GREMLIN Database
FLIR - Flagellar biosynthetic protein FliR
UniProt: P33135 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11977
Length: 261 (241)
Sequences: 2426 (1862)
Seq/√Len: 120.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
198_N221_T5.4141.00
21_L74_A5.1671.00
152_D155_H5.0691.00
25_A78_I4.9041.00
95_V133_A4.1811.00
40_K43_K3.3331.00
106_M225_G3.2561.00
115_D118_S3.1251.00
97_T183_G3.0731.00
54_I151_V3.0571.00
141_N144_L3.0201.00
125_L229_M2.7641.00
148_S152_D2.6601.00
137_F142_G2.6391.00
129_M229_M2.4371.00
197_L224_V2.3311.00
103_G221_T2.2491.00
24_L47_A2.2351.00
16_Y55_A2.2251.00
27_I50_I2.1111.00
18_W73_L2.0851.00
21_L78_I2.0831.00
77_Q154_F1.9761.00
173_T176_G1.9421.00
205_N213_I1.9191.00
23_V50_I1.9001.00
246_E249_N1.8341.00
111_A214_F1.8091.00
92_F137_F1.8031.00
25_A28_S1.7871.00
25_A85_G1.7431.00
141_N148_S1.7381.00
103_G125_L1.7041.00
170_L174_K1.6951.00
29_T82_I1.6881.00
24_L28_S1.6751.00
103_G198_N1.6571.00
174_K178_L1.6221.00
21_L25_A1.5971.00
64_P67_S1.5931.00
211_L216_I1.5921.00
86_F90_F1.5831.00
103_G108_L1.5621.00
31_P189_P1.5551.00
77_Q160_G1.5391.00
223_T227_S1.5021.00
190_L228_L1.4761.00
177_S181_L1.4761.00
106_M135_L1.4651.00
245_S249_N1.4511.00
66_F69_F1.3981.00
219_P222_L1.3861.00
73_L76_Q1.3781.00
193_L197_L1.3401.00
23_V54_I1.3391.00
188_L192_T1.3161.00
102_I125_L1.3101.00
26_L84_L1.2961.00
20_L47_A1.2891.00
58_L61_N1.2891.00
19_P23_V1.2871.00
39_P42_V1.2811.00
137_F146_L1.2701.00
89_Q93_A1.2620.99
76_Q160_G1.2590.99
92_F133_A1.2560.99
108_L222_L1.2520.99
188_L217_G1.2450.99
201_L217_G1.2440.99
212_S215_V1.2390.99
197_L201_L1.2370.99
29_T85_G1.2310.99
106_M194_L1.2170.99
242_H246_E1.2040.99
198_N203_L1.2020.99
48_M52_F1.1960.99
75_V79_L1.1930.99
125_L206_R1.1830.99
27_I43_K1.1660.99
131_M135_L1.1590.99
84_L251_L1.1560.99
28_S82_I1.1560.99
100_E137_F1.1410.99
212_S218_F1.1390.99
104_L133_A1.1350.99
65_V70_A1.1320.99
136_L237_A1.1290.99
110_F114_V1.1210.99
187_A191_I1.1190.99
97_T179_I1.1170.99
12_W15_L1.1010.99
134_L138_L1.0910.99
42_V234_P1.0880.98
84_L153_T1.0880.98
204_L215_V1.0770.98
110_F221_T1.0690.98
193_L228_L1.0650.98
146_L251_L1.0650.98
130_D134_L1.0580.98
20_L51_T1.0580.98
151_V155_H1.0500.98
88_M149_L1.0420.98
24_L44_L1.0420.98
49_M52_F1.0400.98
205_N212_S1.0350.98
184_L187_A1.0230.98
23_V154_F1.0210.98
19_P154_F1.0180.98
23_V47_A1.0150.98
208_A215_V1.0050.97
27_I47_A1.0020.97
115_D121_N1.0000.97
49_M53_A0.9960.97
136_L193_L0.9930.97
101_I147_I0.9880.97
246_E250_L0.9860.97
91_A247_I0.9780.97
99_G129_M0.9720.97
77_Q161_G0.9690.97
171_A175_A0.9690.97
106_M222_L0.9670.97
100_E127_R0.9590.97
96_R130_D0.9550.97
77_Q80_I0.9550.97
118_S196_T0.9550.97
25_A30_A0.9510.96
20_L48_M0.9470.96
103_G176_G0.9460.96
46_L50_I0.9450.96
169_F173_T0.9400.96
125_L129_M0.9390.96
19_P51_T0.9280.96
88_M103_G0.9270.96
25_A29_T0.9250.96
198_N213_I0.9160.96
121_N235_L0.9130.96
101_I105_Q0.9130.96
114_V123_P0.9120.95
18_W159_I0.9080.95
215_V218_F0.9060.95
132_L237_A0.9030.95
103_G106_M0.9010.95
15_L61_N0.8970.95
27_I46_L0.8940.95
16_Y20_L0.8890.95
163_P167_N0.8820.95
93_A96_R0.8800.95
136_L140_F0.8770.94
46_L49_M0.8720.94
35_E109_S0.8680.94
16_Y48_M0.8660.94
114_V119_H0.8610.94
25_A35_E0.8600.94
139_T226_I0.8580.94
166_S169_F0.8550.94
50_I147_I0.8460.93
56_P59_P0.8450.93
140_F241_E0.8420.93
16_Y51_T0.8390.93
200_A203_L0.8380.93
157_L210_Q0.8380.93
32_I138_L0.8310.93
171_A174_K0.8310.93
215_V219_P0.8300.93
32_I233_M0.8250.92
58_L154_F0.8250.92
208_A211_L0.8230.92
77_Q244_F0.8210.92
220_L231_A0.8190.92
30_A186_L0.8080.92
21_L204_L0.8070.92
129_M201_L0.7980.91
25_A47_A0.7940.91
204_L212_S0.7880.91
232_L236_I0.7860.90
141_N230_A0.7850.90
193_L207_M0.7800.90
172_L177_S0.7800.90
137_F140_F0.7800.90
160_G163_P0.7750.90
144_L147_I0.7740.90
53_A57_S0.7720.90
212_S217_G0.7720.90
14_N70_A0.7700.90
109_S123_P0.7650.89
37_S42_V0.7630.89
48_M55_A0.7630.89
105_Q204_L0.7610.89
76_Q159_I0.7610.89
29_T74_A0.7570.89
113_F116_P0.7570.89
63_V78_I0.7560.89
121_N124_V0.7470.88
35_E208_A0.7460.88
63_V73_L0.7450.88
177_S180_F0.7440.88
123_P126_A0.7430.88
122_M206_R0.7400.88
178_L181_L0.7360.87
213_I223_T0.7350.87
201_L210_Q0.7310.87
106_M109_S0.7310.87
128_I204_L0.7290.87
98_A102_I0.7280.87
195_L225_G0.7270.87
18_W154_F0.7270.87
54_I57_S0.7260.87
116_P216_I0.7260.87
100_E109_S0.7250.87
115_D215_V0.7250.87
91_A149_L0.7250.87
20_L206_R0.7230.86
87_T183_G0.7220.86
18_W77_Q0.7180.86
202_G205_N0.7140.86
197_L205_N0.7080.85
35_E240_C0.7050.85
70_A74_A0.7050.85
220_L244_F0.7030.85
67_S71_L0.7010.85
101_I184_L0.7010.85
189_P219_P0.7010.85
23_V150_L0.6980.84
109_S137_F0.6950.84
35_E212_S0.6920.84
19_P54_I0.6910.84
108_L198_N0.6900.84
104_L127_R0.6880.84
117_A128_I0.6870.83
230_A234_P0.6850.83
48_M82_I0.6820.83
174_K177_S0.6810.83
37_S150_L0.6800.83
213_I216_I0.6740.82
97_T100_E0.6700.82
48_M51_T0.6690.82
182_N243_L0.6680.82
24_L143_H0.6640.81
220_L249_N0.6640.81
105_Q210_Q0.6630.81
186_L234_P0.6620.81
166_S170_L0.6600.81
99_G228_L0.6590.81
54_I150_L0.6580.81
42_V47_A0.6570.81
228_L232_L0.6570.81
34_S37_S0.6550.80
172_L233_M0.6520.80
170_L173_T0.6510.80
19_P208_A0.6440.79
123_P183_G0.6440.79
65_V227_S0.6440.79
11_S66_F0.6440.79
19_P55_A0.6410.79
242_H245_S0.6410.79
90_F176_G0.6390.79
114_V183_G0.6390.79
176_G179_I0.6360.79
222_L225_G0.6350.78
164_L168_A0.6340.78
26_L29_T0.6320.78
33_L147_I0.6310.78
204_L208_A0.6280.78
41_R44_L0.6270.78
48_M84_L0.6230.77
106_M127_R0.6210.77
181_L185_M0.6200.77
100_E123_P0.6200.77
110_F216_I0.6190.77
76_Q162_E0.6170.76
88_M186_L0.6170.76
172_L176_G0.6170.76
33_L137_F0.6140.76
121_N178_L0.6120.76
207_M212_S0.6110.76
26_L30_A0.6110.76
178_L182_N0.6070.75
178_L246_E0.6040.75
28_S84_L0.6040.75
42_V46_L0.6020.75
167_N170_L0.6020.75
21_L79_L0.6020.75
11_S15_L0.6010.75
45_G53_A0.5990.74
115_D123_P0.5980.74
88_M248_F0.5970.74
154_F218_F0.5930.74
29_T89_Q0.5920.73
49_M71_L0.5890.73
135_L139_T0.5880.73
115_D212_S0.5880.73
30_A88_M0.5870.73
185_M239_F0.5870.73
88_M182_N0.5870.73
192_T216_I0.5840.72
126_A140_F0.5830.72
50_I58_L0.5820.72
51_T230_A0.5810.72
109_S236_I0.5810.72
188_L205_N0.5790.72
104_L214_F0.5790.72
127_R201_L0.5780.72
142_G248_F0.5770.72
183_G187_A0.5750.71
66_F229_M0.5740.71
138_L143_H0.5730.71
53_A56_P0.5720.71
42_V51_T0.5700.71
50_I53_A0.5690.71
126_A195_L0.5660.70
96_R124_V0.5650.70
117_A131_M0.5570.69
105_Q194_L0.5560.69
60_A162_E0.5560.69
27_I33_L0.5540.68
35_E129_M0.5540.68
192_T205_N0.5520.68
118_S123_P0.5510.68
30_A33_L0.5490.68
150_L153_T0.5480.68
39_P49_M0.5480.68
98_A187_A0.5470.68
18_W70_A0.5470.68
52_F83_A0.5430.67
87_T244_F0.5410.67
205_N211_L0.5410.67
30_A190_L0.5380.66
175_A178_L0.5340.66
235_L238_P0.5330.66
194_L222_L0.5320.65
68_F71_L0.5290.65
210_Q221_T0.5290.65
179_I200_A0.5290.65
56_P95_V0.5260.65
92_F130_D0.5250.64
130_D133_A0.5250.64
79_L82_I0.5240.64
80_I237_A0.5230.64
66_F70_A0.5200.64
36_R48_M0.5190.64
241_E245_S0.5170.63
149_L186_L0.5170.63
116_P212_S0.5160.63
13_L83_A0.5140.63
73_L196_T0.5130.63
147_I151_V0.5130.63
36_R195_L0.5120.62
45_G156_T0.5090.62
106_M192_T0.5080.62
13_L29_T0.5080.62
138_L141_N0.5070.62
152_D240_C0.5070.62
205_N214_F0.5050.61
43_K225_G0.5050.61
216_I239_F0.5040.61
20_L44_L0.5030.61
137_F188_L0.5020.61
125_L247_I0.5020.61
39_P50_I0.5010.61
87_T161_G0.5010.61
19_P91_A0.5010.61
100_E104_L0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lh9A 4 0.092 2.6 0.968 Contact Map
2zy9A 2 0.5211 2.5 0.968 Contact Map
2m0sA 1 0.1073 2.2 0.969 Contact Map
3j00Z 1 0.1264 2.2 0.969 Contact Map
4cbcA 3 0.1839 1.3 0.973 Contact Map
2k59B 1 0.1073 1.1 0.974 Contact Map
2mi2A 1 0.1877 1.1 0.975 Contact Map
2lzrA 1 0.1877 1 0.975 Contact Map
2m20A 2 0.1839 1 0.975 Contact Map
4httA 1 0.5172 1 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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