GREMLIN Database
TORC - Cytochrome c-type protein TorC
UniProt: P33226 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11815
Length: 390 (366)
Sequences: 191 (119)
Seq/√Len: 6.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
237_K244_Q4.5460.97
43_S82_I4.2210.96
110_D114_K3.8710.93
82_I100_I3.5040.89
53_S103_T3.2720.85
20_L24_G3.1660.83
45_T76_E2.9960.79
99_D137_T2.9660.78
57_V122_L2.7890.74
139_R167_N2.7040.71
111_T114_K2.6620.70
168_Q340_H2.6460.69
234_K246_E2.5320.66
57_V99_D2.5070.65
92_R99_D2.5040.65
32_I43_S2.4540.63
30_A44_T2.4030.62
130_M171_I2.3670.60
112_P116_E2.2960.58
126_E129_R2.2860.58
108_S118_K2.1820.54
134_N169_S2.1470.53
19_A313_D2.1320.52
128_A204_D2.1240.52
36_H86_I2.0880.50
92_R122_L2.0720.50
354_I376_S2.0710.50
363_E371_L2.0700.50
199_A260_L2.0480.49
363_E367_L2.0330.48
195_L199_A2.0060.47
252_E345_G1.9880.47
61_Y67_F1.9560.46
318_W321_A1.9510.45
113_E231_S1.9340.45
70_A157_A1.9250.45
220_D242_W1.8940.43
49_V85_D1.8930.43
73_V160_M1.8900.43
245_I303_A1.8870.43
89_M92_R1.8850.43
249_G260_L1.8690.43
203_G367_L1.8660.42
313_D316_P1.8530.42
118_K126_E1.8430.42
98_N125_R1.8190.41
56_P112_P1.8190.41
57_V115_F1.8080.40
99_D122_L1.7930.40
18_L35_P1.7880.40
48_C51_C1.7600.39
47_F52_H1.7600.39
48_C52_H1.7600.39
47_F51_C1.7600.39
36_H89_M1.7370.38
169_S376_S1.7270.38
37_V86_I1.7260.38
131_K139_R1.7200.37
232_E247_I1.6620.35
233_V247_I1.6520.35
168_Q172_D1.6440.35
341_F374_N1.6360.35
134_N368_L1.6140.34
57_V261_T1.6070.34
158_R161_K1.5910.33
107_H132_E1.5890.33
64_S177_I1.5860.33
39_I78_H1.5790.33
19_A201_D1.5700.32
95_E99_D1.5630.32
153_H156_A1.5350.31
19_A260_L1.5340.31
139_R357_T1.5320.31
202_S237_K1.5320.31
43_S137_T1.5300.31
120_A143_N1.5290.31
92_R126_E1.5240.31
349_T357_T1.5220.31
36_H40_K1.5190.31
124_E259_V1.5140.31
86_I89_M1.5060.31
91_K94_L1.4910.30
97_S130_M1.4810.30
325_Y371_L1.4800.30
32_I35_P1.4730.30
139_R155_E1.4540.29
139_R143_N1.4490.29
39_I90_V1.4180.28
354_I364_E1.4080.28
115_F119_R1.4010.27
32_I89_M1.4000.27
144_Y169_S1.4000.27
342_D345_G1.3960.27
227_L250_W1.3950.27
34_L38_G1.3850.27
85_D88_G1.3840.27
286_K365_R1.3740.27
118_K121_E1.3710.27
338_I371_L1.3690.26
154_P204_D1.3680.26
33_V86_I1.3670.26
213_P308_G1.3640.26
180_Q368_L1.3260.25
160_M324_L1.3250.25
109_I367_L1.3210.25
152_Q375_A1.3190.25
251_T257_Q1.3190.25
92_R95_E1.3190.25
250_W289_V1.3150.25
165_K363_E1.2990.25
33_V43_S1.2890.24
227_L347_I1.2880.24
209_I347_I1.2700.24
319_A380_G1.2610.24
292_T325_Y1.2570.23
242_W306_K1.2520.23
125_R129_R1.2510.23
317_I374_N1.2500.23
120_A184_M1.2490.23
345_G350_L1.2460.23
75_A83_P1.2400.23
148_D352_G1.2360.23
342_D376_S1.2350.23
274_R315_K1.2330.23
268_I348_G1.2300.23
181_L292_T1.2290.23
148_D151_K1.2170.22
32_I38_G1.2150.22
67_F146_A1.2140.22
311_V328_T1.2040.22
325_Y350_L1.1970.22
224_S293_N1.1920.22
356_F368_L1.1900.22
169_S356_F1.1810.22
214_I303_A1.1800.22
24_G92_R1.1700.21
89_M137_T1.1670.21
41_V140_S1.1670.21
149_H160_M1.1650.21
102_Q108_S1.1640.21
347_I365_R1.1630.21
98_N108_S1.1620.21
152_Q367_L1.1610.21
320_Y375_A1.1550.21
21_V295_E1.1530.21
227_L299_L1.1430.21
139_R169_S1.1380.21
30_A194_E1.1380.21
315_K319_A1.1300.20
93_K179_H1.1290.20
93_K123_A1.1290.20
123_A179_H1.1290.20
347_I350_L1.1220.20
352_G376_S1.1150.20
232_E237_K1.1100.20
68_Q207_Y1.1090.20
55_Q59_E1.1080.20
224_S354_I1.1080.20
338_I342_D1.1070.20
97_S100_I1.1060.20
335_A363_E1.1040.20
19_A40_K1.0990.20
131_K198_S1.0980.20
354_I357_T1.0980.20
249_G270_V1.0980.20
35_P137_T1.0950.20
96_A255_G1.0870.19
35_P89_M1.0850.19
53_S311_V1.0850.19
201_D207_Y1.0830.19
57_V92_R1.0800.19
25_I31_L1.0730.19
169_S375_A1.0710.19
265_G271_A1.0650.19
317_I323_S1.0650.19
20_L225_G1.0640.19
103_T166_D1.0580.19
263_F378_T1.0490.18
45_T136_A1.0320.18
231_S373_M1.0320.18
89_M99_D1.0310.18
268_I292_T1.0290.18
128_A241_D1.0280.18
225_G293_N1.0240.18
121_E177_I1.0230.18
289_V292_T1.0190.18
130_M151_K1.0180.18
46_E238_R1.0170.18
73_V304_W1.0120.18
92_R376_S1.0100.18
139_R166_D1.0090.18
26_V41_V1.0070.18
119_R182_P1.0060.18
218_K239_D1.0030.18
160_M368_L0.9990.17
144_Y164_A0.9990.17
77_C80_C0.9950.17
77_C81_H0.9950.17
23_I31_L0.9930.17
159_Q374_N0.9930.17
21_V190_K0.9920.17
181_L250_W0.9870.17
165_K285_E0.9840.17
82_I303_A0.9830.17
212_K305_M0.9810.17
157_A373_M0.9740.17
238_R307_K0.9730.17
100_I104_F0.9690.17
59_E120_A0.9680.17
171_I317_I0.9680.17
199_A241_D0.9650.17
31_L38_G0.9640.17
99_D140_S0.9630.17
157_A194_E0.9620.17
342_D356_F0.9620.17
314_I317_I0.9590.17
34_L44_T0.9580.17
250_W292_T0.9540.17
256_R368_L0.9510.16
134_N375_A0.9490.16
43_S140_S0.9450.16
118_K122_L0.9430.16
40_K43_S0.9370.16
208_S247_I0.9350.16
345_G354_I0.9340.16
61_Y146_A0.9260.16
116_E119_R0.9240.16
244_Q302_T0.9230.16
70_A151_K0.9190.16
64_S121_E0.9170.16
15_W19_A0.9160.16
19_A90_V0.9150.16
159_Q273_I0.9140.16
164_A258_R0.9120.16
109_I193_D0.9050.16
61_Y110_D0.9020.16
128_A239_D0.9000.15
86_I121_E0.9000.15
252_E365_R0.8990.15
105_I366_T0.8970.15
342_D350_L0.8940.15
317_I355_G0.8910.15
251_T261_T0.8880.15
24_G87_P0.8750.15
118_K222_E0.8730.15
143_N270_V0.8710.15
46_E118_K0.8690.15
143_N249_G0.8680.15
213_P247_I0.8580.15
85_D145_D0.8580.15
98_N107_H0.8560.15
132_E246_E0.8560.15
125_R373_M0.8550.15
70_A320_Y0.8550.15
148_D377_D0.8540.15
177_I359_L0.8540.15
53_S122_L0.8540.15
356_F360_D0.8520.15
152_Q267_R0.8520.15
183_D189_R0.8520.15
66_H123_A0.8520.15
66_H179_H0.8520.15
66_H93_K0.8520.15
226_S295_E0.8490.15
73_V180_Q0.8470.14
347_I373_M0.8450.14
110_D165_K0.8450.14
193_D198_S0.8410.14
126_E342_D0.8390.14
250_W268_I0.8370.14
288_T311_V0.8350.14
139_R227_L0.8350.14
248_T305_M0.8340.14
53_S97_S0.8300.14
185_S334_G0.8300.14
250_W286_K0.8290.14
14_R305_M0.8290.14
124_E322_D0.8210.14
234_K302_T0.8180.14
99_D115_F0.8170.14
124_E158_R0.8160.14
54_M77_C0.8130.14
54_M80_C0.8130.14
54_M81_H0.8130.14
234_K319_A0.8100.14
190_K200_N0.8060.14
30_A281_V0.8020.14
145_D360_D0.8020.14
340_H344_N0.8000.14
207_Y244_Q0.7980.14
53_S202_S0.7960.14
101_Y320_Y0.7920.14
109_I195_L0.7910.14
348_G373_M0.7900.14
228_L335_A0.7900.14
130_M352_G0.7870.13
22_A361_K0.7870.13
57_V118_K0.7870.13
67_F140_S0.7860.13
146_A152_Q0.7860.13
53_S99_D0.7820.13
74_R343_A0.7800.13
84_P330_N0.7790.13
163_A258_R0.7780.13
116_E180_Q0.7780.13
91_K97_S0.7730.13
44_T85_D0.7690.13
362_R371_L0.7690.13
231_S270_V0.7680.13
300_Q315_K0.7660.13
157_A328_T0.7650.13
153_H164_A0.7650.13
181_L293_N0.7640.13
35_P90_V0.7620.13
288_T302_T0.7620.13
95_E125_R0.7610.13
280_Q301_A0.7610.13
71_S108_S0.7520.13
163_A371_L0.7520.13
169_S267_R0.7510.13
58_Y225_G0.7510.13
294_T297_S0.7460.13
30_A259_V0.7460.13
33_V37_V0.7420.13
82_I133_N0.7400.13
168_Q352_G0.7360.13
43_S57_V0.7360.13
107_H110_D0.7350.13
126_E252_E0.7330.13
346_W372_Q0.7320.13
56_P108_S0.7310.13
252_E348_G0.7250.12
28_G96_A0.7240.12
249_G285_E0.7230.12
32_I82_I0.7200.12
49_V113_E0.7180.12
257_Q336_P0.7180.12
53_S180_Q0.7160.12
78_H281_V0.7120.12
131_K194_E0.7110.12
203_G238_R0.7090.12
134_N320_Y0.7080.12
27_I31_L0.7070.12
233_V241_D0.7060.12
252_E256_R0.7020.12
90_V314_I0.7010.12
210_D305_M0.6990.12
342_D368_L0.6980.12
130_M378_T0.6970.12
288_T291_D0.6960.12
181_L348_G0.6940.12
311_V316_P0.6930.12
95_E98_N0.6920.12
58_Y235_V0.6910.12
25_I53_S0.6900.12
74_R146_A0.6890.12
36_H39_I0.6880.12
165_K262_Q0.6860.12
375_A378_T0.6840.12
49_V270_V0.6830.12
171_I320_Y0.6820.12
43_S103_T0.6820.12
124_E326_N0.6780.12
60_E119_R0.6700.12
42_T243_L0.6690.12
171_I334_G0.6670.12
334_G376_S0.6670.12
103_T124_E0.6670.12
169_S368_L0.6650.12
86_I140_S0.6650.12
144_Y376_S0.6640.12
22_A197_A0.6640.12
122_L189_R0.6640.12
352_G355_G0.6620.11
227_L337_E0.6610.11
115_F335_A0.6600.11
127_W182_P0.6570.11
176_G296_W0.6560.11
225_G321_A0.6550.11
53_S117_A0.6530.11
115_F137_T0.6510.11
57_V359_L0.6510.11
320_Y367_L0.6500.11
357_T364_E0.6490.11
68_Q148_D0.6480.11
148_D235_V0.6460.11
85_D207_Y0.6450.11
14_R271_A0.6430.11
32_I137_T0.6430.11
28_G42_T0.6430.11
152_Q169_S0.6420.11
202_S218_K0.6400.11
124_E232_E0.6400.11
137_T356_F0.6390.11
178_A182_P0.6390.11
36_H225_G0.6380.11
292_T343_A0.6370.11
33_V140_S0.6370.11
73_V368_L0.6360.11
117_A236_L0.6340.11
227_L266_K0.6280.11
69_N72_G0.6260.11
292_T348_G0.6250.11
160_M164_A0.6240.11
228_L274_R0.6210.11
201_D313_D0.6210.11
82_I101_Y0.6210.11
46_E94_L0.6200.11
66_H81_H0.6190.11
66_H80_C0.6190.11
66_H77_C0.6190.11
38_G78_H0.6170.11
100_I144_Y0.6170.11
115_F122_L0.6130.11
82_I99_D0.6110.11
134_N345_G0.6080.11
303_A351_N0.6060.11
206_L350_L0.6060.11
118_K247_I0.6030.11
41_V181_L0.6020.11
23_I104_F0.6000.11
264_P287_T0.5990.11
109_I202_S0.5990.11
23_I85_D0.5980.11
129_R257_Q0.5970.11
211_I261_T0.5950.11
228_L252_E0.5930.11
70_A378_T0.5930.11
118_K349_T0.5920.10
209_I266_K0.5910.10
252_E267_R0.5910.10
136_A140_S0.5900.10
222_E336_P0.5880.10
39_I286_K0.5870.10
241_D313_D0.5840.10
21_V193_D0.5840.10
100_I306_K0.5820.10
143_N355_G0.5810.10
135_S296_W0.5790.10
134_N144_Y0.5770.10
22_A328_T0.5770.10
109_I218_K0.5760.10
39_I357_T0.5740.10
118_K261_T0.5740.10
102_Q159_Q0.5730.10
233_V284_L0.5710.10
219_G284_L0.5670.10
13_A124_E0.5670.10
26_V30_A0.5660.10
350_L364_E0.5660.10
18_L358_S0.5650.10
88_G143_N0.5650.10
161_K165_K0.5620.10
89_M160_M0.5580.10
350_L356_F0.5570.10
251_T297_S0.5570.10
103_T122_L0.5560.10
100_I350_L0.5550.10
284_L341_F0.5540.10
131_K345_G0.5540.10
51_C77_C0.5540.10
51_C80_C0.5540.10
51_C81_H0.5540.10
47_F77_C0.5540.10
47_F80_C0.5540.10
52_H80_C0.5540.10
52_H77_C0.5540.10
47_F81_H0.5540.10
52_H81_H0.5540.10
48_C80_C0.5540.10
48_C77_C0.5540.10
48_C81_H0.5540.10
211_I231_S0.5520.10
354_I359_L0.5510.10
227_L303_A0.5490.10
290_A347_I0.5480.10
169_S342_D0.5470.10
232_E283_T0.5450.10
228_L365_R0.5450.10
88_G133_N0.5450.10
349_T356_F0.5440.10
240_G313_D0.5430.10
248_T285_E0.5410.10
330_N339_A0.5410.10
60_E83_P0.5380.10
53_S305_M0.5370.10
230_A318_W0.5370.10
25_I352_G0.5350.10
329_C332_C0.5340.10
138_C170_C0.5340.10
174_H332_C0.5340.10
174_H329_C0.5340.10
170_C332_C0.5340.10
170_C329_C0.5340.10
173_C333_H0.5340.10
173_C332_C0.5340.10
173_C329_C0.5340.10
170_C174_H0.5340.10
329_C333_H0.5340.10
170_C173_C0.5340.10
174_H333_H0.5340.10
170_C333_H0.5340.10
141_C174_H0.5340.10
141_C329_C0.5340.10
141_C332_C0.5340.10
141_C333_H0.5340.10
142_H170_C0.5340.10
142_H173_C0.5340.10
142_H174_H0.5340.10
142_H329_C0.5340.10
142_H332_C0.5340.10
142_H333_H0.5340.10
141_C173_C0.5340.10
141_C170_C0.5340.10
138_C333_H0.5340.10
138_C174_H0.5340.10
138_C141_C0.5340.10
138_C142_H0.5340.10
138_C173_C0.5340.10
138_C329_C0.5340.10
138_C332_C0.5340.10
88_G352_G0.5340.10
26_V316_P0.5340.10
73_V356_F0.5290.10
295_E380_G0.5280.10
278_Q347_I0.5230.10
155_E227_L0.5230.10
49_V91_K0.5220.10
86_I136_A0.5210.10
103_T107_H0.5200.10
305_M309_D0.5200.10
23_I299_L0.5200.10
14_R295_E0.5180.10
35_P281_V0.5160.10
85_D167_N0.5150.09
230_A330_N0.5120.09
129_R251_T0.5100.09
330_N370_Y0.5090.09
289_V310_M0.5070.09
144_Y375_A0.5060.09
266_K377_D0.5050.09
234_K323_S0.5020.09
213_P263_F0.5020.09
285_E341_F0.5020.09
245_I339_A0.5020.09
154_P238_R0.5010.09
42_T51_C0.5000.09
42_T47_F0.5000.09
42_T52_H0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2j7aC 2 0.3692 100 0.781 Contact Map
4fasA 3 0.841 99.9 0.873 Contact Map
1oahA 2 0.6795 99.8 0.876 Contact Map
1sp3A 1 0.7974 99.8 0.877 Contact Map
2j7aA 5 0.6077 99.8 0.886 Contact Map
3u99A 1 0.1513 99.8 0.889 Contact Map
2fw5A 1 0.1897 99.7 0.893 Contact Map
2fwtA 1 0.1641 99.7 0.893 Contact Map
3ucpA 1 0.6718 99.6 0.906 Contact Map
4lm8A 1 0.8436 99.5 0.908 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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