GREMLIN Database
YJFC - Putative acid--amine ligase YjfC
UniProt: P33222 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11812
Length: 387 (359)
Sequences: 1245 (841)
Seq/√Len: 44.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_A361_A5.6561.00
53_T354_S5.4111.00
66_R274_F4.5771.00
344_R347_D4.2221.00
100_G117_Y4.1481.00
314_I339_F3.6591.00
311_N327_G3.4711.00
65_D69_K3.3631.00
42_L46_E3.3361.00
57_H117_Y3.3071.00
154_A158_R3.1991.00
300_V314_I3.0301.00
77_L266_G2.7701.00
75_T84_W2.7341.00
107_C110_A2.5991.00
52_P112_V2.5701.00
40_F45_I2.5481.00
269_P286_F2.5151.00
15_I18_D2.4831.00
75_T81_P2.4071.00
26_I377_T2.3191.00
67_A73_I2.3111.00
175_C206_I2.2911.00
158_R362_C2.2891.00
17_A24_H2.2631.00
301_R313_T2.2431.00
14_Q17_A2.2361.00
74_L88_A2.2121.00
209_L225_I2.1961.00
255_E263_S2.1931.00
27_D377_T2.1791.00
173_Y204_I2.1391.00
63_V274_F2.1281.00
216_V224_V2.0910.99
257_L260_S2.0730.99
160_I193_C2.0620.99
63_V270_L2.0590.99
56_L102_M2.0560.99
191_Q195_Q2.0020.99
188_L191_Q1.9850.99
71_E74_L1.9240.99
191_Q201_S1.9210.99
74_L84_W1.9050.99
59_M281_L1.8970.99
176_C203_F1.8770.99
73_I273_R1.8740.99
205_Y208_D1.8730.99
37_A384_Y1.8210.99
66_R70_D1.7940.98
369_D375_K1.7860.98
160_I196_Q1.7820.98
62_E275_F1.7710.98
195_Q200_E1.7260.98
23_F186_T1.7240.98
323_D372_L1.7230.98
352_I366_I1.7050.98
49_I364_M1.6910.98
238_M260_S1.6850.98
330_A333_P1.6620.97
269_P335_I1.6520.97
235_E307_R1.6340.97
42_L385_I1.6290.97
300_V312_V1.6270.97
128_S155_I1.6120.97
174_F190_L1.6090.97
115_L342_L1.6000.97
299_Y315_F1.5820.96
344_R349_Y1.5790.96
233_P307_R1.5760.96
67_A261_I1.5540.96
163_F193_C1.5320.96
200_E223_N1.5310.96
15_I138_D1.5230.96
33_D379_R1.5170.95
27_D375_K1.5170.95
114_L268_M1.5160.95
297_E338_A1.4910.95
298_S338_A1.4890.95
15_I19_N1.4750.95
123_T231_L1.4560.94
230_K234_L1.4510.94
63_V267_L1.4420.94
52_P280_N1.4410.94
103_D302_K1.4400.94
53_T356_I1.4290.94
102_M114_L1.4270.94
228_A253_W1.4230.94
62_E278_H1.4120.93
64_V262_L1.4070.93
161_S165_E1.4030.93
105_A115_L1.3940.93
43_R48_Q1.3920.93
208_D220_L1.3920.93
14_Q18_D1.3850.93
204_I220_L1.3660.92
103_D265_K1.3560.92
255_E259_K1.3510.92
351_L374_T1.3470.92
71_E88_A1.3450.91
176_C205_Y1.3440.91
44_Q48_Q1.3410.91
268_M284_S1.3340.91
301_R336_Y1.3200.91
265_K302_K1.3190.91
178_Q205_Y1.3180.91
173_Y225_I1.3020.90
301_R334_M1.2950.90
352_I364_M1.2940.90
59_M275_F1.2850.89
191_Q203_F1.2830.89
171_P200_E1.2820.89
150_D385_I1.2810.89
202_R221_D1.2800.89
56_L281_L1.2800.89
102_M356_I1.2780.89
266_G304_I1.2740.89
170_E226_Q1.2660.89
225_I228_A1.2660.89
270_L274_F1.2640.89
16_A21_F1.2570.88
123_T308_E1.2480.88
53_T104_F1.2430.88
87_I257_L1.2430.88
174_F191_Q1.2350.88
103_D116_E1.2260.87
57_H356_I1.2220.87
106_W112_V1.2170.87
175_C228_A1.2040.86
122_P255_E1.1950.86
116_E302_K1.1890.85
173_Y202_R1.1870.85
121_T308_E1.1800.85
103_D337_Q1.1780.85
84_W88_A1.1770.85
63_V66_R1.1730.85
60_C119_A1.1480.83
202_R223_N1.1470.83
302_K337_Q1.1410.83
236_W384_Y1.1380.83
38_Y368_E1.1350.83
25_I29_E1.1350.83
22_D26_I1.1310.82
54_A360_E1.1210.82
120_D235_E1.1190.82
85_D89_E1.1140.81
88_A92_R1.1070.81
265_K337_Q1.1040.81
316_D320_N1.1030.81
116_E265_K1.1010.81
113_K338_A1.0930.80
79_I261_I1.0870.80
231_L307_R1.0780.79
17_A25_I1.0780.79
204_I208_D1.0770.79
104_F114_L1.0670.79
162_R165_E1.0660.78
321_V324_H1.0650.78
46_E385_I1.0520.78
73_I76_Q1.0470.77
171_P226_Q1.0420.77
311_N326_D1.0360.76
263_S307_R1.0260.76
78_A333_P1.0220.75
183_D186_T1.0170.75
19_N138_D1.0080.74
278_H282_L1.0020.74
155_I160_I0.9900.73
355_W368_E0.9890.73
99_Y229_F0.9850.73
166_L254_V0.9790.72
128_S366_I0.9780.72
212_G218_T0.9750.72
48_Q52_P0.9720.72
48_Q112_V0.9700.72
228_A251_E0.9690.71
178_Q207_E0.9680.71
85_D95_D0.9670.71
217_L242_N0.9660.71
182_E307_R0.9660.71
127_E307_R0.9650.71
298_S316_D0.9600.71
49_I354_S0.9540.70
116_E337_Q0.9530.70
41_T44_Q0.9490.70
252_Q285_W0.9490.70
115_L340_Q0.9490.70
120_D230_K0.9460.70
49_I110_A0.9450.70
277_G280_N0.9440.69
120_D123_T0.9440.69
26_I375_K0.9410.69
149_A384_Y0.9380.69
313_T324_H0.9370.69
187_V203_F0.9360.69
212_G216_V0.9290.68
296_G315_F0.9270.68
121_T255_E0.9260.68
218_T222_D0.9250.68
127_E353_G0.9220.68
216_V226_Q0.9190.67
121_T183_D0.9160.67
31_Y374_T0.9150.67
21_F185_S0.9120.67
130_Y156_Q0.9070.66
86_V257_L0.9070.66
172_F199_Q0.9060.66
59_M208_D0.9060.66
177_C207_E0.9040.66
57_H359_D0.9010.66
89_E93_A0.8970.65
249_R253_W0.8960.65
122_P308_E0.8930.65
188_L195_Q0.8930.65
173_Y219_D0.8930.65
287_D336_Y0.8930.65
54_A58_Q0.8890.65
339_F372_L0.8790.64
233_P308_E0.8750.64
192_D196_Q0.8740.63
216_V250_R0.8710.63
60_C262_L0.8680.63
231_L235_E0.8660.63
65_D295_A0.8630.62
225_I251_E0.8590.62
18_D22_D0.8520.61
101_R353_G0.8520.61
101_R363_G0.8520.61
175_C203_F0.8470.61
21_F126_Y0.8450.61
202_R219_D0.8450.61
320_N323_D0.8440.61
16_A20_G0.8430.61
156_Q189_Y0.8410.60
267_L303_P0.8390.60
182_E235_E0.8370.60
105_A340_Q0.8370.60
121_T127_E0.8340.60
300_V339_F0.8340.60
228_A257_L0.8330.60
57_H102_M0.8330.60
123_T235_E0.8330.60
238_M241_D0.8320.60
297_E335_I0.8270.59
244_P248_K0.8270.59
24_H28_N0.8200.58
165_E360_E0.8200.58
14_Q214_G0.8190.58
190_L362_C0.8160.58
16_A131_F0.8140.58
120_D127_E0.8130.58
379_R382_P0.8120.58
63_V73_I0.8120.58
312_V339_F0.8110.58
83_Y238_M0.8090.57
17_A110_A0.8070.57
323_D340_Q0.8060.57
231_L308_E0.8030.57
180_T183_D0.8010.57
323_D373_I0.7980.56
323_D375_K0.7940.56
172_F175_C0.7940.56
365_G380_F0.7920.56
260_S305_Y0.7840.55
234_L253_W0.7840.55
348_S379_R0.7830.55
369_D378_S0.7830.55
118_N265_K0.7810.55
313_T321_V0.7810.55
186_T307_R0.7780.55
219_D369_D0.7730.54
183_D353_G0.7720.54
172_F315_F0.7720.54
102_M117_Y0.7690.54
211_L245_L0.7650.53
124_S365_G0.7630.53
150_D154_A0.7620.53
330_A334_M0.7610.53
287_D315_F0.7570.52
200_E360_E0.7540.52
167_Y226_Q0.7530.52
120_D255_E0.7530.52
184_R203_F0.7530.52
43_R320_N0.7520.52
295_A336_Y0.7510.52
186_T308_E0.7490.52
195_Q201_S0.7480.52
15_I30_I0.7480.52
127_E233_P0.7460.51
107_C300_V0.7420.51
87_I261_I0.7400.51
375_K378_S0.7390.51
30_I35_S0.7370.51
21_F26_I0.7370.51
337_Q367_R0.7370.51
45_I364_M0.7350.50
256_P268_M0.7350.50
302_K309_G0.7320.50
199_Q358_D0.7320.50
22_D181_D0.7290.50
119_A262_L0.7290.50
123_T186_T0.7270.50
224_V251_E0.7260.49
154_A157_E0.7250.49
93_A249_R0.7210.49
206_I335_I0.7150.48
165_E358_D0.7150.48
155_I363_G0.7130.48
135_W308_E0.7080.48
104_F175_C0.7080.48
228_A246_L0.7060.48
97_S100_G0.7030.47
103_D118_N0.7030.47
127_E255_E0.6990.47
29_E53_T0.6980.47
176_C251_E0.6980.47
49_I112_V0.6940.46
19_N375_K0.6920.46
176_C236_W0.6920.46
63_V275_F0.6870.46
210_G218_T0.6830.45
354_S361_A0.6820.45
165_E195_Q0.6810.45
182_E308_E0.6770.45
244_P247_R0.6770.45
90_S95_D0.6770.45
50_E150_D0.6770.45
304_I332_E0.6760.45
71_E84_W0.6760.45
36_R348_S0.6760.45
158_R161_S0.6760.45
101_R302_K0.6730.44
127_E182_E0.6710.44
118_N302_K0.6690.44
196_Q244_P0.6680.44
378_S383_H0.6670.44
56_L218_T0.6670.44
121_T233_P0.6670.44
186_T231_L0.6660.44
43_R164_S0.6650.44
29_E378_S0.6630.43
102_M132_Q0.6620.43
186_T229_F0.6620.43
21_F24_H0.6610.43
48_Q285_W0.6610.43
174_F203_F0.6610.43
255_E258_W0.6600.43
65_D87_I0.6570.43
16_A126_Y0.6570.43
169_R175_C0.6560.43
202_R220_L0.6540.43
311_N329_Y0.6530.42
323_D327_G0.6520.42
180_T376_D0.6500.42
29_E381_V0.6490.42
192_D311_N0.6480.42
315_F321_V0.6480.42
16_A300_V0.6470.42
192_D385_I0.6470.42
297_E320_N0.6450.42
61_L262_L0.6440.42
120_D231_L0.6440.42
105_A114_L0.6430.42
164_S224_V0.6430.42
270_L273_R0.6410.41
123_T307_R0.6400.41
67_A84_W0.6400.41
290_K336_Y0.6390.41
316_D319_N0.6390.41
158_R360_E0.6380.41
78_A340_Q0.6370.41
272_W278_H0.6360.41
90_S132_Q0.6360.41
99_Y123_T0.6350.41
343_P350_T0.6350.41
312_V319_N0.6330.41
62_E66_R0.6320.41
72_E215_G0.6320.41
43_R223_N0.6290.40
15_I22_D0.6290.40
228_A237_M0.6270.40
219_D223_N0.6270.40
22_D126_Y0.6250.40
263_S306_S0.6250.40
77_L228_A0.6240.40
172_F227_R0.6230.40
116_E309_G0.6210.40
69_K88_A0.6200.39
100_G356_I0.6170.39
183_D307_R0.6160.39
56_L104_F0.6150.39
36_R381_V0.6120.39
23_F376_D0.6110.39
316_D341_P0.6090.38
240_D306_S0.6080.38
211_L217_L0.6070.38
248_K251_E0.6030.38
161_S164_S0.6030.38
59_M169_R0.6010.38
240_D384_Y0.6000.38
97_S374_T0.6000.38
61_L91_W0.5990.37
134_L137_E0.5980.37
140_R147_R0.5950.37
349_Y372_L0.5950.37
42_L50_E0.5940.37
275_F280_N0.5930.37
17_A317_G0.5920.37
225_I303_P0.5890.37
40_F345_F0.5890.37
246_L376_D0.5870.36
150_D172_F0.5850.36
162_R358_D0.5850.36
338_A341_P0.5810.36
76_Q288_G0.5800.36
218_T224_V0.5800.36
166_L249_R0.5800.36
45_I50_E0.5790.36
52_P104_F0.5790.36
221_D224_V0.5790.36
67_A74_L0.5780.36
61_L359_D0.5780.36
101_R265_K0.5760.35
120_D307_R0.5760.35
226_Q295_A0.5760.35
259_K368_E0.5750.35
205_Y245_L0.5740.35
283_A338_A0.5740.35
174_F187_V0.5720.35
62_E312_V0.5720.35
82_L85_D0.5700.35
155_I159_L0.5700.35
123_T376_D0.5700.35
134_L261_I0.5690.35
159_L163_F0.5680.35
178_Q208_D0.5670.35
287_D301_R0.5650.34
227_R252_Q0.5650.34
232_Y353_G0.5640.34
287_D326_D0.5640.34
189_Y192_D0.5640.34
119_A123_T0.5620.34
43_R51_K0.5610.34
66_R69_K0.5590.34
245_L250_R0.5590.34
133_W151_Q0.5560.34
232_Y236_W0.5560.34
137_E328_D0.5550.34
315_F325_A0.5550.34
183_D233_P0.5540.34
15_I384_Y0.5540.34
235_E256_P0.5540.34
236_W305_Y0.5540.34
31_Y34_E0.5530.33
353_G374_T0.5530.33
32_W368_E0.5520.33
93_A370_N0.5510.33
245_L248_K0.5510.33
121_T263_S0.5510.33
27_D30_I0.5500.33
14_Q168_S0.5500.33
30_I33_D0.5490.33
204_I221_D0.5470.33
65_D91_W0.5460.33
349_Y373_I0.5410.32
274_F282_L0.5410.32
15_I134_L0.5400.32
75_T283_A0.5400.32
18_D248_K0.5390.32
180_T378_S0.5390.32
263_S303_P0.5370.32
182_E186_T0.5360.32
252_Q312_V0.5360.32
71_E75_T0.5360.32
321_V336_Y0.5340.32
344_R350_T0.5330.32
154_A385_I0.5320.32
92_R335_I0.5320.32
219_D230_K0.5310.32
151_Q159_L0.5310.32
354_S364_M0.5300.31
150_D192_D0.5300.31
128_S201_S0.5300.31
154_A362_C0.5300.31
57_H258_W0.5290.31
288_G335_I0.5290.31
246_L253_W0.5280.31
128_S350_T0.5280.31
152_Y163_F0.5280.31
87_I248_K0.5270.31
235_E266_G0.5270.31
129_A135_W0.5270.31
42_L52_P0.5270.31
171_P215_G0.5260.31
201_S204_I0.5260.31
204_I242_N0.5240.31
339_F349_Y0.5230.31
64_V68_V0.5230.31
45_I106_W0.5220.31
115_L206_I0.5220.31
65_D114_L0.5220.31
20_G32_W0.5210.31
222_D273_R0.5210.31
53_T97_S0.5210.31
255_E307_R0.5200.31
122_P259_K0.5180.30
26_I30_I0.5160.30
156_Q159_L0.5160.30
286_F315_F0.5150.30
178_Q181_D0.5140.30
62_E274_F0.5130.30
124_S363_G0.5130.30
294_A320_N0.5130.30
91_W124_S0.5120.30
225_I356_I0.5120.30
97_S119_A0.5110.30
112_V314_I0.5100.30
14_Q296_G0.5100.30
364_M383_H0.5090.30
186_T189_Y0.5080.30
311_N325_A0.5070.30
204_I225_I0.5070.30
77_L247_R0.5060.30
135_W258_W0.5060.30
231_L310_G0.5050.29
166_L321_V0.5050.29
79_I83_Y0.5050.29
160_I192_D0.5040.29
316_D339_F0.5040.29
363_G372_L0.5030.29
101_R118_N0.5030.29
301_R311_N0.5030.29
95_D257_L0.5020.29
161_S321_V0.5020.29
120_D233_P0.5020.29
255_E309_G0.5020.29
166_L172_F0.5010.29
65_D94_R0.5000.29
246_L286_F0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vobA 1 0.8682 100 0.206 Contact Map
2io8A 2 0.9664 100 0.23 Contact Map
3n6xA 2 0.9432 100 0.495 Contact Map
3kalA 2 0.9638 99.3 0.851 Contact Map
1m0wA 2 0.9664 99.3 0.854 Contact Map
2hgsA 2 0.969 99.2 0.855 Contact Map
1gsaA 3 0.5245 99 0.871 Contact Map
2wyoA 2 0.9483 98.9 0.875 Contact Map
3vpbA 3 0.5116 98.6 0.887 Contact Map
3r5xA 2 0.5245 98.4 0.894 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0108 seconds.