GREMLIN Database
DUSC - tRNA-dihydrouridine synthase C
UniProt: P33371 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12022
Length: 315 (290)
Sequences: 6620 (3969)
Seq/√Len: 233.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_E255_K4.6351.00
190_R219_D4.4171.00
205_D208_S3.2201.00
204_W208_S2.9931.00
127_R163_T2.8751.00
85_V133_H2.8111.00
211_Q215_I2.6501.00
63_T90_W2.5931.00
158_Q194_N2.5671.00
187_G191_Q2.4361.00
123_A162_A2.4241.00
184_Q215_I2.3821.00
77_L94_L2.3301.00
124_K128_E2.3091.00
210_Q214_A2.2501.00
199_A212_C2.2141.00
81_A130_V2.1881.00
114_K144_W2.1711.00
16_V20_L2.1701.00
299_N302_D2.0911.00
142_L185_A2.0441.00
188_D191_Q2.0071.00
130_V134_L1.9881.00
203_I212_C1.9711.00
79_E82_A1.9441.00
120_Y160_A1.9401.00
96_C119_I1.9371.00
254_Q304_A1.9041.00
130_V136_V1.9011.00
158_Q195_I1.8621.00
211_Q214_A1.8511.00
66_R91_G1.8501.00
115_D118_L1.8431.00
174_Q182_D1.8351.00
204_W226_G1.8221.00
82_A129_A1.8031.00
75_Q79_E1.7921.00
182_D185_A1.7911.00
258_R304_A1.7701.00
186_I199_A1.7561.00
120_Y156_A1.7531.00
119_I153_I1.7411.00
208_S211_Q1.7251.00
292_Q296_V1.7221.00
67_V84_A1.7191.00
28_L66_R1.7141.00
77_L126_M1.6901.00
117_E121_Q1.6521.00
155_D192_R1.6341.00
150_K189_I1.6281.00
209_A221_V1.6231.00
107_G115_D1.6141.00
120_Y124_K1.6031.00
4_L198_I1.6021.00
78_A129_A1.6001.00
27_D238_K1.5991.00
73_F76_W1.5851.00
256_Y280_L1.5741.00
152_E155_D1.5641.00
198_I220_A1.5621.00
181_I202_E1.5621.00
193_L197_V1.5371.00
199_A203_I1.5361.00
198_I222_M1.5361.00
120_Y159_Q1.5231.00
164_E198_I1.5211.00
140_V167_V1.5201.00
153_I156_A1.5121.00
121_Q124_K1.5001.00
118_L121_Q1.4991.00
207_Q211_Q1.4951.00
117_E156_A1.4871.00
94_L126_M1.4851.00
185_A188_D1.4801.00
71_G77_L1.4791.00
151_F192_R1.4791.00
85_V134_L1.4751.00
74_P78_A1.4731.00
230_I236_V1.4571.00
187_G212_C1.4441.00
235_R248_E1.4301.00
187_G215_I1.4191.00
85_V130_V1.4121.00
145_D148_E1.4061.00
138_V157_V1.4051.00
289_E292_Q1.3981.00
124_K160_A1.3971.00
84_A92_V1.3511.00
37_V76_W1.3291.00
190_R197_V1.3271.00
155_D158_Q1.3141.00
130_V133_H1.3031.00
137_S164_E1.2931.00
82_A86_E1.2841.00
146_S174_Q1.2751.00
110_A172_K1.2631.00
154_A193_L1.2461.00
258_R262_Q1.2411.00
199_A218_C1.2321.00
6_A224_G1.2191.00
169_G186_I1.2081.00
250_V254_Q1.2011.00
3_V237_V1.1991.00
18_E259_L1.1961.00
297_L302_D1.1911.00
30_I166_V1.1871.00
209_A237_V1.1761.00
113_L140_V1.1711.00
206_W236_V1.1691.00
152_E156_A1.1661.00
142_L182_D1.1641.00
18_E22_E1.1641.00
123_A160_A1.1621.00
155_D159_Q1.1611.00
188_D192_R1.1571.00
154_A189_I1.1411.00
3_V221_V1.1301.00
153_I157_V1.1301.00
28_L91_G1.1291.00
245_P248_E1.1181.00
255_K259_L1.1101.00
74_P118_L1.1101.00
113_L153_I1.1041.00
18_E61_S1.0991.00
30_I66_R1.0911.00
21_T62_G1.0861.00
127_R136_V1.0861.00
39_Q83_R1.0821.00
223_I237_V1.0821.00
212_C218_C1.0741.00
4_L28_L1.0721.00
138_V162_A1.0711.00
142_L169_G1.0711.00
267_L271_A1.0681.00
156_A160_A1.0681.00
297_L303_I1.0631.00
112_L122_G1.0571.00
113_L149_K1.0561.00
248_E251_A1.0561.00
298_N302_D1.0551.00
77_L122_G1.0541.00
167_V189_I1.0521.00
263_G268_Y1.0501.00
281_R287_A1.0471.00
183_W212_C1.0441.00
212_C216_S1.0381.00
14_S18_E1.0311.00
119_I157_V1.0291.00
253_L277_L1.0271.00
23_V252_L1.0261.00
256_Y277_L1.0241.00
123_A138_V1.0241.00
123_A157_V1.0191.00
289_E293_H1.0171.00
5_L20_L1.0161.00
36_V80_N1.0051.00
158_Q193_L0.9981.00
151_F188_D0.9891.00
5_L227_A0.9861.00
116_P152_E0.9831.00
15_L263_G0.9791.00
78_A82_A0.9761.00
256_Y260_E0.9751.00
232_N249_V0.9741.00
150_K185_A0.9701.00
23_V235_R0.9691.00
271_A274_K0.9691.00
264_D272_R0.9651.00
75_Q125_A0.9581.00
162_A165_L0.9521.00
21_T64_L0.9491.00
203_I209_A0.9431.00
37_V41_L0.9281.00
210_Q240_N0.9261.00
151_F193_L0.9251.00
15_L259_L0.9141.00
83_R86_E0.9111.00
107_G111_T0.9081.00
227_A234_S0.9081.00
227_A233_L0.9071.00
246_W249_V0.9041.00
18_E59_T0.9021.00
251_A255_K0.9010.99
117_E120_Y0.8980.99
206_W210_Q0.8960.99
140_V153_I0.8930.99
151_F189_I0.8930.99
247_P251_A0.8930.99
256_Y273_I0.8920.99
149_K153_I0.8890.99
166_V222_M0.8880.99
249_V284_Y0.8810.99
293_H297_L0.8810.99
187_G217_G0.8800.99
81_A126_M0.8760.99
202_E225_R0.8720.99
79_E83_R0.8710.99
100_S103_V0.8700.99
66_R137_S0.8680.99
203_I221_V0.8670.99
254_Q258_R0.8660.99
125_A128_E0.8640.99
39_Q44_K0.8640.99
14_S57_S0.8610.99
157_V162_A0.8600.99
124_K159_Q0.8560.99
281_R290_L0.8550.99
207_Q240_N0.8490.99
167_V197_V0.8440.99
4_L30_I0.8400.99
275_Q279_Y0.8390.99
300_S304_A0.8350.99
58_R65_V0.8330.99
226_G230_I0.8330.99
174_Q178_A0.8310.99
84_A89_S0.8300.99
207_Q210_Q0.8300.99
74_P121_Q0.8280.99
149_K152_E0.8280.99
83_R87_L0.8230.99
259_L262_Q0.8220.99
58_R62_G0.8210.99
40_L79_E0.8210.99
257_T261_K0.8170.99
164_E196_P0.8150.99
119_I123_A0.8080.99
104_N111_T0.8080.99
78_A125_A0.8070.99
76_W79_E0.7990.99
44_K54_Q0.7990.99
114_K145_D0.7940.99
249_V253_L0.7910.99
20_L26_Y0.7820.99
213_M221_V0.7790.99
145_D171_T0.7760.98
101_K105_G0.7760.98
5_L12_L0.7700.98
3_V234_S0.7670.98
6_A222_M0.7660.98
97_G200_N0.7630.98
78_A130_V0.7620.98
265_T269_H0.7610.98
228_L279_Y0.7590.98
301_P304_A0.7530.98
213_M218_C0.7520.98
11_V279_Y0.7520.98
96_C138_V0.7460.98
127_R162_A0.7420.98
184_Q188_D0.7410.98
126_M136_V0.7410.98
239_Y242_P0.7410.98
31_T65_V0.7410.98
20_L227_A0.7400.98
88_G134_L0.7390.98
288_T292_Q0.7370.98
74_P122_G0.7340.98
26_Y227_A0.7340.98
261_K265_T0.7320.98
57_S87_L0.7310.98
69_L77_L0.7300.98
155_D193_L0.7290.98
186_I197_V0.7260.98
93_D166_V0.7250.98
140_V154_A0.7230.98
258_R300_S0.7200.98
22_E61_S0.7200.98
244_M248_E0.7120.97
257_T300_S0.7060.97
140_V150_K0.7040.97
91_G137_S0.7040.97
21_T29_C0.7030.97
150_K154_A0.7030.97
206_W209_A0.7020.97
36_V77_L0.7010.97
242_P245_P0.7000.97
151_F155_D0.7000.97
111_T114_K0.6950.97
140_V165_L0.6940.97
268_Y272_R0.6910.97
72_Q107_G0.6900.97
261_K304_A0.6870.97
204_W224_G0.6870.97
232_N244_M0.6830.97
35_R70_L0.6800.97
208_S212_C0.6800.97
149_K156_A0.6790.97
258_R261_K0.6790.97
9_E33_F0.6770.96
178_A181_I0.6760.96
151_F154_A0.6750.96
72_Q108_G0.6740.96
158_Q165_L0.6710.96
101_K104_N0.6700.96
135_P163_T0.6700.96
291_F295_R0.6690.96
40_L80_N0.6680.96
20_L23_V0.6660.96
92_V130_V0.6650.96
261_K300_S0.6650.96
125_A129_A0.6640.96
164_E220_A0.6640.96
11_V228_L0.6620.96
165_L195_I0.6610.96
210_Q213_M0.6600.96
28_L164_E0.6590.96
235_R239_Y0.6590.96
113_L119_I0.6580.96
56_A62_G0.6560.96
255_K258_R0.6540.96
263_G266_G0.6540.96
40_L76_W0.6530.96
26_Y29_C0.6530.96
19_L259_L0.6510.96
81_A92_V0.6500.96
253_L256_Y0.6500.96
20_L234_S0.6460.95
36_V76_W0.6420.95
15_L18_E0.6420.95
145_D173_E0.6400.95
207_Q241_E0.6370.95
3_V209_A0.6370.95
54_Q57_S0.6370.95
4_L166_V0.6350.95
165_L193_L0.6330.95
154_A165_L0.6320.95
127_R160_A0.6300.95
187_G218_C0.6280.95
116_P156_A0.6260.95
104_N144_W0.6220.94
206_W237_V0.6200.94
96_C157_V0.6150.94
197_V218_C0.6150.94
78_A128_E0.6140.94
287_A291_F0.6130.94
230_I233_L0.6100.94
151_F185_A0.6080.94
31_T67_V0.6070.94
281_R291_F0.6030.93
156_A159_Q0.6030.93
187_G203_I0.6030.93
154_A167_V0.6000.93
94_L123_A0.6000.93
268_Y273_I0.5990.93
35_R38_D0.5970.93
26_Y234_S0.5940.93
67_V89_S0.5940.93
183_W199_A0.5930.93
236_V243_R0.5900.93
223_I233_L0.5900.93
166_V198_I0.5880.93
223_I227_A0.5840.92
147_G185_A0.5830.92
187_G216_S0.5820.92
272_R275_Q0.5770.92
82_A130_V0.5770.92
147_G182_D0.5740.92
115_D121_Q0.5740.92
12_L20_L0.5730.92
266_G299_N0.5690.91
262_Q266_G0.5650.91
69_L126_M0.5640.91
85_V129_A0.5620.91
114_K149_K0.5620.91
209_A213_M0.5610.91
150_K156_A0.5610.91
270_V274_K0.5580.90
78_A126_M0.5570.90
278_S295_R0.5570.90
58_R63_T0.5560.90
267_L298_N0.5560.90
233_L237_V0.5550.90
126_M130_V0.5550.90
58_R90_W0.5540.90
146_S173_E0.5530.90
249_V252_L0.5530.90
264_D269_H0.5520.90
107_G118_L0.5520.90
189_I192_R0.5510.90
239_Y244_M0.5490.90
103_V108_G0.5460.90
8_M11_V0.5430.89
14_S58_R0.5430.89
162_A195_I0.5420.89
100_S175_G0.5410.89
260_E273_I0.5400.89
154_A192_R0.5390.89
253_L280_L0.5380.89
30_I91_G0.5370.89
158_Q196_P0.5360.89
236_V240_N0.5360.89
4_L164_E0.5350.89
264_D268_Y0.5340.88
101_K175_G0.5340.88
223_I234_S0.5330.88
203_I223_I0.5330.88
53_L87_L0.5320.88
233_L236_V0.5310.88
236_V239_Y0.5310.88
269_H272_R0.5300.88
3_V27_D0.5290.88
183_W215_I0.5280.88
290_L293_H0.5270.88
14_S59_T0.5270.88
110_A113_L0.5270.88
82_A128_E0.5270.88
19_L23_V0.5270.88
97_G222_M0.5260.88
185_A192_R0.5250.88
186_I212_C0.5240.88
122_G125_A0.5240.88
66_R164_E0.5200.87
33_F70_L0.5190.87
27_D223_I0.5180.87
277_L303_I0.5160.87
247_P252_L0.5160.87
145_D149_K0.5150.87
250_V253_L0.5150.87
192_R197_V0.5140.87
81_A136_V0.5140.87
176_Y202_E0.5130.86
119_I140_V0.5120.86
3_V238_K0.5110.86
186_I218_C0.5110.86
82_A85_V0.5110.86
235_R244_M0.5100.86
8_M228_L0.5100.86
267_L270_V0.5100.86
143_G224_G0.5070.86
37_V73_F0.5060.86
9_E34_V0.5060.86
77_L81_A0.5050.86
5_L26_Y0.5050.86
39_Q43_V0.5020.85
273_I277_L0.5010.85
71_G94_L0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bfaA 1 0.9968 100 0.324 Contact Map
1vhnA 1 0.9524 100 0.353 Contact Map
3b0pA 1 0.927 100 0.362 Contact Map
4xp7A 1 0.9175 100 0.406 Contact Map
1gteA 4 0.9683 100 0.596 Contact Map
3tjlA 2 0.8889 100 0.626 Contact Map
3l5aA 1 0.8762 100 0.63 Contact Map
1o94A 2 0.9556 100 0.633 Contact Map
4gbuA 2 0.8635 100 0.636 Contact Map
3sgzA 4 0.7587 100 0.637 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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