GCSP - ECOLI - GREMLIN Contacts

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GCSP - Glycine dehydrogenase (decarboxylating)

UniProt:	P33195	Sequences: MTQTLSQLENSGAFIERHIGPDAAQQQEMLNAVGAQSLNALTGQIVPKDIQLATPPQVGAPATEYAALAELKAIASRNKRFTSYIGMGYTAVQLPPVILRNMLENPGWYTAYTPYQPEVSQGRLEALLNFQQVTLDLTGLDMASASLLDEATAAAEAMAMAKRVSKLKNANRFFVASDVHPQTLDVVRTRAETFGFEVIVDDAQKVLDHQDVFGVLLQQVGTTGEIHDYTALISELKSRKIVVSVAADIMALVLLTAPGKQGADIVFGSAQRFGVPMGYGGPHAAFFAAKDEYKRSMPGRIIGVSKDAAGNTALRMAMQTREQHIRREKANSNICTSQVLLANIASLYAVYHGPVGLKRIANRIHRLTDILAAGLQQKGLKLRHAHYFDTLCVEVADKAGVLTRAEAAEINLRSDILNAVGITLDETTTRENVMQLFNVLLGDNHGLDIDTLDKDVAHDSRSIQPAMLRDDEILTHPVFNRYHSETEMMRYMHSLERKDLALNQAMIPLGSCTMKLNAAAEMIPITWPEFAELHPFCPPEQAEGYQQMIAQLADWLVKLTGYDAVCMQPNSGAQGEYAGLLAIRHYHESRNEGHRDICLIPASAHGTNPASAHMAGMQVVVVACDKNGNIDLTDLRAKAEQAGDNLSCIMVTYPSTHGVYEETIREVCEVVHQFGGQVYLDGANMNAQVGITSPGFIGADVSHLNLHKTFCIPHGGGGPGMGPIGVKAHLAPFVPGHSVVQIEGMLTRQGAVSAAPFGSASILPISWMYIRMMGAEGLKKASQVAILNANYIASRLQDAFPVLYTGRDGRVAHECILDIRPLKEETGISELDIAKRLIDYGFHAPTMSFPVAGTLMVEPTESESKVELDRFIDAMLAIRAEIDQVKAGVWPLEDNPLVNAPHIQSELVAEWAHPYSREVAVFPAGVADKYWPTVKRLDDVYGDRNLFCSCVPISEYQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11810
Length:	957 (937)
Sequences:	1774 (859)
Seq/√Len:	28.1

ECOLI - GCSP

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
589_S	733_F	5.540	1.00
489_M	519_A	4.787	1.00
799_A	876_L	4.603	1.00
250_M	364_I	4.432	1.00
247_A	286_F	4.395	1.00
563_D	727_K	4.152	1.00
180_H	222_T	4.028	1.00
651_V	664_I	4.022	1.00
77_R	547_Q	3.984	1.00
253_V	357_L	3.539	1.00
279_Y	542_A	3.485	1.00
883_D	886_K	3.458	1.00
371_L	424_L	3.447	1.00
779_K	783_Q	3.437	1.00
236_L	241_I	3.430	1.00
669_E	673_Q	3.420	1.00
894_D	913_H	3.420	1.00
643_G	674_F	3.379	1.00
67_A	772_M	3.373	1.00
817_L	857_V	3.342	1.00
625_D	629_N	3.258	1.00
270_A	286_F	3.199	1.00
187_V	198_V	3.171	1.00
639_A	670_V	3.143	1.00
140_L	266_V	3.124	1.00
67_A	768_M	3.103	1.00
102_M	347_L	3.040	1.00
587_H	590_R	2.976	1.00
233_I	261_Q	2.974	1.00
185_D	738_S	2.956	1.00
151_A	754_A	2.955	1.00
564_A	731_A	2.937	1.00
819_I	833_I	2.917	1.00
28_E	865_K	2.914	1.00
500_L	505_A	2.889	1.00
44_Q	810_R	2.869	1.00
884_Q	919_V	2.844	1.00
840_Y	877_A	2.805	1.00
260_K	471_D	2.794	1.00
374_G	437_F	2.724	1.00
174_F	201_D	2.722	1.00
128_L	314_L	2.697	1.00
894_D	914_P	2.684	1.00
639_A	674_F	2.651	0.99
35_A	44_Q	2.645	0.99
36_Q	40_A	2.637	0.99
883_D	887_A	2.617	0.99
126_A	346_S	2.606	0.99
230_T	256_T	2.588	0.99
70_E	771_R	2.586	0.99
412_L	436_L	2.579	0.99
890_W	896_P	2.531	0.99
677_Q	729_H	2.529	0.99
794_S	797_Q	2.524	0.99
278_G	761_S	2.520	0.99
416_I	419_A	2.507	0.99
693_S	696_F	2.498	0.99
480_N	483_H	2.493	0.99
636_R	666_E	2.486	0.99
179_V	184_L	2.484	0.99
99_L	523_I	2.476	0.99
90_T	423_T	2.474	0.99
411_N	541_Q	2.460	0.99
349_A	474_L	2.451	0.99
884_Q	889_V	2.441	0.99
487_E	864_S	2.431	0.99
173_F	216_L	2.414	0.99
533_L	542_A	2.407	0.99
94_L	344_I	2.398	0.99
711_C	773_M	2.396	0.99
831_L	939_D	2.383	0.99
381_K	394_E	2.359	0.99
339_V	343_N	2.355	0.99
253_V	473_I	2.326	0.99
555_W	771_R	2.323	0.99
38_L	783_Q	2.322	0.99
413_R	421_G	2.318	0.99
891_P	898_V	2.316	0.99
792_I	872_I	2.309	0.99
368_T	391_L	2.281	0.98
537_C	542_A	2.274	0.98
795_R	873_D	2.263	0.98
172_R	197_E	2.237	0.98
309_A	935_K	2.225	0.98
899_N	913_H	2.224	0.98
406_E	540_E	2.218	0.98
680_L	699_A	2.213	0.98
563_D	731_A	2.207	0.98
596_D	618_Q	2.202	0.98
96_P	520_A	2.199	0.98
830_E	847_M	2.198	0.98
880_A	883_D	2.197	0.98
291_D	294_K	2.196	0.98
895_N	898_V	2.181	0.98
35_A	810_R	2.173	0.98
891_P	895_N	2.170	0.98
233_I	243_V	2.169	0.98
368_T	424_L	2.138	0.98
91_A	532_E	2.132	0.98
596_D	645_N	2.131	0.98
43_G	51_Q	2.108	0.97
358_K	473_I	2.105	0.97
81_F	409_E	2.089	0.97
302_I	316_M	2.086	0.97
930_Y	933_T	2.077	0.97
640_E	643_G	2.073	0.97
161_A	244_S	2.072	0.97
215_V	236_L	2.054	0.97
894_D	912_A	2.044	0.97
84_Y	432_N	2.033	0.97
40_A	44_Q	2.027	0.97
562_Y	702_S	2.010	0.96
547_Q	551_Q	2.009	0.96
82_T	432_N	2.004	0.96
906_E	935_K	2.004	0.96
378_K	441_L	2.002	0.96
42_T	783_Q	1.992	0.96
367_L	433_V	1.989	0.96
410_I	439_V	1.967	0.96
256_T	260_K	1.953	0.96
795_R	872_I	1.935	0.96
249_I	270_A	1.930	0.96
636_R	670_V	1.929	0.96
257_A	260_K	1.928	0.96
906_E	913_H	1.927	0.96
639_A	646_L	1.920	0.95
87_M	739_V	1.913	0.95
630_I	667_V	1.912	0.95
184_L	200_V	1.912	0.95
402_L	414_S	1.907	0.95
185_D	751_A	1.905	0.95
97_V	488_M	1.895	0.95
520_A	772_M	1.888	0.95
234_S	237_K	1.881	0.95
587_H	592_E	1.854	0.94
773_M	781_A	1.841	0.94
226_I	255_L	1.837	0.94
247_A	270_A	1.837	0.94
90_T	180_H	1.827	0.94
371_L	391_L	1.823	0.94
649_I	667_V	1.821	0.94
916_S	919_V	1.821	0.94
309_A	906_E	1.820	0.94
178_D	223_T	1.817	0.94
825_E	886_K	1.814	0.94
234_S	238_S	1.808	0.94
39_N	783_Q	1.805	0.94
464_Q	467_M	1.802	0.94
158_M	173_F	1.802	0.94
344_I	525_I	1.801	0.94
594_H	645_N	1.798	0.93
257_A	471_D	1.796	0.93
22_D	25_Q	1.795	0.93
780_K	783_Q	1.795	0.93
128_L	304_V	1.785	0.93
662_E	807_R	1.779	0.93
279_Y	546_Q	1.772	0.93
62_A	70_E	1.770	0.93
176_A	203_A	1.768	0.93
736_G	748_R	1.762	0.93
395_V	399_A	1.753	0.93
518_A	521_E	1.752	0.93
72_K	529_E	1.749	0.92
688_Q	692_T	1.748	0.92
91_A	425_D	1.739	0.92
179_V	216_L	1.738	0.92
70_E	551_Q	1.738	0.92
896_P	919_V	1.729	0.92
565_V	725_G	1.726	0.92
768_M	772_M	1.721	0.92
90_T	425_D	1.719	0.92
520_A	768_M	1.719	0.92
879_R	883_D	1.714	0.92
563_D	728_A	1.713	0.92
217_L	243_V	1.707	0.92
632_L	663_T	1.707	0.92
371_L	422_I	1.697	0.91
77_R	543_E	1.693	0.91
795_R	876_L	1.687	0.91
82_T	435_Q	1.687	0.91
891_P	914_P	1.684	0.91
424_L	428_T	1.677	0.91
685_M	704_L	1.677	0.91
173_F	214_G	1.674	0.91
245_V	261_Q	1.672	0.91
244_S	267_F	1.667	0.91
308_A	935_K	1.665	0.90
872_I	876_L	1.663	0.90
161_A	265_I	1.651	0.90
277_M	533_L	1.648	0.90
126_A	347_L	1.635	0.90
136_D	476_H	1.633	0.90
391_L	422_I	1.630	0.90
363_R	367_L	1.620	0.89
598_C	648_C	1.614	0.89
236_L	243_V	1.610	0.89
826_T	886_K	1.608	0.89
680_L	697_I	1.604	0.89
84_Y	410_I	1.604	0.89
247_A	251_A	1.596	0.88
42_T	786_I	1.589	0.88
542_A	546_Q	1.588	0.88
493_H	497_R	1.587	0.88
289_A	293_Y	1.581	0.88
531_A	761_S	1.578	0.88
642_A	645_N	1.576	0.88
879_R	886_K	1.576	0.88
96_P	99_L	1.573	0.88
230_T	261_Q	1.568	0.88
172_R	199_I	1.560	0.87
496_E	503_N	1.553	0.87
590_R	733_F	1.551	0.87
311_N	905_S	1.545	0.87
793_A	802_V	1.540	0.87
362_N	473_I	1.536	0.86
135_L	141_D	1.530	0.86
129_N	346_S	1.525	0.86
828_I	885_V	1.521	0.86
214_G	244_S	1.521	0.86
230_T	234_S	1.514	0.86
79_K	540_E	1.513	0.86
802_V	817_L	1.512	0.86
497_R	504_Q	1.511	0.86
493_H	496_E	1.507	0.85
103_L	525_I	1.503	0.85
91_A	427_T	1.500	0.85
670_V	674_F	1.493	0.85
154_A	216_L	1.482	0.84
884_Q	890_W	1.480	0.84
346_S	350_V	1.478	0.84
602_A	621_V	1.477	0.84
738_S	751_A	1.476	0.84
536_F	737_H	1.472	0.84
797_Q	805_T	1.471	0.84
107_G	496_E	1.470	0.84
737_H	756_P	1.464	0.84
75_A	530_F	1.464	0.84
103_L	526_T	1.463	0.84
634_D	638_K	1.462	0.84
895_N	913_H	1.456	0.83
632_L	667_V	1.455	0.83
275_V	341_L	1.447	0.83
68_L	527_W	1.444	0.83
895_N	899_N	1.431	0.82
588_E	593_G	1.421	0.82
355_V	483_H	1.421	0.82
660_Y	786_I	1.421	0.82
215_V	232_L	1.411	0.81
884_Q	896_P	1.409	0.81
549_I	567_M	1.407	0.81
249_I	253_V	1.406	0.81
183_T	246_A	1.405	0.81
380_L	393_V	1.402	0.81
84_Y	424_L	1.400	0.81
62_A	771_R	1.396	0.81
562_Y	699_A	1.395	0.81
539_P	757_F	1.382	0.80
51_Q	779_K	1.380	0.80
415_D	421_G	1.379	0.80
354_P	480_N	1.376	0.80
347_L	492_M	1.373	0.79
179_V	218_Q	1.370	0.79
219_Q	255_L	1.366	0.79
908_V	918_E	1.361	0.79
677_Q	727_K	1.358	0.79
727_K	731_A	1.357	0.79
79_K	409_E	1.355	0.79
711_C	762_I	1.352	0.78
57_Q	558_K	1.351	0.78
551_Q	767_W	1.351	0.78
175_V	187_V	1.343	0.78
907_L	921_V	1.340	0.78
879_R	882_I	1.337	0.78
45_I	810_R	1.335	0.78
91_A	277_M	1.335	0.78
158_M	216_L	1.334	0.77
59_G	771_R	1.333	0.77
368_T	423_T	1.332	0.77
192_E	588_E	1.329	0.77
83_S	277_M	1.327	0.77
788_N	865_K	1.323	0.77
549_I	757_F	1.315	0.76
178_D	221_G	1.314	0.76
159_A	196_F	1.312	0.76
383_R	419_A	1.303	0.76
472_E	475_T	1.299	0.76
26_Q	784_V	1.290	0.75
618_Q	645_N	1.289	0.75
736_G	745_M	1.287	0.75
393_V	440_L	1.286	0.75
93_Q	427_T	1.285	0.75
59_G	555_W	1.283	0.75
500_L	930_Y	1.279	0.74
632_L	670_V	1.278	0.74
550_A	553_A	1.276	0.74
892_L	895_N	1.273	0.74
187_V	216_L	1.271	0.74
89_Y	152_T	1.264	0.73
133_V	273_F	1.261	0.73
21_P	484_S	1.260	0.73
35_A	40_A	1.259	0.73
102_M	492_M	1.254	0.73
365_H	387_Y	1.252	0.73
602_A	624_C	1.252	0.73
542_A	757_F	1.247	0.72
728_A	731_A	1.245	0.72
375_L	440_L	1.241	0.72
189_T	750_G	1.240	0.72
161_A	173_F	1.240	0.72
233_I	245_V	1.238	0.72
72_K	76_S	1.236	0.72
408_A	438_N	1.234	0.72
865_K	869_D	1.233	0.72
38_L	784_V	1.230	0.71
250_M	253_V	1.230	0.71
111_A	339_V	1.225	0.71
688_Q	697_I	1.221	0.71
463_I	468_L	1.217	0.71
953_I	956_Y	1.217	0.71
680_L	688_Q	1.216	0.71
726_V	734_V	1.215	0.70
488_M	492_M	1.207	0.70
229_Y	261_Q	1.204	0.70
822_L	826_T	1.203	0.70
838_I	932_P	1.203	0.70
398_K	418_N	1.203	0.70
551_Q	771_R	1.202	0.70
256_T	261_Q	1.201	0.70
478_V	482_Y	1.199	0.69
396_A	399_A	1.199	0.69
811_V	815_C	1.198	0.69
177_S	202_D	1.197	0.69
249_I	286_F	1.197	0.69
74_I	547_Q	1.196	0.69
397_D	418_N	1.188	0.69
582_A	749_Q	1.187	0.69
267_F	287_F	1.184	0.68
257_A	261_Q	1.183	0.68
692_T	697_I	1.182	0.68
546_Q	550_A	1.180	0.68
562_Y	680_L	1.179	0.68
913_H	920_A	1.179	0.68
256_T	471_D	1.177	0.68
952_P	955_E	1.176	0.68
269_S	286_F	1.176	0.68
597_I	645_N	1.174	0.68
828_I	898_V	1.173	0.68
384_H	391_L	1.173	0.68
62_A	772_M	1.170	0.67
306_K	941_Y	1.169	0.67
401_V	420_V	1.167	0.67
497_R	501_A	1.162	0.67
96_P	519_A	1.160	0.67
228_D	466_A	1.158	0.67
405_A	412_L	1.156	0.67
261_Q	266_V	1.155	0.66
92_V	277_M	1.154	0.66
543_E	546_Q	1.153	0.66
873_D	876_L	1.149	0.66
521_E	711_C	1.145	0.66
217_L	233_I	1.144	0.66
218_Q	246_A	1.142	0.66
90_T	249_I	1.141	0.66
152_T	753_S	1.140	0.65
695_G	704_L	1.138	0.65
895_N	914_P	1.135	0.65
175_V	179_V	1.133	0.65
42_T	691_I	1.133	0.65
67_A	520_A	1.131	0.65
279_Y	740_V	1.131	0.65
501_A	504_Q	1.131	0.65
126_A	343_N	1.129	0.65
792_I	876_L	1.127	0.65
394_E	418_N	1.125	0.64
536_F	756_P	1.124	0.64
392_C	419_A	1.123	0.64
871_F	875_M	1.122	0.64
797_Q	802_V	1.119	0.64
585_H	588_E	1.117	0.64
56_P	558_K	1.116	0.64
161_A	242_V	1.115	0.64
347_L	350_V	1.109	0.63
902_H	915_Y	1.109	0.63
132_Q	135_L	1.107	0.63
759_S	762_I	1.107	0.63
562_Y	649_I	1.106	0.63
71_L	527_W	1.105	0.63
741_Q	744_G	1.104	0.63
549_I	721_M	1.103	0.63
107_G	493_H	1.103	0.63
692_T	696_F	1.100	0.63
551_Q	555_W	1.094	0.62
117_P	847_M	1.093	0.62
61_P	776_E	1.092	0.62
890_W	919_V	1.092	0.62
139_G	257_A	1.091	0.62
41_L	45_I	1.090	0.62
665_R	669_E	1.089	0.62
107_G	503_N	1.088	0.62
468_L	471_D	1.088	0.62
525_I	531_A	1.086	0.62
358_K	362_N	1.085	0.62
505_A	508_P	1.083	0.61
504_Q	930_Y	1.082	0.61
621_V	953_I	1.081	0.61
904_Q	922_F	1.078	0.61
76_S	529_E	1.076	0.61
97_V	489_M	1.073	0.61
102_M	343_N	1.070	0.60
402_L	406_E	1.070	0.60
549_I	763_L	1.066	0.60
192_E	584_R	1.063	0.60
365_H	462_S	1.062	0.60
525_I	764_P	1.060	0.60
371_L	428_T	1.060	0.60
892_L	898_V	1.058	0.60
817_L	855_L	1.054	0.59
185_D	188_R	1.054	0.59
174_F	232_L	1.052	0.59
584_R	588_E	1.051	0.59
374_G	433_V	1.049	0.59
847_M	855_L	1.049	0.59
355_V	480_N	1.046	0.59
56_P	559_L	1.045	0.59
391_L	424_L	1.044	0.58
383_R	394_E	1.041	0.58
617_M	648_C	1.041	0.58
237_K	243_V	1.036	0.58
562_Y	695_G	1.034	0.58
539_P	546_Q	1.031	0.58
736_G	741_Q	1.031	0.58
794_S	810_R	1.030	0.57
371_L	433_V	1.029	0.57
65_Y	93_Q	1.028	0.57
391_L	421_G	1.027	0.57
94_L	99_L	1.026	0.57
133_V	270_A	1.024	0.57
13_A	16_E	1.024	0.57
204_Q	227_H	1.022	0.57
87_M	180_H	1.018	0.57
160_M	289_A	1.018	0.57
799_A	879_R	1.016	0.56
81_F	406_E	1.013	0.56
141_D	292_E	1.013	0.56
633_T	636_R	1.013	0.56
167_L	170_A	1.012	0.56
822_L	879_R	1.012	0.56
371_L	375_L	1.011	0.56
657_H	804_Y	1.008	0.56
557_V	565_V	1.006	0.56
587_H	647_S	1.004	0.55
585_H	749_Q	1.004	0.55
372_A	382_L	1.001	0.55
202_D	205_K	1.001	0.55
521_E	773_M	1.000	0.55
905_S	922_F	0.999	0.55
640_E	674_F	0.999	0.55
412_L	421_G	0.998	0.55
913_H	935_K	0.998	0.55
279_Y	539_P	0.998	0.55
247_A	266_V	0.995	0.55
154_A	183_T	0.991	0.54
497_R	503_N	0.991	0.54
493_H	504_Q	0.988	0.54
63_T	66_A	0.986	0.54
184_L	187_V	0.984	0.54
378_K	442_G	0.979	0.54
883_D	889_V	0.979	0.54
401_V	436_L	0.978	0.54
163_R	702_S	0.977	0.53
375_L	393_V	0.977	0.53
184_L	188_R	0.973	0.53
613_H	619_V	0.972	0.53
476_H	951_V	0.972	0.53
52_L	696_F	0.972	0.53
253_V	471_D	0.968	0.53
369_D	387_Y	0.968	0.53
494_S	498_K	0.964	0.52
176_A	221_G	0.963	0.52
392_C	421_G	0.960	0.52
890_W	895_N	0.960	0.52
586_Y	590_R	0.959	0.52
257_A	266_V	0.958	0.52
826_T	885_V	0.953	0.52
533_L	545_Y	0.952	0.52
505_A	926_V	0.951	0.51
70_E	767_W	0.948	0.51
553_A	573_A	0.947	0.51
624_C	629_N	0.946	0.51
821_P	825_E	0.946	0.51
711_C	781_A	0.946	0.51
486_T	489_M	0.945	0.51
133_V	269_S	0.943	0.51
52_L	56_P	0.943	0.51
410_I	435_Q	0.940	0.51
233_I	257_A	0.938	0.50
894_D	899_N	0.932	0.50
164_V	293_Y	0.932	0.50
401_V	440_L	0.931	0.50
646_L	674_F	0.928	0.50
111_A	501_A	0.926	0.50
376_Q	381_K	0.925	0.49
582_A	724_I	0.925	0.49
885_V	890_W	0.925	0.49
179_V	200_V	0.922	0.49
559_L	770_I	0.919	0.49
740_V	757_F	0.918	0.49
636_R	640_E	0.911	0.48
876_L	880_A	0.911	0.48
160_M	265_I	0.910	0.48
798_D	801_P	0.910	0.48
111_A	343_N	0.909	0.48
144_S	288_A	0.909	0.48
174_F	199_I	0.908	0.48
548_M	764_P	0.908	0.48
287_F	297_M	0.906	0.48
134_T	144_S	0.906	0.48
408_A	435_Q	0.905	0.48
229_Y	233_I	0.903	0.48
380_L	440_L	0.903	0.48
505_A	924_A	0.900	0.48
23_A	26_Q	0.900	0.48
217_L	245_V	0.897	0.47
222_T	413_R	0.896	0.47
160_M	164_V	0.896	0.47
539_P	542_A	0.895	0.47
341_L	344_I	0.894	0.47
175_V	184_L	0.893	0.47
58_V	558_K	0.893	0.47
825_E	883_D	0.890	0.47
267_F	343_N	0.888	0.47
481_R	866_V	0.885	0.46
350_V	478_V	0.882	0.46
820_R	854_T	0.882	0.46
368_T	387_Y	0.882	0.46
75_A	548_M	0.882	0.46
158_M	214_G	0.880	0.46
172_R	211_D	0.878	0.46
87_M	413_R	0.878	0.46
308_A	906_E	0.877	0.46
96_P	523_I	0.876	0.46
482_Y	864_S	0.875	0.46
263_A	305_S	0.875	0.46
314_L	956_Y	0.873	0.45
80_R	533_L	0.872	0.45
691_I	783_Q	0.872	0.45
424_L	433_V	0.867	0.45
96_P	489_M	0.867	0.45
574_Q	753_S	0.864	0.45
831_L	847_M	0.863	0.45
380_L	401_V	0.863	0.45
38_L	787_L	0.862	0.45
909_A	921_V	0.860	0.44
504_Q	933_T	0.860	0.44
176_A	685_M	0.859	0.44
519_A	526_T	0.858	0.44
799_A	880_A	0.856	0.44
441_L	446_G	0.854	0.44
526_T	711_C	0.853	0.44
129_N	491_Y	0.853	0.44
494_S	927_A	0.852	0.44
173_F	244_S	0.849	0.44
21_P	784_V	0.849	0.44
820_R	853_G	0.849	0.44
52_L	693_S	0.847	0.43
526_T	773_M	0.847	0.43
566_C	734_V	0.846	0.43
699_A	702_S	0.844	0.43
80_R	83_S	0.844	0.43
75_A	529_E	0.844	0.43
231_A	234_S	0.843	0.43
26_Q	780_K	0.842	0.43
437_F	442_G	0.842	0.43
951_V	955_E	0.841	0.43
594_H	642_A	0.841	0.43
665_R	696_F	0.840	0.43
70_E	73_A	0.839	0.43
60_A	776_E	0.836	0.43
368_T	384_H	0.835	0.43
221_G	227_H	0.835	0.43
519_A	711_C	0.833	0.42
581_L	752_V	0.832	0.42
371_L	436_L	0.832	0.42
174_F	215_V	0.831	0.42
237_K	242_V	0.831	0.42
354_P	483_H	0.830	0.42
141_D	290_K	0.830	0.42
14_F	18_H	0.829	0.42
489_M	522_M	0.829	0.42
341_L	759_S	0.825	0.42
84_Y	439_V	0.823	0.42
203_A	232_L	0.820	0.41
275_V	344_I	0.819	0.41
243_V	261_Q	0.816	0.41
87_M	222_T	0.816	0.41
644_D	674_F	0.814	0.41
410_I	432_N	0.814	0.41
84_Y	428_T	0.814	0.41
560_T	704_L	0.813	0.41
96_P	351_Y	0.813	0.41
55_P	779_K	0.812	0.41
21_P	25_Q	0.812	0.41
693_S	697_I	0.811	0.41
801_P	821_P	0.811	0.41
792_I	815_C	0.810	0.41
44_Q	808_D	0.809	0.41
297_M	301_I	0.809	0.41
602_A	804_Y	0.807	0.40
370_I	430_R	0.807	0.40
67_A	767_W	0.806	0.40
49_D	665_R	0.806	0.40
27_Q	31_N	0.804	0.40
376_Q	385_A	0.803	0.40
107_G	497_R	0.801	0.40
305_S	937_L	0.801	0.40
391_L	423_T	0.800	0.40
788_N	792_I	0.799	0.40
103_L	344_I	0.799	0.40
909_A	918_E	0.798	0.40
737_H	771_R	0.797	0.40
617_M	647_S	0.796	0.40
793_A	811_V	0.795	0.40
833_I	847_M	0.794	0.40
87_M	421_G	0.792	0.39
151_A	186_V	0.792	0.39
908_V	921_V	0.792	0.39
97_V	519_A	0.791	0.39
372_A	387_Y	0.791	0.39
275_V	345_A	0.790	0.39
663_T	666_E	0.790	0.39
117_P	486_T	0.789	0.39
187_V	193_T	0.789	0.39
14_F	17_R	0.788	0.39
229_Y	243_V	0.788	0.39
436_L	439_V	0.786	0.39
74_I	548_M	0.785	0.39
415_D	418_N	0.785	0.39
387_Y	391_L	0.785	0.39
582_A	585_H	0.784	0.39
899_N	920_A	0.783	0.39
185_D	737_H	0.782	0.39
277_M	425_D	0.781	0.39
22_D	26_Q	0.781	0.39
269_S	285_A	0.781	0.39
351_Y	483_H	0.781	0.39
134_T	251_A	0.780	0.39
137_L	253_V	0.779	0.38
554_D	558_K	0.779	0.38
373_A	376_Q	0.779	0.38
736_G	744_G	0.778	0.38
219_Q	252_L	0.775	0.38
441_L	445_H	0.774	0.38
41_L	944_R	0.772	0.38
542_A	740_V	0.772	0.38
70_E	74_I	0.771	0.38
25_Q	28_E	0.770	0.38
589_S	592_E	0.770	0.38
202_D	206_V	0.769	0.38
643_G	646_L	0.769	0.38
822_L	882_I	0.769	0.38
891_P	899_N	0.769	0.38
23_A	780_K	0.769	0.38
316_M	830_E	0.768	0.38
602_A	849_F	0.768	0.38
233_I	263_A	0.767	0.38
226_I	463_I	0.765	0.37
634_D	637_A	0.764	0.37
775_A	779_K	0.764	0.37
476_H	952_P	0.763	0.37
68_L	520_A	0.763	0.37
99_L	103_L	0.762	0.37
685_M	695_G	0.761	0.37
249_I	269_S	0.761	0.37
176_A	227_H	0.761	0.37
829_S	898_V	0.760	0.37
40_A	43_G	0.760	0.37
680_L	702_S	0.759	0.37
641_Q	645_N	0.759	0.37
402_L	412_L	0.759	0.37
245_V	266_V	0.758	0.37
640_E	673_Q	0.757	0.37
126_A	339_V	0.754	0.37
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803_L	820_R	0.754	0.37
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408_A	439_V	0.754	0.37
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629_N	657_H	0.754	0.37
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301_I	316_M	0.753	0.37
252_L	258_P	0.753	0.37
135_L	140_L	0.752	0.36
180_H	221_G	0.751	0.36
21_P	788_N	0.750	0.36
105_N	519_A	0.750	0.36
431_E	435_Q	0.748	0.36
780_K	784_V	0.747	0.36
893_E	898_V	0.747	0.36
29_M	787_L	0.747	0.36
562_Y	704_L	0.746	0.36
392_C	415_D	0.745	0.36
582_A	847_M	0.744	0.36
558_K	693_S	0.744	0.36
386_H	464_Q	0.743	0.36
217_L	229_Y	0.742	0.36
947_F	951_V	0.741	0.36
711_C	764_P	0.741	0.36
179_V	872_I	0.740	0.36
906_E	921_V	0.740	0.36
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422_I	436_L	0.740	0.36
132_Q	830_E	0.739	0.36
69_A	93_Q	0.738	0.35
414_S	417_L	0.737	0.35
245_V	263_A	0.737	0.35
317_A	946_L	0.737	0.35
498_K	922_F	0.737	0.35
566_C	724_I	0.736	0.35
494_S	928_D	0.736	0.35
126_A	350_V	0.735	0.35
143_A	288_A	0.734	0.35
639_A	643_G	0.733	0.35
302_I	697_I	0.733	0.35
633_T	637_A	0.732	0.35
823_K	829_S	0.732	0.35
404_R	407_A	0.731	0.35
249_I	473_I	0.731	0.35
822_L	825_E	0.730	0.35
882_I	886_K	0.730	0.35
89_Y	755_A	0.724	0.35
179_V	187_V	0.723	0.34
873_D	926_V	0.722	0.34
834_A	848_S	0.722	0.34
873_D	877_A	0.722	0.34
193_T	196_F	0.721	0.34
532_E	761_S	0.720	0.34
163_R	562_Y	0.720	0.34
792_I	838_I	0.720	0.34
533_L	537_C	0.718	0.34
162_K	196_F	0.718	0.34
62_A	67_A	0.715	0.34
256_T	470_D	0.715	0.34
140_L	288_A	0.715	0.34
179_V	222_T	0.715	0.34
406_E	541_Q	0.714	0.34
623_A	634_D	0.714	0.34
302_I	830_E	0.714	0.34
367_L	428_T	0.713	0.34
375_L	391_L	0.713	0.34
370_I	437_F	0.713	0.34
401_V	439_V	0.712	0.34
559_L	689_V	0.710	0.34
38_L	42_T	0.710	0.34
143_A	287_F	0.710	0.34
17_R	20_G	0.710	0.34
523_I	526_T	0.709	0.33
61_P	775_A	0.709	0.33
498_K	928_D	0.708	0.33
90_T	277_M	0.705	0.33
633_T	640_E	0.704	0.33
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369_D	462_S	0.704	0.33
378_K	446_G	0.704	0.33
139_G	471_D	0.703	0.33
524_P	768_M	0.703	0.33
404_R	442_G	0.703	0.33
553_A	757_F	0.703	0.33
347_L	519_A	0.703	0.33
45_I	721_M	0.702	0.33
73_A	286_F	0.701	0.33
244_S	571_S	0.699	0.33
187_V	750_G	0.699	0.33
74_I	767_W	0.698	0.33
588_E	592_E	0.698	0.33
130_F	270_A	0.697	0.33
132_Q	316_M	0.697	0.33
161_A	339_V	0.697	0.33
43_G	48_K	0.696	0.33
221_G	225_E	0.696	0.33
402_L	420_V	0.695	0.33
559_L	693_S	0.695	0.33
154_A	158_M	0.695	0.33
193_T	213_F	0.694	0.32
290_K	533_L	0.693	0.32
87_M	181_P	0.693	0.32
46_V	691_I	0.692	0.32
347_L	423_T	0.692	0.32
33_V	794_S	0.691	0.32
486_T	502_L	0.691	0.32
119_V	500_L	0.691	0.32
663_T	667_V	0.691	0.32
800_F	880_A	0.691	0.32
164_V	296_S	0.690	0.32
380_L	441_L	0.690	0.32
213_F	339_V	0.690	0.32
696_F	727_K	0.688	0.32
314_L	317_A	0.687	0.32
223_T	415_D	0.686	0.32
162_K	171_N	0.685	0.32
70_E	547_Q	0.685	0.32
559_L	680_L	0.685	0.32
160_M	337_S	0.685	0.32
905_S	927_A	0.684	0.32
941_Y	947_F	0.684	0.32
341_L	762_I	0.684	0.32
147_L	287_F	0.684	0.32
147_L	680_L	0.684	0.32
301_I	721_M	0.683	0.32
496_E	504_Q	0.683	0.32
85_I	411_N	0.683	0.32
482_Y	487_E	0.681	0.32
216_L	244_S	0.681	0.32
132_Q	302_I	0.680	0.32
947_F	952_P	0.679	0.31
188_R	200_V	0.679	0.31
493_H	503_N	0.679	0.31
630_I	885_V	0.678	0.31
646_L	670_V	0.676	0.31
632_L	636_R	0.676	0.31
784_V	788_N	0.675	0.31
120_S	930_Y	0.675	0.31
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434_M	438_N	0.674	0.31
637_A	640_E	0.673	0.31
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543_E	547_Q	0.672	0.31
226_I	946_L	0.672	0.31
59_G	558_K	0.671	0.31
592_E	733_F	0.671	0.31
577_Y	752_V	0.670	0.31
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904_Q	908_V	0.670	0.31
630_I	806_G	0.670	0.31
158_M	191_A	0.669	0.31
736_G	743_E	0.669	0.31
632_L	649_I	0.668	0.31
201_D	205_K	0.668	0.31
197_E	211_D	0.667	0.31
503_N	930_Y	0.667	0.31
237_K	241_I	0.666	0.31
245_V	463_I	0.666	0.31
165_S	169_N	0.665	0.31
98_I	351_Y	0.665	0.31
374_G	378_K	0.665	0.31
83_S	91_A	0.665	0.31
75_A	526_T	0.664	0.30
884_Q	887_A	0.664	0.30
668_C	697_I	0.663	0.30
899_N	912_A	0.662	0.30
597_I	617_M	0.662	0.30
826_T	849_F	0.662	0.30
285_A	345_A	0.662	0.30
367_L	424_L	0.661	0.30
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736_G	750_G	0.660	0.30
225_E	385_A	0.659	0.30
664_I	699_A	0.658	0.30
711_C	886_K	0.658	0.30
396_A	418_N	0.658	0.30
26_Q	32_A	0.658	0.30
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253_V	301_I	0.658	0.30
210_Q	239_R	0.657	0.30
279_Y	537_C	0.656	0.30
219_Q	261_Q	0.656	0.30
643_G	673_Q	0.656	0.30
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500_L	786_I	0.655	0.30
688_Q	933_T	0.655	0.30
120_S	503_N	0.654	0.30
545_Y	762_I	0.654	0.30
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152_T	614_M	0.653	0.30
907_L	916_S	0.652	0.30
657_H	661_E	0.652	0.30
141_D	289_A	0.652	0.30
178_D	225_E	0.651	0.30
454_K	457_A	0.650	0.30
302_I	692_T	0.650	0.30
217_L	226_I	0.649	0.30
873_D	924_A	0.649	0.30
439_V	828_I	0.649	0.30
35_A	41_L	0.649	0.30
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562_Y	727_K	0.647	0.29
571_S	711_C	0.647	0.29
952_P	956_Y	0.646	0.29
825_E	879_R	0.644	0.29
598_C	767_W	0.644	0.29
302_I	937_L	0.644	0.29
496_E	505_A	0.643	0.29
486_T	864_S	0.642	0.29
172_R	212_V	0.642	0.29
344_I	762_I	0.642	0.29
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237_K	261_Q	0.641	0.29
562_Y	930_Y	0.641	0.29
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211_D	239_R	0.640	0.29
468_L	473_I	0.640	0.29
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111_A	930_Y	0.640	0.29
489_M	711_C	0.640	0.29
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649_I	657_H	0.632	0.28
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275_V	759_S	0.507	0.21
170_A	210_Q	0.507	0.21
657_H	803_L	0.506	0.21
635_L	840_Y	0.506	0.21
547_Q	767_W	0.506	0.21
25_Q	865_K	0.506	0.21
624_C	651_V	0.506	0.21
619_V	950_C	0.506	0.21
497_R	702_S	0.505	0.21
838_I	933_T	0.505	0.21
259_G	266_V	0.505	0.21
254_L	362_N	0.505	0.21
463_I	757_F	0.505	0.21
500_L	924_A	0.505	0.21
46_V	170_A	0.505	0.21
94_L	275_V	0.504	0.21
141_D	174_F	0.504	0.21
32_A	35_A	0.504	0.21
345_A	350_V	0.504	0.21
134_T	247_A	0.504	0.21
173_F	821_P	0.504	0.21
68_L	526_T	0.503	0.21
819_I	855_L	0.503	0.21
107_G	500_L	0.503	0.21
129_N	478_V	0.503	0.21
523_I	609_P	0.503	0.21
180_H	415_D	0.502	0.21
496_E	501_A	0.502	0.21
380_L	582_A	0.502	0.21
769_Y	782_S	0.502	0.21
526_T	531_A	0.502	0.21
76_S	548_M	0.502	0.21
82_T	409_E	0.502	0.21
117_P	831_L	0.501	0.21
252_L	255_L	0.501	0.21
147_L	269_S	0.501	0.21
553_A	567_M	0.501	0.21
339_V	830_E	0.501	0.21
133_V	349_A	0.500	0.21
635_L	671_V	0.500	0.21
486_T	630_I	0.500	0.21
103_L	489_M	0.500	0.21

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4lhdA	2	0.9843	100	0.546	Contact Map
1wyuA	2	0.4399	100	0.873	Contact Map
1wyuB	2	0.4786	100	0.877	Contact Map
3wcnA	2	0.4127	100	0.921	Contact Map
3mc6A	2	0.3929	100	0.924	Contact Map
3hl2A	3	0.4138	100	0.932	Contact Map
3bc8A	3	0.4054	100	0.935	Contact Map
2z67A	4	0.4117	100	0.946	Contact Map
4w8iA	2	0.3647	100	0.947	Contact Map
2jisA	2	0.4201	99.9	0.951	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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