GREMLIN Database
YEHX - Putative osmoprotectant uptake system ATP-binding protein YehX
UniProt: P33360 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12010
Length: 308 (239)
Sequences: 93005 (55116)
Seq/√Len: 3565.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_S204_H3.4731.00
76_R154_Q2.9861.00
3_E23_N2.9781.00
15_K18_N2.9421.00
31_V202_A2.9161.00
6_H19_D2.8581.00
5_S57_E2.8391.00
57_E64_E2.7581.00
204_H216_Q2.7211.00
30_S206_V2.6951.00
127_L130_R2.5301.00
25_Q28_S2.4861.00
3_E59_R2.4491.00
10_L15_K2.4451.00
218_N221_T2.3831.00
217_G221_T2.3141.00
9_K46_M2.2491.00
18_N212_E2.2351.00
8_S15_K2.2341.00
8_S55_S2.2271.00
5_S59_R2.1871.00
61_A154_Q2.1751.00
8_S19_D2.0851.00
106_S109_R2.0601.00
206_V213_V2.0471.00
206_V216_Q2.0221.00
113_R152_D1.9771.00
120_L184_L1.9411.00
4_F7_V1.9271.00
115_D128_R1.9171.00
90_W94_Q1.8121.00
179_R183_L1.7671.00
26_E154_Q1.7561.00
93_A97_A1.6461.00
113_R116_E1.6321.00
44_L191_V1.6201.00
11_F42_T1.5941.00
199_L220_L1.5821.00
178_T200_R1.5811.00
111_D115_D1.5801.00
44_L157_L1.5701.00
217_G222_M1.5491.00
119_A124_E1.5411.00
125_S128_R1.5181.00
115_D123_L1.5081.00
6_H21_N1.5081.00
9_K51_V1.5061.00
11_F16_A1.4981.00
192_T198_A1.4801.00
9_K54_D1.4661.00
22_L206_V1.4501.00
116_E120_L1.4411.00
93_A129_E1.4391.00
97_A110_I1.4331.00
93_A128_R1.4131.00
10_L54_D1.4101.00
214_V228_N1.4071.00
152_D186_R1.4061.00
64_E67_S1.3971.00
115_D119_A1.3951.00
117_L150_A1.3871.00
120_L183_L1.3691.00
8_S18_N1.3641.00
228_N231_V1.3581.00
28_S203_E1.3501.00
4_F22_L1.3471.00
61_A76_R1.3441.00
97_A114_I1.3381.00
7_V53_H1.3011.00
24_F30_S1.2991.00
59_R64_E1.2931.00
93_A111_D1.2841.00
130_R134_Q1.2831.00
158_M188_I1.2791.00
209_D214_V1.2771.00
31_V198_A1.2701.00
221_T225_R1.2631.00
69_P72_E1.2581.00
30_S216_Q1.2531.00
4_F47_I1.2521.00
229_D233_Q1.2511.00
30_S204_H1.2381.00
91_S94_Q1.2341.00
118_M128_R1.2341.00
49_R52_E1.2281.00
25_Q204_H1.2271.00
105_W109_R1.2251.00
109_R112_D1.2201.00
29_F181_H1.2181.00
22_L43_T1.2171.00
20_L43_T1.2141.00
10_L13_A1.1691.00
97_A111_D1.1631.00
180_I186_R1.1611.00
127_L135_L1.1511.00
105_W110_I1.1471.00
152_D184_L1.1431.00
120_L179_R1.1261.00
92_V135_L1.1171.00
47_I189_V1.1161.00
26_E61_A1.1151.00
5_S23_N1.1131.00
46_M53_H1.1051.00
112_D116_E1.1041.00
108_A112_D1.0921.00
220_L224_T1.0911.00
48_N79_Y1.0881.00
17_V46_M1.0661.00
93_A114_I1.0661.00
94_Q97_A1.0611.00
96_I150_A1.0581.00
174_Q197_E1.0511.00
119_A125_S1.0471.00
229_D232_R1.0441.00
95_N147_R1.0441.00
231_V235_F1.0441.00
32_L43_T1.0331.00
5_S21_N1.0291.00
116_E119_A1.0281.00
109_R113_R1.0241.00
4_F43_T1.0231.00
232_R236_G1.0171.00
29_F188_I1.0071.00
107_R111_D1.0071.00
110_I114_I1.0001.00
96_I118_M0.9991.00
43_T208_M0.9971.00
91_S129_E0.9971.00
106_S110_I0.9901.00
80_A158_M0.9761.00
70_V73_L0.9751.00
107_R110_I0.9701.00
45_K51_V0.9701.00
29_F202_A0.9651.00
178_T181_H0.9641.00
93_A115_D0.9591.00
101_Q110_I0.9541.00
181_H188_I0.9511.00
91_S131_Y0.9461.00
135_L143_V0.9431.00
171_G175_Q0.9421.00
205_L219_P0.9421.00
78_G153_P0.9401.00
63_E72_E0.9401.00
2_I155_V0.9391.00
122_G172_A0.9201.00
126_N130_R0.9191.00
170_R194_D0.9021.00
6_H55_S0.9011.00
26_E185_G0.8951.00
165_L173_L0.8941.00
63_E76_R0.8931.00
215_Q226_P0.8931.00
156_L186_R0.8911.00
176_E179_R0.8861.00
121_L146_A0.8821.00
181_H203_E0.8811.00
158_M177_M0.8781.00
32_L189_V0.8761.00
113_R117_L0.8761.00
219_P230_F0.8751.00
32_L206_V0.8721.00
78_G148_A0.8681.00
4_F58_I0.8651.00
221_T224_T0.8621.00
233_Q237_R0.8581.00
115_D125_S0.8531.00
156_L188_I0.8501.00
35_T209_D0.8391.00
86_L140_Q0.8391.00
29_F190_L0.8331.00
209_D233_Q0.8311.00
46_M58_I0.8311.00
92_V143_V0.8281.00
213_V216_Q0.8271.00
9_K42_T0.8251.00
90_W98_T0.8241.00
215_Q225_R0.8241.00
49_R73_L0.8241.00
100_P150_A0.8221.00
111_D128_R0.8191.00
160_E193_H0.8171.00
111_D114_I0.8171.00
170_R197_E0.8171.00
103_Q151_A0.8161.00
80_A145_V0.8081.00
7_V46_M0.8081.00
117_L146_A0.8021.00
48_N157_L0.8021.00
215_Q227_A0.7991.00
25_Q187_T0.7981.00
10_L16_A0.7961.00
124_E127_L0.7931.00
97_A101_Q0.7921.00
131_Y134_Q0.7911.00
17_V20_L0.7901.00
29_F201_L0.7901.00
19_D212_E0.7871.00
70_V74_R0.7831.00
63_E68_L0.7831.00
222_M231_V0.7801.00
29_F178_T0.7761.00
64_E68_L0.7671.00
10_L18_N0.7631.00
46_M51_V0.7591.00
177_M188_I0.7551.00
105_W113_R0.7441.00
175_Q178_T0.7401.00
112_D115_D0.7341.00
100_P104_K0.7311.00
226_P231_V0.7291.00
57_E66_R0.7261.00
230_F233_Q0.7251.00
68_L72_E0.7241.00
89_H133_H0.7231.00
234_F237_R0.7211.00
24_F187_T0.7201.00
38_S208_M0.7161.00
59_R62_G0.7151.00
195_I223_L0.7141.00
122_G179_R0.7121.00
178_T201_L0.7101.00
207_L222_M0.7081.00
30_S189_V0.7031.00
219_P223_L0.7021.00
24_F189_V0.7021.00
117_L120_L0.6991.00
174_Q200_R0.6971.00
53_H66_R0.6911.00
101_Q107_R0.6901.00
175_Q200_R0.6901.00
24_F155_V0.6891.00
132_P143_V0.6861.00
33_I195_I0.6851.00
33_I198_A0.6821.00
82_Q137_G0.6781.00
80_A148_A0.6771.00
10_L55_S0.6771.00
209_D228_N0.6761.00
6_H9_K0.6731.00
175_Q179_R0.6731.00
20_L213_V0.6701.00
45_K50_L0.6671.00
190_L202_A0.6661.00
19_D55_S0.6641.00
28_S216_Q0.6631.00
9_K17_V0.6631.00
52_E66_R0.6631.00
109_R123_L0.6621.00
235_F238_S0.6611.00
157_L189_V0.6581.00
233_Q236_G0.6581.00
199_L219_P0.6581.00
116_E152_D0.6571.00
99_V151_A0.6541.00
68_L73_L0.6461.00
155_V187_T0.6461.00
154_Q186_R0.6441.00
90_W95_N0.6421.00
77_M155_V0.6401.00
221_T227_A0.6401.00
16_A42_T0.6351.00
17_V43_T0.6351.00
162_F173_L0.6341.00
124_E128_R0.6311.00
209_D230_F0.6301.00
60_F76_R0.6301.00
197_E201_L0.6281.00
114_I117_L0.6271.00
49_R53_H0.6241.00
117_L149_L0.6231.00
33_I207_L0.6221.00
202_A219_P0.6211.00
127_L139_Q0.6201.00
199_L223_L0.6171.00
99_V147_R0.6121.00
2_I47_I0.6081.00
49_R70_V0.6031.00
209_D212_E0.6031.00
192_T197_E0.6011.00
78_G151_A0.6011.00
137_G142_R0.6011.00
32_L208_M0.5991.00
57_E67_S0.5991.00
202_A205_L0.5961.00
118_M123_L0.5961.00
172_A175_Q0.5951.00
117_L121_L0.5931.00
100_P105_W0.5921.00
91_S95_N0.5921.00
162_F197_E0.5911.00
15_K19_D0.5911.00
47_I58_I0.5901.00
27_G187_T0.5831.00
35_T230_F0.5811.00
84_I144_G0.5801.00
3_E62_G0.5791.00
215_Q231_V0.5781.00
46_M54_D0.5761.00
2_I60_F0.5761.00
177_M190_L0.5751.00
128_R131_Y0.5741.00
135_L139_Q0.5711.00
23_N216_Q0.5701.00
141_Q164_A0.5691.00
207_L226_P0.5691.00
231_V234_F0.5691.00
36_S160_E0.5681.00
48_N77_M0.5671.00
95_N132_P0.5671.00
111_D129_E0.5641.00
190_L201_L0.5641.00
41_S45_K0.5601.00
237_R240_L0.5601.00
181_H185_G0.5581.00
123_L127_L0.5581.00
83_S140_Q0.5571.00
210_H233_Q0.5571.00
100_P103_Q0.5551.00
60_F155_V0.5551.00
108_A111_D0.5531.00
112_D119_A0.5531.00
115_D124_E0.5511.00
65_I68_L0.5501.00
173_L176_E0.5491.00
232_R235_F0.5421.00
106_S115_D0.5411.00
181_H186_R0.5401.00
96_I114_I0.5391.00
87_F90_W0.5391.00
155_V189_V0.5371.00
198_A202_A0.5351.00
181_H184_L0.5321.00
234_F238_S0.5311.00
110_I115_D0.5281.00
72_E75_R0.5271.00
100_P110_I0.5261.00
29_F203_E0.5261.00
204_H218_N0.5231.00
12_G15_K0.5221.00
11_F51_V0.5211.00
98_T101_Q0.5211.00
223_L226_P0.5201.00
169_T172_A0.5181.00
230_F234_F0.5181.00
98_T102_L0.5151.00
18_N210_H0.5151.00
237_R241_G0.5151.00
136_S139_Q0.5141.00
198_A205_L0.5121.00
26_E187_T0.5111.00
225_R228_N0.5081.00
149_L186_R0.5061.00
215_Q222_M0.5061.00
71_L74_R0.5031.00
49_R66_R0.5031.00
158_M190_L0.5011.00
14_Q210_H0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tuiC 2 0.9968 100 0.184 Contact Map
2yyzA 1 0.9708 100 0.192 Contact Map
1v43A 2 0.9383 100 0.193 Contact Map
2it1A 1 0.987 100 0.195 Contact Map
4u00A 1 0.7727 100 0.195 Contact Map
4yerA 2 0.8896 100 0.196 Contact Map
4f4cA 1 0.7175 100 0.196 Contact Map
1g291 4 0.9188 100 0.196 Contact Map
4ymuJ 2 0.7695 100 0.196 Contact Map
1z47A 2 0.961 100 0.197 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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