GREMLIN Database
YEHL - Uncharacterized protein YehL
UniProt: P33348 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11998
Length: 362 (285)
Sequences: 10737 (6158)
Seq/√Len: 364.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_G53_Q4.0951.00
46_F113_S2.9341.00
312_E315_D2.8751.00
339_F342_R2.7751.00
115_T118_Q2.7621.00
329_E332_R2.6021.00
308_N312_E2.5701.00
38_L41_P2.4521.00
45_A50_D2.2961.00
145_Q149_D2.2231.00
309_R312_E2.2171.00
321_A324_I2.1521.00
236_E239_A2.1381.00
234_E264_V2.1231.00
231_F268_R2.1051.00
308_N315_D2.0891.00
324_I328_N2.0831.00
231_F264_V2.0771.00
236_E240_S2.0471.00
299_V302_R2.0071.00
131_H135_T1.9921.00
145_Q148_R1.9431.00
325_V328_N1.9031.00
309_R313_P1.9021.00
65_A68_R1.8761.00
336_R340_E1.8541.00
229_M233_Q1.8431.00
332_R336_R1.8371.00
329_E333_A1.7431.00
314_A318_E1.7071.00
331_D334_R1.7031.00
118_Q122_G1.6991.00
311_G315_D1.6921.00
331_D339_F1.6911.00
107_T110_G1.6841.00
321_A325_V1.6611.00
338_Y342_R1.6581.00
80_M158_I1.6561.00
269_D273_N1.6551.00
109_Q112_A1.6511.00
142_P146_G1.6451.00
302_R306_L1.6441.00
148_R177_V1.6241.00
311_G314_A1.6231.00
330_E334_R1.6211.00
291_E295_V1.6141.00
298_A301_V1.6101.00
310_A314_A1.5921.00
290_A293_V1.5631.00
282_T286_I1.5621.00
320_I324_I1.5571.00
331_D338_Y1.5541.00
106_L109_Q1.5481.00
321_A328_N1.5341.00
54_N57_R1.5271.00
231_F265_R1.5241.00
117_D168_C1.5141.00
329_E336_R1.4771.00
235_L261_E1.4591.00
103_D110_G1.4531.00
223_E226_F1.4521.00
291_E299_V1.4471.00
115_T122_G1.4361.00
291_E294_N1.4331.00
333_A337_R1.4291.00
117_D122_G1.4261.00
289_T292_A1.4211.00
57_R98_T1.4191.00
239_A257_D1.4011.00
323_T327_D1.4001.00
335_L339_F1.4001.00
336_R339_F1.4001.00
116_E119_I1.3911.00
322_G326_K1.3771.00
335_L342_R1.3761.00
330_E333_A1.3631.00
295_V298_A1.3571.00
313_P316_L1.3551.00
293_V296_A1.3551.00
331_D342_R1.3511.00
332_R339_F1.3481.00
109_Q113_S1.3461.00
37_Q41_P1.3431.00
310_A313_P1.3361.00
308_N311_G1.3301.00
308_N313_P1.3121.00
320_I328_N1.3051.00
327_D331_D1.2811.00
320_I323_T1.2801.00
315_D320_I1.2791.00
44_R47_I1.2771.00
326_K329_E1.2701.00
323_T326_K1.2661.00
39_S142_P1.2661.00
322_G325_V1.2581.00
288_S292_A1.2541.00
329_E339_F1.2531.00
30_A33_P1.2361.00
49_G52_A1.2361.00
277_K280_M1.2361.00
50_D53_Q1.2201.00
276_K281_D1.2121.00
116_E122_G1.2111.00
114_T122_G1.2081.00
328_N332_R1.2081.00
292_A295_V1.2071.00
295_V299_V1.2061.00
309_R315_D1.2031.00
277_K281_D1.1991.00
293_V299_V1.1981.00
276_K280_M1.1921.00
337_R341_Q1.1901.00
276_K282_T1.1861.00
334_R338_Y1.1861.00
312_E316_L1.1821.00
243_A247_A1.1691.00
116_E121_Y1.1661.00
281_D285_A1.1661.00
30_A36_W1.1611.00
35_G38_L1.1491.00
34_P37_Q1.1481.00
324_I327_D1.1461.00
291_E298_A1.1391.00
56_S63_P1.1381.00
155_F198_I1.1351.00
263_L266_T1.1291.00
296_A299_V1.1281.00
146_G153_V1.1241.00
231_F235_L1.1241.00
262_L266_T1.1231.00
336_R342_R1.1201.00
299_V303_A1.1171.00
68_R71_V1.1121.00
158_I210_N1.1121.00
316_L321_A1.1001.00
333_A336_R1.1001.00
65_A92_L1.0941.00
261_E265_R1.0901.00
279_S282_T1.0871.00
115_T121_Y1.0841.00
292_A299_V1.0761.00
145_Q153_V1.0751.00
319_C323_T1.0731.00
50_D55_I1.0571.00
276_K279_S1.0471.00
337_R340_E1.0431.00
280_M285_A1.0361.00
278_T281_D1.0341.00
282_T285_A1.0331.00
72_T79_L1.0321.00
297_H301_V1.0291.00
277_K285_A1.0231.00
262_L267_F1.0231.00
40_L43_A1.0171.00
69_M223_E1.0131.00
178_M196_F1.0121.00
307_A311_G1.0051.00
277_K282_T1.0011.00
199_I203_N0.9951.00
31_P34_P0.9941.00
93_S199_I0.9941.00
105_G109_Q0.9921.00
144_Y147_M0.9911.00
110_G113_S0.9881.00
307_A314_A0.9881.00
289_T293_V0.9871.00
256_P259_V0.9851.00
117_D120_K0.9841.00
142_P147_M0.9821.00
321_A327_D0.9811.00
130_N133_P0.9781.00
116_E120_K0.9771.00
115_T120_K0.9771.00
300_G303_A0.9771.00
288_S291_E0.9751.00
32_C35_G0.9661.00
325_V329_E0.9661.00
33_P36_W0.9621.00
310_A316_L0.9621.00
335_L338_Y0.9591.00
294_N297_H0.9581.00
307_A310_A0.9551.00
177_V196_F0.9441.00
154_R201_T0.9411.00
283_L287_M0.9401.00
72_T223_E0.9401.00
296_A300_G0.9391.00
59_V62_S0.9391.00
235_L264_V0.9381.00
315_D321_A0.9351.00
278_T285_A0.9341.00
267_F270_L0.9321.00
118_Q121_Y0.9221.00
292_A298_A0.9171.00
315_D324_I0.9171.00
255_V288_S0.9131.00
56_S98_T0.9091.00
311_G316_L0.9081.00
235_L239_A0.8981.00
294_N298_A0.8931.00
68_R73_L0.8861.00
308_N316_L0.8861.00
333_A339_F0.8831.00
328_N336_R0.8821.00
106_L110_G0.8791.00
298_A302_R0.8771.00
328_N331_D0.8771.00
235_L260_L0.8761.00
308_N314_A0.8761.00
38_L43_A0.8731.00
280_M286_I0.8731.00
33_P37_Q0.8691.00
293_V298_A0.8681.00
60_V240_S0.8681.00
301_V305_F0.8621.00
31_P38_L0.8601.00
329_E335_L0.8581.00
279_S285_A0.8571.00
294_N299_V0.8531.00
328_N339_F0.8491.00
308_N327_D0.8471.00
108_I113_S0.8451.00
197_N203_N0.8421.00
46_F49_G0.8411.00
277_K284_T0.8381.00
41_P49_G0.8301.00
291_E296_A0.8271.00
58_K98_T0.8231.00
98_T102_G0.8191.00
241_A244_R0.8181.00
239_A260_L0.8161.00
298_A303_A0.8151.00
295_V301_V0.8111.00
319_C324_I0.8101.00
48_L52_A0.7991.00
334_R339_F0.7981.00
321_A342_R0.7961.00
307_A315_D0.7951.00
292_A297_H0.7951.00
146_G149_D0.7931.00
140_P143_L0.7901.00
204_T224_T0.7891.00
30_A34_P0.7891.00
319_C322_G0.7861.00
142_P145_Q0.7851.00
338_Y341_Q0.7841.00
41_P44_R0.7791.00
144_Y172_M0.7781.00
130_N137_A0.7771.00
318_E321_A0.7771.00
325_V338_Y0.7751.00
276_K285_A0.7751.00
331_D335_L0.7751.00
332_R338_Y0.7681.00
263_L271_R0.7681.00
322_G328_N0.7641.00
108_I111_G0.7641.00
263_L267_F0.7611.00
315_D319_C0.7561.00
321_A339_F0.7561.00
69_M96_L0.7561.00
290_A296_A0.7561.00
332_R335_L0.7531.00
297_H300_G0.7501.00
217_K222_F0.7481.00
267_F271_R0.7451.00
34_P38_L0.7441.00
46_F50_D0.7431.00
117_D121_Y0.7411.00
320_I325_V0.7411.00
158_I200_A0.7411.00
161_T169_L0.7401.00
334_R342_R0.7371.00
327_D330_E0.7371.00
85_P217_K0.7361.00
274_G279_S0.7341.00
259_V263_L0.7331.00
207_R213_S0.7331.00
45_A49_G0.7301.00
333_A338_Y0.7281.00
30_A37_Q0.7271.00
93_S154_R0.7241.00
260_L264_V0.7231.00
97_A152_I0.7201.00
281_D286_I0.7130.99
316_L319_C0.7130.99
279_S284_T0.7120.99
297_H302_R0.7110.99
325_V339_F0.7070.99
302_R305_F0.7060.99
309_R314_A0.7060.99
277_K286_I0.7040.99
204_T211_E0.7040.99
332_R337_R0.7030.99
41_P46_F0.7020.99
48_L51_E0.7020.99
325_V331_D0.7000.99
322_G329_E0.7000.99
222_F225_V0.6980.99
31_P36_W0.6960.99
108_I112_A0.6940.99
84_E204_T0.6940.99
90_S156_E0.6870.99
316_L325_V0.6870.99
215_A219_R0.6870.99
330_E337_R0.6870.99
64_S68_R0.6830.99
106_L153_V0.6820.99
292_A296_A0.6820.99
43_A51_E0.6820.99
325_V342_R0.6820.99
288_S296_A0.6810.99
262_L270_L0.6770.99
318_E322_G0.6770.99
322_G327_D0.6760.99
32_C36_W0.6750.99
143_L146_G0.6700.99
279_S286_I0.6690.99
303_A306_L0.6670.99
329_E342_R0.6610.99
307_A312_E0.6600.99
201_T204_T0.6600.99
299_V305_F0.6550.99
278_T286_I0.6540.99
291_E297_H0.6530.99
293_V297_H0.6410.99
262_L265_R0.6400.99
300_G304_W0.6400.99
197_N201_T0.6390.99
326_K330_E0.6390.99
44_R48_L0.6380.99
327_D335_L0.6370.99
280_M284_T0.6360.99
34_P41_P0.6350.99
324_I342_R0.6350.99
296_A303_A0.6320.99
331_D337_R0.6300.99
321_A326_K0.6290.99
280_M287_M0.6270.99
233_Q236_E0.6270.99
263_L270_L0.6270.99
333_A342_R0.6240.99
319_C327_D0.6230.99
253_H270_L0.6220.99
329_E340_E0.6180.99
332_R342_R0.6130.98
43_A50_D0.6130.98
299_V304_W0.6120.98
105_G154_R0.6100.98
164_E167_D0.6080.98
47_I50_D0.6080.98
222_F226_F0.6050.98
320_I342_R0.6040.98
296_A302_R0.6040.98
320_I327_D0.6020.98
225_V228_I0.6020.98
266_T270_L0.6010.98
74_A108_I0.5990.98
278_T284_T0.5970.98
231_F272_A0.5960.98
309_R316_L0.5950.98
292_A300_G0.5940.98
58_K62_S0.5940.98
132_G135_T0.5930.98
135_T139_V0.5910.98
247_A252_P0.5900.98
319_C325_V0.5880.98
323_T328_N0.5870.98
297_H303_A0.5860.98
296_A301_V0.5860.98
43_A46_F0.5820.98
233_Q237_L0.5770.98
264_V271_R0.5760.98
106_L113_S0.5740.98
276_K284_T0.5730.98
307_A318_E0.5720.98
264_V267_F0.5720.98
263_L284_T0.5720.98
297_H305_F0.5710.98
39_S42_A0.5710.98
298_A306_L0.5700.97
57_R62_S0.5690.97
38_L51_E0.5680.97
32_C37_Q0.5670.97
325_V336_R0.5670.97
63_P233_Q0.5650.97
39_S146_G0.5610.97
47_I51_E0.5610.97
208_G213_S0.5610.97
66_V95_L0.5580.97
36_W39_S0.5540.97
114_T117_D0.5500.97
54_N99_A0.5500.97
243_A262_L0.5490.97
36_W40_L0.5490.97
278_T282_T0.5480.97
45_A148_R0.5440.97
270_L274_G0.5440.97
279_S283_L0.5400.97
157_E203_N0.5400.97
106_L112_A0.5390.97
81_L225_V0.5340.96
82_V224_T0.5330.96
106_L111_G0.5330.96
48_L101_S0.5310.96
310_A315_D0.5300.96
244_R247_A0.5300.96
223_E227_P0.5290.96
329_E337_R0.5280.96
292_A301_V0.5270.96
311_G318_E0.5230.96
119_I143_L0.5180.96
34_P42_A0.5170.96
308_N318_E0.5170.96
333_A341_Q0.5160.96
282_T287_M0.5150.95
105_G108_I0.5150.95
281_D284_T0.5140.95
259_V262_L0.5130.95
264_V268_R0.5130.95
198_I203_N0.5120.95
321_A329_E0.5110.95
327_D342_R0.5100.95
71_V197_N0.5100.95
267_F273_N0.5090.95
327_D336_R0.5030.95
30_A38_L0.5010.95
143_L147_M0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3vkgA 2 0.9448 100 0.405 Contact Map
4rh7A 1 0.9006 100 0.432 Contact Map
4akgA 2 0.895 100 0.478 Contact Map
2r44A 1 0.8287 99.9 0.607 Contact Map
4r7yA 3 0.8343 99.9 0.631 Contact Map
1r6bX 1 0.837 99.9 0.635 Contact Map
3ja83 1 0.8343 99.9 0.637 Contact Map
3pxiA 3 0.779 99.9 0.641 Contact Map
1qvrA 3 0.826 99.9 0.643 Contact Map
1ofhA 3 0.7541 99.9 0.654 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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