GREMLIN Database
PURT - Phosphoribosylglycinamide formyltransferase 2
UniProt: P33221 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11809
Length: 392 (369)
Sequences: 22971 (12798)
Seq/√Len: 666.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
146_A171_A3.6751.00
131_T196_G3.2121.00
170_S173_Q3.1991.00
142_R175_A3.1231.00
137_S140_L2.9511.00
249_E253_K2.9231.00
14_R37_E2.9221.00
69_R73_L2.8881.00
271_C274_E2.8281.00
92_I109_K2.6971.00
63_D66_A2.6011.00
150_Y171_A2.5961.00
373_S376_D2.5611.00
371_A376_D2.5371.00
133_R147_D2.5151.00
252_R256_L2.4491.00
305_R310_L2.3711.00
92_I96_E2.3401.00
124_E257_A2.3141.00
30_E33_R2.2601.00
246_R274_E2.2501.00
250_I253_K2.2391.00
169_R173_Q2.1491.00
245_E249_E2.1321.00
240_S243_A2.1151.00
122_A254_V2.0871.00
241_P245_E2.0471.00
93_Q97_E2.0331.00
72_E97_E2.0151.00
144_A147_D1.9131.00
116_G119_R1.9021.00
119_R124_E1.8981.00
87_A112_M1.8941.00
171_A175_A1.8771.00
352_L355_K1.8751.00
68_R97_E1.8621.00
301_A305_R1.8511.00
167_F197_V1.8501.00
296_D318_Y1.8281.00
372_E376_D1.8081.00
144_A148_I1.8051.00
235_Q294_S1.8031.00
246_R249_E1.7971.00
64_G93_Q1.7891.00
17_L28_A1.7761.00
33_R301_A1.7721.00
199_K272_G1.7621.00
296_D316_R1.7611.00
250_I275_V1.7471.00
109_K116_G1.7121.00
212_V261_Y1.7101.00
68_R72_E1.7041.00
138_E142_R1.6951.00
175_A179_K1.6791.00
169_R199_K1.6781.00
138_E175_A1.6661.00
119_R123_E1.6401.00
31_C38_V1.6041.00
243_A246_R1.6031.00
142_R171_A1.6001.00
253_K256_L1.6001.00
115_E134_F1.5941.00
57_H70_V1.5911.00
115_E119_R1.5821.00
138_E179_K1.5781.00
324_A381_A1.5711.00
110_L120_L1.5631.00
44_Y58_V1.5621.00
104_C107_A1.5531.00
209_V302_L1.5411.00
176_Q180_Y1.5391.00
152_C194_V1.5381.00
95_E105_A1.5371.00
66_A69_R1.5361.00
120_L257_A1.5311.00
79_I99_L1.5241.00
133_R144_A1.5221.00
210_S216_H1.5211.00
143_E147_D1.5211.00
32_Q54_H1.5061.00
245_E248_Q1.5001.00
243_A270_V1.4971.00
334_N337_F1.4841.00
30_E301_A1.4771.00
347_D350_I1.4461.00
125_L257_A1.4461.00
182_Q190_G1.4461.00
118_R195_E1.4441.00
209_V263_L1.4431.00
120_L125_L1.4371.00
145_V150_Y1.4291.00
64_G68_R1.4281.00
15_V102_V1.4101.00
204_I270_V1.4071.00
110_L116_G1.4061.00
136_D140_L1.4061.00
93_Q96_E1.4021.00
123_E131_T1.3891.00
69_R72_E1.3881.00
95_E104_C1.3861.00
113_N157_V1.3851.00
246_R250_I1.3771.00
65_D93_Q1.3751.00
142_R146_A1.3661.00
293_I368_L1.3651.00
248_Q252_R1.3621.00
351_R355_K1.3621.00
106_R110_L1.3541.00
196_G276_I1.3501.00
14_R39_I1.3481.00
157_V191_R1.3441.00
15_V31_C1.3211.00
120_L124_E1.3201.00
293_I370_T1.3181.00
128_P274_E1.3131.00
34_L305_R1.3131.00
50_M56_S1.3071.00
16_M41_V1.3051.00
70_V74_E1.2981.00
143_E146_A1.2961.00
209_V306_A1.2921.00
136_D191_R1.2831.00
29_I33_R1.2821.00
122_A277_F1.2771.00
119_R132_Y1.2721.00
139_S143_E1.2701.00
349_Q353_F1.2601.00
150_Y170_S1.2431.00
135_A144_A1.2421.00
138_E178_W1.2411.00
375_V379_E1.2351.00
117_I122_A1.2341.00
94_L99_L1.2281.00
71_V99_L1.2271.00
198_V278_S1.2271.00
208_T255_V1.2261.00
145_V152_C1.2251.00
123_E129_T1.2161.00
94_L101_V1.2101.00
179_K183_Q1.2091.00
36_V308_L1.1971.00
139_S142_R1.1931.00
376_D380_R1.1911.00
338_D341_Q1.1841.00
327_L362_R1.1821.00
153_I167_F1.1771.00
115_E157_V1.1721.00
382_K386_G1.1721.00
244_L248_Q1.1661.00
371_A380_R1.1611.00
208_T251_A1.1571.00
37_E55_R1.1521.00
206_L247_A1.1521.00
16_M71_V1.1471.00
324_A366_V1.1421.00
111_T280_V1.1411.00
140_L143_E1.1411.00
55_R74_E1.1271.00
100_N308_L1.1261.00
241_P244_L1.1221.00
104_C261_Y1.1181.00
134_F191_R1.1141.00
118_R129_T1.1141.00
40_A55_R1.1131.00
336_T339_N1.1121.00
351_R354_G1.1081.00
131_T148_I1.1061.00
59_I63_D1.1011.00
255_V258_L1.0991.00
371_A377_A1.0981.00
92_I106_R1.0951.00
211_A215_V1.0911.00
166_T180_Y1.0891.00
213_D311_P1.0881.00
369_A381_A1.0831.00
270_V275_V1.0821.00
378_I382_K1.0811.00
208_T264_F1.0781.00
320_P372_E1.0741.00
57_H74_E1.0721.00
27_V80_V1.0661.00
42_D47_A1.0641.00
54_H57_H1.0621.00
380_R383_H1.0581.00
92_I105_A1.0551.00
242_L246_R1.0531.00
128_P250_I1.0521.00
166_T181_A1.0491.00
68_R93_Q1.0461.00
15_V36_V1.0461.00
14_R77_H1.0421.00
208_T266_V1.0401.00
87_A90_M1.0391.00
153_I197_V1.0381.00
367_A384_A1.0271.00
254_V258_L1.0241.00
150_Y174_L1.0201.00
343_A346_A1.0171.00
34_L298_S1.0121.00
148_I152_C1.0091.00
353_F356_P1.0081.00
216_H252_R1.0061.00
254_V257_A1.0061.00
131_T147_D1.0041.00
141_F174_L1.0001.00
327_L385_A0.9961.00
166_T177_A0.9931.00
106_R109_K0.9901.00
172_E176_Q0.9881.00
90_M94_L0.9871.00
266_V280_V0.9861.00
53_A56_S0.9821.00
44_Y47_A0.9801.00
292_L368_L0.9791.00
239_M243_A0.9771.00
123_E132_Y0.9711.00
347_D355_K0.9711.00
347_D351_R0.9701.00
200_F272_G0.9701.00
146_A175_A0.9681.00
302_L305_R0.9641.00
176_Q179_K0.9641.00
383_H386_G0.9631.00
297_L302_L0.9591.00
340_V343_A0.9581.00
178_W182_Q0.9511.00
251_A266_V0.9481.00
318_Y370_T0.9461.00
79_I94_L0.9461.00
334_N338_D0.9451.00
284_P299_E0.9441.00
199_K271_C0.9421.00
127_L277_F0.9411.00
335_V338_D0.9401.00
65_D69_R0.9361.00
379_E383_H0.9351.00
15_V304_V0.9341.00
28_A53_A0.9331.00
173_Q176_Q0.9301.00
210_S256_L0.9301.00
221_V244_L0.9291.00
251_A268_L0.9291.00
28_A38_V0.9281.00
31_C304_V0.9241.00
34_L301_A0.9181.00
249_E252_R0.9181.00
221_V224_R0.9161.00
145_V174_L0.9161.00
153_I165_Q0.9141.00
337_F341_Q0.9131.00
70_V76_P0.9071.00
206_L251_A0.9041.00
141_F178_W0.9001.00
152_C168_I0.8981.00
242_L245_E0.8971.00
255_V264_F0.8931.00
202_F223_H0.8871.00
334_N339_N0.8841.00
253_K257_A0.8841.00
369_A384_A0.8841.00
210_S255_V0.8821.00
168_I177_A0.8811.00
341_Q344_V0.8801.00
113_N158_M0.8791.00
92_I95_E0.8771.00
246_R275_V0.8761.00
95_E261_Y0.8721.00
342_N345_G0.8711.00
138_E182_Q0.8711.00
206_L248_Q0.8681.00
325_V328_P0.8661.00
71_V79_I0.8651.00
107_A259_G0.8621.00
334_N341_Q0.8581.00
91_L101_V0.8541.00
178_W192_V0.8531.00
223_H238_Q0.8511.00
342_N346_A0.8481.00
135_A141_F0.8461.00
304_V308_L0.8451.00
154_V168_I0.8441.00
338_D377_A0.8431.00
348_L355_K0.8421.00
218_C248_Q0.8401.00
198_V276_I0.8391.00
215_V256_L0.8351.00
335_V339_N0.8321.00
17_L31_C0.8311.00
289_M292_L0.8291.00
111_T258_L0.8291.00
302_L313_G0.8281.00
172_E175_A0.8271.00
305_R308_L0.8251.00
123_E133_R0.8221.00
31_C80_V0.8211.00
104_C259_G0.8171.00
202_F270_V0.8151.00
340_V356_P0.8131.00
80_V303_H0.8101.00
220_P224_R0.8071.00
154_V177_A0.8011.00
47_A50_M0.8011.00
347_D380_R0.7981.00
115_E191_R0.7951.00
64_G90_M0.7931.00
31_C36_V0.7911.00
350_I353_F0.7911.00
89_D92_I0.7911.00
369_A377_A0.7841.00
55_R58_V0.7751.00
340_V344_V0.7751.00
95_E106_R0.7751.00
180_Y184_G0.7741.00
247_A275_V0.7711.00
348_L351_R0.7701.00
349_Q352_L0.7661.00
269_F278_S0.7661.00
218_C252_R0.7651.00
154_V192_V0.7641.00
320_P370_T0.7561.00
40_A51_H0.7531.00
40_A53_A0.7511.00
14_R74_E0.7451.00
89_D93_Q0.7431.00
322_A377_A0.7421.00
145_V149_G0.7401.00
68_R96_E0.7381.00
234_W374_V0.7371.00
59_I66_A0.7351.00
294_S321_A0.7351.00
198_V271_C0.7351.00
180_Y183_Q0.7351.00
67_L94_L0.7331.00
158_M189_A0.7301.00
16_M76_P0.7291.00
166_T184_G0.7291.00
94_L97_E0.7271.00
141_F194_V0.7231.00
113_N191_R0.7221.00
376_D379_E0.7211.00
219_A223_H0.7181.00
347_D353_F0.7161.00
25_K51_H0.7151.00
181_A192_V0.7151.00
115_E193_I0.7141.00
60_N63_D0.7131.00
349_Q355_K0.7101.00
350_I369_A0.7071.00
88_T109_K0.7041.00
148_I196_G0.7031.00
43_R54_H0.7011.00
375_V378_I0.6981.00
196_G274_E0.6981.00
140_L144_A0.6971.00
339_N343_A0.6961.00
352_L356_P0.6951.00
220_P223_H0.6921.00
348_L354_G0.6901.00
311_P314_G0.6901.00
107_A261_Y0.6881.00
14_R55_R0.6851.00
204_I247_A0.6841.00
337_F340_V0.6841.00
89_D109_K0.6821.00
216_H256_L0.6821.00
18_L90_M0.6821.00
154_V178_W0.6821.00
279_E283_R0.6821.00
250_I268_L0.6781.00
100_N212_V0.6751.00
347_D354_G0.6751.00
168_I174_L0.6741.00
335_V341_Q0.6731.00
231_R327_L0.6721.00
142_R179_K0.6701.00
14_R75_K0.6691.00
207_L263_L0.6681.00
350_I355_K0.6681.00
138_E141_F0.6671.00
260_G264_F0.6631.00
120_L258_L0.6631.00
254_V280_V0.6631.00
322_A378_I0.6631.00
210_S261_Y0.6601.00
32_Q38_V0.6601.00
116_G120_L0.6581.00
87_A91_L0.6551.00
119_R134_F0.6551.00
71_V94_L0.6521.00
239_M244_L0.6521.00
34_L304_V0.6501.00
144_A194_V0.6491.00
214_G256_L0.6491.00
381_A385_A0.6471.00
247_A253_K0.6431.00
213_D309_G0.6421.00
15_V38_V0.6401.00
330_L333_Q0.6391.00
248_Q253_K0.6381.00
206_L221_V0.6371.00
349_Q354_G0.6371.00
182_Q192_V0.6351.00
211_A214_G0.6321.00
133_R140_L0.6321.00
177_A181_A0.6301.00
270_V273_D0.6291.00
128_P276_I0.6291.00
154_V194_V0.6281.00
106_R116_G0.6251.00
207_L265_G0.6251.00
247_A250_I0.6231.00
251_A255_V0.6231.00
339_N342_N0.6211.00
266_V277_F0.6211.00
138_E174_L0.6201.00
149_G171_A0.6201.00
352_L365_G0.6161.00
91_L94_L0.6151.00
30_E34_L0.6151.00
14_R40_A0.6141.00
137_S178_W0.6141.00
219_A224_R0.6111.00
42_D56_S0.6091.00
271_C276_I0.6081.00
222_G233_S0.6071.00
66_A70_V0.6061.00
204_I268_L0.6021.00
303_H307_F0.6011.00
91_L95_E0.6011.00
226_E231_R0.5991.00
232_E324_A0.5981.00
114_R155_K0.5971.00
42_D45_A0.5971.00
219_A295_Q0.5961.00
250_I254_V0.5961.00
105_A109_K0.5961.00
377_A381_A0.5961.00
341_Q345_G0.5951.00
110_L124_E0.5951.00
221_V237_Q0.5941.00
113_N116_G0.5931.00
326_I329_Q0.5931.00
230_Y233_S0.5931.00
150_Y169_R0.5921.00
220_P317_Q0.5921.00
219_A222_G0.5911.00
157_V193_I0.5891.00
295_Q317_Q0.5891.00
39_I57_H0.5871.00
145_V178_W0.5861.00
222_G234_W0.5831.00
184_G187_A0.5831.00
374_V378_I0.5821.00
90_M93_Q0.5811.00
219_A294_S0.5781.00
196_G271_C0.5771.00
39_I55_R0.5751.00
243_A275_V0.5741.00
351_R356_P0.5731.00
348_L353_F0.5721.00
70_V73_L0.5721.00
102_V304_V0.5711.00
204_I239_M0.5671.00
235_Q290_V0.5671.00
305_R309_G0.5661.00
292_L298_S0.5661.00
247_A268_L0.5651.00
235_Q238_Q0.5651.00
91_L105_A0.5651.00
177_A180_Y0.5631.00
41_V67_L0.5621.00
263_L284_P0.5621.00
100_N261_Y0.5611.00
347_D352_L0.5611.00
78_Y307_F0.5601.00
30_E298_S0.5601.00
218_C221_V0.5601.00
220_P315_I0.5601.00
25_K50_M0.5531.00
202_F237_Q0.5531.00
323_S328_P0.5521.00
348_L352_L0.5521.00
71_V76_P0.5521.00
145_V148_I0.5501.00
337_F344_V0.5481.00
240_S270_V0.5481.00
206_L268_L0.5471.00
227_D361_S0.5461.00
168_I173_Q0.5451.00
142_R145_V0.5441.00
260_G282_P0.5431.00
132_Y195_E0.5421.00
338_D343_A0.5421.00
173_Q177_A0.5411.00
289_M323_S0.5401.00
43_R47_A0.5391.00
214_G217_F0.5391.00
261_Y306_A0.5391.00
341_Q346_A0.5381.00
304_V307_F0.5361.00
220_P294_S0.5351.00
118_R130_S0.5341.00
163_K184_G0.5341.00
337_F342_N0.5341.00
290_V322_A0.5341.00
213_D261_Y0.5341.00
317_Q320_P0.5331.00
28_A54_H0.5331.00
54_H58_V0.5321.00
322_A325_V0.5311.00
323_S378_I0.5281.00
127_L250_I0.5281.00
151_P197_V0.5270.99
338_D342_N0.5270.99
126_Q253_K0.5250.99
251_A254_V0.5240.99
36_V77_H0.5240.99
37_E54_H0.5240.99
59_I70_V0.5240.99
325_V329_Q0.5240.99
77_H100_N0.5230.99
154_V174_L0.5210.99
209_V218_C0.5210.99
122_A127_L0.5210.99
273_D276_I0.5200.99
64_G89_D0.5200.99
290_V293_I0.5170.99
305_R313_G0.5170.99
310_L314_G0.5160.99
335_V340_V0.5140.99
53_A57_H0.5140.99
122_A280_V0.5130.99
324_A328_P0.5130.99
65_D68_R0.5130.99
204_I223_H0.5120.99
43_R50_M0.5110.99
169_R197_V0.5110.99
53_A58_V0.5100.99
246_R253_K0.5090.99
130_S198_V0.5090.99
232_E235_Q0.5090.99
308_L311_P0.5060.99
67_L79_I0.5060.99
134_F157_V0.5050.99
167_F228_G0.5050.99
329_Q333_Q0.5040.99
219_A299_E0.5040.99
42_D52_V0.5030.99
118_R123_E0.5020.99
323_S326_I0.5020.99
211_A312_V0.5020.99
44_Y48_P0.5010.99
106_R259_G0.5010.99
218_C224_R0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kjqA 2 0.9847 100 0.262 Contact Map
2dwcA 4 0.9643 100 0.283 Contact Map
4dimA 1 0.9439 100 0.309 Contact Map
3n6rA 1 0.8036 100 0.31 Contact Map
3u9tA 3 0.9464 100 0.31 Contact Map
3va7A 1 0.8036 100 0.311 Contact Map
4qshA 4 0.8316 100 0.312 Contact Map
4rcnA 6 0.8852 100 0.313 Contact Map
3hblA 4 0.9719 100 0.32 Contact Map
3glkA 1 0.9184 100 0.321 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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