GREMLIN Database
ADIY - HTH-type transcriptional regulator AdiY
UniProt: P33234 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11966
Length: 253 (228)
Sequences: 36775 (31661)
Seq/√Len: 2096.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
203_V236_Y3.2661.00
188_T196_T3.1961.00
156_E197_C3.0441.00
199_M236_Y2.9221.00
211_K219_S2.9081.00
154_I158_D2.8061.00
166_S176_P2.7211.00
201_Y204_N2.6891.00
196_T235_F2.5481.00
232_F243_Y2.5241.00
158_D161_K2.3311.00
151_V179_L2.2941.00
202_A228_F2.2471.00
205_E219_S2.2431.00
183_L193_I2.1661.00
205_E220_C2.0431.00
159_I197_C2.0011.00
211_K215_Q1.9591.00
164_N167_M1.9321.00
154_I171_C1.9051.00
238_M246_Q1.8811.00
19_W27_P1.8281.00
199_M235_F1.8241.00
155_I194_I1.8191.00
9_C44_I1.8031.00
191_S195_T1.7881.00
151_V172_L1.7811.00
205_E211_K1.7301.00
225_T229_I1.7191.00
212_N215_Q1.7111.00
121_L124_T1.6711.00
168_V190_Y1.6711.00
178_L182_K1.6591.00
203_V243_Y1.6431.00
19_W29_S1.6431.00
165_L180_K1.6261.00
231_V234_D1.6251.00
21_R27_P1.6141.00
31_K34_H1.6071.00
204_N208_M1.5871.00
153_Q157_S1.5831.00
201_Y205_E1.5731.00
17_D29_S1.5431.00
176_P180_K1.5421.00
188_T192_Q1.5291.00
214_S225_T1.5251.00
197_C201_Y1.5201.00
124_T128_R1.5151.00
179_L190_Y1.5081.00
190_Y194_I1.5011.00
156_E193_I1.5011.00
15_E52_N1.4921.00
154_I163_W1.4881.00
227_Y231_V1.4761.00
206_L213_I1.4521.00
159_I201_Y1.4451.00
145_N186_E1.4441.00
152_Y156_E1.4271.00
14_T54_L1.4231.00
238_M242_H1.4131.00
214_S218_Q1.4121.00
215_Q219_S1.4081.00
151_V168_V1.4051.00
120_A127_S1.3971.00
178_L181_K1.3761.00
120_A124_T1.3701.00
17_D31_K1.3691.00
155_I197_C1.3691.00
202_A220_C1.3661.00
241_L245_S1.3631.00
215_Q218_Q1.3591.00
189_S192_Q1.3561.00
98_F104_H1.3411.00
196_T200_R1.3391.00
201_Y220_C1.3351.00
180_K190_Y1.3351.00
177_S181_K1.3321.00
222_Y231_V1.3291.00
174_L178_L1.3281.00
216_V220_C1.3221.00
166_S170_S1.2501.00
226_S229_I1.2481.00
167_M171_C1.2471.00
174_L179_L1.2311.00
197_C200_R1.2311.00
209_D244_V1.2251.00
39_N42_N1.2231.00
195_T231_V1.2231.00
160_H219_S1.2191.00
230_S234_D1.2001.00
229_I239_T1.1921.00
175_S178_L1.1821.00
147_V174_L1.1661.00
203_V207_M1.1511.00
229_I241_L1.1471.00
24_G42_N1.1411.00
99_R103_Q1.1191.00
127_S131_D1.1151.00
165_L190_Y1.1131.00
117_R121_L1.1041.00
224_S230_S1.1021.00
154_I172_L1.1021.00
15_E32_A1.0921.00
200_R203_V1.0691.00
195_T234_D1.0661.00
211_K216_V1.0611.00
169_A176_P1.0571.00
182_K186_E1.0561.00
123_F127_S1.0421.00
19_W46_D1.0281.00
182_K185_S1.0191.00
116_E119_R1.0181.00
34_H89_T1.0171.00
96_D99_R1.0171.00
147_V172_L1.0071.00
146_C150_S1.0001.00
177_S180_K0.9871.00
98_F102_A0.9851.00
242_H245_S0.9851.00
14_T52_N0.9821.00
192_Q195_T0.9811.00
161_K167_M0.9801.00
163_W168_V0.9781.00
162_D167_M0.9721.00
239_T242_H0.9691.00
241_L244_V0.9691.00
149_D153_Q0.9691.00
152_Y193_I0.9681.00
168_V171_C0.9651.00
213_I216_V0.9651.00
229_I233_K0.9541.00
117_R124_T0.9531.00
154_I168_V0.9451.00
96_D100_V0.9421.00
205_E216_V0.9381.00
167_M170_S0.9361.00
105_S108_P0.9351.00
116_E120_A0.9321.00
165_L176_P0.9281.00
147_V182_K0.9271.00
120_A123_F0.9261.00
13_L18_V0.9251.00
150_S171_C0.9221.00
100_V103_Q0.9191.00
100_V104_H0.9141.00
115_K119_R0.9131.00
231_V235_F0.9121.00
162_D223_N0.9081.00
203_V232_F0.9031.00
160_H201_Y0.8971.00
174_L182_K0.8961.00
150_S153_Q0.8941.00
236_Y243_Y0.8881.00
119_R123_F0.8841.00
227_Y230_S0.8821.00
192_Q196_T0.8801.00
233_K239_T0.8771.00
195_T235_F0.8761.00
110_E114_E0.8751.00
155_I190_Y0.8731.00
148_S182_K0.8681.00
124_T127_S0.8641.00
22_V26_E0.8611.00
199_M231_V0.8571.00
183_L190_Y0.8541.00
18_V30_L0.8511.00
148_S186_E0.8491.00
148_S151_V0.8451.00
172_L179_L0.8441.00
95_P99_R0.8411.00
191_S227_Y0.8401.00
149_D152_Y0.8401.00
148_S152_Y0.8371.00
150_S172_L0.8331.00
242_H246_Q0.8321.00
209_D216_V0.8311.00
198_R220_C0.8311.00
111_T114_E0.8291.00
159_I194_I0.8221.00
159_I163_W0.8221.00
158_D171_C0.8211.00
103_Q107_M0.8191.00
21_R25_K0.8081.00
191_S194_I0.8071.00
102_A108_P0.7991.00
193_I197_C0.7981.00
192_Q235_F0.7851.00
152_Y183_L0.7841.00
206_L244_V0.7821.00
9_C57_H0.7791.00
199_M228_F0.7771.00
206_L216_V0.7761.00
60_H63_I0.7741.00
180_K189_S0.7671.00
181_K185_S0.7651.00
159_I220_C0.7621.00
202_A205_E0.7591.00
18_V29_S0.7581.00
238_M243_Y0.7581.00
218_Q223_N0.7551.00
20_I36_A0.7541.00
117_R120_A0.7501.00
224_S227_Y0.7501.00
147_V150_S0.7481.00
60_H64_K0.7461.00
159_I198_R0.7431.00
180_K191_S0.7431.00
207_M243_Y0.7421.00
180_K184_K0.7401.00
99_R102_A0.7391.00
144_R185_S0.7311.00
38_L44_I0.7311.00
145_N182_K0.7261.00
102_A106_M0.7261.00
96_D103_Q0.7211.00
101_A104_H0.7191.00
223_N227_Y0.7171.00
155_I193_I0.7171.00
158_D167_M0.7151.00
151_V190_Y0.7131.00
121_L125_V0.7121.00
12_L35_M0.7091.00
87_I90_L0.7071.00
116_E127_S0.7041.00
217_S225_T0.7031.00
104_H107_M0.7031.00
151_V154_I0.7011.00
163_W167_M0.7011.00
30_L36_A0.7001.00
11_V55_V0.6991.00
84_A87_I0.6981.00
48_S51_N0.6931.00
233_K242_H0.6931.00
151_V183_L0.6931.00
103_Q106_M0.6921.00
228_F232_F0.6801.00
195_T227_Y0.6801.00
86_P89_T0.6781.00
98_F101_A0.6771.00
225_T228_F0.6751.00
11_V20_I0.6741.00
188_T193_I0.6641.00
232_F238_M0.6571.00
168_V179_L0.6551.00
116_E123_F0.6551.00
121_L128_R0.6481.00
124_T129_F0.6451.00
102_A105_S0.6371.00
104_H108_P0.6351.00
184_K189_S0.6331.00
144_R147_V0.6321.00
65_D68_R0.6281.00
145_N149_D0.6281.00
200_R236_Y0.6251.00
226_S239_T0.6241.00
228_F240_P0.6241.00
212_N216_V0.6231.00
226_S230_S0.6231.00
95_P98_F0.6231.00
128_R131_D0.6141.00
199_M222_Y0.6131.00
165_L191_S0.6111.00
62_I65_D0.6111.00
67_L70_L0.6091.00
169_A172_L0.6061.00
97_V105_S0.6041.00
210_G216_V0.6031.00
163_W198_R0.6021.00
11_V36_A0.6011.00
13_L53_T0.5971.00
118_T121_L0.5941.00
216_V244_V0.5911.00
195_T199_M0.5901.00
97_V101_A0.5891.00
11_V38_L0.5871.00
148_S179_L0.5851.00
144_R186_E0.5851.00
205_E208_M0.5831.00
11_V53_T0.5821.00
168_V172_L0.5821.00
101_A105_S0.5801.00
151_V171_C0.5781.00
224_S234_D0.5741.00
13_L30_L0.5741.00
64_K68_R0.5741.00
154_I167_M0.5731.00
47_V51_N0.5721.00
222_Y227_Y0.5711.00
17_D48_S0.5711.00
68_R72_K0.5691.00
54_L57_H0.5671.00
20_I38_L0.5661.00
22_V25_K0.5641.00
97_V108_P0.5621.00
151_V182_K0.5601.00
117_R131_D0.5591.00
202_A216_V0.5591.00
22_V38_L0.5571.00
90_L93_L0.5571.00
155_I163_W0.5561.00
156_E201_Y0.5551.00
165_L177_S0.5551.00
123_F129_F0.5551.00
144_R178_L0.5551.00
110_E113_S0.5541.00
146_C186_E0.5541.00
151_V155_I0.5541.00
232_F236_Y0.5531.00
153_Q156_E0.5491.00
19_W48_S0.5491.00
204_N207_M0.5481.00
52_N55_V0.5471.00
200_R235_F0.5451.00
206_L243_Y0.5441.00
203_V238_M0.5421.00
208_M211_K0.5411.00
194_I197_C0.5401.00
163_W194_I0.5391.00
170_S173_C0.5381.00
192_Q234_D0.5381.00
231_V236_Y0.5371.00
94_T108_P0.5371.00
103_Q121_L0.5351.00
125_V129_F0.5341.00
10_I35_M0.5341.00
118_T129_F0.5321.00
168_V198_R0.5311.00
20_I44_I0.5311.00
35_M38_L0.5241.00
53_T57_H0.5191.00
21_R24_G0.5191.00
13_L34_H0.5171.00
117_R127_S0.5161.00
100_V108_P0.5121.00
149_D186_E0.5081.00
154_I159_I0.5061.00
10_I37_L0.5061.00
195_T222_Y0.5041.00
201_Y219_S0.5031.00
9_C38_L0.5011.00
21_R46_D0.5001.00
124_T131_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gbgA 1 0.9249 100 0.201 Contact Map
3mklA 1 0.4387 100 0.433 Contact Map
1bl0A 1 0.4348 100 0.438 Contact Map
3oouA 1 0.4111 100 0.438 Contact Map
3oioA 1 0.4387 100 0.442 Contact Map
3mn2A 1 0.415 100 0.445 Contact Map
2k9sA 1 0.415 99.9 0.453 Contact Map
3w6vA 1 0.4308 99.9 0.454 Contact Map
3lsgA 2 0.3992 99.9 0.461 Contact Map
1d5yA 1 0.4348 99.9 0.47 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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