GREMLIN Database
BGLX - Periplasmic beta-glucosidase
UniProt: P33363 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12013
Length: 765 (633)
Sequences: 6763 (4944)
Seq/√Len: 196.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
392_R583_D4.2371.00
682_E715_P3.8861.00
676_T718_T3.7761.00
137_T389_E3.7691.00
682_E714_K3.7481.00
674_Q718_T3.5901.00
136_K190_E3.4151.00
131_N393_E3.3321.00
650_T678_T3.2091.00
649_T679_G3.1251.00
389_E393_E3.0471.00
655_D674_Q3.0381.00
233_F277_Q3.0251.00
449_A588_D2.9941.00
551_N569_E2.9231.00
312_K341_E2.8361.00
590_N683_G2.7981.00
509_V535_I2.7231.00
707_G723_F2.6791.00
653_V752_T2.6711.00
684_A712_T2.6601.00
128_S596_P2.5931.00
395_L584_V2.5481.00
141_V386_E2.5181.00
212_A227_M2.4931.00
672_S720_T2.4921.00
392_R589_Y2.4901.00
267_S272_D2.4391.00
138_V390_V2.4391.00
450_V586_F2.4321.00
442_V508_V2.4221.00
388_R583_D2.3901.00
228_S231_R2.3561.00
182_S242_A2.3431.00
673_V687_V2.3411.00
590_N647_S2.3351.00
207_V248_S2.3281.00
752_T758_K2.3011.00
670_T722_S2.2591.00
689_M723_F2.2391.00
693_D746_F2.2231.00
547_L564_A2.2211.00
684_A710_K2.2151.00
694_V747_N2.2061.00
726_D729_A2.1651.00
459_A494_E2.1621.00
132_L183_T2.1451.00
272_D276_D2.1291.00
316_N348_H2.1251.00
682_E712_T2.1171.00
703_K749_F2.1001.00
446_I586_F2.0841.00
674_Q720_T2.0801.00
206_S250_A2.0791.00
393_E684_A2.0731.00
584_V589_Y2.0631.00
275_R344_D2.0621.00
267_S271_K2.0331.00
268_W273_V1.9921.00
253_V264_T1.9841.00
161_V235_D1.9751.00
388_R392_R1.9651.00
537_A540_A1.9601.00
204_M249_G1.9521.00
583_D588_D1.9481.00
649_T683_G1.9441.00
536_A563_Q1.9411.00
189_V243_G1.9371.00
672_S722_S1.9321.00
443_L447_K1.9111.00
412_T455_K1.9011.00
125_G394_S1.8911.00
409_K588_D1.8711.00
183_T242_A1.8711.00
752_T756_R1.8671.00
329_P333_K1.8651.00
268_W272_D1.8621.00
714_K717_E1.8531.00
713_L719_Q1.8431.00
330_G334_S1.8231.00
576_E579_N1.8171.00
670_T724_P1.8071.00
384_R576_E1.7761.00
560_E567_I1.7721.00
656_V759_K1.7681.00
254_A263_A1.7581.00
120_F141_V1.7581.00
507_A538_L1.7481.00
692_Q747_N1.7441.00
338_T341_E1.7341.00
412_T457_L1.7311.00
497_Q501_Q1.7271.00
734_N740_D1.7231.00
388_R579_N1.7221.00
654_S674_Q1.7211.00
448_N579_N1.7081.00
249_G355_D1.7031.00
283_I352_V1.7011.00
652_T676_T1.6691.00
668_K724_P1.6621.00
633_D755_A1.6601.00
538_L545_L1.6601.00
132_L709_E1.6551.00
505_V538_L1.6521.00
692_Q749_F1.6451.00
312_K338_T1.6381.00
573_A577_G1.6291.00
381_R385_K1.6281.00
341_E344_D1.6211.00
641_P644_Y1.6171.00
443_L458_Y1.6151.00
526_T556_A1.6131.00
697_S742_E1.6111.00
506_V548_V1.6101.00
401_R565_D1.6101.00
653_V685_T1.6061.00
407_L504_V1.6051.00
651_F683_G1.6031.00
183_T186_K1.5981.00
561_D640_Y1.5851.00
328_L337_V1.5781.00
391_A580_A1.5611.00
654_S676_T1.5601.00
161_V627_Y1.5491.00
685_T752_T1.5431.00
533_D537_A1.5401.00
700_R704_Q1.5291.00
594_K685_T1.5271.00
229_P233_F1.5271.00
402_L565_D1.5251.00
135_V184_M1.5241.00
637_G755_A1.5221.00
451_G454_G1.5201.00
544_P565_D1.5201.00
136_K140_R1.5191.00
497_Q500_K1.5091.00
159_V185_G1.5061.00
734_N738_K1.5021.00
413_I504_V1.5011.00
159_V207_V1.4901.00
530_S533_D1.4851.00
421_D443_L1.4801.00
539_K564_A1.4711.00
379_E384_R1.4711.00
126_L135_V1.4711.00
691_L706_K1.4661.00
271_K276_D1.4611.00
404_T566_A1.4571.00
94_D98_E1.4571.00
548_V570_T1.4541.00
492_I496_V1.4511.00
713_L717_E1.4461.00
570_T573_A1.4441.00
412_T501_Q1.4411.00
311_L345_A1.4411.00
258_L263_A1.4411.00
592_S684_A1.4311.00
79_A82_N1.4271.00
457_L501_Q1.4221.00
641_P753_D1.4221.00
339_M343_D1.4221.00
549_L569_E1.4131.00
118_T387_A1.4061.00
686_V710_K1.4001.00
691_L748_V1.3981.00
539_K565_D1.3931.00
343_D346_A1.3921.00
445_G582_A1.3921.00
457_L502_S1.3901.00
329_P332_I1.3861.00
207_V251_V1.3821.00
659_S670_T1.3811.00
389_E392_R1.3721.00
204_M352_V1.3711.00
536_A559_K1.3681.00
697_S732_F1.3661.00
446_I456_V1.3641.00
442_V581_I1.3611.00
416_V507_A1.3481.00
601_R637_G1.3461.00
751_G757_V1.3461.00
440_V579_N1.3441.00
507_A535_I1.3441.00
498_T502_S1.3431.00
270_L284_T1.3431.00
404_T565_D1.3421.00
136_K194_G1.3411.00
140_R194_G1.3401.00
78_G347_R1.3381.00
415_V446_I1.3251.00
261_T266_D1.3211.00
652_T678_T1.3171.00
274_L284_T1.3121.00
440_V445_G1.3091.00
345_A348_H1.3051.00
504_V546_V1.2991.00
711_I721_V1.2911.00
568_L585_L1.2861.00
312_K337_V1.2841.00
244_L251_V1.2821.00
414_A502_S1.2791.00
594_K752_T1.2771.00
457_L498_T1.2721.00
689_M750_I1.2721.00
244_L248_S1.2721.00
509_V549_L1.2711.00
641_P755_A1.2691.00
211_A269_L1.2661.00
388_R576_E1.2641.00
183_T245_D1.2571.00
253_V290_A1.2561.00
340_A343_D1.2561.00
136_K191_A1.2551.00
186_K242_A1.2531.00
411_A504_V1.2481.00
137_T140_R1.2441.00
459_A498_T1.2431.00
656_V750_I1.2421.00
533_D536_A1.2371.00
253_V270_L1.2371.00
682_E713_L1.2371.00
753_D756_R1.2361.00
393_E710_K1.2261.00
126_L138_V1.2241.00
725_I730_L1.2231.00
570_T581_I1.2221.00
286_S291_I1.2171.00
251_V274_L1.2101.00
532_R536_A1.2091.00
731_K741_A1.2061.00
673_V759_K1.2061.00
559_K563_Q1.2061.00
696_A742_E1.1921.00
170_A597_M1.1901.00
76_Q79_A1.1891.00
496_V537_A1.1861.00
395_L570_T1.1841.00
179_Y707_G1.1831.00
491_M494_E1.1811.00
449_A583_D1.1691.00
127_A596_P1.1621.00
156_A192_M1.1571.00
330_G333_K1.1491.00
638_A641_P1.1491.00
264_T290_A1.1461.00
399_K640_Y1.1441.00
250_A283_I1.1421.00
496_V500_K1.1411.00
660_A667_G1.1411.00
241_K245_D1.1391.00
731_K739_Y1.1391.00
207_V243_G1.1381.00
332_I342_L1.1371.00
415_V443_L1.1331.00
460_K463_N1.1331.00
271_K313_S1.1261.00
76_Q80_I1.1211.00
141_V383_H1.1201.00
129_S390_V1.1181.00
493_D497_Q1.1171.00
505_V545_L1.1171.00
671_A689_M1.1151.00
188_M192_M1.1131.00
234_N733_W1.1111.00
237_M273_V1.1111.00
263_A266_D1.1051.00
192_M205_T1.1051.00
647_S683_G1.1031.00
183_T708_F1.1001.00
732_F742_E1.1001.00
495_A499_A1.0991.00
673_V723_F1.0971.00
85_T332_I1.0951.00
526_T532_R1.0951.00
281_K355_D1.0921.00
658_L671_A1.0911.00
185_G243_G1.0881.00
489_Q493_D1.0871.00
508_V581_I1.0861.00
238_P242_A1.0851.00
253_V315_I1.0841.00
549_L557_L1.0811.00
579_N583_D1.0811.00
136_K187_T1.0771.00
132_L187_T1.0721.00
657_K672_S1.0701.00
99_L102_L1.0671.00
230_Q698_M1.0661.00
649_T678_T1.0661.00
354_Y359_F1.0651.00
190_E246_A1.0641.00
396_V571_W1.0611.00
733_W739_Y1.0611.00
694_V745_K1.0581.00
230_Q234_N1.0571.00
311_L328_L1.0551.00
145_E383_H1.0551.00
229_P268_W1.0541.00
159_V243_G1.0531.00
709_E719_Q1.0521.00
134_A386_E1.0511.00
675_V687_V1.0501.00
193_Q205_T1.0491.00
413_I450_V1.0451.00
673_V750_I1.0421.00
492_I537_A1.0401.00
75_G80_I1.0381.00
681_R715_P1.0331.00
182_S186_K1.0311.00
749_F757_V1.0311.00
671_A750_I1.0311.00
231_R624_P1.0311.00
229_P737_M1.0291.00
129_S394_S1.0281.00
567_I640_Y1.0281.00
496_V541_T1.0281.00
706_K729_A1.0271.00
733_W737_M1.0261.00
395_L568_L1.0251.00
186_K190_E1.0221.00
85_T88_D1.0211.00
449_A586_F1.0201.00
446_I585_L1.0151.00
332_I338_T1.0141.00
333_K339_M1.0141.00
87_Q101_R1.0141.00
444_T448_N1.0121.00
144_Y195_K1.0111.00
505_V543_K1.0091.00
317_M349_V1.0071.00
243_G248_S1.0061.00
271_K344_D1.0051.00
689_M725_I0.9991.00
327_Y330_G0.9981.00
539_K545_L0.9961.00
590_N681_R0.9941.00
154_T192_M0.9931.00
602_S605_Q0.9911.00
594_K686_V0.9901.00
326_K330_G0.9891.00
711_I719_Q0.9851.00
133_D709_E0.9830.99
594_K754_S0.9830.99
88_D343_D0.9830.99
446_I582_A0.9820.99
140_R195_K0.9800.99
133_D137_T0.9770.99
509_V547_L0.9770.99
179_Y183_T0.9760.99
601_R639_L0.9750.99
416_V505_V0.9740.99
706_K725_I0.9730.99
535_I560_E0.9730.99
557_L639_L0.9700.99
385_K389_E0.9700.99
742_E746_F0.9690.99
134_A390_V0.9680.99
407_L546_V0.9650.99
441_T444_T0.9630.99
126_L390_V0.9620.99
413_I586_F0.9610.99
165_P606_I0.9600.99
458_Y461_G0.9590.99
238_P241_K0.9580.99
286_S315_I0.9570.99
489_Q533_D0.9560.99
153_M250_A0.9540.99
93_Q97_M0.9530.99
592_S710_K0.9530.99
186_K246_A0.9520.99
547_L560_E0.9510.99
440_V578_G0.9470.99
158_M173_G0.9460.99
241_K728_E0.9430.99
725_I729_A0.9420.99
529_Q533_D0.9410.99
751_G754_S0.9390.99
414_A505_V0.9360.99
541_T544_P0.9340.99
600_P606_I0.9330.99
547_L567_I0.9320.99
412_T503_D0.9310.99
174_F184_M0.9300.99
594_K653_V0.9280.99
244_L280_F0.9280.99
700_R732_F0.9280.99
140_R144_Y0.9260.99
408_K681_R0.9210.99
263_A269_L0.9200.99
525_I556_A0.9170.99
693_D696_A0.9160.99
517_H520_S0.9160.99
132_L708_F0.9140.99
654_S718_T0.9120.99
550_M570_T0.9110.99
257_S699_S0.9110.99
657_K720_T0.9100.99
693_D744_G0.9090.99
442_V550_M0.9080.99
404_T504_V0.9080.99
669_V730_L0.9060.99
137_T386_E0.9050.99
728_E731_K0.9040.99
241_K278_W0.9040.99
415_V420_A0.9030.99
331_L336_K0.9020.99
568_L591_P0.9020.99
543_K565_D0.9010.99
228_S735_Q0.9000.99
244_L278_W0.9000.99
494_E498_T0.8990.99
94_D97_M0.8980.99
663_M669_V0.8970.99
377_N380_S0.8960.99
709_E721_V0.8950.99
558_V639_L0.8900.99
86_R329_P0.8900.99
689_M748_V0.8870.99
421_D441_T0.8850.99
606_I632_F0.8850.99
414_A498_T0.8770.99
129_S184_M0.8750.99
211_A237_M0.8740.99
656_V671_A0.8720.99
505_V542_G0.8710.99
658_L663_M0.8700.99
224_T257_S0.8700.99
644_Y753_D0.8690.99
144_Y383_H0.8690.99
443_L456_V0.8680.99
583_D589_Y0.8670.99
332_I337_V0.8660.99
445_G449_A0.8660.99
161_V181_T0.8650.99
444_T447_K0.8650.99
265_S293_E0.8640.99
446_I506_V0.8620.99
242_A245_D0.8620.99
275_R348_H0.8580.99
133_D136_K0.8570.99
146_A154_T0.8550.99
265_S294_L0.8540.99
75_G79_A0.8540.99
143_A192_M0.8520.99
626_K699_S0.8510.99
88_D91_A0.8500.99
462_A530_S0.8450.98
380_S383_H0.8450.98
584_V591_P0.8450.98
613_L699_S0.8440.98
250_A352_V0.8420.98
446_I450_V0.8410.98
590_N594_K0.8410.98
212_A232_L0.8400.98
247_G281_K0.8390.98
445_G448_N0.8380.98
404_T546_V0.8340.98
83_T91_A0.8330.98
257_S613_L0.8330.98
420_A458_Y0.8320.98
633_D703_K0.8320.98
589_Y592_S0.8310.98
346_A349_V0.8310.98
505_V541_T0.8290.98
112_V154_T0.8290.98
680_K715_P0.8290.98
725_I748_V0.8270.98
87_Q91_A0.8260.98
508_V550_M0.8260.98
461_G495_A0.8250.98
181_T239_P0.8240.98
288_H319_M0.8230.98
139_G192_M0.8220.98
671_A748_V0.8220.98
601_R638_A0.8220.98
147_A203_V0.8160.98
109_A317_M0.8150.98
445_G578_G0.8100.98
664_K667_G0.8100.98
736_Q740_D0.8080.98
498_T501_Q0.8060.98
276_D279_G0.8050.98
653_V758_K0.8040.98
153_M352_V0.8040.98
77_V81_F0.8020.98
233_F273_V0.7990.98
233_F241_K0.7980.98
671_A674_Q0.7980.98
673_V720_T0.7970.98
127_A180_L0.7940.98
494_E497_Q0.7900.98
507_A545_L0.7880.98
204_M356_M0.7880.98
344_D347_R0.7880.98
344_D348_H0.7860.98
83_T87_Q0.7810.97
78_G81_F0.7800.97
537_A541_T0.7800.97
653_V687_V0.7780.97
604_G636_N0.7770.97
210_F237_M0.7750.97
92_M342_L0.7740.97
191_A194_G0.7720.97
489_Q492_I0.7710.97
162_S597_M0.7710.97
496_V538_L0.7710.97
578_G582_A0.7700.97
653_V673_V0.7690.97
703_K757_V0.7690.97
98_E106_L0.7670.97
392_R579_N0.7660.97
542_G565_D0.7650.97
600_P632_F0.7620.97
506_V585_L0.7610.97
409_K449_A0.7610.97
84_V87_Q0.7600.97
415_V456_V0.7590.97
532_R559_K0.7580.97
560_E639_L0.7560.97
122_I171_S0.7560.97
706_K748_V0.7550.97
249_G352_V0.7550.97
557_L567_I0.7550.97
416_V495_A0.7550.97
132_L184_M0.7530.97
535_I539_K0.7520.97
138_V386_E0.7500.97
109_A153_M0.7500.97
409_K586_F0.7500.97
450_V454_G0.7490.97
421_D447_K0.7480.97
657_K674_Q0.7470.97
416_V538_L0.7460.97
539_K563_Q0.7450.97
382_L385_K0.7430.97
556_A603_V0.7410.97
91_A94_D0.7400.96
139_G188_M0.7380.96
421_D444_T0.7360.96
257_S262_P0.7350.96
130_F686_V0.7340.96
668_K726_D0.7320.96
386_E389_E0.7320.96
395_L580_A0.7310.96
350_L353_K0.7310.96
232_L273_V0.7290.96
538_L541_T0.7290.96
348_H351_N0.7290.96
174_F188_M0.7280.96
412_T502_S0.7280.96
499_A502_S0.7280.96
351_N355_D0.7280.96
508_V548_V0.7270.96
140_R202_S0.7270.96
392_R580_A0.7270.96
542_G545_L0.7260.96
204_M250_A0.7250.96
532_R558_V0.7240.96
696_A700_R0.7230.96
631_Y635_A0.7220.96
507_A534_L0.7220.96
265_S309_V0.7200.96
134_A137_T0.7200.96
154_T203_V0.7190.96
698_M732_F0.7180.96
493_D537_A0.7170.96
142_S192_M0.7160.96
162_S170_A0.7160.96
77_V80_I0.7160.96
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505_V508_V0.5620.87
727_I741_A0.5600.86
218_G612_H0.5600.86
139_G189_V0.5590.86
392_R590_N0.5580.86
270_L313_S0.5580.86
229_P273_V0.5580.86
506_V546_V0.5580.86
560_E640_Y0.5570.86
226_D231_R0.5570.86
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438_Q579_N0.5550.86
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289_G292_K0.5550.86
386_E390_V0.5550.86
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429_S433_A0.5510.86
362_P365_H0.5500.85
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311_L337_V0.5480.85
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178_T182_S0.5400.84
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644_Y758_K0.5380.84
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541_T545_L0.5330.84
214_G621_A0.5330.84
584_V592_S0.5320.84
226_D259_N0.5320.84
694_V746_F0.5320.84
141_V390_V0.5310.83
385_K392_R0.5310.83
125_G128_S0.5300.83
696_A746_F0.5280.83
238_P248_S0.5280.83
654_S673_V0.5280.83
428_G431_S0.5270.83
511_E572_F0.5270.83
747_N750_I0.5270.83
275_R341_E0.5270.83
688_Q754_S0.5260.83
205_T249_G0.5260.83
331_L334_S0.5250.83
698_M742_E0.5250.83
316_N344_D0.5250.83
148_D378_A0.5240.83
590_N684_A0.5240.83
449_A582_A0.5240.83
109_A319_M0.5230.82
131_N389_E0.5220.82
509_V527_I0.5210.82
689_M729_A0.5200.82
698_M735_Q0.5200.82
667_G726_D0.5190.82
118_T383_H0.5190.82
691_L730_L0.5190.82
631_Y634_E0.5190.82
337_V342_L0.5180.82
611_S704_Q0.5180.82
556_A640_Y0.5180.82
528_P531_Q0.5180.82
440_V444_T0.5160.82
289_G320_S0.5160.82
500_K541_T0.5130.81
156_A188_M0.5130.81
499_A541_T0.5120.81
656_V673_V0.5120.81
654_S759_K0.5120.81
438_Q576_E0.5100.81
459_A495_A0.5100.81
551_N555_L0.5100.81
590_N682_E0.5100.81
499_A537_A0.5090.81
155_W320_S0.5090.81
219_G222_Y0.5090.81
174_F181_T0.5080.81
352_V355_D0.5080.81
523_T602_S0.5080.81
399_K646_L0.5080.81
709_E722_S0.5080.81
337_V341_E0.5070.81
401_R404_T0.5070.81
663_M727_I0.5070.81
230_Q732_F0.5070.81
75_G78_G0.5070.81
235_D625_N0.5060.80
714_K719_Q0.5060.80
322_E325_S0.5060.80
603_V606_I0.5060.80
107_F353_K0.5050.80
361_D364_S0.5050.80
459_A491_M0.5040.80
253_V271_K0.5030.80
634_E702_V0.5030.80
752_T755_A0.5030.80
143_A203_V0.5020.80
332_I335_G0.5010.80
560_E564_A0.5010.80
104_I350_L0.5010.80
155_W285_V0.5010.80
418_P531_Q0.5010.80
123_S156_A0.5010.80
230_Q259_N0.5010.80
291_I324_Y0.5000.80
408_K586_F0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3u48A 2 0.9516 100 0.195 Contact Map
3abzA 3 0.8654 100 0.197 Contact Map
4i3gA 1 0.8667 100 0.197 Contact Map
2x41A 1 0.8627 100 0.218 Contact Map
3zyzA 1 0.8562 100 0.225 Contact Map
4iibA 2 0.8824 100 0.238 Contact Map
4d0jA 4 0.8719 100 0.24 Contact Map
3rrxA 1 0.7529 100 0.324 Contact Map
3wliA 1 0.7399 100 0.381 Contact Map
3bmxA 1 0.7085 100 0.458 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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