GREMLIN Database
YEHY - Putative osmoprotectant uptake system permease protein YehY
UniProt: P33361 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12011
Length: 385 (306)
Sequences: 3171 (2511)
Seq/√Len: 143.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
290_R299_R4.2021.00
295_S298_Q3.5991.00
128_R132_T3.1131.00
289_A299_R2.7181.00
129_R132_T2.7161.00
155_G159_D2.6991.00
155_G158_N2.6731.00
136_W140_L2.6131.00
126_A129_R2.5731.00
297_A301_L2.5041.00
125_D128_R2.4351.00
286_L299_R2.3231.00
140_L144_I2.3121.00
134_P137_R2.2281.00
126_A132_T2.1791.00
122_A125_D2.1541.00
192_L316_L2.0921.00
122_A126_A2.0901.00
128_R131_S2.0231.00
157_L161_S2.0221.00
110_S113_W2.0201.00
151_L155_G2.0171.00
188_V320_M2.0071.00
141_H144_I1.9921.00
66_P70_G1.9881.00
124_S130_I1.9761.00
147_I150_W1.9611.00
122_A127_I1.9531.00
140_L147_I1.9461.00
118_L121_L1.9071.00
95_Q98_Q1.8841.00
137_R147_I1.8581.00
156_T159_D1.8561.00
143_Q147_I1.8441.00
144_I147_I1.8421.00
126_A130_I1.8251.00
90_G95_Q1.8031.00
126_A133_H1.7901.00
201_W212_I1.7781.00
99_N103_L1.7701.00
123_C129_R1.7391.00
87_W90_G1.7371.00
144_I148_P1.7301.00
112_F119_A1.7291.00
148_P157_L1.7081.00
250_I253_T1.6971.00
89_A92_A1.6911.00
137_R140_L1.6891.00
154_S157_L1.6751.00
163_M168_N1.6571.00
147_I151_L1.6531.00
145_A151_L1.6201.00
68_K71_S1.6111.00
68_K72_I1.6061.00
128_R133_H1.6001.00
123_C126_A1.5991.00
158_N161_S1.5751.00
125_D129_R1.5711.00
138_W141_H1.5701.00
155_G161_S1.5541.00
130_I133_H1.5531.00
158_N162_L1.5501.00
146_I150_W1.5331.00
140_L143_Q1.5131.00
190_P263_V1.5111.00
129_R133_H1.5031.00
143_Q155_G1.4881.00
141_H145_A1.4801.00
70_G74_A1.4571.00
250_I254_G1.4451.00
79_Q82_F1.4291.00
137_R148_P1.4241.00
152_L156_T1.4201.00
88_G92_A1.4091.00
159_D162_L1.3981.00
136_W141_H1.3971.00
298_Q301_L1.3911.00
73_C77_L1.3911.00
151_L158_N1.3901.00
151_L156_T1.3871.00
151_L157_L1.3841.00
89_A94_T1.3831.00
78_A82_F1.3681.00
71_S74_A1.3661.00
81_V86_V1.3621.00
285_V307_L1.3401.00
112_F115_A1.3351.00
93_A96_L1.3301.00
134_P147_I1.3261.00
156_T161_S1.3231.00
136_W150_W1.3141.00
119_A125_D1.3141.00
71_S75_L1.3131.00
124_S128_R1.3121.00
74_A78_A1.3041.00
136_W139_L1.2901.00
150_W155_G1.2891.00
195_G270_L1.2851.00
349_S352_D1.2791.00
94_T98_Q1.2791.00
67_G70_G1.2751.00
140_L150_W1.2741.00
103_L106_T1.2731.00
91_K98_Q1.2721.00
110_S114_L1.2711.00
137_R144_I1.2701.00
101_S104_A1.2601.00
286_L304_Q1.2511.00
324_V364_L1.2491.00
126_A131_S1.2481.00
151_L154_S1.2411.00
125_D131_S1.2331.00
75_L79_Q1.2301.00
249_G254_G1.2281.00
99_N104_A1.2241.00
102_A105_R1.2131.00
148_P151_L1.2121.00
125_D130_I1.2101.00
95_Q99_N1.2071.00
127_I132_T1.2051.00
75_L78_A1.2051.00
84_L88_G1.1991.00
144_I150_W1.1981.00
196_V274_V1.1921.00
100_G105_R1.1891.00
141_H152_L1.1821.00
150_W153_Y1.1801.00
93_A98_Q1.1791.00
72_I76_I1.1791.00
134_P144_I1.1781.00
145_A148_P1.1721.00
72_I82_F1.1711.00
138_W143_Q1.1671.00
137_R151_L1.1651.00
155_G160_L1.1631.00
134_P141_H1.1631.00
146_I149_L1.1571.00
273_G315_S1.1520.99
374_L377_A1.1480.99
72_I75_L1.1350.99
179_Q335_A1.1350.99
127_I130_I1.1280.99
97_A108_L1.1100.99
97_A100_G1.0990.99
135_L140_L1.0880.99
152_L155_G1.0850.99
125_D132_T1.0830.99
115_A118_L1.0780.99
337_G348_S1.0730.99
341_L345_G1.0720.99
66_P69_K1.0700.99
135_L139_L1.0640.99
102_A106_T1.0630.99
195_G274_V1.0560.99
227_L261_A1.0510.99
134_P145_A1.0490.99
125_D133_H1.0470.99
122_A131_S1.0420.99
95_Q100_G1.0420.99
83_V86_V1.0380.99
138_W145_A1.0340.99
71_S79_Q1.0250.99
122_A129_R1.0210.99
134_P138_W1.0160.99
143_Q150_W1.0120.99
109_G113_W1.0110.99
339_G343_F1.0070.99
109_G119_A1.0060.99
148_P156_T1.0030.99
82_F86_V0.9990.99
73_C82_F0.9980.99
141_H147_I0.9960.99
181_L185_F0.9940.98
121_L125_D0.9900.98
156_T160_L0.9890.98
139_L143_Q0.9880.98
67_G71_S0.9860.98
124_S131_S0.9810.98
233_A342_V0.9790.98
337_G340_A0.9750.98
251_A254_G0.9730.98
127_I133_H0.9690.98
134_P140_L0.9660.98
183_L262_L0.9620.98
67_G72_I0.9570.98
141_H150_W0.9560.98
95_Q102_A0.9550.98
117_A120_L0.9490.98
115_A119_A0.9480.98
143_Q152_L0.9280.98
69_K74_A0.9220.98
116_A120_L0.9180.97
155_G162_L0.9180.97
150_W154_S0.9150.97
139_L142_M0.9050.97
144_I151_L0.9000.97
239_V242_F0.8970.97
79_Q84_L0.8930.97
79_Q83_V0.8920.97
122_A128_R0.8880.97
143_Q146_I0.8850.97
186_G259_L0.8850.97
91_K97_A0.8770.97
186_G190_P0.8750.97
337_G343_F0.8750.97
152_L159_D0.8740.97
136_W146_I0.8670.96
290_R296_G0.8660.96
148_P155_G0.8620.96
69_K72_I0.8580.96
127_I131_S0.8570.96
123_C132_T0.8570.96
138_W144_I0.8540.96
99_N106_T0.8540.96
134_P156_T0.8500.96
110_S128_R0.8470.96
66_P73_C0.8430.96
136_W151_L0.8400.96
178_A182_T0.8370.96
66_P74_A0.8350.96
157_L160_L0.8320.95
142_M145_A0.8310.95
345_G348_S0.8290.95
370_A373_D0.8290.95
315_S319_V0.8270.95
93_A97_A0.8250.95
258_A333_I0.8250.95
143_Q149_L0.8250.95
90_G94_T0.8220.95
154_S159_D0.8220.95
110_S119_A0.8210.95
74_A77_L0.8210.95
275_V279_N0.8210.95
123_C128_R0.8170.95
340_A343_F0.8160.95
122_A133_H0.8130.95
143_Q151_L0.8120.95
184_L320_M0.8110.95
134_P150_W0.8100.95
325_G328_V0.8090.95
89_A93_A0.8080.95
217_N272_R0.8070.95
289_A294_M0.8040.95
99_N108_L0.8030.95
238_L241_A0.8030.95
79_Q89_A0.7920.94
110_S116_A0.7880.94
249_G253_T0.7860.94
100_G106_T0.7830.94
121_L129_R0.7820.94
137_R141_H0.7760.93
138_W150_W0.7720.93
123_C127_I0.7700.93
65_I68_K0.7690.93
274_V278_L0.7690.93
63_C66_P0.7680.93
256_T260_I0.7670.93
134_P139_L0.7660.93
148_P152_L0.7660.93
103_L107_S0.7650.93
67_G74_A0.7640.93
91_K96_L0.7620.93
121_L124_S0.7620.93
135_L138_W0.7620.93
65_I70_G0.7590.93
135_L150_W0.7580.93
146_I153_Y0.7540.92
75_L80_F0.7540.92
72_I79_Q0.7520.92
67_G75_L0.7480.92
151_L159_D0.7450.92
100_G104_A0.7440.92
112_F121_L0.7430.92
94_T99_N0.7410.92
154_S158_N0.7400.92
113_W119_A0.7400.92
118_L132_T0.7390.92
198_L216_L0.7370.92
188_V323_T0.7350.92
87_W95_Q0.7340.91
72_I86_V0.7330.91
193_V197_P0.7320.91
140_L145_A0.7280.91
105_R108_L0.7280.91
144_I156_T0.7220.91
78_A89_A0.7220.91
113_W120_L0.7210.91
153_Y159_D0.7200.91
123_C133_H0.7170.90
143_Q154_S0.7160.90
93_A101_S0.7130.90
124_S132_T0.7090.90
272_R369_D0.7090.90
154_S162_L0.7080.90
85_L89_A0.7070.90
83_V87_W0.7050.90
228_F322_Q0.7040.90
98_Q102_A0.7030.90
70_G73_C0.6990.89
112_F118_L0.6980.89
66_P79_Q0.6980.89
66_P71_S0.6950.89
208_R211_A0.6940.89
75_L92_A0.6940.89
143_Q148_P0.6930.89
124_S129_R0.6930.89
109_G118_L0.6920.89
343_F346_L0.6910.89
313_L375_L0.6900.89
196_V305_L0.6890.89
88_G91_K0.6880.89
70_G77_L0.6860.88
110_S121_L0.6850.88
203_Y279_N0.6850.88
80_F84_L0.6840.88
219_I227_L0.6840.88
115_A121_L0.6800.88
141_H151_L0.6790.88
367_L371_L0.6780.88
70_G75_L0.6770.88
111_G114_L0.6740.88
87_W98_Q0.6740.88
136_W143_Q0.6710.87
100_G107_S0.6680.87
286_L290_R0.6670.87
87_W91_K0.6640.87
145_A150_W0.6630.87
77_L81_V0.6610.87
192_L320_M0.6590.86
109_G112_F0.6590.86
137_R150_W0.6580.86
283_R290_R0.6570.86
315_S353_L0.6560.86
342_V357_G0.6560.86
338_F357_G0.6550.86
104_A107_S0.6550.86
140_L151_L0.6530.86
123_C131_S0.6520.86
89_A96_L0.6510.86
281_I308_A0.6500.86
101_S106_T0.6490.86
273_G318_V0.6420.85
96_L99_N0.6420.85
140_L153_Y0.6410.85
69_K86_V0.6380.85
64_F70_G0.6360.84
96_L100_G0.6360.84
321_V329_I0.6340.84
141_H149_L0.6330.84
82_F91_K0.6330.84
144_I152_L0.6310.84
124_S133_H0.6290.84
71_S78_A0.6270.84
75_L103_L0.6270.84
317_R320_M0.6260.83
199_G203_Y0.6260.83
124_S127_I0.6230.83
63_C68_K0.6220.83
63_C67_G0.6210.83
281_I286_L0.6190.83
344_Q348_S0.6190.83
77_L94_T0.6170.83
135_L144_I0.6150.82
66_P72_I0.6150.82
119_A122_A0.6140.82
259_L263_V0.6100.82
257_P356_L0.6100.82
111_G119_A0.6080.82
149_L153_Y0.6070.82
113_W128_R0.6020.81
63_C74_A0.6000.81
289_A303_V0.5980.81
119_A123_C0.5980.81
144_I159_D0.5970.81
92_A95_Q0.5940.80
154_S161_S0.5930.80
137_R156_T0.5900.80
116_A127_I0.5900.80
94_T103_L0.5890.80
77_L87_W0.5880.80
81_V84_L0.5860.79
110_S117_A0.5840.79
237_A241_A0.5810.79
203_Y278_L0.5790.78
81_V91_K0.5790.78
296_G299_R0.5780.78
97_A102_A0.5780.78
104_A108_L0.5780.78
76_I79_Q0.5780.78
72_I91_K0.5770.78
267_L271_V0.5750.78
134_P143_Q0.5730.78
68_K75_L0.5700.77
123_C130_I0.5670.77
111_G127_I0.5660.77
85_L96_L0.5640.77
134_P152_L0.5620.76
220_Q269_P0.5620.76
94_T100_G0.5600.76
257_P277_G0.5600.76
97_A112_F0.5590.76
101_S105_R0.5580.76
314_R318_V0.5570.76
140_L148_P0.5560.76
134_P158_N0.5540.75
341_L344_Q0.5540.75
322_Q326_M0.5530.75
93_A104_A0.5520.75
118_L122_A0.5490.75
147_I159_D0.5490.75
111_G128_R0.5480.75
268_L354_V0.5470.75
113_W124_S0.5450.74
114_L121_L0.5440.74
171_D174_D0.5430.74
121_L126_A0.5420.74
63_C69_K0.5420.74
120_L127_I0.5400.74
70_G79_Q0.5400.74
120_L128_R0.5390.73
151_L162_L0.5370.73
191_A270_L0.5330.73
69_K82_F0.5310.72
68_K79_Q0.5300.72
78_A86_V0.5300.72
98_Q104_A0.5300.72
86_V93_A0.5270.72
79_Q86_V0.5270.72
78_A90_G0.5270.72
68_K73_C0.5250.71
72_I83_V0.5250.71
75_L82_F0.5230.71
134_P151_L0.5230.71
143_Q157_L0.5230.71
209_Q279_N0.5210.71
199_G330_A0.5210.71
86_V90_G0.5200.71
95_Q106_T0.5180.70
98_Q103_L0.5170.70
281_I304_Q0.5170.70
70_G76_I0.5170.70
119_A128_R0.5140.70
145_A153_Y0.5130.70
249_G252_G0.5110.69
324_V369_D0.5110.69
98_Q105_R0.5090.69
109_G117_A0.5080.69
115_A132_T0.5070.69
359_I363_V0.5060.69
270_L319_V0.5060.69
75_L96_L0.5040.68
90_G93_A0.5040.68
321_V365_A0.5030.68
75_L86_V0.5030.68
145_A157_L0.5010.68
91_K95_Q0.5010.68
228_F265_Y0.5000.68
204_F296_G0.5000.68
150_W157_L0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2onkC 2 0.626 100 0.492 Contact Map
4tquM 1 0.6519 100 0.5 Contact Map
3d31C 2 0.613 100 0.5 Contact Map
3rlfG 1 0.6416 100 0.555 Contact Map
4ymuD 2 0.5506 100 0.556 Contact Map
3tuiA 2 0.5377 100 0.559 Contact Map
3rlfF 1 0.8312 100 0.586 Contact Map
4tquN 1 0.6208 100 0.592 Contact Map
4mrsA 2 0.2442 11 0.959 Contact Map
4ev6A 3 0.1714 7.9 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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