_K0.8680.99
481_L484_T0.8670.99
531_Q538_G0.8660.99
549_P578_R0.8640.99
210_H234_K0.8630.99
479_A616_D0.8630.99
532_V539_G0.8630.99
362_N390_K0.8620.99
68_M86_L0.8610.99
250_S271_L0.8610.99
338_K341_Q0.8610.99
597_E603_N0.8590.99
629_V654_I0.8560.99
129_E423_H0.8540.99
331_G336_W0.8530.99
584_S587_I0.8510.99
334_K339_T0.8500.99
201_A214_E0.8500.99
458_Y514_A0.8470.99
181_Y239_L0.8470.99
480_S483_L0.8470.99
367_Y371_L0.8470.99
383_P405_H0.8470.99
129_E176_K0.8460.99
278_W286_P0.8450.99
406_Y417_A0.8450.99
416_I419_G0.8450.99
221_Q225_E0.8450.99
335_D342_K0.8440.99
110_T422_H0.8390.99
161_I415_A0.8390.99
632_T637_S0.8370.99
608_V658_A0.8370.99
610_V654_I0.8330.99
210_H235_D0.8330.99
210_H236_K0.8320.99
411_F443_A0.8310.99
375_L426_F0.8310.99
488_S590_A0.8310.99
537_R540_Y0.8280.99
548_K576_N0.8270.99
616_D619_Y0.8270.99
117_Q415_A0.8270.99
477_Q610_V0.8250.99
565_Q652_E0.8230.99
129_E146_H0.8230.99
585_T617_Y0.8230.99
444_A514_A0.8190.98
96_T100_P0.8190.98
609_A613_G0.8180.98
633_G636_E0.8170.98
541_V578_R0.8160.98
601_P604_V0.8160.98
531_Q535_I0.8160.98
321_A325_T0.8140.98
283_F287_K0.8130.98
438_E477_Q0.8130.98
267_E270_A0.8130.98
545_S548_K0.8120.98
553_L577_V0.8110.98
133_A141_H0.8080.98
224_K231_Q0.8080.98
638_A642_K0.8060.98
337_E341_Q0.8030.98
304_Q307_N0.8020.98
633_G647_F0.7990.98
320_L323_E0.7980.98
490_W584_S0.7980.98
406_Y412_G0.7980.98
140_D143_I0.7970.98
141_H316_A0.7950.98
582_L614_I0.7920.98
132_L423_H0.7920.98
438_E441_R0.7910.98
552_I604_V0.7910.98
127_I416_I0.7910.98
437_V458_Y0.7910.98
650_T653_N0.7890.98
572_G576_N0.7890.98
641_D645_P0.7870.98
151_F180_F0.7860.98
377_G413_M0.7860.98
555_A579_V0.7820.98
552_I595_Y0.7810.98
332_L335_D0.7800.98
144_V235_D0.7790.98
322_E326_R0.7760.98
185_G191_E0.7750.98
130_R175_G0.7740.98
313_Y317_H0.7730.98
654_I657_K0.7730.98
152_M156_C0.7730.98
68_M72_S0.7720.98
336_W341_Q0.7710.98
281_P285_I0.7700.98
299_G302_A0.7690.98
655_V659_H0.7690.98
535_I538_G0.7680.98
645_P650_T0.7670.98
546_G571_A0.7620.98
589_D596_R0.7610.98
214_E241_I0.7590.97
388_I392_S0.7590.97
532_V537_R0.7580.97
94_S98_G0.7570.97
189_D383_P0.7570.97
215_I242_C0.7540.97
484_T489_T0.7480.97
163_H166_C0.7480.97
60_I122_A0.7480.97
501_G535_I0.7470.97
63_N66_A0.7470.97
556_T582_L0.7460.97
222_A226_A0.7440.97
608_V627_A0.7430.97
99_H102_I0.7430.97
331_G509_H0.7430.97
61_L70_L0.7410.97
364_L389_W0.7410.97
333_P336_W0.7400.97
626_G629_V0.7390.97
117_Q411_F0.7380.97
254_A257_E0.7380.97
328_M338_K0.7380.97
417_A456_M0.7360.97
265_G268_E0.7360.97
618_W621_Y0.7360.97
302_A305_S0.7360.97
289_I293_W0.7350.97
600_L604_V0.7340.97
331_G335_D0.7340.97
416_I420_I0.7340.97
522_L558_S0.7310.97
615_A628_I0.7310.97
600_L607_R0.7300.97
376_G381_L0.7300.97
447_A454_Q0.7300.97
233_V238_S0.7290.97
55_D309_K0.7290.97
414_T458_Y0.7270.97
334_K337_E0.7260.97
567_A577_V0.7240.97
548_K604_V0.7230.97
550_D577_V0.7230.97
554_I585_T0.7210.97
149_Y231_Q0.7200.97
626_G631_M0.7190.96
466_G473_Q0.7190.96
417_A428_P0.7180.96
548_K603_N0.7170.96
128_A423_H0.7170.96
363_T499_A0.7160.96
394_S405_H0.7150.96
566_A658_A0.7150.96
563_T654_I0.7150.96
117_Q444_A0.7140.96
284_E287_K0.7130.96
495_Q524_Q0.7130.96
273_R282_P0.7120.96
644_F648_G0.7120.96
181_Y241_I0.7120.96
299_G303_Q0.7110.96
310_F321_A0.7080.96
349_A352_A0.7070.96
337_E507_E0.7050.96
567_A571_A0.7040.96
622_V626_G0.7040.96
631_M649_F0.7030.96
365_N390_K0.7020.96
596_R599_V0.7020.96
442_N446_M0.7020.96
77_T295_A0.7010.96
216_D219_D0.7010.96
443_A447_A0.6990.96
507_E536_A0.6990.96
273_R278_W0.6980.96
348_Q351_P0.6980.96
614_I617_Y0.6930.96
617_Y622_V0.6930.96
592_D600_L0.6920.96
539_G585_T0.6920.96
547_G576_N0.6910.96
227_I240_I0.6900.96
117_Q440_A0.6890.96
551_I608_V0.6870.95
175_G233_V0.6850.95
364_L368_G0.6840.95
596_R601_P0.6840.95
299_G304_Q0.6830.95
478_L613_G0.6810.95
334_K342_K0.6800.95
127_I420_I0.6790.95
536_A541_V0.6780.95
553_L579_V0.6760.95
613_G616_D0.6740.95
492_P501_G0.6720.95
615_A618_W0.6700.95
266_E282_P0.6700.95
178_I230_A0.6690.95
554_I607_R0.6680.95
656_A659_H0.6680.95
102_I450_M0.6670.95
500_V503_K0.6660.95
168_L407_G0.6660.95
634_Y638_A0.6660.95
556_T585_T0.6650.95
102_I422_H0.6630.95
463_I647_F0.6630.95
414_T444_A0.6620.94
283_F286_P0.6620.94
631_M634_Y0.6620.94
559_E601_P0.6620.94
141_H317_H0.6610.94
390_K393_V0.6590.94
629_V657_K0.6590.94
298_K302_A0.6550.94
230_A238_S0.6540.94
127_I404_I0.6540.94
494_D564_L0.6540.94
310_F313_Y0.6530.94
617_Y621_Y0.6520.94
290_Y295_A0.6520.94
191_E257_E0.6510.94
312_A316_A0.6510.94
254_A259_A0.6490.94
488_S504_L0.6480.94
455_I502_W0.6480.94
460_H558_S0.6470.94
562_I644_F0.6460.94
317_H321_A0.6460.94
339_T343_Y0.6440.94
440_A456_M0.6440.94
440_A443_A0.6430.94
489_T516_I0.6430.94
525_V561_E0.6420.94
253_K259_A0.6410.93
503_K532_V0.6390.93
365_N369_P0.6390.93
248_F254_A0.6390.93
367_Y506_V0.6390.93
255_G258_E0.6370.93
577_V658_A0.6360.93
310_F314_K0.6350.93
440_A458_Y0.6320.93
282_P285_I0.6300.93
94_S100_P0.6290.93
113_G116_G0.6290.93
337_E340_T0.6280.93
298_K301_K0.6270.93
626_G630_G0.6270.93
551_I597_E0.6270.93
465_L640_A0.6250.93
417_A420_I0.6240.93
121_N450_M0.6240.93
328_M334_K0.6240.93
285_I292_A0.6240.93
453_R509_H0.6230.93
307_N316_A0.6230.93
168_L412_G0.6220.92
64_G182_D0.6210.92
329_S333_P0.6210.92
328_M339_T0.6210.92
272_A276_L0.6190.92
615_A631_M0.6180.92
214_E218_H0.6180.92
566_A610_V0.6170.92
368_G389_W0.6170.92
411_F442_N0.6170.92
127_I131_T0.6160.92
427_V455_I0.6160.92
444_A481_L0.6150.92
593_E600_L0.6140.92
554_I600_L0.6130.92
359_A498_A0.6130.92
117_Q439_Y0.6120.92
157_L239_L0.6110.92
444_A484_T0.6110.92
382_A388_I0.6100.92
222_A225_E0.6080.92
631_M643_L0.6070.92
504_L587_I0.6070.92
226_A230_A0.6060.91
273_R276_L0.6060.91
223_V227_I0.6050.91
541_V545_S0.6050.91
191_E194_G0.6050.91
329_S339_T0.6050.91
215_I218_H0.6050.91
73_L77_T0.6040.91
493_C522_L0.6040.91
329_S334_K0.6030.91
334_K340_T0.6020.91
285_I290_Y0.6010.91
329_S342_K0.6010.91
253_K256_K0.6010.91
427_V506_V0.6000.91
285_I291_H0.6000.91
354_I521_N0.5970.91
209_W239_L0.5960.91
251_P268_E0.5940.91
434_L478_L0.5940.91
526_E568_E0.5940.91
608_V611_E0.5930.91
504_L513_T0.5930.91
494_D542_L0.5920.90
343_Y348_Q0.5920.90
393_V398_D0.5910.90
460_H518_S0.5910.90
648_G653_N0.5900.90
183_H243_R0.5890.90
212_I233_V0.5890.90
549_P552_I0.5890.90
284_E288_E0.5890.90
334_K338_K0.5890.90
296_R299_G0.5890.90
312_A315_K0.5880.90
500_V532_V0.5870.90
604_V607_R0.5860.90
612_A644_F0.5840.90
504_L511_G0.5840.90
340_T499_A0.5830.90
629_V632_T0.5810.90
335_D341_Q0.5770.89
266_E269_V0.5770.89
359_A363_T0.5760.89
655_V658_A0.5760.89
328_M335_D0.5750.89
388_I395_L0.5740.89
329_S335_D0.5730.89
636_E643_L0.5730.89
380_D384_S0.5730.89
167_S407_G0.5720.89
332_L338_K0.5720.89
477_Q556_T0.5720.89
319_Q322_E0.5720.89
125_L148_T0.5700.89
54_Y312_A0.5700.89
538_G545_S0.5700.89
441_R477_Q0.5690.89
75_H82_P0.5690.89
571_A575_R0.5670.89
606_A613_G0.5660.88
75_H83_L0.5660.88
495_Q528_T0.5660.88
560_M579_V0.5640.88
586_D589_D0.5630.88
607_R624_L0.5620.88
534_E540_Y0.5610.88
545_S567_A0.5610.88
120_A161_I0.5580.88
490_W504_L0.5580.88
214_E242_C0.5570.88
593_E601_P0.5570.88
639_P643_L0.5560.88
378_S382_A0.5560.88
466_G520_Q0.5540.87
427_V430_T0.5540.87
328_M332_L0.5530.87
98_G102_I0.5530.87
559_E654_I0.5530.87
415_A440_A0.5520.87
274_Q277_G0.5520.87
435_M438_E0.5520.87
157_L163_H0.5500.87
337_E342_K0.5490.87
484_T586_D0.5490.87
451_K486_N0.5480.87
103_G451_K0.5480.87
343_Y362_N0.5480.87
490_W515_L0.5480.87
127_I375_L0.5480.87
329_S336_W0.5480.87
420_I428_P0.5470.87
368_G374_L0.5460.87
513_T584_S0.5450.87
131_T134_A0.5450.87
328_M336_W0.5450.87
335_D340_T0.5440.86
596_R621_Y0.5440.86
537_R542_L0.5420.86
600_L609_A0.5420.86
478_L489_T0.5410.86
63_N152_M0.5410.86
365_N368_G0.5410.86
430_T456_M0.5390.86
365_N389_W0.5390.86
435_M465_L0.5390.86
214_E243_R0.5390.86
361_Q365_N0.5380.86
179_G239_L0.5380.86
87_K293_W0.5380.86
567_A576_N0.5380.86
532_V538_G0.5370.86
383_P386_L0.5370.86
592_D597_E0.5370.86
223_V242_C0.5370.86
331_G342_K0.5370.86
554_I598_S0.5370.86
165_V412_G0.5360.86
194_G405_H0.5360.86
373_E399_P0.5360.86
500_V511_G0.5360.86
333_P342_K0.5350.86
552_I578_R0.5350.86
127_I168_L0.5340.85
74_L315_K0.5340.85
133_A143_I0.5340.85
163_H203_R0.5340.85
323_E328_M0.5340.85
92_L636_E0.5340.85
223_V244_T0.5320.85
149_Y227_I0.5300.85
143_I310_F0.5300.85
140_D317_H0.5300.85
352_A362_N0.5290.85
293_W297_E0.5290.85
205_E210_H0.5290.85
591_Q595_Y0.5290.85
490_W587_I0.5290.85
216_D222_A0.5290.85
163_H379_A0.5280.85
498_A501_G0.5270.85
98_G103_G0.5270.85
606_A610_V0.5260.85
93_H101_E0.5260.85
627_A631_M0.5260.85
134_A400_A0.5250.84
606_A609_A0.5250.84
301_K304_Q0.5250.84
269_V272_A0.5240.84
367_Y370_M0.5240.84
81_L106_P0.5240.84
148_T423_H0.5240.84
93_H98_G0.5230.84
614_I632_T0.5230.84
643_L648_G0.5230.84
601_P606_A0.5230.84
218_H242_C0.5220.84
82_P88_N0.5200.84
322_E325_T0.5200.84
618_W622_V0.5180.84
102_I105_T0.5160.83
615_A622_V0.5160.83
119_L152_M0.5150.83
121_N418_N0.5150.83
645_P653_N0.5140.83
532_V535_I0.5140.83
535_I540_Y0.5140.83
128_A426_F0.5130.83
431_A457_V0.5120.83
563_T601_P0.5120.83
123_V169_A0.5120.83
611_E618_W0.5120.83
419_G422_H0.5120.83
371_L506_V0.5120.83
606_A625_K0.5120.83
445_R457_V0.5110.83
133_A142_E0.5110.83
544_D547_G0.5110.83
163_H412_G0.5100.83
500_V504_L0.5100.83
458_Y517_L0.5100.83
121_N411_F0.5090.83
297_E300_E0.5090.83
616_D620_K0.5090.83
96_T105_T0.5080.83
600_L603_N0.5070.82
458_Y515_L0.5060.82
329_S332_L0.5060.82
333_P338_K0.5050.82
382_A431_A0.5050.82
328_M342_K0.5040.82
224_K227_I0.5040.82
205_E211_V0.5040.82
110_T125_L0.5030.82
97_P108_V0.5030.82
562_I565_Q0.5020.82
276_L295_A0.5020.82
264_L268_E0.5010.82
616_D621_Y0.5010.82
318_P322_E0.5010.82
585_T616_D0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r8oA 2 0.9985 100 0.215 Contact Map
1r9jA 2 0.9715 100 0.222 Contact Map
3komA 2 0.9775 100 0.227 Contact Map
3uk1A 2 0.988 100 0.23 Contact Map
1itzA 2 0.9775 100 0.231 Contact Map
3m49A 2 0.9835 100 0.239 Contact Map
3rimA 2 0.9835 100 0.241 Contact Map
4c7vA 2 0.979 100 0.244 Contact Map
1gpuA 2 0.976 100 0.247 Contact Map
2e6kA 2 0.9655 100 0.253 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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