GREMLIN Database
MLRA - HTH-type transcriptional regulator MlrA
UniProt: P33358 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12008
Length: 243 (224)
Sequences: 1196 (869)
Seq/√Len: 58.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
167_V178_L4.0691.00
4_Y44_D3.8341.00
9_V47_I3.7721.00
12_L51_R3.4191.00
140_A174_D2.9121.00
129_Q132_Q2.8691.00
9_V50_I2.8371.00
9_V13_C2.5491.00
129_Q174_D2.5401.00
140_A200_N2.4561.00
139_L174_D2.4481.00
129_Q139_L2.4401.00
174_D177_R2.2291.00
84_Q107_R2.1211.00
139_L143_D2.1051.00
48_D51_R2.1011.00
147_I175_T2.0941.00
143_D174_D2.0451.00
165_A185_A2.0301.00
10_A17_P2.0281.00
43_N46_D1.9931.00
22_A25_R1.9471.00
16_N19_T1.9071.00
139_L196_A1.9061.00
53_I63_V1.8831.00
165_A190_W1.8501.00
24_Q34_R1.8270.99
21_R26_R1.8000.99
112_P116_L1.7920.99
129_Q177_R1.7810.99
35_T38_G1.7330.99
6_I32_P1.7220.99
92_L100_L1.6980.99
29_L53_I1.6690.99
132_Q139_L1.6380.99
54_K58_D1.5970.99
9_V30_L1.5950.99
132_Q140_A1.5920.99
53_I66_V1.5750.98
10_A22_A1.5540.98
24_Q32_P1.5470.98
204_P209_G1.5420.98
34_R38_G1.5230.98
132_Q196_A1.5210.98
108_G149_Y1.5130.98
132_Q177_R1.5050.98
13_C50_I1.4800.98
129_Q140_A1.4760.98
76_D219_N1.4660.98
174_D200_N1.4550.97
6_I24_Q1.4480.97
174_D196_A1.4300.97
22_A41_L1.4170.97
105_K109_Q1.4160.97
181_E184_I1.4160.97
129_Q196_A1.4150.97
105_K149_Y1.4140.97
66_V70_L1.4120.97
164_D191_R1.4090.97
165_A169_G1.4060.97
6_I34_R1.4030.97
137_A140_A1.3830.96
112_P115_T1.3760.96
140_A177_R1.3750.96
107_R120_L1.3570.96
62_Q100_L1.3510.96
125_R132_Q1.3410.96
5_T8_E1.3050.95
97_L209_G1.2910.95
111_Y120_L1.2770.94
108_G116_L1.2670.94
22_A30_L1.2630.94
15_I20_L1.2410.94
140_A143_D1.2160.93
53_I56_W1.2110.93
132_Q174_D1.2110.93
105_K152_I1.2110.93
49_R71_S1.2020.92
140_A172_I1.2000.92
139_L172_I1.1960.92
129_Q143_D1.1890.92
26_R42_F1.1820.92
99_S103_W1.1630.91
94_S99_S1.1610.91
52_E56_W1.1610.91
21_R27_Y1.1360.90
101_R105_K1.1360.90
217_G220_R1.1270.90
147_I179_W1.1150.89
125_R142_L1.1140.89
113_A170_W1.1080.89
149_Y152_I1.1060.89
167_V185_A1.1030.89
88_L100_L1.0940.88
158_R186_S1.0930.88
96_N99_S1.0890.88
33_Q36_D1.0760.88
53_I67_K1.0760.88
95_G141_I1.0730.87
103_W107_R1.0650.87
53_I70_L1.0580.87
29_L67_K1.0570.87
18_V38_G1.0500.86
32_P41_L1.0490.86
23_W26_R1.0440.86
44_D48_D1.0400.86
140_A196_A1.0340.85
21_R42_F1.0330.85
97_L141_I1.0240.85
26_R32_P1.0230.85
168_V196_A1.0220.85
165_A211_T1.0210.85
21_R32_P1.0200.85
6_I18_V1.0110.84
17_P39_H1.0110.84
15_I19_T1.0010.83
29_L57_I1.0010.83
53_I57_I0.9980.83
158_R178_L0.9930.83
121_F146_L0.9840.82
102_T202_L0.9790.82
81_W119_H0.9790.82
19_T39_H0.9780.82
154_L183_W0.9700.82
173_Q198_S0.9550.80
6_I21_R0.9520.80
22_A70_L0.9510.80
172_I178_L0.9460.80
129_Q172_I0.9460.80
154_L182_G0.9420.80
13_C32_P0.9420.80
218_E221_T0.9400.79
46_D67_K0.9390.79
179_W194_V0.9380.79
102_T105_K0.9320.79
132_Q143_D0.9270.78
18_V25_R0.9260.78
195_L199_L0.9240.78
50_I158_R0.9230.78
93_Q131_Q0.9220.78
104_I121_F0.9190.78
13_C66_V0.9150.78
80_G83_D0.9040.77
143_D177_R0.9040.77
22_A32_P0.9000.76
11_L167_V0.9000.76
132_Q200_N0.8990.76
18_V35_T0.8980.76
35_T39_H0.8960.76
20_L213_L0.8880.75
76_D102_T0.8840.75
29_L35_T0.8740.74
8_E11_L0.8710.74
142_L194_V0.8710.74
16_N63_V0.8690.74
70_L74_N0.8610.73
93_Q119_H0.8570.73
139_L177_R0.8520.72
125_R139_L0.8440.72
33_Q109_Q0.8420.71
18_V34_R0.8420.71
6_I42_F0.8400.71
9_V16_N0.8400.71
87_T94_S0.8380.71
23_W42_F0.8360.71
168_V214_V0.8300.70
140_A199_L0.8260.70
50_I80_G0.8240.70
52_E55_R0.8200.69
105_K141_I0.8160.69
76_D210_R0.8120.69
29_L46_D0.8070.68
43_N94_S0.8060.68
18_V56_W0.7980.67
83_D208_E0.7970.67
115_T119_H0.7970.67
132_Q172_I0.7960.67
205_E225_Q0.7960.67
20_L25_R0.7950.67
125_R143_D0.7940.67
75_V79_N0.7770.65
113_A180_L0.7730.65
141_I145_V0.7690.64
165_A171_N0.7670.64
100_L145_V0.7660.64
8_E13_C0.7640.64
23_W40_R0.7600.64
24_Q27_Y0.7550.63
86_E127_R0.7530.63
169_G174_D0.7510.63
33_Q46_D0.7460.62
47_I137_A0.7460.62
164_D210_R0.7450.62
177_R196_A0.7450.62
29_L59_N0.7430.62
182_G192_I0.7380.61
37_G57_I0.7360.61
139_L169_G0.7340.61
114_Q188_Q0.7290.60
188_Q222_S0.7260.60
18_V22_A0.7250.60
13_C22_A0.7240.60
162_G191_R0.7230.60
48_D94_S0.7230.60
212_L223_A0.7220.60
158_R185_A0.7180.59
5_T47_I0.7110.58
90_T176_T0.7110.58
22_A34_R0.7070.58
210_R219_N0.7050.58
125_R174_D0.7010.57
88_L124_L0.6960.57
42_F50_I0.6950.57
18_V39_H0.6940.57
143_D196_A0.6930.56
144_G194_V0.6910.56
20_L92_L0.6900.56
140_A197_H0.6890.56
166_L170_W0.6880.56
61_V66_V0.6870.56
7_G18_V0.6860.56
72_N89_L0.6820.55
59_N66_V0.6820.55
43_N85_Q0.6810.55
26_R60_G0.6810.55
32_P42_F0.6770.55
182_G194_V0.6760.55
36_D120_L0.6750.54
109_Q156_S0.6730.54
176_T197_H0.6730.54
54_K57_I0.6720.54
12_L85_Q0.6710.54
52_E74_N0.6690.54
20_L42_F0.6680.54
128_L186_S0.6660.53
172_I196_A0.6650.53
137_A202_L0.6630.53
5_T41_L0.6590.53
216_C221_T0.6580.53
116_L120_L0.6560.52
79_N103_W0.6530.52
37_G67_K0.6480.52
4_Y12_L0.6460.51
37_G92_L0.6440.51
128_L140_A0.6440.51
206_L228_L0.6420.51
148_N151_A0.6390.51
202_L205_E0.6370.50
57_I69_L0.6350.50
105_K165_A0.6350.50
11_L44_D0.6320.50
102_T156_S0.6320.50
95_G206_L0.6300.50
46_D49_R0.6290.49
16_N34_R0.6280.49
137_A200_N0.6280.49
104_I145_V0.6270.49
16_N47_I0.6270.49
104_I152_I0.6270.49
169_G181_E0.6260.49
14_D26_R0.6240.49
39_H66_V0.6220.49
6_I38_G0.6180.48
169_G172_I0.6180.48
13_C37_G0.6160.48
206_L223_A0.6150.48
107_R197_H0.6150.48
180_L184_I0.6120.48
66_V181_E0.6080.47
10_A39_H0.6040.47
21_R24_Q0.6020.46
114_Q187_Q0.5990.46
10_A193_D0.5980.46
51_R58_D0.5970.46
101_R118_T0.5970.46
137_A174_D0.5970.46
160_K163_K0.5960.46
165_A191_R0.5960.46
118_T184_I0.5920.45
5_T39_H0.5920.45
24_Q132_Q0.5910.45
127_R131_Q0.5890.45
168_V171_N0.5890.45
84_Q87_T0.5880.45
157_A199_L0.5850.45
56_W199_L0.5830.44
56_W61_V0.5800.44
76_D94_S0.5790.44
166_L169_G0.5740.43
211_T215_W0.5740.43
26_R34_R0.5730.43
5_T112_P0.5720.43
18_V70_L0.5700.43
97_L124_L0.5700.43
58_D163_K0.5600.42
176_T183_W0.5550.41
156_S165_A0.5550.41
18_V66_V0.5490.41
39_H53_I0.5480.41
21_R60_G0.5460.40
82_R94_S0.5450.40
45_A205_E0.5410.40
110_D155_A0.5350.39
221_T226_Q0.5350.39
26_R40_R0.5340.39
45_A71_S0.5340.39
23_W27_Y0.5330.39
145_V149_Y0.5330.39
8_E213_L0.5310.39
108_G112_P0.5300.39
208_E228_L0.5270.38
19_T23_W0.5260.38
17_P25_R0.5230.38
151_A182_G0.5220.38
201_Q216_C0.5170.37
14_D21_R0.5150.37
71_S226_Q0.5140.37
20_L117_T0.5140.37
48_D167_V0.5130.37
126_R130_C0.5120.37
161_Q166_L0.5120.37
59_N163_K0.5120.37
120_L178_L0.5120.37
52_E67_K0.5110.37
76_D212_L0.5110.37
161_Q167_V0.5100.37
76_D137_A0.5070.36
175_T194_V0.5050.36
50_I224_Q0.5040.36
74_N121_F0.5040.36
27_Y42_F0.5040.36
212_L215_W0.5030.36
57_I61_V0.5020.36
87_T208_E0.5020.36
20_L26_R0.5010.36
15_I54_K0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3whpA 1 0.6626 100 0.428 Contact Map
3ezxA 2 0.6626 99.7 0.724 Contact Map
1y80A 1 0.3498 99.7 0.726 Contact Map
2i2xB 1 0.8107 99.7 0.727 Contact Map
4hh0A 2 0.9095 99.7 0.737 Contact Map
4jgiA 2 0.6543 99.7 0.738 Contact Map
3hh0A 4 0.535 99.7 0.739 Contact Map
3bulA 1 0.6831 99.7 0.739 Contact Map
2zhgA 2 0.4733 99.7 0.74 Contact Map
2dg6A 2 0.7449 99.7 0.741 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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