GREMLIN Database
TORA - Trimethylamine-N-oxide reductase 1
UniProt: P33225 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11814
Length: 848 (688)
Sequences: 8586 (5456)
Seq/√Len: 208.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
102_Y128_R5.8611.00
735_I754_A4.6551.00
136_D573_R4.4881.00
742_R816_E4.3661.00
739_D817_K3.9111.00
561_R569_E3.7601.00
308_E360_R3.4201.00
141_E144_R3.3711.00
742_R749_Q3.3671.00
342_A352_A3.3541.00
300_A344_A3.3231.00
729_D763_G3.2821.00
690_L733_R3.2281.00
565_D569_E3.1371.00
552_Q555_P3.0351.00
304_T308_E3.0121.00
137_M523_I2.9541.00
313_K317_A2.9171.00
728_Q762_P2.9111.00
144_R148_T2.8921.00
744_F816_E2.8791.00
509_A521_A2.8761.00
138_F523_I2.8671.00
135_L573_R2.8421.00
107_V127_V2.7991.00
303_H307_S2.7951.00
321_V648_S2.7881.00
744_F814_E2.7441.00
130_S133_E2.6911.00
145_V153_A2.6631.00
297_L348_T2.6611.00
745_N813_V2.6571.00
585_D588_G2.6111.00
725_I754_A2.6061.00
741_V754_A2.5821.00
264_E361_Q2.5741.00
345_E352_A2.5721.00
285_K357_G2.5711.00
720_K753_G2.5571.00
228_W298_Q2.5551.00
302_A394_M2.5511.00
725_I815_I2.5471.00
129_V523_I2.5191.00
102_Y559_E2.5091.00
311_Y316_L2.4841.00
351_D354_T2.4721.00
105_V137_M2.4311.00
354_T357_G2.4281.00
223_K367_T2.4051.00
730_A756_V2.4021.00
105_V129_V2.3801.00
302_A326_F2.3711.00
352_A356_R2.3601.00
105_V523_I2.3481.00
135_L569_E2.3401.00
648_S652_E2.3121.00
340_D343_W2.3071.00
314_N318_N2.2691.00
733_R814_E2.2541.00
142_L479_M2.2521.00
309_N313_K2.2451.00
744_F749_Q2.2351.00
732_A762_P2.2091.00
493_Q796_D2.1751.00
222_S225_I2.1561.00
357_G361_Q2.1161.00
137_M141_E2.1111.00
737_N756_V2.1041.00
138_F508_I2.0801.00
128_R559_E2.0741.00
735_I741_V2.0731.00
221_N401_P2.0721.00
723_V765_A2.0551.00
145_V479_M2.0481.00
723_V741_V2.0281.00
569_E573_R2.0241.00
129_V137_M1.9891.00
752_A767_I1.9741.00
723_V767_I1.9731.00
63_R78_E1.9561.00
224_T361_Q1.9541.00
267_S279_L1.9481.00
478_K505_E1.9441.00
740_V751_L1.9321.00
287_I358_L1.9321.00
224_T266_I1.9311.00
287_I350_I1.9241.00
557_Q560_A1.9231.00
285_K354_T1.9031.00
742_R751_L1.8961.00
297_L355_I1.8871.00
303_H341_A1.8711.00
613_D617_N1.8441.00
737_N755_V1.8331.00
293_T347_L1.8251.00
105_V127_V1.8231.00
306_Y323_F1.8231.00
610_A613_D1.7991.00
723_V743_V1.7931.00
342_A356_R1.7651.00
136_D140_E1.7651.00
104_M524_V1.7531.00
690_L765_A1.7521.00
499_E502_R1.7481.00
223_K365_N1.7421.00
725_I765_A1.7371.00
514_W518_C1.7321.00
101_R558_F1.7291.00
498_I502_R1.7241.00
304_T360_R1.7221.00
400_L403_G1.7041.00
308_E356_R1.6991.00
362_M395_L1.6821.00
310_L363_A1.6641.00
728_Q731_S1.6611.00
481_I510_I1.6501.00
143_E147_K1.6491.00
569_E572_R1.6451.00
285_K361_Q1.6401.00
534_N552_Q1.6391.00
740_V753_G1.6381.00
750_V767_I1.6371.00
345_E351_D1.6321.00
304_T341_A1.6171.00
226_V268_I1.6171.00
504_L507_V1.6161.00
724_F757_S1.6131.00
304_T356_R1.6001.00
360_R364_A1.5951.00
690_L729_D1.5951.00
268_I297_L1.5901.00
254_L263_I1.5871.00
345_E355_I1.5861.00
528_T562_N1.5851.00
129_V133_E1.5801.00
394_M653_I1.5791.00
310_L360_R1.5741.00
587_M591_K1.5691.00
142_L508_I1.5661.00
316_L323_F1.5631.00
765_A813_V1.5631.00
61_A80_D1.5621.00
107_V125_R1.5611.00
506_T523_I1.5611.00
138_F525_L1.5561.00
695_V766_R1.5521.00
446_S449_I1.5471.00
344_A355_I1.5471.00
685_S746_A1.5451.00
736_R739_D1.5391.00
297_L358_L1.5351.00
306_Y327_L1.5201.00
328_P337_Q1.4981.00
64_A71_F1.4981.00
149_H478_K1.4961.00
320_C653_I1.4891.00
296_P347_L1.4861.00
140_E144_R1.4851.00
307_S356_R1.4851.00
104_M128_R1.4791.00
305_L311_Y1.4781.00
311_Y323_F1.4601.00
551_K615_W1.4601.00
634_A637_E1.4501.00
482_F507_V1.4441.00
174_A181_G1.4401.00
440_S444_G1.4351.00
133_E137_M1.4251.00
304_T310_L1.4251.00
255_K284_V1.4181.00
306_Y330_L1.4171.00
65_T75_K1.4141.00
226_V358_L1.3881.00
307_S337_Q1.3881.00
708_S711_L1.3781.00
137_M506_T1.3771.00
690_L814_E1.3681.00
224_T358_L1.3661.00
509_A518_C1.3651.00
285_K358_L1.3641.00
103_P131_W1.3621.00
143_E146_Q1.3511.00
733_R815_I1.3511.00
272_V277_E1.3481.00
727_P758_D1.3451.00
620_Y623_F1.3431.00
289_V350_I1.3421.00
656_K660_D1.3391.00
631_R635_F1.3341.00
612_D616_N1.3321.00
588_G591_K1.3321.00
301_L362_M1.3271.00
707_E711_L1.3221.00
146_Q154_L1.3141.00
339_K343_W1.3131.00
71_F94_V1.3081.00
49_S66_V1.3071.00
562_N565_D1.3071.00
375_V388_I1.3061.00
339_K347_L1.3041.00
514_W524_V1.3041.00
50_K63_R1.3041.00
267_S276_H1.3021.00
349_G761_A1.2981.00
155_L477_L1.2981.00
632_H635_F1.2961.00
442_Y446_S1.2941.00
726_N762_P1.2911.00
313_K327_L1.2911.00
270_P286_H1.2891.00
512_N529_T1.2851.00
305_L363_A1.2711.00
343_W346_K1.2691.00
218_V221_N1.2661.00
306_Y311_Y1.2641.00
325_Q328_P1.2621.00
133_E523_I1.2591.00
321_V652_E1.2571.00
723_V752_A1.2571.00
561_R565_D1.2541.00
625_H629_F1.2511.00
646_T652_E1.2501.00
253_Q256_A1.2411.00
48_I63_R1.2411.00
314_N317_A1.2391.00
304_T307_S1.2391.00
139_Y573_R1.2381.00
722_P755_V1.2291.00
339_K344_A1.2211.00
583_G588_G1.2141.00
266_I358_L1.2111.00
287_I354_T1.2091.00
572_R577_E1.2081.00
64_A74_A1.2081.00
591_K594_W1.2071.00
154_L479_M1.2051.00
70_R95_H1.2041.00
198_I385_A1.2031.00
135_L561_R1.2021.00
301_L359_A1.1991.00
106_R126_F1.1981.00
298_Q388_I1.1981.00
303_H337_Q1.1941.00
322_G325_Q1.1891.00
496_R499_E1.1871.00
565_D572_R1.1851.00
310_L364_A1.1811.00
510_I566_I1.1811.00
51_E64_A1.1801.00
146_Q151_P1.1771.00
441_D445_Y1.1771.00
197_V802_L1.1751.00
301_L305_L1.1751.00
63_R75_K1.1711.00
633_Q637_E1.1711.00
687_K814_E1.1701.00
156_T174_A1.1691.00
63_R77_F1.1681.00
493_Q496_R1.1651.00
293_T348_T1.1641.00
153_A478_K1.1631.00
223_K366_R1.1621.00
687_K746_A1.1561.00
225_I263_I1.1551.00
289_V293_T1.1531.00
767_I790_P1.1531.00
145_V505_E1.1521.00
227_L230_S1.1511.00
107_V123_D1.1491.00
528_T560_A1.1481.00
442_Y445_Y1.1451.00
304_T355_I1.1441.00
397_Q403_G1.1441.00
305_L395_L1.1421.00
743_V767_I1.1411.00
723_V815_I1.1381.00
724_F755_V1.1381.00
765_A815_I1.1281.00
226_V301_L1.1281.00
757_S760_Y1.1271.00
316_L653_I1.1211.00
704_Q707_E1.1161.00
344_A348_T1.1131.00
301_L358_L1.1121.00
277_E759_R1.1061.00
50_K77_F1.1041.00
48_I65_T1.1031.00
223_K261_G1.1011.00
92_D710_T1.0991.00
224_T365_N1.0981.00
704_Q708_S1.0861.00
350_I355_I1.0851.00
510_I527_A1.0831.00
692_L813_V1.0811.00
633_Q636_R1.0801.00
150_G153_A1.0791.00
338_P343_W1.0771.00
479_M508_I1.0721.00
742_R818_Y1.0701.00
631_R636_R1.0701.00
688_Y814_E1.0641.00
345_E348_T1.0641.00
445_Y448_T1.0631.00
94_V554_V1.0611.00
549_A615_W1.0601.00
142_L574_F1.0591.00
101_R128_R1.0591.00
145_V506_T1.0541.00
172_M175_K1.0501.00
323_F394_M1.0501.00
483_A567_F1.0491.00
127_V133_E1.0461.00
590_L594_W1.0461.00
219_L368_Q1.0461.00
138_F506_T1.0421.00
80_D83_P1.0421.00
300_A355_I1.0361.00
482_F517_T1.0301.00
303_H340_D1.0291.00
225_I251_Y1.0271.00
326_F394_M1.0241.00
135_L565_D1.0241.00
525_L566_I1.0171.00
126_F524_V1.0161.00
228_W268_I1.0051.00
591_K612_D1.0051.00
131_W525_L1.0041.00
468_N477_L1.0031.00
268_I287_I1.0031.00
298_Q387_M1.0021.00
591_K595_Q0.9981.00
101_R557_Q0.9981.00
473_K496_R0.9981.00
323_F327_L0.9981.00
301_L391_L0.9951.00
100_I524_V0.9941.00
724_F759_R0.9931.00
341_A356_R0.9931.00
345_E350_I0.9921.00
534_N587_M0.9881.00
693_Q764_V0.9881.00
689_P814_E0.9861.00
499_E503_K0.9841.00
61_A77_F0.9841.00
479_M506_T0.9811.00
300_A304_T0.9781.00
152_S182_N0.9761.00
131_W566_I0.9761.00
141_E145_V0.9731.00
46_A67_K0.9711.00
449_I452_A0.9691.00
706_C711_L0.9671.00
527_A566_I0.9651.00
132_D573_R0.9631.00
264_E284_V0.9621.00
357_G360_R0.9621.00
266_I361_Q0.9611.00
142_L481_I0.9611.00
690_L815_I0.9591.00
725_I735_I0.9571.00
202_V386_W0.9561.00
138_F570_L0.9540.99
290_N761_A0.9530.99
531_F553_V0.9520.99
135_L570_L0.9510.99
345_E353_E0.9500.99
743_V813_V0.9490.99
321_V650_L0.9480.99
304_T359_A0.9470.99
65_T73_A0.9470.99
443_K446_S0.9450.99
295_V384_W0.9440.99
320_C393_A0.9440.99
688_Y745_N0.9440.99
446_S450_P0.9430.99
268_I358_L0.9430.99
629_F632_H0.9420.99
311_Y394_M0.9410.99
255_K278_Y0.9400.99
312_D400_L0.9400.99
518_C524_V0.9400.99
587_M611_F0.9380.99
390_V653_I0.9370.99
173_L176_A0.9370.99
481_I570_L0.9370.99
121_R124_N0.9360.99
453_R456_D0.9350.99
534_N549_A0.9350.99
264_E285_K0.9340.99
356_R360_R0.9290.99
305_L391_L0.9270.99
64_A531_F0.9230.99
488_F494_I0.9220.99
353_E356_R0.9210.99
340_D344_A0.9190.99
299_L339_K0.9160.99
67_K72_V0.9160.99
291_P764_V0.9160.99
685_S812_L0.9150.99
326_F330_L0.9120.99
324_E327_L0.9120.99
630_V633_Q0.9110.99
289_V297_L0.9110.99
604_R607_H0.9090.99
268_I289_V0.9060.99
488_F498_I0.9060.99
728_Q758_D0.9060.99
158_S184_V0.9050.99
441_D444_G0.9040.99
360_R363_A0.9010.99
480_C504_L0.9010.99
451_I454_F0.8990.99
225_I254_L0.8980.99
362_M369_I0.8980.99
227_L265_V0.8950.99
272_V758_D0.8930.99
725_I730_A0.8930.99
272_V759_R0.8930.99
528_T556_P0.8930.99
353_E357_G0.8910.99
486_N703_S0.8900.99
304_T352_A0.8890.99
750_V793_L0.8880.99
56_G60_G0.8870.99
470_K496_R0.8860.99
64_A553_V0.8820.99
343_W347_L0.8800.99
631_R634_A0.8790.99
224_T264_E0.8790.99
198_I389_V0.8790.99
393_A651_I0.8780.99
69_G555_P0.8740.99
48_I75_K0.8710.99
647_P652_E0.8670.99
266_I285_K0.8600.99
361_Q365_N0.8600.99
684_G812_L0.8590.99
302_A330_L0.8590.99
84_S253_Q0.8580.99
515_T518_C0.8580.99
632_H636_R0.8570.99
534_N586_E0.8560.99
350_I354_T0.8560.99
464_V467_W0.8530.99
726_N756_V0.8530.99
227_L275_T0.8530.99
352_A355_I0.8520.99
726_N760_Y0.8520.99
103_P130_S0.8520.99
727_P731_S0.8510.99
270_P288_A0.8500.99
139_Y143_E0.8490.99
747_R811_T0.8490.99
547_I609_P0.8470.99
367_T403_G0.8460.99
300_A346_K0.8460.99
279_L284_V0.8460.99
232_L251_Y0.8400.99
725_I741_V0.8380.99
105_V133_E0.8370.99
761_A764_V0.8340.99
746_A812_L0.8300.99
495_N499_E0.8290.99
473_K503_K0.8270.99
554_V557_Q0.8260.99
307_S341_A0.8250.99
138_F141_E0.8220.98
142_L146_Q0.8210.98
620_Y624_D0.8200.98
255_K265_V0.8190.98
706_C710_T0.8190.98
218_V402_G0.8190.98
611_F615_W0.8180.98
175_K178_A0.8180.98
178_A181_G0.8170.98
131_W561_R0.8170.98
747_R794_T0.8160.98
102_Y130_S0.8150.98
287_I297_L0.8140.98
341_A344_A0.8120.98
290_N349_G0.8110.98
50_K79_L0.8100.98
104_M514_W0.8080.98
807_S810_T0.8080.98
252_A255_K0.8070.98
288_A761_A0.8060.98
502_R520_F0.8060.98
297_L301_L0.8050.98
296_P300_A0.8040.98
592_R596_E0.8030.98
316_L394_M0.8020.98
629_F633_Q0.8010.98
467_W471_S0.8010.98
354_T361_Q0.8010.98
473_K499_E0.7990.98
685_S689_P0.7990.98
728_Q732_A0.7960.98
224_T362_M0.7950.98
373_W377_R0.7950.98
752_A790_P0.7940.98
721_E771_A0.7940.98
652_E655_S0.7930.98
637_E642_E0.7910.98
155_L468_N0.7910.98
129_V134_A0.7910.98
300_A343_W0.7900.98
447_S450_P0.7900.98
137_M140_E0.7880.98
141_E506_T0.7880.98
96_N513_Q0.7870.98
220_Q250_Y0.7860.98
472_V475_P0.7840.98
463_K471_S0.7820.98
375_V384_W0.7800.98
482_F509_A0.7800.98
587_M615_W0.7800.98
58_H238_A0.7800.98
470_K474_L0.7770.98
488_F501_L0.7760.98
725_I756_V0.7750.98
587_M594_W0.7750.98
135_L139_Y0.7720.98
214_S218_V0.7720.98
495_N792_V0.7720.98
272_V288_A0.7710.98
226_V369_I0.7700.98
215_W218_V0.7700.98
300_A341_A0.7690.98
730_A735_I0.7670.98
568_R572_R0.7650.98
49_S553_V0.7650.98
173_L574_F0.7630.98
140_E143_E0.7630.98
49_S64_A0.7610.98
220_Q253_Q0.7600.97
743_V815_I0.7600.97
369_I388_I0.7600.97
747_R812_L0.7570.97
94_V529_T0.7570.97
171_G175_K0.7560.97
707_E714_Q0.7460.97
369_I392_A0.7440.97
450_P453_R0.7430.97
327_L330_L0.7430.97
233_L275_T0.7420.97
735_I756_V0.7390.97
685_S688_Y0.7380.97
529_T557_Q0.7380.97
148_T478_K0.7380.97
359_A363_A0.7370.97
707_E710_T0.7360.97
561_R566_I0.7360.97
62_I85_K0.7350.97
729_D762_P0.7340.97
471_S476_P0.7340.97
604_R608_L0.7330.97
611_F614_F0.7310.97
53_I56_G0.7310.97
316_L320_C0.7310.97
379_Q807_S0.7300.97
300_A340_D0.7300.97
135_L566_I0.7300.97
603_G607_H0.7290.97
326_F653_I0.7280.97
341_A352_A0.7280.97
302_A391_L0.7260.97
367_T400_L0.7260.97
590_L593_I0.7260.97
628_M631_R0.7240.97
53_I60_G0.7230.97
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444_G449_I0.5210.84
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423_I428_S0.5200.84
329_Y338_P0.5200.84
228_W391_L0.5190.84
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427_F431_T0.5140.83
391_L395_L0.5120.83
629_F634_A0.5120.83
373_W376_Q0.5120.83
132_D136_D0.5120.83
228_W375_V0.5120.83
501_L507_V0.5120.83
157_A485_T0.5120.83
293_T344_A0.5110.83
492_Q808_A0.5110.83
409_W413_G0.5100.83
195_A371_A0.5100.83
295_V298_Q0.5100.83
443_K452_A0.5090.83
445_Y449_I0.5090.83
733_R765_A0.5090.83
586_E592_R0.5080.83
141_E523_I0.5070.82
301_L304_T0.5070.82
432_S435_P0.5070.82
299_L330_L0.5060.82
70_R557_Q0.5060.82
69_G95_H0.5060.82
470_K473_K0.5060.82
418_G422_V0.5060.82
425_S429_G0.5060.82
293_T296_P0.5050.82
493_Q499_E0.5040.82
234_K724_F0.5040.82
568_R581_T0.5040.82
144_R505_E0.5030.82
176_A180_H0.5030.82
303_H344_A0.5030.82
182_N186_T0.5020.82
512_N527_A0.5020.82
421_G425_S0.5020.82
325_Q654_Y0.5010.82
745_N812_L0.5010.82
159_G164_G0.5010.82
645_G649_G0.5010.82
235_N372_G0.5000.82
129_V506_T0.5000.82
133_E506_T0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kqfA 3 0.8443 100 0.28 Contact Map
2vpzA 1 0.8467 100 0.282 Contact Map
2ivfA 1 0.8408 100 0.291 Contact Map
1tmoA 1 0.9116 100 0.302 Contact Map
1q16A 2 0.9399 100 0.303 Contact Map
2e7zA 1 0.8208 100 0.313 Contact Map
1h0hA 1 0.8491 100 0.315 Contact Map
2iv2X 1 0.8019 100 0.326 Contact Map
1eu1A 1 0.8927 100 0.326 Contact Map
2napA 1 0.809 100 0.33 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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