YEHX - ECOLI - GREMLIN Contacts

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YEHX - Putative osmoprotectant uptake system ATP-binding protein YehX

UniProt:	P33360	Sequences: MIEFSHVSKLFGAQKAVNDLNLNFQEGSFSVLIGTSGSGKSTTLKMINRLVEHDSGEIRFAGEEIRSLPVLELRRRMGYAIQSIGLFPHWSVAQNIATVPQLQKWSRARIDDRIDELMALLGLESNLRERYPHQLSGGQQQRVGVARALAADPQVLLMDEPFGALDPVTRGALQQEMTRIHRLLGRTIVLVTHDIDEALRLAEHLVLMDHGEVVQQGNPLTMLTRPANDFVRQFFGRSELGVRLLSLRSVADYVRREERADGEALAEEMTLRDALSLFVARGCEVLPVVNMQGQPCGTLHFQDLLVEA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12010
Length:	308 (239)
Sequences:	93005 (55116)
Seq/√Len:	3565.2

ECOLI - YEHX PROV POTG FBPC MALK METN POTA CYSA UGPC YCJV YDCT OPPF DPPF SAPD DPPD OPPD DDPD YADG MODC ARAG RBSA GSIA DDPF MACB FEPC YHES UUP MLAF SAPF MDLA MDLB TAUB FECE YTFR CYDC YECC HISP FHUC NIKE MSBA LSRA PHNC YOJI GLNQ LPTB CYDD SSUB YHDZ GLTL XYLG YPHE LIVG PHNK SUFC ALSA PSTB MODF LIVF FTSE ETTA ARTP ZNUC THIQ LOLD BTUD MGLA FETA YBBA NIKD PHNL CCMA YEJF YDDA YBHF YNJD YBIT YHIH
BACSU - OPUCA OPUBA OPUAA YVRA YURJ MSMX METN YKFD DPPD OPPD YFIL YHCH APPD YXLF YHAQ APPF YKPA OPPF YCBN TAGH YDBJ YVFR YFMM RBSA YUSV ECFA1 YHEH YFMF YTRB FHUC SUNT YFMR YDIF TCYN YFIC YFIB YCLP YGAD ECFA2 BMRA YLMA SUFC YKNV YKNU YHEI BCEA YWJA ECSA YXDL YVCR YXEO SKFE YTLC TCYC GLNQ CYDC NATA ARTM CYDD FTSE YKOD PSTB1 ALBC MNTB YJKB YVRO SSUB YTHP PSTB2 YKNY YUFO YCLH ZNUC EXPZ YYBJ YHCG YTRE YYDI
HALSA - BTUDA Q9HMX3 Q9HMW0 Q9HHQ5 Q9HR06 Q9HMX2 Q9HNZ9 Q9HMT3 Q9HMU8 Q9HRJ6 Q9HMG1 Q9HRH8 PHNC PSTB2 Q9HSQ7 Q9HHM2 Q9HMG6 Q9HNY3 Q9HRZ9 Q9HRV7 Y2317 Y1631 PSTB1 Q9HR96 Q9HHR7 Q9HT03 Q9HS04 Q9HR21 Q9HQA8 Q9HMC1 Q9HMW1
SULSO - Q97UF2 Q97YY4 Q97UY8 Q97VC1 Q97UH3 Q7LX64 Q97VF5 Q97ZC0 Q97VH6 Q97YP3 Q97VK8 Q97YP7 Q97UJ9 Q97VK9 Q97VF4 Q97YK2 Q97YP8 Q97UD4 Q97X18 Q97YQ7 Q97U54 Q97Z03 Y1893 Y2030 Q97UH4 PSTB Q97V01 Q97W42 Q980W0 Q7LY07 Q97V00 Q7LXM4 Q97VY4 Q97VM2 Q7LX80 Q97Z56 Q97UC2 Q97UG5 Q97YP4 Q97Z96 Q97ZU0 Q980K5 Q980E6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
28_S	204_H	3.473	1.00
76_R	154_Q	2.986	1.00
3_E	23_N	2.978	1.00
15_K	18_N	2.942	1.00
31_V	202_A	2.916	1.00
6_H	19_D	2.858	1.00
5_S	57_E	2.839	1.00
57_E	64_E	2.758	1.00
204_H	216_Q	2.721	1.00
30_S	206_V	2.695	1.00
127_L	130_R	2.530	1.00
25_Q	28_S	2.486	1.00
3_E	59_R	2.449	1.00
10_L	15_K	2.445	1.00
218_N	221_T	2.383	1.00
217_G	221_T	2.314	1.00
9_K	46_M	2.249	1.00
18_N	212_E	2.235	1.00
8_S	15_K	2.234	1.00
8_S	55_S	2.227	1.00
5_S	59_R	2.187	1.00
61_A	154_Q	2.175	1.00
8_S	19_D	2.085	1.00
106_S	109_R	2.060	1.00
206_V	213_V	2.047	1.00
206_V	216_Q	2.022	1.00
113_R	152_D	1.977	1.00
120_L	184_L	1.941	1.00
4_F	7_V	1.927	1.00
115_D	128_R	1.917	1.00
90_W	94_Q	1.812	1.00
179_R	183_L	1.767	1.00
26_E	154_Q	1.756	1.00
93_A	97_A	1.646	1.00
113_R	116_E	1.632	1.00
44_L	191_V	1.620	1.00
11_F	42_T	1.594	1.00
199_L	220_L	1.582	1.00
178_T	200_R	1.581	1.00
111_D	115_D	1.580	1.00
44_L	157_L	1.570	1.00
217_G	222_M	1.549	1.00
119_A	124_E	1.541	1.00
125_S	128_R	1.518	1.00
115_D	123_L	1.508	1.00
6_H	21_N	1.508	1.00
9_K	51_V	1.506	1.00
11_F	16_A	1.498	1.00
192_T	198_A	1.480	1.00
9_K	54_D	1.466	1.00
22_L	206_V	1.450	1.00
116_E	120_L	1.441	1.00
93_A	129_E	1.439	1.00
97_A	110_I	1.433	1.00
93_A	128_R	1.413	1.00
10_L	54_D	1.410	1.00
214_V	228_N	1.407	1.00
152_D	186_R	1.406	1.00
64_E	67_S	1.397	1.00
115_D	119_A	1.395	1.00
117_L	150_A	1.387	1.00
120_L	183_L	1.369	1.00
8_S	18_N	1.364	1.00
228_N	231_V	1.358	1.00
28_S	203_E	1.350	1.00
4_F	22_L	1.347	1.00
61_A	76_R	1.344	1.00
97_A	114_I	1.338	1.00
7_V	53_H	1.301	1.00
24_F	30_S	1.299	1.00
59_R	64_E	1.293	1.00
93_A	111_D	1.284	1.00
130_R	134_Q	1.283	1.00
158_M	188_I	1.279	1.00
209_D	214_V	1.277	1.00
31_V	198_A	1.270	1.00
221_T	225_R	1.263	1.00
69_P	72_E	1.258	1.00
30_S	216_Q	1.253	1.00
4_F	47_I	1.252	1.00
229_D	233_Q	1.251	1.00
30_S	204_H	1.238	1.00
91_S	94_Q	1.234	1.00
118_M	128_R	1.234	1.00
49_R	52_E	1.228	1.00
25_Q	204_H	1.227	1.00
105_W	109_R	1.225	1.00
109_R	112_D	1.220	1.00
29_F	181_H	1.218	1.00
22_L	43_T	1.217	1.00
20_L	43_T	1.214	1.00
10_L	13_A	1.169	1.00
97_A	111_D	1.163	1.00
180_I	186_R	1.161	1.00
127_L	135_L	1.151	1.00
105_W	110_I	1.147	1.00
152_D	184_L	1.143	1.00
120_L	179_R	1.126	1.00
92_V	135_L	1.117	1.00
47_I	189_V	1.116	1.00
26_E	61_A	1.115	1.00
5_S	23_N	1.113	1.00
46_M	53_H	1.105	1.00
112_D	116_E	1.104	1.00
108_A	112_D	1.092	1.00
220_L	224_T	1.091	1.00
48_N	79_Y	1.088	1.00
17_V	46_M	1.066	1.00
93_A	114_I	1.066	1.00
94_Q	97_A	1.061	1.00
96_I	150_A	1.058	1.00
174_Q	197_E	1.051	1.00
119_A	125_S	1.047	1.00
229_D	232_R	1.044	1.00
95_N	147_R	1.044	1.00
231_V	235_F	1.044	1.00
32_L	43_T	1.033	1.00
5_S	21_N	1.029	1.00
116_E	119_A	1.028	1.00
109_R	113_R	1.024	1.00
4_F	43_T	1.023	1.00
232_R	236_G	1.017	1.00
29_F	188_I	1.007	1.00
107_R	111_D	1.007	1.00
110_I	114_I	1.000	1.00
96_I	118_M	0.999	1.00
43_T	208_M	0.997	1.00
91_S	129_E	0.997	1.00
106_S	110_I	0.990	1.00
80_A	158_M	0.976	1.00
70_V	73_L	0.975	1.00
107_R	110_I	0.970	1.00
45_K	51_V	0.970	1.00
29_F	202_A	0.965	1.00
178_T	181_H	0.964	1.00
93_A	115_D	0.959	1.00
101_Q	110_I	0.954	1.00
181_H	188_I	0.951	1.00
91_S	131_Y	0.946	1.00
135_L	143_V	0.943	1.00
171_G	175_Q	0.942	1.00
205_L	219_P	0.942	1.00
78_G	153_P	0.940	1.00
63_E	72_E	0.940	1.00
2_I	155_V	0.939	1.00
122_G	172_A	0.920	1.00
126_N	130_R	0.919	1.00
170_R	194_D	0.902	1.00
6_H	55_S	0.901	1.00
26_E	185_G	0.895	1.00
165_L	173_L	0.894	1.00
63_E	76_R	0.893	1.00
215_Q	226_P	0.893	1.00
156_L	186_R	0.891	1.00
176_E	179_R	0.886	1.00
121_L	146_A	0.882	1.00
181_H	203_E	0.881	1.00
158_M	177_M	0.878	1.00
32_L	189_V	0.876	1.00
113_R	117_L	0.876	1.00
219_P	230_F	0.875	1.00
32_L	206_V	0.872	1.00
78_G	148_A	0.868	1.00
4_F	58_I	0.865	1.00
221_T	224_T	0.862	1.00
233_Q	237_R	0.858	1.00
115_D	125_S	0.853	1.00
156_L	188_I	0.850	1.00
35_T	209_D	0.839	1.00
86_L	140_Q	0.839	1.00
29_F	190_L	0.833	1.00
209_D	233_Q	0.831	1.00
46_M	58_I	0.831	1.00
92_V	143_V	0.828	1.00
213_V	216_Q	0.827	1.00
9_K	42_T	0.825	1.00
90_W	98_T	0.824	1.00
215_Q	225_R	0.824	1.00
49_R	73_L	0.824	1.00
100_P	150_A	0.822	1.00
111_D	128_R	0.819	1.00
160_E	193_H	0.817	1.00
111_D	114_I	0.817	1.00
170_R	197_E	0.817	1.00
103_Q	151_A	0.816	1.00
80_A	145_V	0.808	1.00
7_V	46_M	0.808	1.00
117_L	146_A	0.802	1.00
48_N	157_L	0.802	1.00
215_Q	227_A	0.799	1.00
25_Q	187_T	0.798	1.00
10_L	16_A	0.796	1.00
124_E	127_L	0.793	1.00
97_A	101_Q	0.792	1.00
131_Y	134_Q	0.791	1.00
17_V	20_L	0.790	1.00
29_F	201_L	0.790	1.00
19_D	212_E	0.787	1.00
70_V	74_R	0.783	1.00
63_E	68_L	0.783	1.00
222_M	231_V	0.780	1.00
29_F	178_T	0.776	1.00
64_E	68_L	0.767	1.00
10_L	18_N	0.763	1.00
46_M	51_V	0.759	1.00
177_M	188_I	0.755	1.00
105_W	113_R	0.744	1.00
175_Q	178_T	0.740	1.00
112_D	115_D	0.734	1.00
100_P	104_K	0.731	1.00
226_P	231_V	0.729	1.00
57_E	66_R	0.726	1.00
230_F	233_Q	0.725	1.00
68_L	72_E	0.724	1.00
89_H	133_H	0.723	1.00
234_F	237_R	0.721	1.00
24_F	187_T	0.720	1.00
38_S	208_M	0.716	1.00
59_R	62_G	0.715	1.00
195_I	223_L	0.714	1.00
122_G	179_R	0.712	1.00
178_T	201_L	0.710	1.00
207_L	222_M	0.708	1.00
30_S	189_V	0.703	1.00
219_P	223_L	0.702	1.00
24_F	189_V	0.702	1.00
117_L	120_L	0.699	1.00
174_Q	200_R	0.697	1.00
53_H	66_R	0.691	1.00
101_Q	107_R	0.690	1.00
175_Q	200_R	0.690	1.00
24_F	155_V	0.689	1.00
132_P	143_V	0.686	1.00
33_I	195_I	0.685	1.00
33_I	198_A	0.682	1.00
82_Q	137_G	0.678	1.00
80_A	148_A	0.677	1.00
10_L	55_S	0.677	1.00
209_D	228_N	0.676	1.00
6_H	9_K	0.673	1.00
175_Q	179_R	0.673	1.00
20_L	213_V	0.670	1.00
45_K	50_L	0.667	1.00
190_L	202_A	0.666	1.00
19_D	55_S	0.664	1.00
28_S	216_Q	0.663	1.00
9_K	17_V	0.663	1.00
52_E	66_R	0.663	1.00
109_R	123_L	0.662	1.00
235_F	238_S	0.661	1.00
157_L	189_V	0.658	1.00
233_Q	236_G	0.658	1.00
199_L	219_P	0.658	1.00
116_E	152_D	0.657	1.00
99_V	151_A	0.654	1.00
68_L	73_L	0.646	1.00
155_V	187_T	0.646	1.00
154_Q	186_R	0.644	1.00
90_W	95_N	0.642	1.00
77_M	155_V	0.640	1.00
221_T	227_A	0.640	1.00
16_A	42_T	0.635	1.00
17_V	43_T	0.635	1.00
162_F	173_L	0.634	1.00
124_E	128_R	0.631	1.00
209_D	230_F	0.630	1.00
60_F	76_R	0.630	1.00
197_E	201_L	0.628	1.00
114_I	117_L	0.627	1.00
49_R	53_H	0.624	1.00
117_L	149_L	0.623	1.00
33_I	207_L	0.622	1.00
202_A	219_P	0.621	1.00
127_L	139_Q	0.620	1.00
199_L	223_L	0.617	1.00
99_V	147_R	0.612	1.00
2_I	47_I	0.608	1.00
49_R	70_V	0.603	1.00
209_D	212_E	0.603	1.00
192_T	197_E	0.601	1.00
78_G	151_A	0.601	1.00
137_G	142_R	0.601	1.00
32_L	208_M	0.599	1.00
57_E	67_S	0.599	1.00
202_A	205_L	0.596	1.00
118_M	123_L	0.596	1.00
172_A	175_Q	0.595	1.00
117_L	121_L	0.593	1.00
100_P	105_W	0.592	1.00
91_S	95_N	0.592	1.00
162_F	197_E	0.591	1.00
15_K	19_D	0.591	1.00
47_I	58_I	0.590	1.00
27_G	187_T	0.583	1.00
35_T	230_F	0.581	1.00
84_I	144_G	0.580	1.00
3_E	62_G	0.579	1.00
215_Q	231_V	0.578	1.00
46_M	54_D	0.576	1.00
2_I	60_F	0.576	1.00
177_M	190_L	0.575	1.00
128_R	131_Y	0.574	1.00
135_L	139_Q	0.571	1.00
23_N	216_Q	0.570	1.00
141_Q	164_A	0.569	1.00
207_L	226_P	0.569	1.00
231_V	234_F	0.569	1.00
36_S	160_E	0.568	1.00
48_N	77_M	0.567	1.00
95_N	132_P	0.567	1.00
111_D	129_E	0.564	1.00
190_L	201_L	0.564	1.00
41_S	45_K	0.560	1.00
237_R	240_L	0.560	1.00
181_H	185_G	0.558	1.00
123_L	127_L	0.558	1.00
83_S	140_Q	0.557	1.00
210_H	233_Q	0.557	1.00
100_P	103_Q	0.555	1.00
60_F	155_V	0.555	1.00
108_A	111_D	0.553	1.00
112_D	119_A	0.553	1.00
115_D	124_E	0.551	1.00
65_I	68_L	0.550	1.00
173_L	176_E	0.549	1.00
232_R	235_F	0.542	1.00
106_S	115_D	0.541	1.00
181_H	186_R	0.540	1.00
96_I	114_I	0.539	1.00
87_F	90_W	0.539	1.00
155_V	189_V	0.537	1.00
198_A	202_A	0.535	1.00
181_H	184_L	0.532	1.00
234_F	238_S	0.531	1.00
110_I	115_D	0.528	1.00
72_E	75_R	0.527	1.00
100_P	110_I	0.526	1.00
29_F	203_E	0.526	1.00
204_H	218_N	0.523	1.00
12_G	15_K	0.522	1.00
11_F	51_V	0.521	1.00
98_T	101_Q	0.521	1.00
223_L	226_P	0.520	1.00
169_T	172_A	0.518	1.00
230_F	234_F	0.518	1.00
98_T	102_L	0.515	1.00
18_N	210_H	0.515	1.00
237_R	241_G	0.515	1.00
136_S	139_Q	0.514	1.00
198_A	205_L	0.512	1.00
26_E	187_T	0.511	1.00
225_R	228_N	0.508	1.00
149_L	186_R	0.506	1.00
215_Q	222_M	0.506	1.00
71_L	74_R	0.503	1.00
49_R	66_R	0.503	1.00
158_M	190_L	0.501	1.00
14_Q	210_H	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3tuiC	2	0.9968	100	0.184	Contact Map
2yyzA	1	0.9708	100	0.192	Contact Map
1v43A	2	0.9383	100	0.193	Contact Map
2it1A	1	0.987	100	0.195	Contact Map
4u00A	1	0.7727	100	0.195	Contact Map
4yerA	2	0.8896	100	0.196	Contact Map
4f4cA	1	0.7175	100	0.196	Contact Map
1g291	4	0.9188	100	0.196	Contact Map
4ymuJ	2	0.7695	100	0.196	Contact Map
1z47A	2	0.961	100	0.197	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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