GREMLIN Database
MDTQ - Putative multidrug resistance outer membrane protein MdtQ
UniProt: P33369 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12020
Length: 478 (403)
Sequences: 18330 (13928)
Seq/√Len: 693.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
74_A188_V2.9741.00
315_I377_S2.7081.00
73_N267_N2.6741.00
220_R224_Q2.5151.00
213_N244_R2.4521.00
206_Q247_L2.4241.00
206_Q251_A2.4011.00
220_R237_D2.3981.00
420_L451_R2.2291.00
83_V383_S2.2171.00
90_L376_E2.2011.00
86_Q375_A2.1761.00
202_N251_A2.1431.00
95_A170_V2.1361.00
94_Q372_I2.1221.00
199_A254_M2.1201.00
87_R379_L2.1081.00
427_Q431_N2.0851.00
80_D386_K2.0721.00
176_E303_A2.0441.00
241_S244_R1.9871.00
227_I434_I1.9721.00
421_R424_G1.9701.00
436_A439_R1.9701.00
209_E247_L1.9561.00
230_S421_R1.9471.00
165_A314_T1.9371.00
93_A368_A1.9041.00
213_N240_A1.8961.00
223_Y233_G1.8821.00
413_A454_G1.8771.00
209_E244_R1.8721.00
221_Q428_A1.8581.00
201_L452_A1.8391.00
168_G306_W1.8371.00
66_Q69_S1.8341.00
209_E240_A1.8311.00
312_L377_S1.8181.00
200_A203_T1.8171.00
72_N76_Q1.8161.00
322_F370_L1.7921.00
214_T217_A1.7691.00
175_A302_Q1.7551.00
202_N247_L1.7501.00
376_E379_L1.7481.00
406_A461_W1.7471.00
202_N254_M1.7421.00
88_I177_R1.7191.00
305_H384_Y1.7021.00
197_T459_G1.6981.00
241_S414_Q1.6961.00
454_G458_Q1.6881.00
195_W254_M1.6771.00
216_I237_D1.6741.00
198_Q257_I1.6621.00
190_R463_D1.6541.00
82_Q382_A1.6481.00
169_T310_S1.6471.00
386_K390_E1.6201.00
114_R141_T1.6021.00
420_L424_G1.5961.00
234_V421_R1.5851.00
326_I356_L1.5801.00
172_A307_Y1.5801.00
223_Y230_S1.5691.00
216_I220_R1.5561.00
202_N206_Q1.5541.00
308_V381_I1.5521.00
308_V384_Y1.5421.00
213_N217_A1.5371.00
216_I240_A1.5361.00
248_N407_E1.5271.00
254_M258_E1.5271.00
306_W309_E1.5201.00
384_Y388_V1.5131.00
329_M353_T1.5081.00
169_T314_T1.4901.00
161_A164_T1.4841.00
162_E317_A1.4771.00
377_S381_I1.4621.00
393_N397_R1.4581.00
198_Q250_V1.4581.00
190_R467_Q1.4551.00
95_A167_L1.4541.00
71_I185_A1.4501.00
86_Q382_A1.4361.00
210_K214_T1.4291.00
247_L251_A1.4291.00
447_A451_R1.4261.00
158_K325_D1.4241.00
86_Q378_N1.4241.00
69_S72_N1.4231.00
90_L379_L1.4151.00
405_L457_L1.4131.00
362_D366_L1.4081.00
171_K174_A1.4071.00
175_A178_E1.3971.00
379_L383_S1.3951.00
171_K306_W1.3941.00
201_L456_L1.3921.00
73_N265_T1.3781.00
102_D163_V1.3731.00
217_A221_Q1.3691.00
87_R90_L1.3631.00
207_Q210_K1.3631.00
197_T455_L1.3611.00
315_I370_L1.3591.00
97_A372_I1.3481.00
70_L188_V1.3471.00
240_A244_R1.3461.00
189_A466_I1.3431.00
207_Q451_R1.3351.00
86_Q89_Q1.3351.00
309_E312_L1.3341.00
416_E454_G1.3341.00
88_I174_A1.3331.00
315_I374_K1.3331.00
303_A307_Y1.3321.00
173_R176_E1.3301.00
405_L464_A1.3251.00
93_A371_D1.3111.00
313_S316_D1.3031.00
378_N381_I1.2941.00
89_Q92_E1.2931.00
68_T72_N1.2901.00
449_R453_N1.2891.00
195_W258_E1.2871.00
372_I376_E1.2821.00
209_E213_N1.2821.00
369_N372_I1.2801.00
416_E451_R1.2801.00
221_Q224_Q1.2781.00
75_L185_A1.2751.00
168_G309_E1.2731.00
225_N432_A1.2731.00
263_A393_N1.2721.00
409_N454_G1.2701.00
256_I401_Q1.2661.00
234_V237_D1.2541.00
85_E177_R1.2541.00
164_T313_S1.2531.00
414_Q417_R1.2531.00
73_N77_N1.2521.00
203_T207_Q1.2511.00
428_A431_N1.2461.00
65_N70_L1.2431.00
179_Q183_L1.2401.00
175_A306_W1.2371.00
304_A380_S1.2241.00
172_A310_S1.2231.00
83_V382_A1.2201.00
426_A435_I1.2181.00
423_V447_A1.2141.00
230_S234_V1.2121.00
220_R233_G1.2041.00
420_L447_A1.2031.00
248_N251_A1.2031.00
424_G428_A1.1981.00
385_N388_V1.1981.00
259_A397_R1.1921.00
423_V427_Q1.1881.00
199_A258_E1.1851.00
97_A369_N1.1841.00
165_A317_A1.1841.00
319_K370_L1.1821.00
410_Q414_Q1.1811.00
194_E463_D1.1801.00
178_E181_R1.1711.00
413_A417_R1.1701.00
168_G171_K1.1681.00
206_Q210_K1.1661.00
216_I233_G1.1651.00
92_E170_V1.1631.00
456_L460_Q1.1631.00
186_G470_G1.1611.00
112_M143_G1.1591.00
94_Q97_A1.1571.00
197_T456_L1.1531.00
212_Q243_T1.1501.00
429_R435_I1.1411.00
237_D414_Q1.1411.00
427_Q444_R1.1401.00
71_I189_A1.1341.00
329_M355_G1.1341.00
168_G313_S1.1331.00
203_T206_Q1.1321.00
93_A375_A1.1261.00
71_I75_L1.1221.00
75_L181_R1.1181.00
365_R369_N1.1161.00
95_A99_A1.1101.00
85_E89_Q1.1071.00
179_Q300_D1.0941.00
255_K400_S1.0941.00
183_L187_S1.0921.00
238_I419_A1.0921.00
373_A376_E1.0911.00
402_V461_W1.0911.00
96_K368_A1.0901.00
416_E447_A1.0861.00
217_A220_R1.0861.00
69_S73_N1.0841.00
161_A313_S1.0811.00
307_Y383_S1.0811.00
177_R181_R1.0811.00
210_K213_N1.0811.00
187_S190_R1.0741.00
416_E420_L1.0741.00
442_E445_I1.0701.00
205_L243_T1.0701.00
413_A458_Q1.0661.00
188_V261_L1.0661.00
239_N242_K1.0621.00
370_L374_K1.0561.00
67_L189_A1.0551.00
331_F351_G1.0541.00
304_A387_A1.0501.00
84_A180_T1.0471.00
241_S418_D1.0451.00
74_A184_L1.0441.00
82_Q85_E1.0421.00
371_D374_K1.0351.00
70_L265_T1.0341.00
406_A410_Q1.0321.00
170_V174_A1.0301.00
382_A385_N1.0291.00
366_L370_L1.0211.00
204_V455_L1.0191.00
318_A321_A1.0181.00
465_S469_T1.0161.00
246_Q249_D1.0151.00
79_P382_A1.0151.00
256_I400_S1.0151.00
380_S383_S1.0141.00
100_T365_R1.0141.00
88_I170_V1.0121.00
237_D241_S1.0121.00
430_F437_G1.0121.00
435_I439_R1.0061.00
332_L348_Q1.0051.00
89_Q378_N1.0051.00
93_A96_K1.0021.00
202_N250_V0.9991.00
205_L250_V0.9981.00
237_D418_D0.9951.00
112_M141_T0.9901.00
308_V377_S0.9891.00
461_W465_S0.9881.00
249_D253_K0.9871.00
89_Q375_A0.9831.00
428_A432_A0.9791.00
186_G466_I0.9781.00
219_D228_T0.9721.00
409_N461_W0.9721.00
81_M184_L0.9721.00
408_K460_Q0.9711.00
222_L228_T0.9671.00
459_G463_D0.9661.00
159_N163_V0.9661.00
305_H309_E0.9641.00
361_F364_G0.9561.00
409_N413_A0.9561.00
301_L391_A0.9561.00
407_E410_Q0.9541.00
233_G237_D0.9531.00
200_A458_Q0.9481.00
322_F367_N0.9471.00
191_L257_I0.9471.00
322_F366_L0.9441.00
252_G401_Q0.9421.00
302_Q305_H0.9381.00
176_E307_Y0.9381.00
458_Q462_L0.9361.00
249_D408_K0.9351.00
252_G404_T0.9331.00
403_Q407_E0.9321.00
160_R164_T0.9321.00
314_T318_A0.9291.00
109_S146_G0.9291.00
252_G256_I0.9281.00
311_S373_A0.9261.00
390_E394_D0.9201.00
200_A455_L0.9151.00
221_Q225_N0.9111.00
409_N458_Q0.9101.00
244_R411_H0.9101.00
311_S314_T0.9061.00
412_Q457_L0.9021.00
166_R169_T0.9011.00
248_N411_H0.9001.00
417_R420_L0.8971.00
417_R421_R0.8971.00
99_A163_V0.8971.00
165_A169_T0.8941.00
298_R471_A0.8891.00
163_V167_L0.8861.00
161_A316_D0.8861.00
194_E260_R0.8851.00
97_A368_A0.8851.00
314_T317_A0.8801.00
195_W199_A0.8801.00
91_A173_R0.8771.00
231_V426_A0.8771.00
242_K415_I0.8771.00
263_A386_K0.8761.00
152_H155_I0.8751.00
304_A307_Y0.8751.00
321_A369_N0.8711.00
258_E262_S0.8701.00
467_Q470_G0.8691.00
183_L470_G0.8691.00
255_K258_E0.8651.00
98_V166_R0.8621.00
251_A407_E0.8591.00
193_W466_I0.8581.00
234_V418_D0.8571.00
315_I319_K0.8571.00
107_D362_D0.8561.00
419_A450_E0.8541.00
399_A403_Q0.8501.00
219_D236_T0.8481.00
178_E302_Q0.8471.00
259_A396_A0.8451.00
223_Y228_T0.8421.00
209_E243_T0.8411.00
102_D159_N0.8411.00
83_V87_R0.8411.00
86_Q379_L0.8411.00
228_T232_E0.8381.00
318_A373_A0.8371.00
308_V312_L0.8361.00
245_Q408_K0.8361.00
79_P389_V0.8351.00
95_A163_V0.8341.00
154_D157_G0.8321.00
198_Q201_L0.8281.00
242_K453_N0.8261.00
383_S387_A0.8251.00
169_T172_A0.8211.00
106_I149_A0.8201.00
375_A378_N0.8171.00
374_K378_N0.8171.00
103_G363_S0.8161.00
235_E442_E0.8141.00
387_A390_E0.8121.00
161_A317_A0.8111.00
102_D160_R0.8101.00
332_L350_M0.8071.00
253_K257_I0.8071.00
305_H388_V0.8061.00
150_G327_N0.8041.00
401_Q467_Q0.8041.00
190_R194_E0.8031.00
186_G467_Q0.8031.00
205_L246_Q0.8021.00
83_V386_K0.8021.00
298_R394_D0.8001.00
256_I397_R0.7991.00
214_T218_T0.7971.00
385_N389_V0.7951.00
409_N457_L0.7951.00
198_Q253_K0.7931.00
90_L94_Q0.7931.00
310_S314_T0.7921.00
295_L392_V0.7911.00
241_S411_H0.7911.00
201_L205_L0.7901.00
239_N445_I0.7851.00
229_S232_E0.7831.00
194_E257_I0.7821.00
442_E446_P0.7821.00
408_K412_Q0.7811.00
383_S386_K0.7801.00
242_K246_Q0.7791.00
293_S296_A0.7781.00
191_L264_L0.7781.00
298_R391_A0.7751.00
205_L247_L0.7741.00
193_W459_G0.7741.00
206_Q209_E0.7731.00
423_V444_R0.7731.00
392_V396_A0.7731.00
161_A320_A0.7701.00
83_V379_L0.7611.00
195_W257_I0.7581.00
376_E380_S0.7571.00
410_Q413_A0.7571.00
395_V468_L0.7571.00
405_L408_K0.7551.00
74_A265_T0.7551.00
462_L465_S0.7511.00
301_L384_Y0.7511.00
85_E181_R0.7511.00
311_S380_S0.7501.00
402_V406_A0.7501.00
182_Q299_A0.7501.00
398_A464_A0.7461.00
70_L261_L0.7461.00
294_L395_V0.7461.00
321_A366_L0.7401.00
79_P385_N0.7381.00
402_V465_S0.7371.00
401_Q464_A0.7361.00
103_G361_F0.7341.00
251_A255_K0.7291.00
300_D391_A0.7271.00
214_T427_Q0.7231.00
257_I260_R0.7231.00
84_A87_R0.7221.00
111_D144_T0.7221.00
301_L388_V0.7181.00
403_Q406_A0.7161.00
73_N76_Q0.7151.00
367_N371_D0.7151.00
82_Q385_N0.7091.00
415_I419_A0.7081.00
293_S297_R0.7081.00
453_N456_L0.7071.00
165_A310_S0.7071.00
167_L171_K0.7071.00
260_R393_N0.7071.00
208_I212_Q0.7061.00
201_L253_K0.7051.00
212_Q236_T0.7051.00
184_L188_V0.7041.00
88_I92_E0.7021.00
60_L68_T0.7021.00
398_A471_A0.7011.00
302_Q306_W0.7001.00
327_N355_G0.6971.00
424_G427_Q0.6961.00
80_D83_V0.6961.00
359_P362_D0.6951.00
262_S267_N0.6951.00
110_A145_F0.6951.00
198_Q254_M0.6941.00
222_L227_I0.6931.00
402_V468_L0.6931.00
179_Q303_A0.6901.00
316_D319_K0.6891.00
374_K377_S0.6891.00
405_L460_Q0.6881.00
292_Y296_A0.6881.00
174_A178_E0.6861.00
152_H327_N0.6831.00
295_L388_V0.6811.00
175_A299_A0.6781.00
194_E198_Q0.6781.00
108_F358_L0.6781.00
197_T201_L0.6761.00
404_T407_E0.6731.00
325_D357_T0.6701.00
259_A400_S0.6701.00
81_M181_R0.6681.00
312_L316_D0.6661.00
235_E439_R0.6651.00
59_W68_T0.6631.00
438_S442_E0.6621.00
176_E179_Q0.6621.00
464_A467_Q0.6601.00
172_A176_E0.6581.00
194_E197_T0.6571.00
90_L375_A0.6571.00
253_K256_I0.6561.00
187_S191_L0.6551.00
314_T376_E0.6551.00
245_Q412_Q0.6541.00
162_E165_A0.6521.00
164_T167_L0.6501.00
429_R434_I0.6481.00
250_V253_K0.6481.00
411_H414_Q0.6471.00
362_D365_R0.6451.00
234_V425_L0.6441.00
96_K371_D0.6431.00
231_V425_L0.6421.00
146_G331_F0.6411.00
180_T183_L0.6401.00
460_Q464_A0.6391.00
71_I188_V0.6381.00
439_R442_E0.6371.00
155_I159_N0.6371.00
330_A352_V0.6351.00
154_D323_Y0.6351.00
381_I385_N0.6341.00
189_A469_T0.6331.00
186_G190_R0.6301.00
90_L372_I0.6271.00
426_A443_A0.6261.00
251_A404_T0.6261.00
100_T363_S0.6261.00
205_L452_A0.6251.00
235_E239_N0.6241.00
378_N382_A0.6201.00
158_K320_A0.6201.00
396_A400_S0.6181.00
304_A384_Y0.6151.00
109_S148_T0.6131.00
152_H159_N0.6121.00
390_E393_N0.6121.00
79_P386_K0.6101.00
330_A350_M0.6101.00
218_T222_L0.6091.00
213_N216_I0.6071.00
397_R401_Q0.6071.00
108_F147_L0.6051.00
279_L282_V0.6041.00
263_A390_E0.6031.00
114_R139_W0.6031.00
419_A446_P0.6031.00
212_Q239_N0.6021.00
423_V440_V0.6021.00
223_Y229_S0.6011.00
371_D375_A0.6011.00
446_P449_R0.5971.00
92_E174_A0.5951.00
421_R425_L0.5911.00
445_I449_R0.5901.00
148_T331_F0.5891.00
181_R185_A0.5891.00
204_V452_A0.5861.00
158_K321_A0.5861.00
318_A369_N0.5861.00
172_A303_A0.5851.00
196_Q199_A0.5851.00
312_L315_I0.5851.00
248_N252_G0.5841.00
156_W323_Y0.5841.00
260_R397_R0.5831.00
412_Q415_I0.5821.00
412_Q453_N0.5801.00
307_Y311_S0.5801.00
366_L369_N0.5791.00
460_Q463_D0.5781.00
158_K162_E0.5771.00
405_L461_W0.5761.00
244_R414_Q0.5751.00
368_A371_D0.5741.00
422_V443_A0.5731.00
291_G392_V0.5721.00
314_T373_A0.5721.00
387_A391_A0.5661.00
78_A264_L0.5651.00
197_T460_Q0.5631.00
89_Q93_A0.5631.00
311_S377_S0.5631.00
312_L381_I0.5621.00
196_Q200_A0.5601.00
171_K175_A0.5601.00
81_M177_R0.5591.00
145_F334_Q0.5561.00
164_T168_G0.5561.00
87_R176_E0.5541.00
91_A94_Q0.5541.00
94_Q169_T0.5531.00
400_S403_Q0.5531.00
425_L429_R0.5511.00
427_Q440_V0.5511.00
155_I327_N0.5451.00
99_A103_G0.5441.00
215_I437_G0.5431.00
101_Q159_N0.5381.00
341_D344_R0.5371.00
262_S268_Q0.5371.00
394_D397_R0.5361.00
220_R223_Y0.5361.00
208_I448_L0.5351.00
400_S404_T0.5351.00
153_L328_L0.5341.00
364_G368_A0.5341.00
398_A467_Q0.5341.00
243_T246_Q0.5311.00
406_A409_N0.5301.00
293_S474_G0.5301.00
86_Q90_L0.5291.00
96_K99_A0.5291.00
107_D359_P0.5281.00
307_Y310_S0.5271.00
155_I326_I0.5241.00
82_Q86_Q0.5241.00
199_A203_T0.5241.00
152_H158_K0.5231.00
79_P266_N0.5191.00
201_L250_V0.5181.00
84_A177_R0.5181.00
242_K449_R0.5171.00
457_L460_Q0.5171.00
159_N162_E0.5150.99
205_L209_E0.5150.99
222_L232_E0.5140.99
217_A424_G0.5140.99
219_D223_Y0.5130.99
80_D180_T0.5130.99
191_L261_L0.5110.99
244_R407_E0.5110.99
184_L264_L0.5090.99
93_A372_I0.5080.99
101_Q365_R0.5080.99
245_Q249_D0.5050.99
277_V280_P0.5040.99
408_K457_L0.5040.99
180_T184_L0.5040.99
422_V446_P0.5010.99
67_L71_I0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mt4A 3 0.9351 100 0.203 Contact Map
3d5kA 3 0.931 100 0.212 Contact Map
4mt0A 3 0.9142 100 0.216 Contact Map
1yc9A 3 0.8556 100 0.224 Contact Map
4k7rA 3 0.8912 100 0.225 Contact Map
1ek9A 3 0.8347 100 0.276 Contact Map
4tkoB 1 0.3159 71.8 0.942 Contact Map
3fppA 3 0.295 59.2 0.946 Contact Map
4dk0A 5 0.3096 54 0.948 Contact Map
2f1mA 2 0.2699 37.4 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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